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Open Access Articles


Proteolysis Targeting Chimera (PROTAC): A Paradigm-Shifting Approach in Small Molecule Drug Discovery

, 2018; 18(16): 1354 - 1356

Pingyuan Wang and Jia Zhou*





Role of Biomacromolecules in Biomedical Engineering

, 2018; 18(14): 1171 - 1187

Juan M. Ruso and Natalia Hassan*





Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development

, 2018; 18(11): 883 - 895

Thomas Gross, Mark Mapstone, Ricardo Miramontes, Robert Padilla, Amrita K. Cheema, Fabio Macciardi, Howard J. Federoff* and Massimo S. Fiandaca*





Metabolomics Applications in Precision Medicine: An Oncological Perspective

, 2017; 17(24): 2740 - 2751

Leonor Puchades-Carrasco and Antonio Pineda- Lucena*




InsP3 Signaling in Apicomplexan Parasites

, 2017; 17(19): 2158 - 2165

Celia R.S. Garcia*, Eduardo Alves, Pedro H. S. Pereira, Paula J. Bartlett, Andrew P. Thomas, Katsuhiko Mikoshiba, Helmut Plattner and L. David Sibley




LncRNA as a Therapeutic Target for Angiogenesis

, 2017; 17(15): 1750 - 1757

Mohan M. Kumar and Ravi Goyal*





A Comprehensive Docking and MM/GBSA Rescoring Study of Ligand Recognition upon Binding Antithrombin

, 2017; 17(14): 1631 - 1639

Xiaohua Zhang, Horacio Perez-Sanchez* and Felice C. Lightstone*





Copper Homeostasis for the Developmental Progression of Intraerythrocytic Malarial Parasite

, 2016; 16(27): 3048 - 3057

Hiroko Asahi, Fumie Kobayashi, Shin-Ichi Inoue, Mamoru Niikura, Kenji Yagita and Mohammed Essa Marghany Tolba





The Unexpected Advantages of Using D-Amino Acids for Peptide Self- Assembly into Nanostructured Hydrogels for Medicine

, 2016; 16(18): 2009 - 2018

Michele Melchionna, Katie E. Styan and Silvia Marchesan




HCN Channels Modulators: The Need for Selectivity

, 2016; 16(16): 1764 - 1791

Maria Novella Romanelli, Laura Sartiani, Alessio Masi, Guido Mannaioni, Dina Manetti, Alessandro Mugelli and Elisabetta Cerbai




Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking

, 2016; 16(15): 1705 - 1716

Eric P. Trautman and Jason M. Crawford





Cellular Selenoprotein mRNA Tethering via Antisense Interactions with Ebola and HIV-1 mRNAs May Impact Host Selenium Biochemistry

, 2016; 16(13): 1530 - 1535

Ethan Will Taylor, Jan A. Ruzicka, Lakmini Premadasa and Lijun Zhao





αvβ3 Integrin-Targeted Peptide/Peptidomimetic-Drug Conjugates: In-Depth Analysis of the Linker Technology

, 2016; 16(3): 314 - 329

Alberto Dal Corso, Luca Pignataro, Laura Belvisi and Cesare Gennari





Toxicity of 11 Metal Oxide Nanoparticles to Three Mammalian Cell Types In V itro

, 2015; 15(18): 1914 - 1929

Angela Ivask, Tiina Titma, Meeri Visnapuu, Heiki Vija, Aleksandr Kakinen, Mariliis Sihtmae, Suman Pokhrel, Lutz Madler, Margit Heinlaan, Vambola Kisand, Ruth Shimmo and Anne Kahru




Computer-Aided Drug Design of Bioactive Natural Products

, 2015; 15(18): 1780 - 1800

Veda Prachayasittikul, Apilak Worachartcheewan, Watshara Shoombuatong, Napat Songtawee, Saw Simeon, Virapong Prachayasittikul and Chanin Nantasenamat




Active Targeted Drug Delivery for Microbes Using Nano-Carriers

, 2015; 15(15): 1525 - 1531

Yung-Sheng Lin, Ming-Yuan Lee, Chih-Hui Yang and Keng-Shiang Huang





Computational Studies of Free Radical-Scavenging Properties of Phenolic Compounds

, 2015; 15(2): 85 - 104

Petko Alov, Ivanka Tsakovska and Ilza Pajeva




Intracellular Redox State as Target for Anti-Influenza Therapy: Are Antioxidants Always Effective?

, 2014; 14(22): 2529 - 2541

Rossella Sgarbanti, Donatella Amatore, Ignacio Celestino, Maria Elena Marcocci, Alessandra Fraternale, Maria Rosa Ciriolo, Mauro Magnani, Raffaele Saladino, Enrico Garaci, Anna Teresa Palamara and Lucia Nencioni




Structure-Based Virtual Screening for Drug Discovery: Principles, Applications and Recent Advances

, 2014; 14(16): 1923 - 1938

Evanthia Lionta, George Spyrou, Demetrios K. Vassilatis and Zoe Cournia





Open Innovation Drug Discovery (OIDD): A Potential Path to Novel Therapeutic Chemical Space

, 2014; 14(3): 294 - 303

Maria Alvim-Gaston, Timothy Grese, Abdelaziz Mahoui, Alan D. Palkowitz, Marta Pineiro-Nunez and Ian Watson





A Brief Overview of Antimicrobial Peptides Containing Unnatural Amino Acids and Ligand-Based Approaches for Peptide Ligands

, 2013; 13(24): 3205 - 3224

Jayendra B. Bhonsle, Tiffany Clark, Libero Bartolotti and Rickey P. Hicks





From Polypharmacology to Target Specificity: The Case of PARP Inhibitors

, 2013; 13(23): 2939 - 2954

Paride Liscio, Emidio Camaioni, Andrea Carotti, Roberto Pellicciari and Antonio Macchiarulo





Recent Advances in the Synthesis of New Antimycobacterial Agents Based on the 1H-1,2,3-Triazoles

, 2013; 13(22): 2850 - 2865

Daniel Tadeu G. Gonzaga, David R. da Rocha, Fernando de C. da Silva and Vitor F. Ferreira





Synthesis and Biological Evaluation of Potent Antifungal Agents

, 2013; 13(21): 2684 - 2733

Athina Geronikaki, Maria Fesatidou, Victor Kartsev and Fliur Macaev





Mucosal Vaccines: Where Do We Stand?

, 2013; 13(20): 2609 - 2628

Jean-Pierre Kraehenbuhl and Marian R. Neutra





Challenges and Opportunities for Cancer Vaccines in the Current NSCLC Clinical Scenario

, 2013; 13(20): 2551 - 2561

Pedro C. Rodriguez and Belinda Sanchez




Therapy in Prion Diseases

, 2013; 13(19): 2465 - 2476

Gianluigi Forloni, Vladimiro Artuso, Ignazio Roiter, Michela Morbin and Fabrizio Tagliavini




Prion Chemical Biology: On the Road to Therapeutics?

, 2013; 13(19): 2441 - 2464

Beining Chen, Mark Thompson, Jennifer Louth and Kai Guo





Overview on Theoretical Studies Discriminating the Two-Oxidant Versus Two-State-Reactivity Models for Substrate Monoxygenation by Cytochrome P450 Enzymes

, 2013; 13(18): 2218 - 2232

Sam P. de Visser, Cristina S. Porro, Matthew G. Quesne, Mala A. Sainna and Andrew W. Munro




Mitochondria: A Promising Target for Anticancer Alkaloids

, 2013; 13(17): 2171 - 2183

Félix A. Urra, Miguel Cordova-Delgado, Hernan Pessoa-Mahana, Oney Ramírez-Rodríguez, Boris Weiss-Lopez, Jorge Ferreira and Ramiro Araya-Maturana




Alkaloid-Metal Based Anticancer Agents

, 2013; 13(17): 2104 - 2115

Zhen-Feng Chen, Yan-Cheng Liu, Ke-Bin Huang and Hong Liang





Targeting Host Store-Operated Ca2+ Release to Attenuate Viral Infections

, 2013; 13(16): 1916 - 1932

Kevin B. Clark and E. M. Eisenstein





The Multifactorial Nature of Alzheimer's Disease for Developing Potential Therapeutics

, 2013; 13(15): 1745 - 1770

M. Carmo Carreiras, Eduarda Mendes, M. Jesus Perry, Ana Paula Francisco and J. Marco-Contelles





Recent Advances in Predicting Protein Classification and Their Applications to Drug Development

, 2013; 13(14): 1622 - 1635

Xuan Xiao, Wei-Zhong Lin and Kuo-Chen Chou




The Emerging Role of microRNA in Stroke

, 2013; 13(13): 1573 - 1588

Georgios Koutsis, Gerasimos Siasos and Konstantinos Spengos




Insights in microRNAs Biology

, 2013; 13(13): 1493 - 1502

Antonios N. Gargalionis and Efthimia K. Basdra





CYP17A1: A Biochemistry, Chemistry, and Clinical Review

, 2013; 13(12): 1364 - 1384

David Porubek





Permeability Diagnosis Model in Drug Discovery: A Diagnostic Tool to Identify the Most Influencing Properties for Gastrointestinal Permeability

, 2013; 13(11): 1308 - 1316

Jianling Wang and Suzanne Skolnik





Open Source Software and Web Services for Designing Therapeutic Molecules

, 2013; 13(10): 1172 - 1191

Deepak Singla, Sandeep Kumar Dhanda, Jagat Singh Chauhan, Anshu Bhardwaj, Samir K. Brahmachari, Open Source Drug Discovery Consortium and Gajendra P.S. Raghava





A Novel Integrated Framework and Improved Methodology of Computer-Aided Drug Design

, 2013; 13(9): 965 - 988

Calvin Yu-Chian Chen





Fluorine-18 Labeled Amino Acids for Oncologic Imaging with Positron Emission Tomography

, 2013; 13(8): 871 - 891

Chaofeng Huang and Jonathan McConathy




Medicinal Chemistry Design Principles for Liver Targeting Through OATP Transporters

, 2013; 13(7): 857 - 866

Meihua Tu, Alan M. Mathiowetz, Jeffrey A. Pfefferkorn, Kimberly O. Cameron, Robert L. Dow, John Litchfield, Li Di, Bo Feng and Spiros Liras




Intestinal Targeting of Drugs: Rational Design Approaches and Challenges

, 2013; 13(7): 776 - 802

Kevin J. Filipski, Manthena V. Varma, Ayman F. El-Kattan, Catherine M. Ambler, Roger B. Ruggeri, Theunis C. Goosen and Kimberly O. Cameron





The Genetic Architecture of Rheumatoid Arthritis: From Susceptibility to Clinical Subphenotype Associations

, 2013; 13(6): 720 - 731

Antonio Julia and Sara Marsal





From Protein-Protein Interactions to Rational Drug Design: Are Computational Methods Up to the Challenge?

, 2013; 13(5): 602 - 618

Edgar D. Coelho, Joel P. Arrais and Jose Luis Oliveira




The Impact of Computer Science in Molecular Medicine: Enabling High- Throughput Research

, 2013; 13(5): 526 - 575

Diana de la Iglesia, Miguel Garcia-Remesal, Guillermo de la Calle, Casimir Kulikowski, Ferran Sanz and Victor Maojo




Chemistry and Theranostic Applications of Radiolabeled Nanoparticles for Cardiovascular, Oncological, and Pulmonary Research

, 2013; 13(4): 470 - 478

Yunjun Guo, Tolulope Aweda, Kvar C.L. Black and Yongjian Liu





Endogenous Modulators of TRP Channels

, 2013; 13(3): 398 - 407

Enza Palazzo, Francesco Rossi, Vito de Novellis and Sabatino Maione




Oncogenic and Anti-Oncogenic Effects of Transient Receptor Potential Channels

, 2013; 13(3): 344 - 366

Sonia Liberati, Maria Beatrice Morelli, Massimo Nabissi, Matteo Santoni and Giorgio Santoni




MicroRNAs and the Heart: Small Things Do Matter

, 2013; 13(2): 216 - 230

Nikolaos Papoutsidakis, Spyridon Deftereos, Andreas Kaoukis, Georgios Bouras, Georgios Giannopoulos, Andreas Theodorakis, Christos Angelidis, Georgios Hatzis and Christodoulos Stefanadis




Myeloperoxidase: Expressing Inflammation and Oxidative Stress in Cardiovascular Disease

, 2013; 13(2): 115 - 138

Nikolaos Anatoliotakis, Spyridon Deftereos, Georgios Bouras, Georgios Giannopoulos, Dimitrios Tsounis, Christos Angelidis, Andreas Kaoukis and Christodoulos Stefanadis




Computational Tools in the Discovery of New G-Quadruplex Ligands with Potential Anticancer Activity

, 2012; 12(24): 2843 - 2856

Daimel Castillo-Gonzalez, Gisselle Perez-Machado, Federico Pallardo, Teresa-Maria Garrigues-Pelufo and Miguel-Angel Cabrera-Perez





Tetraamine-Coupled Peptides and Resulting 99mTc-Radioligands: An Effective Route for Receptor-Targeted Diagnostic Imaging of Human Tumors

, 2012; 12(23): 2655 - 2667

Berthold A. Nock and Theodosia Maina




Alpha-Emitters for Immuno-Therapy: A Review of Recent Developments from Chemistry to Clinics

, 2012; 12(23): 2642 - 2654

Sandrine Huclier-Markai, Cyrille Alliot, Nicolas Varmenot, Cathy S. Cutler and Jacques Barbet




SOD1 Aggregation and ALS: Role of Metallation States and Disulfide Status

, 2012; 12(22): 2560 - 2572

Yuewei Sheng, Madhuri Chattopadhyay, Julian Whitelegge and Joan Selverstone Valentine





Protein Misfolding in Disease and Small Molecule Therapies

, 2012; 12(22): 2460 - 2469

Claudio M. Gomes





Neurofunctional Correlates of Theory of Mind Deficits in Schizophrenia

, 2012; 12(21): 2284 - 2302

M. Bosia, R. Riccaboni and S. Poletti





Monoamine Oxidase Inhibitors: Ten Years of Docking Studies

, 2012; 12(20): 2145 - 2162

Giulio Ferino, Santiago Vilar, Maria J. Matos, Eugenio Uriarte and Enzo Cadoni




Effects of Natural Compounds on Xenopus Embryogenesis: A Potential Read Out for Functional Drug Discovery Targeting Wnt/β-catenin Signaling

, 2012; 12(19): 2103 - 2113

Nathalia G. Amado, Barbara F. Fonseca, Debora Malta Cerqueira, Alice H. Reis, Alessandro Bolis Costa Simas, Ricardo Machado Kuster, Fabio A. Mendes and Jose G. Abreu




The Central Nervous System as a Promising Target to Treat Diabetes Mellitus

, 2012; 12(19): 2070 - 2081

Jose Donato Jr.





A Survey of Quantitative Descriptions of Molecular Structure

, 2012; 12(18): 1946 - 1956

Rajarshi Guha and Egon Willighagen




Enzyme Informatics

, 2012; 12(17): 1911 - 1923

Rosanna G. Alderson, Luna De Ferrari, Lazaros Mavridis, James L. McDonagh, John B.O. Mitchell and Neetika Nath




Compound Activity Prediction Using Models of Binding Pockets or Ligand Properties in 3D

, 2012; 12(17): 1869 - 1882

Irina Kufareva, Yu-Chen Chen, Andrey V. Ilatovskiy and Ruben Abagyan





QSAR and Molecular Docking Techniques for the Discovery of Potent Monoamine Oxidase B Inhibitors: Computer-Aided Generation of New Rasagiline Bioisosteres

, 2012; 12(16): 1734 - 1747

Alejandro Speck-Planche and Valeria V. Kleandrova





Novel Gene Transfer Systems: Intelligent Gene Transfer Vectors for Gene Medicines

, 2012; 12(15): 1594 - 1602

Toshihiro Nakajima





Towards Isozyme-Selective HDAC Inhibitors For Interrogating Disease

, 2012; 12(14): 1479 - 1499

Praveer Gupta, Robert C. Reid, Abishek Iyer, Matthew J. Sweet and David P. Fairlie





From the Deepest Sea Shelf to the Uppermost Kitchen Cabinet Shelf: The Quest for Novel TNF-α Inhibitors

, 2012; 12(13): 1392 - 1407

F. Folmer, M. Dicato and M. Diederich





Chemical Genomics and Emerging DNA Technologies in the Identification of Drug Mechanisms and Drug Targets

, 2012; 12(12): 1331 - 1345

Louise Cathrine Braun Olsen and Nils Joakim Faergeman




The IC50 Concept Revisited

, 2012; 12(11): 1282 - 1290

Gary W. Caldwell, Zhengyin Yan, Wensheng Lang and John A. Masucci




An Integrated Data Management Framework for Drug Discovery – From Data Capturing to Decision Support

, 2012; 12(11): 1237 - 1242

Walter Cedeno, Simson Alex, Edward P. Jaeger, Dimitris K. Agrafiotis and Victor S. Lobanov




Novel Therapeutic Approaches Targeting Matrix Metalloproteinases in Cardiovascular Disease

, 2012; 12(10): 1214 - 1221

Alexandros Briasoulis, Dimitris Tousoulis, Nikolaos Papageorgiou, Anna-Maria Kampoli, Emmanuel Androulakis, Charalambos Antoniades, Eleftherios Tsiamis, George Latsios and Christodoulos Stefanadis




Myocardial Structure and Matrix Metalloproteinases

, 2012; 12(10): 1113 - 1131

C. Aggeli, P. Pietri, I. Felekos, L. Rautopoulos, K. Toutouzas, E. Tsiamis and C. Stefanadis





Recent Progress in Anticonvulsant Drug Research: Strategies for Anticonvulsant Drug Development and Applications of Antiepileptic Drugs for Non-Epileptic Central Nervous System Disorders

, 2012; 12(9): 1033 - 1071

Sevim Dalkara and Arzu Karakurt





Computer-Aided Drug Design Methodologies Toward the Design of Anti-Hepatitis C Agents

, 2012; 12(8): 802 - 813

Alejandro Speck-Planche and M. Natalia D. S. Cordeiro





Targeting InhA, the FASII Enoyl-ACP Reductase: SAR Studies on Novel Inhibitor Scaffolds

, 2012; 12(7): 672 - 693

Pan Pan and Peter J. Tonge





General Molecular Biology and Architecture of Nuclear Receptors

, 2012; 12(6): 486 - 504

Michal Pawlak, Philippe Lefebvre and Bart Staels





Targeting Protein Kinases in the Malaria Parasite: Update of an Antimalarial Drug Target

, 2012; 12(5): 456 - 472

Veronica M. Zhang, Marina Chavchich and Norman C. Waters





Synthetic Peroxides as Potent Antimalarials. News and Views

, 2012; 12(5): 373 - 399

Charles W. Jefford





Treatment Strategies of Obsessive-Compulsive Disorder and Panic Disorder/Agoraphobia

, 2012; 12(4): 238 - 253

Donatella Marazziti, Marina Carlini and Liliana Dell'Osso





Multifunctional Ligands in Medicinal Inorganic Chemistry- Current Trends and Future Directions

, 2012; 12(3): 122 - 144

Linus Chiang, Michael R. Jones, Cara L. Ferreira and Tim Storr





Polymeric Carrier Systems for siRNA Delivery

, 2012; 12(2): 108 - 119

P. Vader, L. J. van der Aa, G. Storm, R. M. Schiffelers and J. F.J. Engbersen





Rapid Analysis of Pharmacology for Infectious Diseases

, 2011; 11(10): 1292 - 1300

Andrew L. Hopkins, G. Richard Bickerton, Ian M. Carruthers, Stephen K. Boyer, Harvey Rubin and John P. Overington





Transcriptional Regulation by Promoter Targeted RNAs

, 2009; 9(12): 1079 - 1087

Kazuo Suzuki and Anthony D. Kelleher




IRAK-4 Inhibitors for Inflammation

, 2009; 9(8): 724 - 737

Zhulun Wang, Holger Wesche, Tracey Stevens, Nigel Walker and Wen-Chen Yeh




Melanocortins in the Treatment of Male and Female Sexual Dysfunction

, 2007; 7(11): 1137 - 1144

Trevor J. Hallam, Carl Spana, Dennis C. Earle, Annette M. Shadiack and Shubh D. Sharma






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