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Current Topics in Medicinal Chemistry

Volume 21, 32 Issues, 2021
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Current Topics in Medicinal Chemistry

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Volume 21

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Number 6



Perspectives in Medicinal Chemistry   Open Access









Review Article

Docking Paradigm in Drug Design

, 21(6): 507 - 546

Vladimir B. Sulimov*, Danil C. Kutov, Anna S. Taschilova, Ivan S. Ilin, Eugene E. Tyrtyshnikov and Alexey V. Sulimov


DOI: 10.2174/1568026620666201207095626


Review Article

Tuberculosis: An Update on Pathophysiology, Molecular Mechanisms of Drug Resistance, Newer Anti-TB Drugs, Treatment Regimens and Host- Directed Therapies

, 21(6): 547 - 570

Pobitra Borah, Pran K. Deb*, Katharigatta N. Venugopala, Nizar A. Al-Shar’i, Vinayak Singh, Satyendra Deka, Amavya Srivastava, Vinod Tiwari and Raghu P. Mailavaram


DOI: 10.2174/1568026621999201211200447


Current Topics in Medicinal Chemistry, Volume 21 (2021) - Number 8


This issue is in progress but contains articles that are final and fully citable.

Current Topics in Medicinal Chemistry, Volume 21 (2021) - Number 7


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print


Role of Phytomolecules in the Treatment of Obesity: Targets, Mechanisms and Limitations


Shampa Ghosh, Srividya Manchala , Manchala Raghunath, Gaurav Sharma , Abhishek Kumar Singh* and Jitendra Kumar Sinha *


DOI: 10.2174/1568026621666210305101804
View Abstract View on PubMed



Sterol 14α-Demethylase from Trypanosomatidae Parasites as a Promising Target for Designing New Antiparasitic Agents


Paulo Fernando da Silva Santos-Júnior, Martine Schmitt, João Xavier de Araújo-Júnior and Edeildo Ferreira da Silva-Júnior*


DOI: 10.2174/1568026621666210303144448
View Abstract View on PubMed








Abstracts Ahead of Print


Predicting Metabolic Reaction Networks with Perturbation-Theory Machine Learning (PTML) Models


Karel Diéguez-Santana, Gerardo M. Casañola-Martin, James R. Green, Bakhtiyor Rasulev and Humberto González-Díaz*


DOI: 10.2174/1568026621666210331161144
View Abstract



The Role of Machine Learning in Centralized Authorization Process of Nanomedicines in European Union


Ricardo Santana *, Enrique Onieva, Robin Zuluaga , Aliuska Duardo-Sánchez and Piedad Gañán


DOI: 10.2174/1568026621666210319101847
View Abstract


Potential therapeutic relevance of CRISPR/Cas9 guided Epigenetic Regulations for Neuropsychiatric Disorders


Desh Deepak Singh*, Ravi Verma, Piyush Parimoo, Ashish Sahu, Vikram Kumar, Era Upadhyay and Dharmendra Kumar Yadav


DOI: 10.2174/1568026621666210317154502
View Abstract


A Multi-Target Drug Designing for BTK, MMP9, Proteasome And TAK1 for the clinical treatment of Mantle Cell Lymphoma


Shahrukh Qureshi, Ravina Khandelwal, Maddala Madhavi, Naveesha Khurana, Neha Gupta, Saurav Kumar Choudhary, Revathy Arya Suresh, Lima Hazarika, Chillamcherla Dhanalakshmi Srija, Khushboo Sharma, Mali Ram Hindala, Tajamul Hussain, Anuraj Nayarisseri* and Sanjeev Kumar Singh*


DOI: 10.2174/1568026621666210119112336
View Abstract


Published Contents

Editor's Choice

Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*


DOI: 10.2174/1568026618666180821145215




A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*


DOI: 10.2174/1568026618666180516123229




Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610






Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao


DOI: 10.2174/1568026618666180410151518



Aurora Kinase Inhibitors in Head and Neck Cancer

, 2018; 18(3): 199 - 213

Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang* and Yasusei Kudo*


DOI: 10.2174/1568026618666180112163741



Open Access Articles

An Overview of Ovarian Cancer: Molecular Processes Involved and Development of Target-based Chemotherapeutics

, 2021; 21(4): 329 - 346

Basheerulla Shaik, Tabassum Zafar, Krishnan Balasubramanian and Satya P. Gupta*





Beyond DNA-targeting in Cancer Chemotherapy. Emerging Frontiers - A Review

, 2021; 21(1): 28 - 47

Simon N. Mbugua, Lydia W. Njenga, Ruth A. Odhiambo, Shem O. Wandiga and Martin O. Onani*




Peptide Receptor Radionuclide Therapy: Looking Back, Looking Forward

, 2020; 20(32): 2959 - 2969

Danny Feijtel, Marion de Jong and Julie Nonnekens*




Learning the Edit Costs of Graph Edit Distance Applied to Ligand-Based Virtual Screening

, 2020; 20(18): 1582 - 1592

Carlos Garcia-Hernandez, Alberto Fernández* and Francesc Serratosa




Telomere-related Markers for Cancer

, 2020; 20(6): 410 - 432

Xiaotian Yuan*, Mingkai Dai and Dawei Xu*






Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19(18): 1621 - 1649

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*




Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

, 2019; 19(16): 1399 - 1417

Chenyi Liao, Mathilde P. de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May* and Jianing Li*




Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity

, 2019; 19(11): 957 - 969

Ana Yisel Caballero-Alfonso, Maykel Cruz-Monteagudo, Eduardo Tejera, Emilio Benfenati, Fernanda Borges, M. Natália D.S. Cordeiro, Vinicio Armijos-Jaramillo and Yunierkis Perez-Castillo*





Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*




Mechanical Properties of Composite Hydrogels for Tissue Engineering

, 2018; 18(14): 1214 - 1223

Ramon Rial, J.F. Armando Soltero, Pedro V. Verdes, Zhen Liu and Juan M. Ruso*






Most Cited Articles

Review Article

Biological signatures of alzheimer’s disease

, 2020; 20(9): 770-781.

Poornima Sharma, Anjali Sharma, Faizana Fayaz, Sharad Wakode* and Faheem H. Pottoo


DOI: 10.2174/1568026620666200228095553


Review Article

Emerging proof of protein misfolding and interactions in multifactorial alzheimer's disease

, 2020; 20(26): 2380-2390.

Md. Sahab Uddin*, Abdullah Al Mamun, Md. Ataur Rahman, Tapan Behl, Asma Perveen, Abdul Hafeez, May N. Bin-Jumah, Mohamed M. Abdel-Daim and Ghulam Md Ashraf*


DOI: 10.2174/1568026620666200601161703



Review Article

Emerging promise of immunotherapy for alzheimer’s disease: A new hope for the development of alzheimer’s vaccine

, 2020; 20(13): 1214-1234.

Md. Tanvir Kabir, Md. Sahab Uddin*, Bijo Mathew, Pankoj Kumar Das, Asma Perveen and Ghulam Md. Ashraf*


DOI: 10.2174/1568026620666200422105156




Current Frontiers

Exploring the potential of neuroproteomics in Alzheimer's disease

, 2020; 20(25): 2263-2278.

Md. Sahab Uddin*, Md. Tanvir Kabir, Md. Jakaria, Eduardo Sobarzo-Sánchez, George E. Barreto, Asma Perveen, Abdul Hafeez, May N. Bin-Jumah, Mohamed M. Abdel-Daim and Ghulam M. Ashraf*


DOI: 10.2174/1568026620666200603112030


Current Frontiers

Novel drugs targeting the SARS-CoV-2/COVID-19 machinery

, 2020; 20(16): 1423-1433.

Ariane Sternberg, Dwight L. McKee and Cord Naujokat*


DOI: 10.2174/1568026620999200517043137


Review Article

Telomerase-based cancer therapeutics: A review on their clinical trials

, 2020; 20(6): 433-457.

Nicola Relitti*, Akella P. Saraswati, Stefano Federico, Tuhina Khan, Margherita Brindisi, Daniela Zisterer, Simone Brogi, Sandra Gemma, Stefania Butini and Giuseppe Campiani*


DOI: 10.2174/1568026620666200102104930


Current Frontiers

Evidence linking protein misfolding to quality control in progressive neurodegenerative diseases

, 2020; 20(23): 2025-2043.

Md. Tanvir Kabir, Md. Sahab Uddin*, Ahmed Abdeen, Ghulam Md Ashraf, Asma Perveen, Abdul Hafeez, May N. Bin-Jumah and Mohamed M. Abdel-Daim


DOI: 10.2174/1568026620666200618114924


Review Article

Telomere-related markers for cancer

, 2020; 20(6): 410-432.

Xiaotian Yuan*, Mingkai Dai and Dawei Xu*


DOI: 10.2174/1568026620666200106145340


Systematic Review Article

An update on glutamatergic system in suicidal depression and on the role of esketamine

, 2020; 20(7): 554-584.

Domenico De Berardis*, Carmine Tomasetti, Maurizio Pompili, Gianluca Serafini, Federica Vellante, Michele Fornaro, Alessandro Valchera, Giampaolo Perna, Umberto Volpe, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio, Yong-Ku Kim and Laura Orsolini


DOI: 10.2174/1568026620666200131100316


Review Article

Periodontal pathogens and neuropsychiatric health

, 2020; 20(15): 1353-1397.

Abhishek Wadhawan, Mark A. Reynolds, Hina Makkar, Alison J. Scott, Eileen Potocki, Andrew J. Hoisington, Lisa A. Brenner, Aline Dagdag, Christopher A. Lowry, Yogesh Dwivedi and Teodor T. Postolache*


DOI: 10.2174/1568026620666200110161105





Most Accessed Articles


Akt Pathway Inhibitors

, 2020; 20(10): 883-900.

Nne E. Uko, Osman F. Güner, Diane F. Matesic and J. Phillip Bowen*


DOI: 10.2174/1568026620666200224101808




Fungal Infections in COVID-19-Positive Patients: A Lack of Optimal Treatment Options

, 2020; 20(22): 1951-1957.

Laura Nunes Silva, Thaís Pereira de Mello, Lívia de Souza Ramos, Marta Helena Branquinha, Maryam Roudbary and André Luis Souza dos Santos*


DOI: 10.2174/156802662022200917110102




Natriuretic Peptides as the Basis of Peptide Drug Discovery for Cardiovascular Diseases

, 2020; 20(32): 2904-2921.

Yana Lerner, Wessal Hanout, Shulamit Fluss Ben-Uliel, Samar Gani, Michal (Pellach) Leshem and Nir Qvit*


DOI: 10.2174/1568026620666201013154326



Antimicrobial Peptides and their Multiple Effects at Sub-Inhibitory Concentrations

, 2020; 20(14): 1264-1273.

Bruno Casciaro*, Floriana Cappiello, Walter Verrusio, Mauro Cacciafesta and Maria Luisa Mangoni*


DOI: 10.2174/1568026620666200427090912




Peptide Shuttle-Mediated Delivery for Brain Gene Therapies

, 2020; 20(32): 2945-2958.

Josep Garcia, Pol Arranz-Gibert, Macarena Sánchez-Navarro, Ernest Giralt and Meritxell Teixidó*


DOI: 10.2174/1568026620666201023122903


Computer-Aided Drug Design Applied to Secondary Metabolites as Anticancer Agents

, 2020; 20(19): 1677-1703.

Rodrigo Santos Aquino de Araújo, Edeildo Ferreira da Silva-Junior, Thiago Mendonça de Aquino, Marcus Tullius Scotti, Hamilton M. Ishiki, Luciana Scotti and Francisco Jaime Bezerra Mendonça-Junior*


DOI: 10.2174/1568026620666200607191838





Editor-in-Chief

graphic
Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX
(USA)
Biography
View Full Editorial Board

COPE Compliant

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Journal History

Current Topics in Medicinal Chemistry was introduced in 2001 with the assistance of Dr. Allen B. Reitz, who is the current Editor-in-Chief serving since 2001.

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