Contents

Current Topics in Medicinal Chemistry, Volume 11 - Number 15

Editorial [Hot Topic: Methods for the Successful Application of Chemogenomics to GPCR Drug Design (Guest Editors: Stephen L. Garland & David E. Gloriam)]

, 11(15): 1870 - 1871

Stephen L. Garland and David E. Gloriam


DOI: 10.2174/156802611796391294




A Ligands View of Target Similarity: Chemogenomic Binding Site- Directed Techniques for Drug Discovery

, 11(15): 1872 - 1881

Stephen L. Garland and David E. Gloriam


DOI: 10.2174/156802611796391276




Drug Design of GPCR Ligands Using Physicogenetics and Chemogenomics - Principles and Case Studies

, 11(15): 1882 - 1901

Thomas M. Frimurer and Thomas Hogberg


DOI: 10.2174/156802611796391258




G Protein-Coupled Receptor Transmembrane Binding Pockets and their Applications in GPCR Research and Drug Discovery: A Survey

, 11(15): 1902 - 1924

Nicole A. Kratochwil, Silvia Gatti-McArthur, Marius C. Hoener, Lothar Lindemann, Andreas D. Christ, Luke G. Green, Wolfgang Guba, Rainer E. Martin, Pari Malherbe, Richard H. P. Porter, Jay P. Slack, Marcel Winnig, Henrietta Dehmlow, Uwe Grether, Cornelia Hertel, Robert Narquizian, Constantinos G. Panousis, Sabine Kolczewski and Lucinda Steward


DOI: 10.2174/156802611796391267




Thematic Analysis™ : A Chemogenomic Approach to GPCR Drug Discovery

, 11(15): 1925 - 1943

Roger Crossley, Jacqueline Anne Macritchie and Martin John Slater


DOI: 10.2174/156802611796391302




Chemogenomic Approaches for the Exploration of GPCR Space

, 11(15): 1944 - 1955

Nathanael Weill


DOI: 10.2174/156802611796391212




Cross-Pharmacology Analysis of G Protein-Coupled Receptors

, 11(15): 1956 - 1963

Ferran Brianso, Maria C. Carrascosa, Tudor I. Oprea and Jordi Mestres


DOI: 10.2174/156802611796391285




Chemogenomics Approaches for Receptor Deorphanization and Extensions of the Chemogenomics Concept to Phenotypic Space

, 11(15): 1964 - 1977

Eelke van der Horst, Julio E. Peironcely, Gerard J. P. van Westen, Olaf O. van den Hoven, Warren R. J. D. Galloway, David R. Spring, Joerg K. Wegner, Herman W. T. van Vlijmen, Ad P. IJzerman, John P. Overington and Andreas Bender


DOI: 10.2174/156802611796391230




Quantitative Chemogenomics: Machine-Learning Models of Protein-Ligand Interaction

, 11(15): 1978 - 1993

Claes R. Andersson, Mats G. Gustafsson and Helena Strombergsson


DOI: 10.2174/156802611796391249




Present Perspectives on the Automated Classification of the G-Protein Coupled Receptors (GPCRs) at the Protein Sequence Level

, 11(15): 1994 - 2009

Matthew N. Davies, David E. Gloriam, Andrew Secker, Alex A. Freitas, Jon Timmis and Darren R. Flower


DOI: 10.2174/156802611796391221




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