Open Access Articles

Metabolomics Applications in Precision Medicine: An Oncological Perspective

, 2017; 17(24): 2740 - 2751

Leonor Puchades-Carrasco and Antonio Pineda- Lucena*




InsP3 Signaling in Apicomplexan Parasites

, 2017; 17(19): 2158 - 2165

Celia R.S. Garcia*, Eduardo Alves, Pedro H. S. Pereira, Paula J. Bartlett, Andrew P. Thomas, Katsuhiko Mikoshiba, Helmut Plattner and L. David Sibley




LncRNA as a Therapeutic Target for Angiogenesis

, 2017; 17(15): 1750 - 1757

Mohan M. Kumar and Ravi Goyal*




Bioinformatics and Drug Discovery

, 2017; 17(15): 1709 - 1726

Xuhua Xia*




A Comprehensive Docking and MM/GBSA Rescoring Study of Ligand Recognition upon Binding Antithrombin

, 2017; 17(14): 1631 - 1639

Xiaohua Zhang, Horacio Perez-Sanchez* and Felice C. Lightstone*




Dopamine Targeting Drugs for the Treatment of Schizophrenia: Past, Present and Future

, 2016; 16(29): 3385 - 3403

Peng Li, Gretchen L. Snyder and Kimberly E. Vanover




Copper Homeostasis for the Developmental Progression of Intraerythrocytic Malarial Parasite

, 2016; 16(27): 3048 - 3057

Hiroko Asahi, Fumie Kobayashi, Shin-Ichi Inoue, Mamoru Niikura, Kenji Yagita and Mohammed Essa Marghany Tolba




Telomerase as a Cancer Target. Development of New Molecules

, 2016; 16(22): 2432 - 2440

D.L. Mengual Gomez, R.G. Armando, C.S. Cerrudo, P.D. Ghiringhelli and D.E. Gomez




The Unexpected Advantages of Using D-Amino Acids for Peptide Self- Assembly into Nanostructured Hydrogels for Medicine

, 2016; 16(18): 2009 - 2018

Michele Melchionna, Katie E. Styan and Silvia Marchesan




HCN Channels Modulators: The Need for Selectivity

, 2016; 16(16): 1764 - 1791

Maria Novella Romanelli, Laura Sartiani, Alessio Masi, Guido Mannaioni, Dina Manetti, Alessandro Mugelli and Elisabetta Cerbai




Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking

, 2016; 16(15): 1705 - 1716

Eric P. Trautman and Jason M. Crawford




Biomarkers in the Management of Difficult Asthma

, 2016; 16(14): 1561 - 1573

Florence Schleich, Sophie Demarche and Renaud Louis




Cellular Selenoprotein mRNA Tethering via Antisense Interactions with Ebola and HIV-1 mRNAs May Impact Host Selenium Biochemistry

, 2016; 16(13): 1530 - 1535

Ethan Will Taylor, Jan A. Ruzicka, Lakmini Premadasa and Lijun Zhao




Inhibition of Shikimate Kinase and Type II Dehydroquinase for Antibiotic Discovery: Structure-Based Design and Simulation Studies

, 2016; 16(9): 960 - 977

Concepcion Gonzalez-Bello




αvβ3 Integrin-Targeted Peptide/Peptidomimetic-Drug Conjugates: In-Depth Analysis of the Linker Technology

, 2016; 16(3): 314 - 329

Alberto Dal Corso, Luca Pignataro, Laura Belvisi and Cesare Gennari




Telomere G-Quadruplex as a Potential Target to Accelerate Telomere Shortening by Expanding the Incomplete End-Replication of Telomere DNA

, 2015; 15(19): 1940 - 1946

Zheng Tan, Jun Tang, Zhong-Yuan Kan and Yu-Hua Hao




Toxicity of 11 Metal Oxide Nanoparticles to Three Mammalian Cell Types In V itro

, 2015; 15(18): 1914 - 1929

Angela Ivask, Tiina Titma, Meeri Visnapuu, Heiki Vija, Aleksandr Kakinen, Mariliis Sihtmae, Suman Pokhrel, Lutz Madler, Margit Heinlaan, Vambola Kisand, Ruth Shimmo and Anne Kahru




Computer-Aided Drug Design of Bioactive Natural Products

, 2015; 15(18): 1780 - 1800

Veda Prachayasittikul, Apilak Worachartcheewan, Watshara Shoombuatong, Napat Songtawee, Saw Simeon, Virapong Prachayasittikul and Chanin Nantasenamat




Active Targeted Drug Delivery for Microbes Using Nano-Carriers

, 2015; 15(15): 1525 - 1531

Yung-Sheng Lin, Ming-Yuan Lee, Chih-Hui Yang and Keng-Shiang Huang




Drug Delivery Systems and Combination Therapy by Using Vinca Alkaloids

, 2015; 15(15): 1491 - 1500

Chun-Ting Lee, Yen-Wei Huang, Chih-Hui Yang and Keng-Shiang Huang




Computational Studies of Free Radical-Scavenging Properties of Phenolic Compounds

, 2015; 15(2): 85 - 104

Petko Alov, Ivanka Tsakovska and Ilza Pajeva




Intracellular Redox State as Target for Anti-Influenza Therapy: Are Antioxidants Always Effective?

, 2014; 14(22): 2529 - 2541

Rossella Sgarbanti, Donatella Amatore, Ignacio Celestino, Maria Elena Marcocci, Alessandra Fraternale, Maria Rosa Ciriolo, Mauro Magnani, Raffaele Saladino, Enrico Garaci, Anna Teresa Palamara and Lucia Nencioni




Structure-Based Virtual Screening for Drug Discovery: Principles, Applications and Recent Advances

, 2014; 14(16): 1923 - 1938

Evanthia Lionta, George Spyrou, Demetrios K. Vassilatis and Zoe Cournia




Seeding Collaborations to Advance Kinase Science with the GSK Published Kinase Inhibitor Set (PKIS)

, 2014; 14(3): 340 - 342

David H. Drewry, Timothy M. Willson and William J. Zuercher




Open Innovation Drug Discovery (OIDD): A Potential Path to Novel Therapeutic Chemical Space

, 2014; 14(3): 294 - 303

Maria Alvim-Gaston, Timothy Grese, Abdelaziz Mahoui, Alan D. Palkowitz, Marta Pineiro-Nunez and Ian Watson




Reviewing Colchicaceae Alkaloids – Perspectives of Evolution on Medicinal Chemistry

, 2014; 14(2): 274 - 289

Sonny Larsson and Nina Ronsted




A Brief Overview of Antimicrobial Peptides Containing Unnatural Amino Acids and Ligand-Based Approaches for Peptide Ligands

, 2013; 13(24): 3205 - 3224

Jayendra B. Bhonsle, Tiffany Clark, Libero Bartolotti and Rickey P. Hicks




Native Brazilian Plants Against Nosocomial Infections: A Critical Review on their Potential and the Antimicrobial Methodology

, 2013; 13(24): 3040 - 3078

Paulo Roberto H. Moreno, Fabiana da Costa-Issa, Agnieszka K. Rajca-Ferreira, Marcos A. A. Pereira and Telma M. Kaneko




From Polypharmacology to Target Specificity: The Case of PARP Inhibitors

, 2013; 13(23): 2939 - 2954

Paride Liscio, Emidio Camaioni, Andrea Carotti, Roberto Pellicciari and Antonio Macchiarulo




NAD Biosynthesis in Humans - Enzymes, Metabolites and Therapeutic Aspects

, 2013; 13(23): 2907 - 2917

Christian Dölle, Renate Hvidsten Skoge, Magali R. VanLinden and Mathias Ziegler




Recent Advances in the Synthesis of New Antimycobacterial Agents Based on the 1H-1,2,3-Triazoles

, 2013; 13(22): 2850 - 2865

Daniel Tadeu G. Gonzaga, David R. da Rocha, Fernando de C. da Silva and Vitor F. Ferreira




An Update on the Chemistry and Medicinal Chemistry of Novel Antimycobacterial Compounds

, 2013; 13(22): 2808 - 2849

Frederico Silva Castelo Branco, Angelo C. Pinto and Núbia Boechat




Synthesis and Biological Evaluation of Potent Antifungal Agents

, 2013; 13(21): 2684 - 2733

Athina Geronikaki, Maria Fesatidou, Victor Kartsev and Fliur Macaev




A Review on Antifungal Activity of Mushroom (Basidiomycetes) Extracts and Isolated Compounds

, 2013; 13(21): 2648 - 2659

Maria Jose Alves, Isabel C.F.R. Ferreira, Joana Dias, Vania Teixeira, Anabela Martins and Manuela Pintado




Mucosal Vaccines: Where Do We Stand?

, 2013; 13(20): 2609 - 2628

Jean-Pierre Kraehenbuhl and Marian R. Neutra




Vaccine Adjuvants: Key Tools for Innovative Vaccine Design

, 2013; 13(20): 2562 - 2580

Peggy Riese, Kai Schulze, Thomas Ebensen, Blair Prochnow and Carlos A. Guzmán




Challenges and Opportunities for Cancer Vaccines in the Current NSCLC Clinical Scenario

, 2013; 13(20): 2551 - 2561

Pedro C. Rodriguez and Belinda Sanchez




Therapy in Prion Diseases

, 2013; 13(19): 2465 - 2476

Gianluigi Forloni, Vladimiro Artuso, Ignazio Roiter, Michela Morbin and Fabrizio Tagliavini




Prion Chemical Biology: On the Road to Therapeutics?

, 2013; 13(19): 2441 - 2464

Beining Chen, Mark Thompson, Jennifer Louth and Kai Guo




Drug Repurposing: Translational Pharmacology, Chemistry, Computers and the Clinic

, 2013; 13(18): 2328 - 2336

Naiem T. Issa, Stephen W. Byers and Sivanesan Dakshanamurthy




Overview on Theoretical Studies Discriminating the Two-Oxidant Versus Two-State-Reactivity Models for Substrate Monoxygenation by Cytochrome P450 Enzymes

, 2013; 13(18): 2218 - 2232

Sam P. de Visser, Cristina S. Porro, Matthew G. Quesne, Mala A. Sainna and Andrew W. Munro




Mitochondria: A Promising Target for Anticancer Alkaloids

, 2013; 13(17): 2171 - 2183

Félix A. Urra, Miguel Cordova-Delgado, Hernan Pessoa-Mahana, Oney Ramírez-Rodríguez, Boris Weiss-Lopez, Jorge Ferreira and Ramiro Araya-Maturana




Alkaloid-Metal Based Anticancer Agents

, 2013; 13(17): 2104 - 2115

Zhen-Feng Chen, Yan-Cheng Liu, Ke-Bin Huang and Hong Liang




Retrospection on Polymorphism and Cocrystallization of Anti-Retrovirals

, 2013; 13(16): 1933 - 1962

Renu Chadha, Madhu Bala, Dimpy Rani and Poonam Arora




Targeting Host Store-Operated Ca2+ Release to Attenuate Viral Infections

, 2013; 13(16): 1916 - 1932

Kevin B. Clark and E. M. Eisenstein




Emerging Targets in Neurodegeneration: New Opportunities for Alzheimer's Disease Treatment?

, 2013; 13(15): 1879 - 1904

Angela Rampa, Silvia Gobbi, Federica Belluti and Alessandra Bisi




The Multifactorial Nature of Alzheimer's Disease for Developing Potential Therapeutics

, 2013; 13(15): 1745 - 1770

M. Carmo Carreiras, Eduarda Mendes, M. Jesus Perry, Ana Paula Francisco and J. Marco-Contelles




Simultaneous Modeling of Antimycobacterial Activities and ADMET Profiles: A Chemoinformatic Approach to Medicinal Chemistry

, 2013; 13(14): 1656 - 1665

Alejandro Speck-Planche and M. N.D.S. Cordeiro




Recent Advances in Predicting Protein Classification and Their Applications to Drug Development

, 2013; 13(14): 1622 - 1635

Xuan Xiao, Wei-Zhong Lin and Kuo-Chen Chou




The Emerging Role of microRNA in Stroke

, 2013; 13(13): 1573 - 1588

Georgios Koutsis, Gerasimos Siasos and Konstantinos Spengos




Insights in microRNAs Biology

, 2013; 13(13): 1493 - 1502

Antonios N. Gargalionis and Efthimia K. Basdra




Extra-Hepatic Isozymes from the CYP1 and CYP2 Families as Potential Chemotherapeutic Targets

, 2013; 13(12): 1441 - 1453

Brianne S. Raccor and Rudiger Kaspera




CYP17A1: A Biochemistry, Chemistry, and Clinical Review

, 2013; 13(12): 1364 - 1384

David Porubek




Pharmacophore Modeling for ADME

, 2013; 13(11): 1327 - 1342

Osman F. Guner and J. Phillip Bowen




Permeability Diagnosis Model in Drug Discovery: A Diagnostic Tool to Identify the Most Influencing Properties for Gastrointestinal Permeability

, 2013; 13(11): 1308 - 1316

Jianling Wang and Suzanne Skolnik




Metallo-β-Lactamases: Structural Features, Antibiotic Recognition, Inhibition, and Inhibitor Design

, 2013; 13(10): 1242 - 1253

Jing-Fang Wang and Kuo-Chen Chou




Open Source Software and Web Services for Designing Therapeutic Molecules

, 2013; 13(10): 1172 - 1191

Deepak Singla, Sandeep Kumar Dhanda, Jagat Singh Chauhan, Anshu Bhardwaj, Samir K. Brahmachari, Open Source Drug Discovery Consortium and Gajendra P.S. Raghava




Protein Interface Pharmacophore Mapping Tools for Small Molecule Protein: Protein Interaction Inhibitor Discovery

, 2013; 13(9): 989 - 1001

Arnout Voet, Eleanor F. Banwell, Kamlesh K. Sahu, Jonathan G. Heddle and Kam Y. J. Zhang




A Novel Integrated Framework and Improved Methodology of Computer-Aided Drug Design

, 2013; 13(9): 965 - 988

Calvin Yu-Chian Chen




Fluorine-18 Radiolabeled Heterocycles as PET Tracers for Imaging β - Amyloid Plaques in Alzheimer’s Disease

, 2013; 13(8): 909 - 919

Fanxing Zeng and Mark M. Goodman




Fluorine-18 Labeled Amino Acids for Oncologic Imaging with Positron Emission Tomography

, 2013; 13(8): 871 - 891

Chaofeng Huang and Jonathan McConathy




Medicinal Chemistry Design Principles for Liver Targeting Through OATP Transporters

, 2013; 13(7): 857 - 866

Meihua Tu, Alan M. Mathiowetz, Jeffrey A. Pfefferkorn, Kimberly O. Cameron, Robert L. Dow, John Litchfield, Li Di, Bo Feng and Spiros Liras




Intestinal Targeting of Drugs: Rational Design Approaches and Challenges

, 2013; 13(7): 776 - 802

Kevin J. Filipski, Manthena V. Varma, Ayman F. El-Kattan, Catherine M. Ambler, Roger B. Ruggeri, Theunis C. Goosen and Kimberly O. Cameron




Tyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis

, 2013; 13(6): 760 - 773

Jose A. Gomez-Puerta and Attila Mocsai




The Genetic Architecture of Rheumatoid Arthritis: From Susceptibility to Clinical Subphenotype Associations

, 2013; 13(6): 720 - 731

Antonio Julia and Sara Marsal




Rheumatoid Arthritis: A Clinical Overview of New Diagnostic and Treatment Approaches

, 2013; 13(6): 698 - 704

Raimon Sanmarti, Virginia Ruiz-Esquide and Maria Victoria Hernandez




From Protein-Protein Interactions to Rational Drug Design: Are Computational Methods Up to the Challenge?

, 2013; 13(5): 602 - 618

Edgar D. Coelho, Joel P. Arrais and Jose Luis Oliveira




The Impact of Computer Science in Molecular Medicine: Enabling High- Throughput Research

, 2013; 13(5): 526 - 575

Diana de la Iglesia, Miguel Garcia-Remesal, Guillermo de la Calle, Casimir Kulikowski, Ferran Sanz and Victor Maojo




Chemistry and Theranostic Applications of Radiolabeled Nanoparticles for Cardiovascular, Oncological, and Pulmonary Research

, 2013; 13(4): 470 - 478

Yunjun Guo, Tolulope Aweda, Kvar C.L. Black and Yongjian Liu




Gd-based Macromolecules and Nanoparticles as Magnetic Resonance Contrast Agents for Molecular Imaging

, 2013; 13(4): 411 - 421

Ching-Hui Huang and Andrew Tsourkas




Endogenous Modulators of TRP Channels

, 2013; 13(3): 398 - 407

Enza Palazzo, Francesco Rossi, Vito de Novellis and Sabatino Maione




Oncogenic and Anti-Oncogenic Effects of Transient Receptor Potential Channels

, 2013; 13(3): 344 - 366

Sonia Liberati, Maria Beatrice Morelli, Massimo Nabissi, Matteo Santoni and Giorgio Santoni




MicroRNAs and the Heart: Small Things Do Matter

, 2013; 13(2): 216 - 230

Nikolaos Papoutsidakis, Spyridon Deftereos, Andreas Kaoukis, Georgios Bouras, Georgios Giannopoulos, Andreas Theodorakis, Christos Angelidis, Georgios Hatzis and Christodoulos Stefanadis




Myeloperoxidase: Expressing Inflammation and Oxidative Stress in Cardiovascular Disease

, 2013; 13(2): 115 - 138

Nikolaos Anatoliotakis, Spyridon Deftereos, Georgios Bouras, Georgios Giannopoulos, Dimitrios Tsounis, Christos Angelidis, Andreas Kaoukis and Christodoulos Stefanadis




Computational Tools in the Discovery of New G-Quadruplex Ligands with Potential Anticancer Activity

, 2012; 12(24): 2843 - 2856

Daimel Castillo-Gonzalez, Gisselle Perez-Machado, Federico Pallardo, Teresa-Maria Garrigues-Pelufo and Miguel-Angel Cabrera-Perez




Classification Models for Anticancer Activity

, 2012; 12(24): 2705 - 2726

R. Dutt and A.K. Madan




Tetraamine-Coupled Peptides and Resulting 99mTc-Radioligands: An Effective Route for Receptor-Targeted Diagnostic Imaging of Human Tumors

, 2012; 12(23): 2655 - 2667

Berthold A. Nock and Theodosia Maina




Alpha-Emitters for Immuno-Therapy: A Review of Recent Developments from Chemistry to Clinics

, 2012; 12(23): 2642 - 2654

Sandrine Huclier-Markai, Cyrille Alliot, Nicolas Varmenot, Cathy S. Cutler and Jacques Barbet




SOD1 Aggregation and ALS: Role of Metallation States and Disulfide Status

, 2012; 12(22): 2560 - 2572

Yuewei Sheng, Madhuri Chattopadhyay, Julian Whitelegge and Joan Selverstone Valentine




Phenylalanine Hydroxylase Misfolding and Pharmacological Chaperones

, 2012; 12(22): 2534 - 2545

Jarl Underhaug, Oscar Aubi and Aurora Martinez




Protein Misfolding in Disease and Small Molecule Therapies

, 2012; 12(22): 2460 - 2469

Claudio M. Gomes




Conceptual Issues in Psychiatric Neuroimaging: An Update

, 2012; 12(21): 2348 - 2356

D. Stoyanov, G. Stanghellini and M. Broome




Neurofunctional Correlates of Theory of Mind Deficits in Schizophrenia

, 2012; 12(21): 2284 - 2302

M. Bosia, R. Riccaboni and S. Poletti




History and Therapeutic Use of MAO-A Inhibitors: A Historical Perspective of MAO-A Inhibitors As Antidepressant Drug

, 2012; 12(20): 2275 - 2282

Matilde Yanez, Juan Fernando Padin, Juan Alberto Arranz-Tagarro, Mercedes Camina and Reyes Laguna




Monoamine Oxidase Inhibitors: Ten Years of Docking Studies

, 2012; 12(20): 2145 - 2162

Giulio Ferino, Santiago Vilar, Maria J. Matos, Eugenio Uriarte and Enzo Cadoni




Effects of Natural Compounds on Xenopus Embryogenesis: A Potential Read Out for Functional Drug Discovery Targeting Wnt/β-catenin Signaling

, 2012; 12(19): 2103 - 2113

Nathalia G. Amado, Barbara F. Fonseca, Debora Malta Cerqueira, Alice H. Reis, Alessandro Bolis Costa Simas, Ricardo Machado Kuster, Fabio A. Mendes and Jose G. Abreu




The Central Nervous System as a Promising Target to Treat Diabetes Mellitus

, 2012; 12(19): 2070 - 2081

Jose Donato Jr.




Rational Prediction with Molecular Dynamics for Hit Identification

, 2012; 12(18): 2002 - 2012

Sara E. Nichols, Robert V. Swift and Rommie E. Amaro




A Survey of Quantitative Descriptions of Molecular Structure

, 2012; 12(18): 1946 - 1956

Rajarshi Guha and Egon Willighagen




Enzyme Informatics

, 2012; 12(17): 1911 - 1923

Rosanna G. Alderson, Luna De Ferrari, Lazaros Mavridis, James L. McDonagh, John B.O. Mitchell and Neetika Nath




Compound Activity Prediction Using Models of Binding Pockets or Ligand Properties in 3D

, 2012; 12(17): 1869 - 1882

Irina Kufareva, Yu-Chen Chen, Andrey V. Ilatovskiy and Ruben Abagyan




A Parallel Systematic-Monte Carlo Algorithm for Exploring Conformational Space

, 2012; 12(16): 1790 - 1796

Yasset Perez-Riverol, Roberto Vera, Yuliet Mazola and Alexis Musacchio




QSAR and Molecular Docking Techniques for the Discovery of Potent Monoamine Oxidase B Inhibitors: Computer-Aided Generation of New Rasagiline Bioisosteres

, 2012; 12(16): 1734 - 1747

Alejandro Speck-Planche and Valeria V. Kleandrova




Anticancer Drugs in Liposomal Nanodevices: A Target Delivery for a Targeted Therapy

, 2012; 12(15): 1693 - 1712

Giorgia Urbinati, Veronique Marsaud and Jack-Michel Renoir




Novel Gene Transfer Systems: Intelligent Gene Transfer Vectors for Gene Medicines

, 2012; 12(15): 1594 - 1602

Toshihiro Nakajima




Cysteine-Rich Mini-Proteins in Human Biology

, 2012; 12(14): 1514 - 1533

Vincent Lavergne, Ryan J. Taft and Paul F. Alewood




Towards Isozyme-Selective HDAC Inhibitors For Interrogating Disease

, 2012; 12(14): 1479 - 1499

Praveer Gupta, Robert C. Reid, Abishek Iyer, Matthew J. Sweet and David P. Fairlie




Thalidomide: Chemistry, Therapeutic Potential and Oxidative Stress Induced Teratogenicity

, 2012; 12(13): 1436 - 1455

Neeraj Kumar, Upendra Sharma, Chitra Singh and Bikram Singh




From the Deepest Sea Shelf to the Uppermost Kitchen Cabinet Shelf: The Quest for Novel TNF-α Inhibitors

, 2012; 12(13): 1392 - 1407

F. Folmer, M. Dicato and M. Diederich




Identifying Multiple-target Ligands via Computational Chemogenomics Approaches

, 2012; 12(12): 1363 - 1375

Shiming Peng, Xingyu Lin, Zongru Guo and Niu Huang




Chemical Genomics and Emerging DNA Technologies in the Identification of Drug Mechanisms and Drug Targets

, 2012; 12(12): 1331 - 1345

Louise Cathrine Braun Olsen and Nils Joakim Faergeman




The IC50 Concept Revisited

, 2012; 12(11): 1282 - 1290

Gary W. Caldwell, Zhengyin Yan, Wensheng Lang and John A. Masucci




An Integrated Data Management Framework for Drug Discovery – From Data Capturing to Decision Support

, 2012; 12(11): 1237 - 1242

Walter Cedeno, Simson Alex, Edward P. Jaeger, Dimitris K. Agrafiotis and Victor S. Lobanov




Novel Therapeutic Approaches Targeting Matrix Metalloproteinases in Cardiovascular Disease

, 2012; 12(10): 1214 - 1221

Alexandros Briasoulis, Dimitris Tousoulis, Nikolaos Papageorgiou, Anna-Maria Kampoli, Emmanuel Androulakis, Charalambos Antoniades, Eleftherios Tsiamis, George Latsios and Christodoulos Stefanadis




Myocardial Structure and Matrix Metalloproteinases

, 2012; 12(10): 1113 - 1131

C. Aggeli, P. Pietri, I. Felekos, L. Rautopoulos, K. Toutouzas, E. Tsiamis and C. Stefanadis




Glutamatergic Neurotransmission As Molecular Target of New Anticonvulsants

, 2012; 12(9): 971 - 993

Rosaria Gitto, Laura De Luca, Sara De Grazia and Alba Chimirri




Recent Progress in Anticonvulsant Drug Research: Strategies for Anticonvulsant Drug Development and Applications of Antiepileptic Drugs for Non-Epileptic Central Nervous System Disorders

, 2012; 12(9): 1033 - 1071

Sevim Dalkara and Arzu Karakurt




Freely Accessible Databases of Commercial Compounds For High- Throughput Virtual Screenings

, 2012; 12(8): 866 - 877

Armenio Jorge Moura Barbosa and Alberto Del Rio




Computer-Aided Drug Design Methodologies Toward the Design of Anti-Hepatitis C Agents

, 2012; 12(8): 802 - 813

Alejandro Speck-Planche and M. Natalia D. S. Cordeiro




Natural Products as Leads for Tuberculosis Drug Development

, 2012; 12(7): 735 - 765

Christine E. Salomon and Lori E. Schmidt




Targeting InhA, the FASII Enoyl-ACP Reductase: SAR Studies on Novel Inhibitor Scaffolds

, 2012; 12(7): 672 - 693

Pan Pan and Peter J. Tonge




Biology and Therapeutic Applications of Peroxisome Proliferator- Activated Receptors

, 2012; 12(6): 548 - 584

Maria P. Menendez-Gutierrez, Tamas Roszer and Mercedes Ricote




General Molecular Biology and Architecture of Nuclear Receptors

, 2012; 12(6): 486 - 504

Michal Pawlak, Philippe Lefebvre and Bart Staels




Back to the Future: Lessons Learned in Modern Target-based and Whole-Cell Lead Optimization of Antimalarials

, 2012; 12(5): 473 - 483

Arnab K. Chatterjee and Bryan K.S. Yeung




Targeting Protein Kinases in the Malaria Parasite: Update of an Antimalarial Drug Target

, 2012; 12(5): 456 - 472

Veronica M. Zhang, Marina Chavchich and Norman C. Waters




Reversed Chloroquine Molecules as a Strategy to Overcome Resistance in Malaria

, 2012; 12(5): 400 - 407

David H. Peyton




Synthetic Peroxides as Potent Antimalarials. News and Views

, 2012; 12(5): 373 - 399

Charles W. Jefford




Translocator Protein as a Promising Target for Novel Anxiolytics

, 2012; 12(4): 270 - 285

Barbara Costa, Eleonora Da Pozzo and Claudia Martini




Treatment Strategies of Obsessive-Compulsive Disorder and Panic Disorder/Agoraphobia

, 2012; 12(4): 238 - 253

Donatella Marazziti, Marina Carlini and Liliana Dell'Osso




Terpyridines and their Complexes with First Row Transition Metal Ions:Cytotoxicity, Nuclease Activity and Self-Assembly of Biomacromolecules

, 2012; 12(3): 158 - 175

Andreas Winter, Michael Gottschaldt, George R. Newkome and Ulrich S. Schubert




Multifunctional Ligands in Medicinal Inorganic Chemistry- Current Trends and Future Directions

, 2012; 12(3): 122 - 144

Linus Chiang, Michael R. Jones, Cara L. Ferreira and Tim Storr




RNA Interference-Mediated Validation of Survivin and Apollon/BRUCE as New Therapeutic Targets for Cancer Therapy

, 2012; 12(2): 69 - 78

Marzia Pennati, Enrico Millo, Paolo Gandellini, Marco Folini and Nadia Zaffaroni




Polymeric Carrier Systems for siRNA Delivery

, 2012; 12(2): 108 - 119

P. Vader, L. J. van der Aa, G. Storm, R. M. Schiffelers and J. F.J. Engbersen




Thalamocortical Oscillations: Local Control of EEG Slow Waves

, 2011; 11(19): 2457 - 2471

Igor Timofeev and Sylvain Chauvette




Rapid Analysis of Pharmacology for Infectious Diseases

, 2011; 11(10): 1292 - 1300

Andrew L. Hopkins, G. Richard Bickerton, Ian M. Carruthers, Stephen K. Boyer, Harvey Rubin and John P. Overington




Target Validation: Linking Target and Chemical Properties to Desired Product Profile

, 2011; 11(10): 1275 - 1283

Paul G. Wyatt, Ian H. Gilbert, Kevin D. Read and Alan H. Fairlamb




Transcriptional Regulation by Promoter Targeted RNAs

, 2009; 9(12): 1079 - 1087

Kazuo Suzuki and Anthony D. Kelleher




IRAK-4 Inhibitors for Inflammation

, 2009; 9(8): 724 - 737

Zhulun Wang, Holger Wesche, Tracey Stevens, Nigel Walker and Wen-Chen Yeh




Melanocortins in the Treatment of Male and Female Sexual Dysfunction

, 2007; 7(11): 1137 - 1144

Trevor J. Hallam, Carl Spana, Dennis C. Earle, Annette M. Shadiack and Shubh D. Sharma




Morpholino, siRNA, and S-DNA Compared: Impact of Structure and Mechanism of Action on Off-Target Effects and Sequence Specificity

, 2007; 7(7): 651 - 660

James E. Summerton




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