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Current Topics in Medicinal Chemistry

Volume 19, 32 Issues, 2019
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

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  • 20th of 61 in

    Chemistry, Medicinal

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Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Current Topics in Medicinal Chemistry

,

Volume 19

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Number 16



Editorial   Open Access



Review Article



Review Article



Review Article   Open Access

Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

, 19(16): 1399 - 1417

Chenyi Liao, Mathilde P. de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May* and Jianing Li*


DOI: 10.2174/1568026619666190709092647


Review Article



Review Article



Review Article

PET Imaging of Adenosine Receptors in Diseases

, 19(16): 1445 - 1463

Jindian Li, Xingfang Hong, Guoquan Li, Peter S. Conti, Xianzhong Zhang* and Kai Chen*


DOI: 10.2174/1568026619666190708163407


Review Article



Current Topics in Medicinal Chemistry, Volume 19 (2019) - Number 17


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print





Antimyotoxic Activity of Synthetic Peptides Derived from Bothrops atrox Snake Gamma Phospholipase A2 Inhibitor Selected by Virtual Screening


J.C. Sobrinho, A.F. Francisco, R. Simões-Silva, A.M. Kayano, J.J. Alfonso, A.F. Gomez, A. Arruda, A.S. Ferreira, A.P.A. Santos, M.B. Luiz, C. B. G. Teles, S. S. Pereira, F.B. Zanchi, L.A. Calderon, J.P. Zuliani and A.M. Soares*


DOI: 10.2174/1568026619666190725102812
View Abstract View on PubMed


The Anthelmintic Effect on Strongyloides venezuelensis Induced by BnSP- 6, a Lys49-phospholipase A2 Homologue from Bothrops pauloensis Venom


Jéssica Peixoto Rodrigues, Fernanda Van Petten Vasconcelos Azevedo, Mariana Alves Pereira Zoia, Larissa Prado Maia, Lucas Ian Veloso Correia, Julia Maria Costa-Cruz, Veridiana de Melo Rodrigues and Luiz Ricardo Goulart*


DOI: 10.2174/1568026619666190723152520
View Abstract View on PubMed





Pharmacology of Ivabradine and the Effect on Chronic Heart Failure


Yue Zhou, Jian Wang, Zhuo Meng, Shuang Zhou, Jiayu Peng, Sun Chen, Qingjie Wang* and Kun Sun*


DOI: 10.2174/1568026619666190809093144
View Abstract View on PubMed


Abstracts Ahead of Print






Bothrops alternatus snake venom induces cytokine expression and oxidative stress on renal function


Francisco Assis Nogueira Júnior, Antonio Rafael Coelho Jorge, Aline Diogo Marinho, João Alison de Moraes Silveira, Natacha Teresa Queiroz Alves, Pedro Henrique Sá Costa, Paula Letícia Braga e Silva, Adriano José Maia Chaves-Filho, Dânya Bandeira Lima, Tiago Lima Sampaio, Glayciane Bezerra de Morais, Janaina Serra Azul Monteiro Evangelista, Alice Maria Costa Martins, Rui Seabra Ferreira Jr., Danielle Silveira Macedo, Roberta Jeane Bezerra Jorge* and Helena Serra Azul Monteiro


DOI: 10.2174/1568026619666190809100319
View Abstract


Antitumoral Potential of Lansbermin-I, a Novel Disintegrin from Porthidium lansbergii lansbergii Venom on Breast Cancer Cells


Leonel Montealegre-Sánchez*, Sarah N. C. Gimenes, Daiana S. Lopes, Samuel C. Teixeira, Luis Solano-Redondo, Veridiana de M. Rodrigues and Eliécer Jiménez-Charris*


DOI: 10.2174/1568026619666190806151401
View Abstract


Differences in kynurenine metabolism during depressive, manic, and euthymic phases of bipolar affective disorder


Alexander Maget, Martina Platzer*, Susanne A. Bengesser, Frederike T. Fellendorf, Armin Birner, Robert Queissner, Carlo Hamm, Bernd Reininghaus, Andrzej Hecker, Lukas Tomberger, Renè Pilz, Nina Dalkner, Natalie Moll, Gregor Schütze, Markus Schwarz, Hans P. Kapfhammer and Eva Z. Reininghaus


DOI: 10.2174/1568026619666190802145128
View Abstract



Renal Alterations Induced by the Venom of Colombian Scorpion Centruroides margaritatus


Jessica Dayana Galíndez-Cerón, Roberta Jeane Bezerra Jorge*, Mario H. Chavez-Acosta, Antonio Rafael Coelho Jorge, Natacha Teresa Queiroz Alves, Mara de Moura Gondim Prata, Francisco Adelvane de Paulo Rodrigues, Alexandre Havt, Tiago Lima Sampaio, Alice Maria Costa Martins, Jimmy Alexander Guerrero-Vargas, Helena Serra Azul Monteiro and José T. Beltrán Vidal


DOI: 10.2174/1568026619666190731143523
View Abstract


Published Contents

Editor's Choice

Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*


DOI: 10.2174/1568026618666180821145215




A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*


DOI: 10.2174/1568026618666180516123229




Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610






Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao


DOI: 10.2174/1568026618666180410151518



Aurora Kinase Inhibitors in Head and Neck Cancer

, 2018; 18(3): 199 - 213

Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang* and Yasusei Kudo*


DOI: 10.2174/1568026618666180112163741



Open Access Articles

Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

, 2019; 19(16): 1399 - 1417

Chenyi Liao, Mathilde P. de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May* and Jianing Li*




Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19: 1 - 29 (E-Pub Ahead of Print)

Kenji Maeda, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*






Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*




Mechanical Properties of Composite Hydrogels for Tissue Engineering

, 2018; 18(14): 1214 - 1223

Ramon Rial, J.F. Armando Soltero, Pedro V. Verdes, Zhen Liu and Juan M. Ruso*





Analyzing of Molecular Networks for Human Diseases and Drug Discovery

, 2018; 18(12): 1007 - 1014

Tong Hao, Qian Wang, Lingxuan Zhao, Dan Wu, Edwin Wang* and Jinsheng Sun*




Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development

, 2018; 18(11): 883 - 895

Thomas Gross, Mark Mapstone, Ricardo Miramontes, Robert Padilla, Amrita K. Cheema, Fabio Macciardi, Howard J. Federoff* and Massimo S. Fiandaca*





Ubiquitin Proteasome System as a Potential Drug Target for Malaria

, 2018; 18(5): 315 - 320

Pedro H. Scarpelli Pereira, Chiara Curra and Celia R.S. Garcia*




Metabolomics Applications in Precision Medicine: An Oncological Perspective

, 2017; 17(24): 2740 - 2751

Leonor Puchades-Carrasco and Antonio Pineda- Lucena*




InsP3 Signaling in Apicomplexan Parasites

, 2017; 17(19): 2158 - 2165

Celia R.S. Garcia*, Eduardo Alves, Pedro H. S. Pereira, Paula J. Bartlett, Andrew P. Thomas, Katsuhiko Mikoshiba, Helmut Plattner and L. David Sibley







Most Cited Articles

Review Article

Coumarin compounds in medicinal chemistry: Some important examples from the last years

, 2018; 18(2): 124-148.

Thiago Moreira Pereira, Daiana Portella Franco, Felipe Vitorio and Arthur Eugen Kummerle*


DOI: 10.2174/1568026618666180329115523


Review Article

Bis-coumarin derivatives and their biological activities

, 2018; 18(2): 101-113.

Qing-Cheng Ren, Chuan Gao , Zhi Xu , Lian-Shun Feng, Ming-liang Liu*, Xiang Wu* and Feng Zhao*


DOI: 10.2174/1568026618666180221114515


Review Article

Recent development of small molecule glutaminase inhibitors

, 2018; 18(6): 432-443.

Minsoo Song*, Soong-Hyun Kim, Chun Young Im and Hee-Jong Hwang


DOI: 10.2174/1568026618666180525100830


Review Article

Recent development of coumarin derivatives as potential antiplasmodial and antimalarial agents

, 2018; 18(2): 114-123.

Xin-Liang Hu, Chuan Gao, Zhi Xu, Ming-Liang Liu, Lian-Shun Feng and Guang-De Zhang*


DOI: 10.2174/1568026618666171215101158



Research Article

New benzothiazole-based thiazolidinones as potent antimicrobial agents. Design, synthesis and biological evaluation

, 2018; 18(1): 75-87.

Michelyne Haroun*, Christophe Tratrat, Katerina Kositzi, Evangelia Tsolaki, Anthi Petrou, Bandar Aldhubiab, Mahesh Attimarad, Sree Harsha, Athina Geronikaki*, Katharigatta N. Venugopala, Heba S. Elsewedy, Marina Sokovic, Jasna Glamoclija and Ana Ciric


DOI: 10.2174/1568026618666180206101814


Research Article

Structure-based virtual screening for the identification of high affinity compounds as potent VEGFR2 inhibitors for the treatment of renal cell carcinoma

, 2018; 18(25): 2174-2185.

Khushboo Sharma, Khushboo Patidar, Meer Asif Ali, Pravin Patil, Himshikha Goud, Tajamul Hussain, Anuraj Nayarisseri* and Sanjeev Kumar Singh*


DOI: 10.2174/1568026619666181130142237



Review Article

Applications of machine learning methods in drug toxicity prediction

, 2018; 18(12): 987-997.

Li Zhang, Hui Zhang, Haixin Ai, Huan Hu, Shimeng Li, Jian Zhao and Hongsheng Liu*


DOI: 10.2174/1568026618666180727152557


Review Article

Prediction and targeting of interaction interfaces in G-protein coupled receptor oligomers

, 2018; 18(8): 714-746.

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610



Review Article

Learning from nature: Bioinspired strategies towards antimicrobial nanostructured systems

, 2018; 18(1): 22-41.

Giuseppe Vitiello, Brigida Silvestri and Giuseppina Luciani*


DOI: 10.2174/1568026618666180206101129


Review Article

An update on MDMX and dual MDM2/X inhibitors

, 2018; 18(8): 647-660.

Margarida Espadinha, Valentina Barcherini, Elizabeth A. Lopes and Maria M.M. Santos*


DOI: 10.2174/1568026618666180604080119


Review Article

Targeting sugar uptake and metabolism for cancer identification and therapy: An overview

, 2018; 18(6): 467-483.

Marina Tanasova*, Vagarshak V. Begoyan and Lukasz J. Weselinski


DOI: 10.2174/1568026618666180523110837


Review Article

Biological activities of artemisinin derivatives beyond malaria

, 2019; 19(3): 205-222.

Xiaoyan Liu, Jianguo Cao, Guozheng Huang*, Qingjie Zhao* and Jingshan Shen


DOI: 10.2174/1568026619666190122144217



Most Accessed Articles




3D-QSAR in Drug Design - A Review

, 2010; 10(1): 95-115.

Jitender Verma, Vijay M. Khedkar and Evans C. Coutinho


DOI: 10.2174/156802610790232260



Paracoccidioides spp. and Histoplasma capsulatum: Current and New Perspectives for Diagnosis and Treatment

, 2018; 18(15): 1333-1348.

C.P. Taborda*, R. Buccheri, G. Benard, A.N. Duarte-Neto, J.D. Nosanchuk and L.R. Travassos


DOI: 10.2174/1568026618666181002112231


Leishmaniasis and Chagas Disease – Neglected Tropical Diseases: Treatment Updates

, 2019; 19(3): 174-177.

Leandro Stefano Sangenito, Vanessa da Silva Santos, Claudia Masini d'Avila-Levy, Marta Helena Branquinha, André Luis Souza dos Santos* and Simone S.C. de Oliveira


DOI: 10.2174/156802661903190328155136


Recent Advances in Prostate-Specific Membrane Antigen-Based Radiopharmaceuticals

, 2019; 19(1): 33-56.

Wei Diao, Huawei Cai, Lihong Chen, Xi Jin, Xinyang Liao and Zhiyun Jia*


DOI: 10.2174/1568026619666190201100739


Protein/ Hormone Based Nanoparticles as Carriers for Drugs Targeting Protein-Protein Interactions

, 2019; 19(6): 444-456.

Ebtesam Al-Suhaimi*, Vijaya Ravinayagam, B. Rabindran Jermy, Tarhini Mohamad and Abdelhamid Elaissari


DOI: 10.2174/1568026619666190304152320


Biological Activities of Artemisinin Derivatives Beyond Malaria

, 2019; 19(3): 205-222.

Xiaoyan Liu, Jianguo Cao, Guozheng Huang*, Qingjie Zhao* and Jingshan Shen


DOI: 10.2174/1568026619666190122144217




Editor-in-Chief

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
USA

Biography View Full Editorial Board

Journal History

Current Topics in Medicinal Chemistry was introduced in 2001 with the assistance of Dr. Allen B. Reitz, who is the current Editor-in-Chief serving since 2001.
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Scopus CiteScore Metrics: 1.44


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