Open Access Articles


Role of Biomacromolecules in Biomedical Engineering

, 2018; 18(14): 1171 - 1187

Juan M. Ruso and Natalia Hassan*





Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development

, 2018; 18(11): 883 - 895

Thomas Gross, Mark Mapstone, Ricardo Miramontes, Robert Padilla, Amrita K. Cheema, Fabio Macciardi, Howard J. Federoff* and Massimo S. Fiandaca*





Proteolysis Targeting Chimera (PROTAC): A Paradigm-Shifting Approach in Small Molecule Drug Discovery

, 2018; 18: 1 - 3 (E-Pub Ahead of Print)

Pingyuan Wang and Jia Zhou*





InsP3 Signaling in Apicomplexan Parasites

, 2017; 17(19): 2158 - 2165

Celia R.S. Garcia*, Eduardo Alves, Pedro H. S. Pereira, Paula J. Bartlett, Andrew P. Thomas, Katsuhiko Mikoshiba, Helmut Plattner and L. David Sibley





Bioinformatics and Drug Discovery

, 2017; 17(15): 1709 - 1726

Xuhua Xia*





Dopamine Targeting Drugs for the Treatment of Schizophrenia: Past, Present and Future

, 2016; 16(29): 3385 - 3403

Peng Li, Gretchen L. Snyder and Kimberly E. Vanover




Copper Homeostasis for the Developmental Progression of Intraerythrocytic Malarial Parasite

, 2016; 16(27): 3048 - 3057

Hiroko Asahi, Fumie Kobayashi, Shin-Ichi Inoue, Mamoru Niikura, Kenji Yagita and Mohammed Essa Marghany Tolba




Telomerase as a Cancer Target. Development of New Molecules

, 2016; 16(22): 2432 - 2440

D.L. Mengual Gomez, R.G. Armando, C.S. Cerrudo, P.D. Ghiringhelli and D.E. Gomez





HCN Channels Modulators: The Need for Selectivity

, 2016; 16(16): 1764 - 1791

Maria Novella Romanelli, Laura Sartiani, Alessio Masi, Guido Mannaioni, Dina Manetti, Alessandro Mugelli and Elisabetta Cerbai





Biomarkers in the Management of Difficult Asthma

, 2016; 16(14): 1561 - 1573

Florence Schleich, Sophie Demarche and Renaud Louis





Inhibition of Shikimate Kinase and Type II Dehydroquinase for Antibiotic Discovery: Structure-Based Design and Simulation Studies

, 2016; 16(9): 960 - 977

Concepcion Gonzalez-Bello





Telomere G-Quadruplex as a Potential Target to Accelerate Telomere Shortening by Expanding the Incomplete End-Replication of Telomere DNA

, 2015; 15(19): 1940 - 1946

Zheng Tan, Jun Tang, Zhong-Yuan Kan and Yu-Hua Hao




Toxicity of 11 Metal Oxide Nanoparticles to Three Mammalian Cell Types In V itro

, 2015; 15(18): 1914 - 1929

Angela Ivask, Tiina Titma, Meeri Visnapuu, Heiki Vija, Aleksandr Kakinen, Mariliis Sihtmae, Suman Pokhrel, Lutz Madler, Margit Heinlaan, Vambola Kisand, Ruth Shimmo and Anne Kahru




Computer-Aided Drug Design of Bioactive Natural Products

, 2015; 15(18): 1780 - 1800

Veda Prachayasittikul, Apilak Worachartcheewan, Watshara Shoombuatong, Napat Songtawee, Saw Simeon, Virapong Prachayasittikul and Chanin Nantasenamat





Drug Delivery Systems and Combination Therapy by Using Vinca Alkaloids

, 2015; 15(15): 1491 - 1500

Chun-Ting Lee, Yen-Wei Huang, Chih-Hui Yang and Keng-Shiang Huang





Intracellular Redox State as Target for Anti-Influenza Therapy: Are Antioxidants Always Effective?

, 2014; 14(22): 2529 - 2541

Rossella Sgarbanti, Donatella Amatore, Ignacio Celestino, Maria Elena Marcocci, Alessandra Fraternale, Maria Rosa Ciriolo, Mauro Magnani, Raffaele Saladino, Enrico Garaci, Anna Teresa Palamara and Lucia Nencioni





Seeding Collaborations to Advance Kinase Science with the GSK Published Kinase Inhibitor Set (PKIS)

, 2014; 14(3): 340 - 342

David H. Drewry, Timothy M. Willson and William J. Zuercher





Reviewing Colchicaceae Alkaloids – Perspectives of Evolution on Medicinal Chemistry

, 2014; 14(2): 274 - 289

Sonny Larsson and Nina Ronsted





Native Brazilian Plants Against Nosocomial Infections: A Critical Review on their Potential and the Antimicrobial Methodology

, 2013; 13(24): 3040 - 3078

Paulo Roberto H. Moreno, Fabiana da Costa-Issa, Agnieszka K. Rajca-Ferreira, Marcos A. A. Pereira and Telma M. Kaneko





NAD Biosynthesis in Humans - Enzymes, Metabolites and Therapeutic Aspects

, 2013; 13(23): 2907 - 2917

Christian Dölle, Renate Hvidsten Skoge, Magali R. VanLinden and Mathias Ziegler





An Update on the Chemistry and Medicinal Chemistry of Novel Antimycobacterial Compounds

, 2013; 13(22): 2808 - 2849

Frederico Silva Castelo Branco, Angelo C. Pinto and Núbia Boechat





A Review on Antifungal Activity of Mushroom (Basidiomycetes) Extracts and Isolated Compounds

, 2013; 13(21): 2648 - 2659

Maria Jose Alves, Isabel C.F.R. Ferreira, Joana Dias, Vania Teixeira, Anabela Martins and Manuela Pintado





Vaccine Adjuvants: Key Tools for Innovative Vaccine Design

, 2013; 13(20): 2562 - 2580

Peggy Riese, Kai Schulze, Thomas Ebensen, Blair Prochnow and Carlos A. Guzmán





Therapy in Prion Diseases

, 2013; 13(19): 2465 - 2476

Gianluigi Forloni, Vladimiro Artuso, Ignazio Roiter, Michela Morbin and Fabrizio Tagliavini





Drug Repurposing: Translational Pharmacology, Chemistry, Computers and the Clinic

, 2013; 13(18): 2328 - 2336

Naiem T. Issa, Stephen W. Byers and Sivanesan Dakshanamurthy





Mitochondria: A Promising Target for Anticancer Alkaloids

, 2013; 13(17): 2171 - 2183

Félix A. Urra, Miguel Cordova-Delgado, Hernan Pessoa-Mahana, Oney Ramírez-Rodríguez, Boris Weiss-Lopez, Jorge Ferreira and Ramiro Araya-Maturana





Retrospection on Polymorphism and Cocrystallization of Anti-Retrovirals

, 2013; 13(16): 1933 - 1962

Renu Chadha, Madhu Bala, Dimpy Rani and Poonam Arora





Emerging Targets in Neurodegeneration: New Opportunities for Alzheimer's Disease Treatment?

, 2013; 13(15): 1879 - 1904

Angela Rampa, Silvia Gobbi, Federica Belluti and Alessandra Bisi





Simultaneous Modeling of Antimycobacterial Activities and ADMET Profiles: A Chemoinformatic Approach to Medicinal Chemistry

, 2013; 13(14): 1656 - 1665

Alejandro Speck-Planche and M. N.D.S. Cordeiro





The Emerging Role of microRNA in Stroke

, 2013; 13(13): 1573 - 1588

Georgios Koutsis, Gerasimos Siasos and Konstantinos Spengos





Extra-Hepatic Isozymes from the CYP1 and CYP2 Families as Potential Chemotherapeutic Targets

, 2013; 13(12): 1441 - 1453

Brianne S. Raccor and Rudiger Kaspera





Pharmacophore Modeling for ADME

, 2013; 13(11): 1327 - 1342

Osman F. Guner and J. Phillip Bowen





Metallo-β-Lactamases: Structural Features, Antibiotic Recognition, Inhibition, and Inhibitor Design

, 2013; 13(10): 1242 - 1253

Jing-Fang Wang and Kuo-Chen Chou




Open Source Software and Web Services for Designing Therapeutic Molecules

, 2013; 13(10): 1172 - 1191

Deepak Singla, Sandeep Kumar Dhanda, Jagat Singh Chauhan, Anshu Bhardwaj, Samir K. Brahmachari, Open Source Drug Discovery Consortium and Gajendra P.S. Raghava




Protein Interface Pharmacophore Mapping Tools for Small Molecule Protein: Protein Interaction Inhibitor Discovery

, 2013; 13(9): 989 - 1001

Arnout Voet, Eleanor F. Banwell, Kamlesh K. Sahu, Jonathan G. Heddle and Kam Y. J. Zhang





Fluorine-18 Radiolabeled Heterocycles as PET Tracers for Imaging β - Amyloid Plaques in Alzheimer’s Disease

, 2013; 13(8): 909 - 919

Fanxing Zeng and Mark M. Goodman





Medicinal Chemistry Design Principles for Liver Targeting Through OATP Transporters

, 2013; 13(7): 857 - 866

Meihua Tu, Alan M. Mathiowetz, Jeffrey A. Pfefferkorn, Kimberly O. Cameron, Robert L. Dow, John Litchfield, Li Di, Bo Feng and Spiros Liras




Intestinal Targeting of Drugs: Rational Design Approaches and Challenges

, 2013; 13(7): 776 - 802

Kevin J. Filipski, Manthena V. Varma, Ayman F. El-Kattan, Catherine M. Ambler, Roger B. Ruggeri, Theunis C. Goosen and Kimberly O. Cameron




Tyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis

, 2013; 13(6): 760 - 773

Jose A. Gomez-Puerta and Attila Mocsai





Rheumatoid Arthritis: A Clinical Overview of New Diagnostic and Treatment Approaches

, 2013; 13(6): 698 - 704

Raimon Sanmarti, Virginia Ruiz-Esquide and Maria Victoria Hernandez





The Impact of Computer Science in Molecular Medicine: Enabling High- Throughput Research

, 2013; 13(5): 526 - 575

Diana de la Iglesia, Miguel Garcia-Remesal, Guillermo de la Calle, Casimir Kulikowski, Ferran Sanz and Victor Maojo





Gd-based Macromolecules and Nanoparticles as Magnetic Resonance Contrast Agents for Molecular Imaging

, 2013; 13(4): 411 - 421

Ching-Hui Huang and Andrew Tsourkas




Endogenous Modulators of TRP Channels

, 2013; 13(3): 398 - 407

Enza Palazzo, Francesco Rossi, Vito de Novellis and Sabatino Maione




Oncogenic and Anti-Oncogenic Effects of Transient Receptor Potential Channels

, 2013; 13(3): 344 - 366

Sonia Liberati, Maria Beatrice Morelli, Massimo Nabissi, Matteo Santoni and Giorgio Santoni




MicroRNAs and the Heart: Small Things Do Matter

, 2013; 13(2): 216 - 230

Nikolaos Papoutsidakis, Spyridon Deftereos, Andreas Kaoukis, Georgios Bouras, Georgios Giannopoulos, Andreas Theodorakis, Christos Angelidis, Georgios Hatzis and Christodoulos Stefanadis




Myeloperoxidase: Expressing Inflammation and Oxidative Stress in Cardiovascular Disease

, 2013; 13(2): 115 - 138

Nikolaos Anatoliotakis, Spyridon Deftereos, Georgios Bouras, Georgios Giannopoulos, Dimitrios Tsounis, Christos Angelidis, Andreas Kaoukis and Christodoulos Stefanadis




Computational Tools in the Discovery of New G-Quadruplex Ligands with Potential Anticancer Activity

, 2012; 12(24): 2843 - 2856

Daimel Castillo-Gonzalez, Gisselle Perez-Machado, Federico Pallardo, Teresa-Maria Garrigues-Pelufo and Miguel-Angel Cabrera-Perez




Classification Models for Anticancer Activity

, 2012; 12(24): 2705 - 2726

R. Dutt and A.K. Madan





Alpha-Emitters for Immuno-Therapy: A Review of Recent Developments from Chemistry to Clinics

, 2012; 12(23): 2642 - 2654

Sandrine Huclier-Markai, Cyrille Alliot, Nicolas Varmenot, Cathy S. Cutler and Jacques Barbet




SOD1 Aggregation and ALS: Role of Metallation States and Disulfide Status

, 2012; 12(22): 2560 - 2572

Yuewei Sheng, Madhuri Chattopadhyay, Julian Whitelegge and Joan Selverstone Valentine




Phenylalanine Hydroxylase Misfolding and Pharmacological Chaperones

, 2012; 12(22): 2534 - 2545

Jarl Underhaug, Oscar Aubi and Aurora Martinez





Conceptual Issues in Psychiatric Neuroimaging: An Update

, 2012; 12(21): 2348 - 2356

D. Stoyanov, G. Stanghellini and M. Broome





History and Therapeutic Use of MAO-A Inhibitors: A Historical Perspective of MAO-A Inhibitors As Antidepressant Drug

, 2012; 12(20): 2275 - 2282

Matilde Yanez, Juan Fernando Padin, Juan Alberto Arranz-Tagarro, Mercedes Camina and Reyes Laguna




Monoamine Oxidase Inhibitors: Ten Years of Docking Studies

, 2012; 12(20): 2145 - 2162

Giulio Ferino, Santiago Vilar, Maria J. Matos, Eugenio Uriarte and Enzo Cadoni




Effects of Natural Compounds on Xenopus Embryogenesis: A Potential Read Out for Functional Drug Discovery Targeting Wnt/β-catenin Signaling

, 2012; 12(19): 2103 - 2113

Nathalia G. Amado, Barbara F. Fonseca, Debora Malta Cerqueira, Alice H. Reis, Alessandro Bolis Costa Simas, Ricardo Machado Kuster, Fabio A. Mendes and Jose G. Abreu





Rational Prediction with Molecular Dynamics for Hit Identification

, 2012; 12(18): 2002 - 2012

Sara E. Nichols, Robert V. Swift and Rommie E. Amaro





Enzyme Informatics

, 2012; 12(17): 1911 - 1923

Rosanna G. Alderson, Luna De Ferrari, Lazaros Mavridis, James L. McDonagh, John B.O. Mitchell and Neetika Nath





A Parallel Systematic-Monte Carlo Algorithm for Exploring Conformational Space

, 2012; 12(16): 1790 - 1796

Yasset Perez-Riverol, Roberto Vera, Yuliet Mazola and Alexis Musacchio





Anticancer Drugs in Liposomal Nanodevices: A Target Delivery for a Targeted Therapy

, 2012; 12(15): 1693 - 1712

Giorgia Urbinati, Veronique Marsaud and Jack-Michel Renoir





Cysteine-Rich Mini-Proteins in Human Biology

, 2012; 12(14): 1514 - 1533

Vincent Lavergne, Ryan J. Taft and Paul F. Alewood




Towards Isozyme-Selective HDAC Inhibitors For Interrogating Disease

, 2012; 12(14): 1479 - 1499

Praveer Gupta, Robert C. Reid, Abishek Iyer, Matthew J. Sweet and David P. Fairlie




Thalidomide: Chemistry, Therapeutic Potential and Oxidative Stress Induced Teratogenicity

, 2012; 12(13): 1436 - 1455

Neeraj Kumar, Upendra Sharma, Chitra Singh and Bikram Singh





Identifying Multiple-target Ligands via Computational Chemogenomics Approaches

, 2012; 12(12): 1363 - 1375

Shiming Peng, Xingyu Lin, Zongru Guo and Niu Huang





The IC50 Concept Revisited

, 2012; 12(11): 1282 - 1290

Gary W. Caldwell, Zhengyin Yan, Wensheng Lang and John A. Masucci





Novel Therapeutic Approaches Targeting Matrix Metalloproteinases in Cardiovascular Disease

, 2012; 12(10): 1214 - 1221

Alexandros Briasoulis, Dimitris Tousoulis, Nikolaos Papageorgiou, Anna-Maria Kampoli, Emmanuel Androulakis, Charalambos Antoniades, Eleftherios Tsiamis, George Latsios and Christodoulos Stefanadis




Myocardial Structure and Matrix Metalloproteinases

, 2012; 12(10): 1113 - 1131

C. Aggeli, P. Pietri, I. Felekos, L. Rautopoulos, K. Toutouzas, E. Tsiamis and C. Stefanadis




Glutamatergic Neurotransmission As Molecular Target of New Anticonvulsants

, 2012; 12(9): 971 - 993

Rosaria Gitto, Laura De Luca, Sara De Grazia and Alba Chimirri





Freely Accessible Databases of Commercial Compounds For High- Throughput Virtual Screenings

, 2012; 12(8): 866 - 877

Armenio Jorge Moura Barbosa and Alberto Del Rio





Natural Products as Leads for Tuberculosis Drug Development

, 2012; 12(7): 735 - 765

Christine E. Salomon and Lori E. Schmidt





Biology and Therapeutic Applications of Peroxisome Proliferator- Activated Receptors

, 2012; 12(6): 548 - 584

Maria P. Menendez-Gutierrez, Tamas Roszer and Mercedes Ricote





Back to the Future: Lessons Learned in Modern Target-based and Whole-Cell Lead Optimization of Antimalarials

, 2012; 12(5): 473 - 483

Arnab K. Chatterjee and Bryan K.S. Yeung





Reversed Chloroquine Molecules as a Strategy to Overcome Resistance in Malaria

, 2012; 12(5): 400 - 407

David H. Peyton





Translocator Protein as a Promising Target for Novel Anxiolytics

, 2012; 12(4): 270 - 285

Barbara Costa, Eleonora Da Pozzo and Claudia Martini





Terpyridines and their Complexes with First Row Transition Metal Ions:Cytotoxicity, Nuclease Activity and Self-Assembly of Biomacromolecules

, 2012; 12(3): 158 - 175

Andreas Winter, Michael Gottschaldt, George R. Newkome and Ulrich S. Schubert





RNA Interference-Mediated Validation of Survivin and Apollon/BRUCE as New Therapeutic Targets for Cancer Therapy

, 2012; 12(2): 69 - 78

Marzia Pennati, Enrico Millo, Paolo Gandellini, Marco Folini and Nadia Zaffaroni




Polymeric Carrier Systems for siRNA Delivery

, 2012; 12(2): 108 - 119

P. Vader, L. J. van der Aa, G. Storm, R. M. Schiffelers and J. F.J. Engbersen




Thalamocortical Oscillations: Local Control of EEG Slow Waves

, 2011; 11(19): 2457 - 2471

Igor Timofeev and Sylvain Chauvette




Rapid Analysis of Pharmacology for Infectious Diseases

, 2011; 11(10): 1292 - 1300

Andrew L. Hopkins, G. Richard Bickerton, Ian M. Carruthers, Stephen K. Boyer, Harvey Rubin and John P. Overington




Target Validation: Linking Target and Chemical Properties to Desired Product Profile

, 2011; 11(10): 1275 - 1283

Paul G. Wyatt, Ian H. Gilbert, Kevin D. Read and Alan H. Fairlamb





IRAK-4 Inhibitors for Inflammation

, 2009; 9(8): 724 - 737

Zhulun Wang, Holger Wesche, Tracey Stevens, Nigel Walker and Wen-Chen Yeh




Melanocortins in the Treatment of Male and Female Sexual Dysfunction

, 2007; 7(11): 1137 - 1144

Trevor J. Hallam, Carl Spana, Dennis C. Earle, Annette M. Shadiack and Shubh D. Sharma




Morpholino, siRNA, and S-DNA Compared: Impact of Structure and Mechanism of Action on Off-Target Effects and Sequence Specificity

, 2007; 7(7): 651 - 660

James E. Summerton





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