Contents

Current Topics in Medicinal Chemistry, Volume 11 - Number 6

Editorial [Hot topic: G-Protein Coupled Receptors: Drug Targets of Key Importance (Guest Editors: Luca Piali and Christoph Boss)]

, 11(6): 608

Luca Piali and Christoph Boss


DOI: 10.2174/1568026611109060608




The Role of Corticotropin-Releasing Hormone in the Pathophysiology of Depression: Therapeutic Implications

, 11(6): 609 - 617

R. Brett Lloyd and Charles B. Nemeroff


DOI: 10.2174/1568026611109060609




EBI2, GPR18, and GPR17 – Three Structurally Related but Biologically Distinct 7TM Receptors

, 11(6): 618 - 628

Kristine Norregaard, Tau Benned-Jensen and Mette Marie Rosenkilde


DOI: 10.2174/1568026611109060618




Novel Anti-Inflammatory-Pro-Resolving Mediators and Their Receptors

, 11(6): 629 - 647

Charles N. Serhan, Sriram Krishnamoorthy, Antonio Recchiuti and Nan Chiang


DOI: 10.2174/1568026611109060629




The Evolution of Histamine H3 Antagonists/Inverse Agonists

, 11(6): 648 - 660

Evan P. Lebois, Carrie K. Jones and Craig W. Lindsley


DOI: 10.2174/1568026611109060648




Molecular Determinants of Selective Agonist and Antagonist Binding to the Histamine H4 Receptor

, 11(6): 661 - 679

Enade P. Istyastono, Chris de Graaf, Iwan J.P. de Esch and Rob Leurs


DOI: 10.2174/1568026611109060661




mGluR5 Negative Allosteric Modulators Overview: A Medicinal Chemistry Approach Towards a Series of Novel Therapeutic Agents

, 11(6): 680 - 695

Jean-Philippe Rocher, Beatrice Bonnet, Christelle Bolea, Robert Lutjens, Emmanuel Le Poul, Sonia Poli, Mark Epping-Jordan, Anne-Sophie Bessis, Bernard Ludwig and Vincent Mutel


DOI: 10.2174/1568026611109060680




Discovery of Dual Orexin Receptor Antagonists (DORAs) for the Treatment of Insomnia

, 11(6): 696 - 725

Paul J. Coleman, Christopher D. Cox and Anthony J. Roecker


DOI: 10.2174/1568026611109060696




Synthetic Sphingosine 1-Phosphate Receptor Modulators - Opportunities and Potential Pitfalls

, 11(6): 726 - 757

Martin H. Bolli, Cyrille Lescop and Oliver Nayler


DOI: 10.2174/1568026611109060726




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