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Current Topics in Medicinal Chemistry

Volume 20, 32 Issues, 2020
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

Ranking and Category

  • 20th of 61 in

    Chemistry, Medicinal

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Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Current Topics in Medicinal Chemistry

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Volume 20

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Number 2



Editorial   Open Access

New Developments in the Medicinal Chemistry Targeting Drug-Resistant Infection – Part-I

, 20(2): 87 - 88

Fernando de Carvalho a Silva, Vitor Francisco Ferreira and Luana da Silva Magalhães Forezi


DOI: 10.2174/156802662002200219090340


Research Article



Research Article

Novel Quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione Derivatives Against Chloroquine-resistant Plasmodium falciparum

, 20(2): 99 - 110

Kamilla Rodrigues Rogerio, Cedric Stephan Graebin, Luiza Helena Pinto Domingues, Luana Santos Oliveira, Vitoria de Souza Fernandes da Silva, Claudio Tadeu Daniel-Ribeiro, Leonardo J.M. Carvalho* and Nubia Boechat*


DOI: 10.2174/1568026619666191019100711


Research Article

Agathisflavone, a Biflavonoid from Anacardium occidentale L., Inhibits Influenza Virus Neuraminidase

, 20(2): 111 - 120

Caroline S. de Freitas, Marco E.N. Rocha, Carolina Q. Sacramento, Andressa Marttorelli, André C. Ferreira, Natasha Rocha, Andrea Cheble de Oliveira, Andre Marco de Oliveira Gomes, Patrícia Souza dos Santos, Edilene Oliveira da Silva, Josineide Pantoja da Costa, Davyson de Lima Moreira, Patrícia T. Bozza, Jerson L. Silva, Shana Priscila Coutinho Barroso and Thiago Moreno L. Souza*


DOI: 10.2174/1568026620666191219150738


Research Article

Efficient Synthesis and Antibacterial Profile of Bis(2-hydroxynaphthalene- 1,4-dione)

, 20(2): 121 - 131

Juliana S. Novais, Aline C. Rosandiski, Carolina M. de Carvalho, Letícia S. de Saules Silva, Lais C. dos S. Velasco de Souza, Marcos V. Santana, Nathalia R.C. Martins, Helena C. Castro, Vitor F. Ferreira, Daniel T.G. Gonzaga, Gabriel O. de Resende* and Fernando de C. da Silva*


DOI: 10.2174/1568026619666191210160342


Research Article

Neuraminidase from Influenza A and B Viruses is Susceptible to the Compound 4-(4-Phenyl-1H-1,2,3-Triazol-1-yl)-2,2,6,6-Tetramethylpiperidine-1- Oxyl

, 20(2): 132 - 139

Carolina Q. Sacramento, Alessandro Kappel Jordão, Juliana L. Abrantes, Cristiane M. Alves, Andressa Marttorelli, Natalia Fintelman-Rodrigues, Caroline S. de Freitas, Gabrielle R. de Melo, Anna Claudia Cunha, Vitor F. Ferreira and Thiago Moreno L. Souza*


DOI: 10.2174/1568026620666191227142433


Research Article

Spiro-Lactams as Novel Antimicrobial Agents

, 20(2): 140 - 152

Américo J.S. Alves, Nuno G. Alves, Cátia C. Caratão, Margarida I.M. Esteves, Diana Fontinha, Inês Bártolo, Maria I.L. Soares, Susana M.M. Lopes, Miguel Prudêncio, Nuno Taveira and Teresa M.V.D. Pinho e Melo*


DOI: 10.2174/1568026619666191105110049


Research Article

Synthesis of Coumarin Derivatives as Versatile Scaffolds for GSK-3β Enzyme Inhibition

, 20(2): 153 - 160

Carla S. Francisco, Clara L. Javarini, Iatahanderson de S. Barcelos , Pedro A.B. Morais, Heberth de Paula, Warley de S. Borges, Álvaro Cunha Neto and Valdemar Lacerda*


DOI: 10.2174/1568026619666191019105349


Articles Ahead of Print






Access to a Library of 1,3-disubstituted-1,2,3-triazenes and Evaluation of their Antimicrobial Properties


Insa Seck, Samba Fama Ndoye, Lalla Aicha Ba, Alioune Fall, Abdoulaye Diop, Ismaïla Ciss, Abda Ba, Cheikh Sall, Amadou Diop, Cheikh Sadibou Boye, Generosa Gomez, Yagamare Fall and Matar Seck*


DOI: 10.2174/1568026620666200127143005
View Abstract View on PubMed


In Vitro α-glucosidase Inhibition and Computational Studies of Kaempferol Derivatives from Dryopteris cycanida


Surriya Amin, Barkat Ullah, Mumtaz Ali, Haroon Khan*, Abdur Rauf, Sher Ali Khan and Eduardo Sobarzo-Sánchez*


DOI: 10.2174/1568026620666200130161033
View Abstract View on PubMed



An Update on Glutamatergic System in Suicidal Depression and on the role of Esketamine


Domenico De Berardis*, Carmine Tomasetti, Maurizio Pompili, Gianluca Serafini, Federica Vellante, Michele Fornaro, Alessandro Valchera, Giampaolo Perna, Umberto Volpe, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio, Yong-Ku Kim and Laura Orsolini


DOI: 10.2174/1568026620666200131100316
View Abstract View on PubMed



Abstracts Ahead of Print

Towards a Better Understanding of Computational Models for Predicting DNA Methylation Effects at the Molecular Level


Nathanael K. Proctor, Tugba Ertan-Bolelli, Kayhan Bolelli, Ethan W. Taylor, Norman H. L. Chiu and J. Phillip Bowen*


DOI: 10.2174/1568026620666200226110019
View Abstract




Evaluating hemolytic and photo hemolytic potential of organophosphorus by in vitro method as an alternative tool using Human erythrocytes


Ana Laura García Soria, Fabiola Rivera Ramirez, Alberto Barbabosa Pliego, Héctor Roberto Díaz Guadarrama , Guadalupe Patricia Macías Farrera, Gilberto Yong Angel, Juan Carlos Vázquez Chagoyán, Raafat Mahmoud Mohamed Gomaa and Esvieta Tenorio-Borroto*


DOI: 10.2174/1568026620666200226104029
View Abstract


Akt Pathway Inhibitors


Nne E. Uko, Osman F. Güner, Diane F. Matesic and J. Phillip Bowen*


DOI: 10.2174/1568026620666200224101808
View Abstract





Neuro-Clinical signatures of language impairments after acute stroke: a VBQ analysis of quantitative native CT scans


Sandrine Muller, Kaisar Dauyey, Anne Ruef , Sara Lorio, Ashraf Eskandari, Laurence Schneider, Valérie Beaud, Elisabeth Roggenhofer, Bogdan Draganski, Patrik Michel and Ferath Kherif*


DOI: 10.2174/1568026620666200211113824
View Abstract



Published Contents

Editor's Choice

Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*


DOI: 10.2174/1568026618666180821145215




A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*


DOI: 10.2174/1568026618666180516123229




Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610






Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao


DOI: 10.2174/1568026618666180410151518



Aurora Kinase Inhibitors in Head and Neck Cancer

, 2018; 18(3): 199 - 213

Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang* and Yasusei Kudo*


DOI: 10.2174/1568026618666180112163741



Open Access Articles


Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19(18): 1621 - 1649

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*




Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

, 2019; 19(16): 1399 - 1417

Chenyi Liao, Mathilde P. de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May* and Jianing Li*




Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity

, 2019; 19(11): 957 - 969

Ana Yisel Caballero-Alfonso, Maykel Cruz-Monteagudo, Eduardo Tejera, Emilio Benfenati, Fernanda Borges, M. Natália D.S. Cordeiro, Vinicio Armijos-Jaramillo and Yunierkis Perez-Castillo*






Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*




Mechanical Properties of Composite Hydrogels for Tissue Engineering

, 2018; 18(14): 1214 - 1223

Ramon Rial, J.F. Armando Soltero, Pedro V. Verdes, Zhen Liu and Juan M. Ruso*





Analyzing of Molecular Networks for Human Diseases and Drug Discovery

, 2018; 18(12): 1007 - 1014

Tong Hao, Qian Wang, Lingxuan Zhao, Dan Wu, Edwin Wang* and Jinsheng Sun*




Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development

, 2018; 18(11): 883 - 895

Thomas Gross, Mark Mapstone, Ricardo Miramontes, Robert Padilla, Amrita K. Cheema, Fabio Macciardi, Howard J. Federoff* and Massimo S. Fiandaca*





Ubiquitin Proteasome System as a Potential Drug Target for Malaria

, 2018; 18(5): 315 - 320

Pedro H. Scarpelli Pereira, Chiara Curra and Celia R.S. Garcia*




Metabolomics Applications in Precision Medicine: An Oncological Perspective

, 2017; 17(24): 2740 - 2751

Leonor Puchades-Carrasco and Antonio Pineda- Lucena*




InsP3 Signaling in Apicomplexan Parasites

, 2017; 17(19): 2158 - 2165

Celia R.S. Garcia*, Eduardo Alves, Pedro H. S. Pereira, Paula J. Bartlett, Andrew P. Thomas, Katsuhiko Mikoshiba, Helmut Plattner and L. David Sibley





Most Cited Articles

Review Article

Biological activities of artemisinin derivatives beyond malaria

, 2019; 19(3): 205-222.

Xiaoyan Liu, Jianguo Cao, Guozheng Huang*, Qingjie Zhao* and Jingshan Shen


DOI: 10.2174/1568026619666190122144217



Review Article

Prediction of drug-drug interactions related to inhibition or induction of drug-metabolizing enzymes

, 2019; 19(5): 319-336.

Alexander V. Dmitriev*, Alexey A. Lagunin, Dmitry А. Karasev, Anastasia V. Rudik, Pavel V. Pogodin, Dmitry A. Filimonov and Vladimir V. Poroikov


DOI: 10.2174/1568026619666190123160406


Review Article

Mycobacterial tuberculosis Enzyme Targets and their Inhibitors

, 2019; 19(5): 337-355.

Anil Kumar Saxena* and Anamika Singh


DOI: 10.2174/1568026619666190219105722


Perspectives in Medicinal Chemistry

Functional inhibition of VEGF and EGFR suppressors in cancer treatment

, 2019; 19(3): 178-179.

Sanjeev Kumar Singh and Anuraj Nayarisseri


DOI: 10.2174/156802661903190328155731


Review Article

Zinc-depend ent deacetylase (HDAC) inhibitors with different zinc binding groups

, 2019; 19(3): 223-241.

Yan Li, Fang Wang, Xiaoxue Chen, Jie Wang, Yonglong Zhao, Yongjun Li and Bin He*


DOI: 10.2174/1568026619666190122144949


Review Article

Nanoparticle therapy for prostate cancer: Overview and perspectives

, 2019; 19(1): 57-73.

Junfu Zhang, Liying Wang, Xinru You, Tuzeng Xian, Jun Wu* and Jun Pang*


DOI: 10.2174/1568026619666190125145836


Review Article

Small molecule natural products and Alzheimer’s disease

, 2019; 19(3): 187-204.

Xiaoai Wu, Huawei Cai, Lili Pan, Gang Cui, Feng Qin, YunChun Li and Zhengxin Cai*


DOI: 10.2174/1568026619666190201153257



Research Article

A computer-aided drug designing for pharmacological inhibition of mutant alk for the treatment of non-small cell lung cancer

, 2019; 19(13): 1129-1144.

Saphy Sharda, Ravina Khandelwal, Ritu Adhikary, Diksha Sharma, Manisha Majhi, Tajamul Hussain, Anuraj Nayarisseri* and Sanjeev Kumar Singh*


DOI: 10.2174/1568026619666190521084941


Research Article

Identification of high-affinity small molecules targeting Gamma secretase for the treatment of Alzheimer’s disease

, 2019; 19(13): 1173-1187.

Meer Asif Ali, Sugunakar Vuree, Himshikha Goud, Tajamul Hussain, Anuraj Nayarisseri* and Sanjeev Kumar Singh*


DOI: 10.2174/1568026619666190617155326



Review Article

Research advances in the use of histone deacetylase inhibitors for epigenetic targeting of cancer

, 2019; 19(12): 995-1004.

Yu Bai, Daid Ahmad, Ting Wang*, Guihua Cui and Wenliang Li*


DOI: 10.2174/1568026619666190125145110





Most Accessed Articles

The Present and Future of Novel Protein Degradation Technology

, 2019; 19(20): 1784-1788.

Liwen Xia, Wei Liu, Yinsen Song, Hailiang Zhu* and Yongtao Duan*


DOI: 10.2174/1568026619666191011162955






Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19(18): 1621-1649.

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*


DOI: 10.2174/1568026619666190712204603





Virtual Screening Techniques in Drug Discovery: Review and Recent Applications

, 2019; 19(19): 1751-1767.

Sheisi F.L. da Silva Rocha, Carolina G. Olanda, Harold H. Fokoue and Carlos M.R. Sant'Anna*


DOI: 10.2174/1568026619666190816101948




Editor-in-Chief

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
USA

Biography View Full Editorial Board

Journal History

Current Topics in Medicinal Chemistry was introduced in 2001 with the assistance of Dr. Allen B. Reitz, who is the current Editor-in-Chief serving since 2001.
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Scopus CiteScore Metrics: 2.99


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