Contents

Current Topics in Medicinal Chemistry, Volume 11 - Number 4

Editorial [Hot topic: Drug Design from the ADME/PK Perspective: Does Chemical Intuition Suffice in Multifaceted Drug Discovery? (Guest Editors: Franco Lombardo & Nigel J. Waters)]

, 11(4): 331 - 333

F. Lombardo and Nigel J. Waters


DOI: 10.2174/156802611794480936




Predicting Clearance in Humans from In Vitro Data

, 11(4): 334 - 339

R. Scott Obach


DOI: 10.2174/156802611794480873




Controversies in Allometric Scaling for Predicting Human Drug Clearance: An Historical Problem and Reflections on What Works and What Does Not

, 11(4): 340 - 350

Huadong Tang and Michael Mayersohn


DOI: 10.2174/156802611794480945




Drug Design Tools - In Silico, In Vitro and In Vivo ADME/PK Prediction and Interpretation: Is PK in Monkey An Essential Part of a Good Human PK Prediction?

, 11(4): 351 - 357

Natilie A. Hosea


DOI: 10.2174/156802611794480954




In-Silico ADME Models: A General Assessment of their Utility in Drug Discovery Applications

, 11(4): 358 - 381

M. Paul Gleeson, Anne Hersey and Supa Hannongbua


DOI: 10.2174/156802611794480927




Assessment of Cytochrome P450 Enzyme Inhibition and Inactivation in Drug Discovery and Development

, 11(4): 382 - 403

David O. Nettleton and Heidi J. Einolf


DOI: 10.2174/156802611794480882




Pharmacodynamic-Pharmacokinetic Integration as a Guide to Medicinal Chemistry

, 11(4): 404 - 418

Johan Gabrielsson, Ola Fjellstrom, Johan Ulander, Michael Rowley and Piet H. Van Der Graaf


DOI: 10.2174/156802611794480864




Strategies and Chemical Design Approaches to Reduce the Potential for Formation of Reactive Metabolic Species

, 11(4): 419 - 449

Upendra A. Argikar, James B. Mangold and Shawn P. Harriman


DOI: 10.2174/156802611794480891




Do We Need to Optimize Plasma Protein and Tissue Binding in Drug Discovery?

, 11(4): 450 - 466

Xingrong Liu, Cuiping Chen and Cornelis E.C.A. Hop


DOI: 10.2174/156802611794480918




Discovery and ADMET: Where Are We Now

, 11(4): 467 - 481

Dennis A. Smith


DOI: 10.2174/156802611794480909




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