Contents

Current Topics in Medicinal Chemistry, Volume 11 - Number 12

Editorial [Hot Topic: Opportunities and Potential Challenges for the Treatment of Metabolic Syndrome (Guest Editors: Kak-Shan Shia and Yu-Sheng Chao)]

, 11(12): 1420

Kak-Shan Shia, Yu-Sheng Chao and Yu-Sheng Chao


DOI: 10.2174/156802611795860960




A New Perspective of Cannabinoid 1 Receptor Antagonists: Approaches Toward Peripheral CB1R Blockers without Crossing the Blood-Brain Barrier

, 11(12): 1421 - 1429

Yen-Ku Wu, Ching-Fang Yeh, Tai Wei Ly and Ming-Shiu Hung


DOI: 10.2174/156802611795860997




The Histamine H3 Receptor as a Therapeutic Drug Target for Metabolic Disorders: Status, Challenges and Opportunities

, 11(12): 1430 - 1446

Jean-Marc Plancher


DOI: 10.2174/156802611795860906




Current Advances and Therapeutic Potential of Agents Targeting Dipeptidyl Peptidases-IV, -II, 8/9 and Fibroblast Activation Protein

, 11(12): 1447 - 1463

Shu-Jen Chen and Weir-Torn Jiaang


DOI: 10.2174/156802611795860933




Small Molecule 11β- Hydroxysteroid Dehydrogenase Type 1 Inhibitors

, 11(12): 1464 - 1475

Daqing Sun, Minghan Wang and Zhulun Wang


DOI: 10.2174/156802611795860988




Development of Sodium-Dependent Glucose Co-Transporter 2 Inhibitors as Potential Anti-Diabetic Therapeutics

, 11(12): 1476 - 1512

Low-Tone Ho, Suvarn S. Kulkarni and Jinq-Chyi Lee


DOI: 10.2174/156802611795860915




γ-Secretase Substrates and their Implications for Drug Development in Alzheimer's Disease

, 11(12): 1513 - 1527

Alberto Lleo and Carlos A. Saura


DOI: 10.2174/156802611795861004




Homology Models in Docking and High-Throughput Docking

, 11(12): 1528 - 1534

Claudio N. Cavasotto


DOI: 10.2174/156802611795860951




Peptide Nucleic Acids with a Structurally Biased Backbone. Updated Review and Emerging Challenges

, 11(12): 1535 - 1554

Roberto Corradini, Stefano Sforza, Tullia Tedeschi, Filbert Totsingan, Alex Manicardi and Rosangela Marchelli


DOI: 10.2174/156802611795860979




γ-Secretase Inhibitors and Modulators for the Treatment of Alzheimer's Disease: Disappointments and Hopes

, 11(12): 1555 - 1570

Bruno P. Imbimbo and Giuseppe A.M. Giardina


DOI: 10.2174/156802611795860942




Recent Advances in Small Molecule Inhibitors of VEGFR and EGFR Signaling Pathways

, 11(12): 1571 - 1590

Haizhen Zhong and J. Phillip Bowen


DOI: 10.2174/156802611795860924




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