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Current Topics in Medicinal Chemistry

Volume 21, 32 Issues, 2021
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Current Topics in Medicinal Chemistry


Volume 21


Number 13

Review Article

Review Article

Advances in Anoctamin 1: A Potential New Drug Target in Medicinal Chemistry

, 21(13): 1139 - 1155

Junjie Zhong, Wendi Xuan, Mengting Tang, Shihao Cui, Yuhang Zhou, Xiaosheng Qu*, Xin Cao* and Bing Niu*

DOI: 10.2174/1568026621666210607125614

Research Article

4D-QSAR Models Applied to the Study of TGF- β1 Receptor Inhibitors

, 21(13): 1157 - 1166

Tamiris Maria de Assis, Teodorico Castro Ramalho* and Elaine Fontes Ferreira da Cunha*

DOI: 10.2174/1568026621666210727161431

Current Topics in Medicinal Chemistry, Volume 21 (2021) - Number 15

This issue is in progress but contains articles that are final and fully citable.

Current Topics in Medicinal Chemistry, Volume 21 (2021) - Number 14

This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

A Comprehensive Review on the Medicinal Importance; Biological and Therapeutic Efficacy of Lagenaria siceraria (Mol.) (Bottle Gourd) Standley Fruit

Muhammad Zahoor*, Muhammad Ikram, Nausheen Nazir, Sumaira Naz, Gaber El-Saber Batiha, Abdul Waheed Kamran, Michał Tomczyk* and Ahmed Kabrah

DOI: 10.2174/1568026621666210701124628
View Abstract View on PubMed

Protease Inhibitors as Promising Weapons against COVID-19: Focus on Repurposing of Drugs Used to Treat HIV and HCV Infections

Luciana Jesus da Costa, Matheus Mendonça Pereira, Lívia de Souza Ramos, Thaís Pereira de Mello, Laura Nunes Silva, Marta Helena Branquinha and André Luis Souza dos Santos*

DOI: 10.2174/1568026621666210701093407
View Abstract

Oxidative Stress in the Early Stage of Psychosis

Ventriglio Antonio*, Bellomo Antonello, Favale Donato, Bonfitto Iris, Vitrani Giovanna, Di Sabatino Dario, Cuozzo Edwige, Di Gioia Ilaria, Mauro Pettorruso, Giampaolo Perna, Alessandro Valchera and De Berardis Domenico

DOI: 10.2174/1568026621666210701105839
View Abstract View on PubMed

Abstracts Ahead of Print

Recent Neglected Drug Design Studies

Natália Ferreira de Sousa, Luciana Scotti *, Gabriela Cristina Soares Rodrigues, Érika Paiva de Moura, Renata Priscila Barros Costa Barros, Zoe L. Sessions, Eugene N. Muratov and Marcus Tullius Scotti

DOI: 10.2174/1568026621666210920155939
View Abstract

DHODH hot spots: an underexplored source to guide drug development efforts

Thamires Quadros Froes, Luana Carlos Campisano Zapata, Juliana Sayuri Akamine, Marcelo Santos Castilho* and Maria Cristina Nonato*

DOI: 10.2174/1568026621666210804122320
View Abstract

Current status of novel pyridine fused derivatives as anticancer agents: An insight into future perspectives and structure activity relationship (SAR)

Ajay Manaithiya, Ozair Alam*, Vrinda Sharma, Mohd. Javed Naim, Shruti Mittal, Faizul Azam, Asif Husain, Aadil Ahmad Sheikh, Mohd. Imran and Imran A Khan

DOI: 10.2174/1568026621666210916171015
View Abstract

Nanocarriers as Administration Systems of Natural Products

Guadalupe Y. Solís-Cruz, Luis A. Pérez-López*, Rocio Alvarez-Roman, Verónica M. Rivas-Galindo, David A. Silva-Mares and Tannya R. Ibarra-Rivera

DOI: 10.2174/1568026621666210915121957
View Abstract

Published Contents

Editor's Choice

Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*

DOI: 10.2174/1568026618666180821145215

A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*

DOI: 10.2174/1568026618666180516123229

Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*

DOI: 10.2174/1568026618666180604082610

Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao

DOI: 10.2174/1568026618666180410151518

Open Access Articles

An Overview of Ovarian Cancer: Molecular Processes Involved and Development of Target-based Chemotherapeutics

, 2021; 21(4): 329 - 346

Basheerulla Shaik, Tabassum Zafar, Krishnan Balasubramanian and Satya P. Gupta*

Beyond DNA-targeting in Cancer Chemotherapy. Emerging Frontiers - A Review

, 2021; 21(1): 28 - 47

Simon N. Mbugua, Lydia W. Njenga, Ruth A. Odhiambo, Shem O. Wandiga and Martin O. Onani*

Peptide Receptor Radionuclide Therapy: Looking Back, Looking Forward

, 2020; 20(32): 2959 - 2969

Danny Feijtel, Marion de Jong and Julie Nonnekens*

Learning the Edit Costs of Graph Edit Distance Applied to Ligand-Based Virtual Screening

, 2020; 20(18): 1582 - 1592

Carlos Garcia-Hernandez, Alberto Fernández* and Francesc Serratosa

Telomere-related Markers for Cancer

, 2020; 20(6): 410 - 432

Xiaotian Yuan*, Mingkai Dai and Dawei Xu*

Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19(18): 1621 - 1649

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*

Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

, 2019; 19(16): 1399 - 1417

Chenyi Liao, Mathilde P. de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May* and Jianing Li*

Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity

, 2019; 19(11): 957 - 969

Ana Yisel Caballero-Alfonso, Maykel Cruz-Monteagudo, Eduardo Tejera, Emilio Benfenati, Fernanda Borges, M. Natália D.S. Cordeiro, Vinicio Armijos-Jaramillo and Yunierkis Perez-Castillo*

Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*

Mechanical Properties of Composite Hydrogels for Tissue Engineering

, 2018; 18(14): 1214 - 1223

Ramon Rial, J.F. Armando Soltero, Pedro V. Verdes, Zhen Liu and Juan M. Ruso*

Most Cited Articles

Review Article

Molecular hybridization as a tool for designing multitarget drug candidates for complex diseases

, 2019; 19(19): 1694-1711.

Viktoriya Ivasiv, Claudia Albertini, Ana E. Gonçalves, Michele Rossi and Maria L. Bolognesi*

DOI: 10.2174/1568026619666190619115735

Review Article

Biological signatures of alzheimer’s disease

, 2020; 20(9): 770-781.

Poornima Sharma, Anjali Sharma, Faizana Fayaz, Sharad Wakode* and Faheem H. Pottoo

DOI: 10.2174/1568026620666200228095553

Review Article

Biological activities of artemisinin derivatives beyond malaria

, 2019; 19(3): 205-222.

Xiaoyan Liu, Jianguo Cao, Guozheng Huang*, Qingjie Zhao* and Jingshan Shen

DOI: 10.2174/1568026619666190122144217

Review Article

Mycobacterial tuberculosis Enzyme Targets and their Inhibitors

, 2019; 19(5): 337-355.

Anil Kumar Saxena* and Anamika Singh

DOI: 10.2174/1568026619666190219105722

Review Article

Discovery and development of anti-HIV therapeutic agents: Progress towards improved HIV medication

, 2019; 19(18): 1621-1649.

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*

DOI: 10.2174/1568026619666190712204603

Review Article

STAT3: A potential drug target for tumor and inflammation

, 2019; 19(15): 1305-1317.

Yang Sheng Hu, Xu Han and Xin Hua Liu*

DOI: 10.2174/1568026619666190620145052

Review Article

Virtual screening techniques in drug discovery: Review and recent applications

, 2019; 19(19): 1751-1767.

Sheisi F.L. da Silva Rocha, Carolina G. Olanda, Harold H. Fokoue and Carlos M.R. Sant'Anna*

DOI: 10.2174/1568026619666190816101948

Review Article

Zinc-depend ent deacetylase (HDAC) inhibitors with different zinc binding groups

, 2019; 19(3): 223-241.

Yan Li, Fang Wang, Xiaoxue Chen, Jie Wang, Yonglong Zhao, Yongjun Li and Bin He*

DOI: 10.2174/1568026619666190122144949

Review Article

Emerging complexity and the need for advanced drug delivery in targeting Candida species

, 2019; 19(28): 2593-2609.

Ridhima Wadhwa, Parijat Pandey, Gaurav Gupta, Taru Aggarwal, Nitesh Kumar, Meenu Mehta, Saurabh Satija, Monica Gulati, Jyotsna Madan, Harish Dureja, Sri R. Balusamy, Haribalan Perumalsamy, Pawan K. Maurya, Trudi Collet, Murtaza M. Tambuwala, Philip M. Hansbro, Dinesh Kumar Chellappan* and Kamal Dua*

DOI: 10.2174/1568026619666191026105308

Most Accessed Articles

A Review on Natural Sources Derived Protein Nanoparticles as Anticancer Agents

, 2021; 21(12): 1014-1026.

Tanima Bhattacharya, Samka P. Maishu, Rokeya Akter, Md. H. Rahman*, Muhammad F. Akhtar, Ammara Saleem, May Bin-Jumah, Mohamed Kamel, Mervat A. Abdel-Latif and Mohamed M. Abdel-Daim*

DOI: 10.2174/1568026621666210412151700

NGS-based mtDNA Profiling Could Reveal Genetic Alterations in Schizophrenia

, 2021; 21(11): 938-948.

Elena Mihailova Ivanova*, Snezhina Mihailova Kandilarova, Tzvetelin Ivanov Lukanov, Elissaveta Jordanova Naumova, Katerina Valentinova Akabalieva and Vihra Krumova Milanova

DOI: 10.2174/1568026621666210521155500

Cellular Bioenergetic and Metabolic Changes in Patients with Autism Spectrum Disorder

, 2021; 21(11): 985-994.

Maria Gevezova, Danail Minchev, Iliana Pacheva, Yordan Sbirkov, Ralitsa Yordanova, Elena Timova, Vasil Kotetarov, Ivan Ivanov and Victoria Sarafian*

DOI: 10.2174/1568026621666210521142131

Application of In silico Methods in the Design of Drugs for Neurodegenerative Diseases

, 2021; 21(11): 995-1011.

Mohamad Haider, Anjali Chauhan, Sana Tariq, Dharam Pal Pathak, Nadeem Siddiqui, Soni Ali, Faheem Hyder Pottoo and Ruhi Ali*

DOI: 10.2174/1568026621666210521164545

The Role of Peroxisome Proliferator-Activated Receptor in Addiction: A Novel Drug Target

, 2021; 21(11): 964-975.

Carla Quiroga, Juan José Barberena, Jocelyne Alcaraz-Silva , Sérgio Machado, Claudio Imperatori , Ali Yadollahpour , Henning Budde, Tetsuya Yamamoto, Diogo Telles-Correia and Eric Murillo-Rodríguez *

DOI: 10.2174/1568026621666210521165532

Review on Pharmacological and Phytochemical Prospects of Traditional Medicinal Plant: Persicaria hydropiper (Smartweed)

, 2021; 21(12): 1027-1036.

Abdul Nasir, Atif A.K. Khalil*, Muhammad Z. Bhatti, Ashfaq Ur Rehman, Jiayi Li and Zahida Parveen

DOI: 10.2174/1568026621666210303145045

Does Dysbiosis Increase the Risk of Developing Schizophrenia? - A Comprehensive Narrative Review

, 2021; 21(11): 976-984.

Filipa Novais*, Joana Capela, Sergio Machado, Eric Murillo-Rodriguez and Diogo Telles-Correia

DOI: 10.2174/1568026621666210521163555

Akt Pathway Inhibitors

, 2020; 20(10): 883-900.

Nne E. Uko, Osman F. Güner, Diane F. Matesic and J. Phillip Bowen*

DOI: 10.2174/1568026620666200224101808

COVID-19 and Diabetes Mellitus: Potential Metabolic Associations

, 2021; 21(11): 929-936.

Pedro Henrique Abreu da Silva, Andressa Santos Garcia, Fábio Aguiar Alves, André Luis Souza dos Santos* and Cátia Lacerda Sodré*

DOI: 10.2174/1568026621666210612025938


Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX
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Journal History

Current Topics in Medicinal Chemistry was introduced in 2001 with the assistance of Dr. Allen B. Reitz, who served as the editor-in-chief from 2001 to 2020. Currently, Dr. Jia Zhou is the Editor-in-Chief of the journal.

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