Contents

Current Topics in Medicinal Chemistry, Volume 12 - Number 15

Editorial [Hot Topic: A New Era of Gene Therapy]

, 12(15): 1593

Jun-ichi Suzuki and Ryuichi Morishita


DOI: 10.2174/156802612803531441




Novel Gene Transfer Systems: Intelligent Gene Transfer Vectors for Gene Medicines

, 12(15): 1594 - 1602

Toshihiro Nakajima


DOI: 10.2174/156802612803531487




Modification of Decoy Oligodeoxynucleotides to Achieve the Stability and Therapeutic Efficacy

, 12(15): 1603 - 1607

Mariana Kiomy Osako, Hironori Nakagami and Ryuichi Morishita


DOI: 10.2174/156802612803531397




Applications of Nucleic Acid Drugs for Organ Transplantation

, 12(15): 1608 - 1612

Jun-ichi Suzuki, Mitsuaki Isobe, Ryuichi Morishita and Ryozo Nagai


DOI: 10.2174/156802612803531478




Nucleic Acid Drugs for Preventing Restenosis after Coronary Revascularization

, 12(15): 1613 - 1620

Takashi Miyake, Hironori Nakagami and Ryuichi Morishita


DOI: 10.2174/156802612803531324




Development of Nucleic Acid Drugs for Neurological Disorders

, 12(15): 1621 - 1629

Munehisa Shimamura, Naoyuki Sato, Hironori Nakagami, Yoshiaki Taniyama and Ryuichi Morishita


DOI: 10.2174/156802612803531405




Therapeutic Option of Plasmid-DNA Based Gene Transfer

, 12(15): 1630 - 1637

Yoshiaki Taniyama, Junya Azuma, Yasuo Kunugiza, Kazuma Iekushi, Hiromi Rakugi and Ryuichi Morishita


DOI: 10.2174/156802612803531342




Editorial [Hot Topic: Targeted Therapy, Targeted Dosing and Targeted Delivery in Oncology: Where Do We Stand?]

, 12(15): 1638

Joseph Ciccolini


DOI: 10.2174/156802612803531379




Can Targeted Therapy be Successful without Metronomic Scheduling ?

, 12(15): 1639 - 1642

Nicolas Andre, Eddy Pasquier and Barton Kamen


DOI: 10.2174/156802612803531432




100% Human Monoclonal Antibodies in Oncology: Hype or Breakthrough?

, 12(15): 1643 - 1648

Stephan Benay, Raphaelle Fanciullino, Cedric Mercier, Athanassios Iliadis, Joseph Ciccolini and Bruno Lacarelle


DOI: 10.2174/156802612803531351




Polymorphisms to Predict Outcome to the Tyrosine Kinase Inhibitors Gefitinib, Erlotinib, Sorafenib and Sunitinib

, 12(15): 1649 - 1659

Lale Erdem, Elisa Giovannetti, Leticia G Leon, Richard Honeywell and Godefridus J. Peters


DOI: 10.2174/156802612803531333




A New Model for Determining the MTD During Phase-I Trials in Pediatric Oncology

, 12(15): 1660 - 1664

C. Faivre, D. Barbolosi and A. Iliadis


DOI: 10.2174/156802612803531469




Optimize Administration Protocol of Capecitabine Plus Docetaxel Combination in Metastatic Breast Cancer Patients

, 12(15): 1665 - 1668

Nicolas Frances, Christian Woloch, Hafedh Marouani, Cedric Mercier and Athanassios Iliadis


DOI: 10.2174/156802612803531306




Progress in Strategies for Dosage Regimen Individualization

, 12(15): 1669 - 1677

Hafedh Marouani, Christian Woloch, Stephan Benay, Nicolas Frances and Athanassios Iliadis


DOI: 10.2174/156802612803531315




Targetting Esophageal and Gastric Cancers with Monoclonal Antibodies

, 12(15): 1678 - 1682

Emmanuelle Norguet, Laetitia Dahan and Jean-Francois Seitz


DOI: 10.2174/156802612803531360




Search for Distinctive Markers in DNT and Cortical Grade II Glioma in Children: Same Clinicopathological and Molecular Entities?

, 12(15): 1683 - 1692

Laetitia Padovani, Carole Colin, Carla Fernandez, Andre Maues de Paula, Sandy Mercurio, Didier Scavarda, Frederic Frassineti, Jose Adelaide, Anderson Loundou, Dominique Intagliata, Corinne Bouvier, Gabriel Lena, Daniel Birnbaum, Nadine Girard and Dominique Figarella-Branger


DOI: 10.2174/156802612803531450




Anticancer Drugs in Liposomal Nanodevices: A Target Delivery for a Targeted Therapy

, 12(15): 1693 - 1712

Giorgia Urbinati, Veronique Marsaud and Jack-Michel Renoir


DOI: 10.2174/156802612803531423




Population Pharmacokinetic Analysis of 5-FU and 5-FDHU in Colorectal Cancer Patients: Search for Biomarkers Associated with Gastro-Intestinal Toxicity

, 12(15): 1713 - 1719

Christian Woloch, Antonello Di Paolo, Hafedh Marouani, Guido Bocci, Joseph Ciccolini, Bruno Lacarelle, Romano Danesi and Athanassios Iliadis


DOI: 10.2174/156802612803531414




Genetic Polymorphisms of Drug Metabolizing Enzymes and Transporters: The Long Way from Bench to Bedside

, 12(15): 1720 - 1729

Alexandre Evrard and Litaty Mbatchi


DOI: 10.2174/156802612803531388




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