Contents

Current Topics in Medicinal Chemistry, Volume 11 - Number 2

Editorial [Hot topic: Applying Induced Fit in Drug Discovery: Square Pegs and Round Holes? (Guest Editors: Francesca Spyrakis, Pietro Cozzini, Aurijit Sarkar and Glen E. Kellogg)]

, 11(2): 131 - 132

Francesca Spyrakis, Pietro Cozzini, Aurijit Sarkar and Glen E. Kellogg


DOI: 10.2174/156802611794863553




Induced Fit Simulations on Nuclear Receptors

, 11(2): 133 - 147

Monika Nocker and Pietro Cozzini


DOI: 10.2174/156802611794863526




Biochemical and Structural Investigations on Kynurenine Aminotransferase II: An Example of Conformation-Driven Species-Specific Inhibition?

, 11(2): 148 - 157

Valentina Casazza, Franca Rossi and Menico Rizzi


DOI: 10.2174/156802611794863599




Ligands Turning Around in the Midst of Protein Conformers: The Origin of Ligand-Protein Mating. A NMR View

, 11(2): 158 - 170

T. A. Pertinhez and A. Spisni


DOI: 10.2174/156802611794863535




Accommodating Protein Flexibility for Structure-Based Drug Design

, 11(2): 171 - 178

Jung-Hsin Lin


DOI: 10.2174/156802611794863580




Accounting for Induced-Fit Effects in Docking: What is Possible and What is Not?

, 11(2): 179 - 191

Christoph A. Sotriffer


DOI: 10.2174/156802611794863544




Protein Flexibility and Ligand Recognition: Challenges for Molecular Modeling

, 11(2): 192 - 210

Francesca Spyrakis, Axel BidonChanal, Xavier Barril and F. Javier Luque


DOI: 10.2174/156802611794863571




Thermal Motions of the E. coli Glucose-Galactose Binding Protein Studied Using Well-Sampled Semi-Atomistic Simulations

, 11(2): 211 - 220

D. J. Cashman, A. B. Mamonov, D. Bhatt and D. M. Zuckerman


DOI: 10.2174/156802611794863607




Melatonin-mitochondria Interplay in Health and Disease

, 11(2): 221 - 240

Dario Acuna Castroviejo, Luis C. Lopez, Germaine Escames, Ana Lopez, Jose A. Garcia and Russel J. Reiter


DOI: 10.2174/156802611794863517




A Closer Look at the High Affinity Benzodiazepine Binding Site on GABAA Receptors

, 11(2): 241 - 246

Erwin Sigel and Benjamin P. Luscher


DOI: 10.2174/156802611794863562




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