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Current Topics in Medicinal Chemistry

Volume 20, 32 Issues, 2020
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

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  • 20th of 61 in

    Chemistry, Medicinal

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Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Current Topics in Medicinal Chemistry


Volume 19


Number 32

Editorial   Open Access

Review Article

Review Article

Review Article

Feasibility of Targeting Glioblastoma Stem Cells: From Concept to Clinical Trials

, 19(32): 2974 - 2984

Vadim V. Tarasov, Andrey A. Svistunov, Vladimir N. Chubarev, Tamara A. Zatsepilova, Nina G. Preferanskaya, Olga I. Stepanova, Alexander V. Sokolov, Samira A. Dostdar, Nina N. Minyaeva, Margarita E. Neganova, Sergey G. Klochkov, Liudmila M. Mikhaleva, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*

DOI: 10.2174/1568026619666191112140939

Review Article

The Use of Fibrin-based Tissue Adhesives for Breast in Reconstructive and Plastic Surgery

, 19(32): 2985 - 2990

Kuo Chen*, Mikhail Y. Sinelnikov, Vladimir N. Nikolenko, Igor V. Reshetov, Yu Cao, Zhi Li, Ekaterina V. Kochurova, Svetlana N. Nikolenko, Marco Avila-Rodríguez, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev

DOI: 10.2174/1568026619666191112101448

Review Article

The Posterior Perforated Substance: A Brain Mystery Wrapped in an Enigma

, 19(32): 2991 - 2998

Vladimir N. Nikolenko, Leonid A. Gridin, Marine V. Oganesyan, Negoriya A. Rizaeva, Yury S. Podolskiy, Valentina A. Kudryashova, Ekaterina V. Kochurova, Roman K. Kostin, Ekaterina E. Tyagunova, Liudmila M. Mikhaleva, Marco Avila-Rodriguez, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*

DOI: 10.2174/1568026619666191127122452

Review Article

Acknowledgement   Open Access

Articles Ahead of Print

MCDCalc: Markov Chain Molecular Descriptors Calculator for Medicinal Chemistry

Paula Carracedo-Reboredo, Ramiro Corona, Mikel Martinez-Nunes, Carlos Fernandez-Lozano, Georgia Tsiliki, Haralambos Sarimveis, Eider Aranzamendi, Sonia Arrasate, Nuria Sotomayor, Esther Lete, Cristian Robert Munteanu and Humbert González-Díaz *

DOI: 10.2174/1568026620666191226092431
View Abstract View on PubMed

Antibacterial Activity of Cissus incisa Extracts against Multidrug- Resistant Bacteria

Deyani Nocedo-Mena, Elvira Garza-González, Mauricio González-Ferrara and María del Rayo Camacho-Corona*

DOI: 10.2174/1568026619666191121123926
View Abstract View on PubMed

Novel [6]-gingerol Triazole Derivatives and their Antiproliferative Potential against Tumor Cells

William Cezar de Lima Silva, Raphael Conti, Larissa Costa de Almeida, Pedro Alves Bezerra Morais, Keyller Bastos Borges, Valdemar Lacerda Júnior, Letícia Veras Costa-Lotufo and Warley de Souza Borges*

DOI: 10.2174/1568026620666191227125507
View Abstract View on PubMed

Neuraminidase from Influenza A and B Viruses is Susceptible to the Compound 4-(4-Phenyl-1H-1,2,3-Triazol-1-yl)-2,2,6,6-Tetramethylpiperidine-1- Oxyl

Carolina Q. Sacramento, Alessandro Kappel Jordão, Juliana L. Abrantes, Cristiane M. Alves, Andressa Marttorelli, Natalia Fintelman-Rodrigues, Caroline S. de Freitas, Gabrielle R. de Melo, Anna Claudia Cunha, Vitor F. Ferreira and Thiago Moreno L. Souza*

DOI: 10.2174/1568026620666191227142433
View Abstract View on PubMed

Synthesis of Coumarin Derivatives as Versatile Scaffolds for GSK-3β Enzyme Inhibition

Carla S. Franciscoa, Clara L. Javarini, Iatahanderson de S. Barcelos , Pedro A. B. Morais, Heberth de Paula, Warley de S. Borges, Álvaro Cunha Neto and Valdemar Lacerda Jr.*

DOI: 10.2174/1568026619666191019105349
View Abstract View on PubMed

Efficient Synthesis and Antibacterial Profile of Bis(2-hydroxynaphthalene- 1,4-dione)

Juliana S. Novais, Aline C. Rosandiski, Carolina M. de Carvalho, Letícia S. de Saules Silva, Lais C. dos S. Velasco de Souza, Marcos V. Santana, Nathalia R. C. Martins, Helena C. Castro, Vitor F. Ferreira, Daniel T. G. Gonzaga, Gabriel O. de Resende and Fernando de C. da Silva*

DOI: 10.2174/1568026619666191210160342
View Abstract View on PubMed

Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials

Nicola Relitti*, A Prasanth Saraswati, Stefano Federico, Tuhina Khan, Margherita Brindisi, Daniela Zisterer, Simone Brogi, Sandra Gemma, Stefania Butini and Giuseppe Campiani

DOI: 10.2174/1568026620666200102104930
View Abstract View on PubMed

Agathisflavone, a Biflavonoid from Anacardium occidentale L., Inhibits Influenza Virus Neuraminidase

Caroline S. de Freitas, Marco E. N. Rocha, Carolina Q. Sacramento, Andressa Marttorelli, André C. Ferreira, Natasha Rocha, Andrea Cheble de Oliveira, Andre Marco de Oliveira Gomes, Patrícia Souza dos Santos, Edilene Oliveira da Silva, Josineide Pantoja da Costa, Davyson de Lima Moreira, Patrícia T. Bozza, Jerson Lima da Silva, Shana Priscila Coutinho Barroso and Thiago Moreno L. Souza*

DOI: 10.2174/1568026620666191219150738
View Abstract View on PubMed

Abstracts Ahead of Print

Potential Telomere-Related Pharmacological Targets

Joseph Berei, Adam Eckburg, Edward Miliavski, Austin D. Anderson, Rachel J. Miller, Joshua Dein, Allison M. Giuffre, Diana Tang, Shreya Deb, Kavya Sri Racherla, Meet Patel, Monica Saravana Vela and Neelu Puri*

DOI: 10.2174/1568026620666200109114339
View Abstract

Periodontal pathogens and neuropsychiatric health.

Abhishek Wadhawan, Mark A. Reynolds, Hina Makkar, Alison J. Scott, Eileen Potocki, Andrew J. Hoisington, Lisa A. Brenner, Aline Dagdag, Christopher A. Lowry, Yogesh Dwivedi and Teodor T. Postolache*

DOI: 10.2174/1568026620666200110161105
View Abstract

Focusing on DNA Repair and Damage Tolerance mechanisms in Mycobacterium tuberculosis: an Emerging Therapeutic Theme

Pooja Mittal, Rajesh Sinha, Amit Kumar, Pooja Singh, Archana Singh, Moses Rinchui Ngasainao and Indrakant K. Singh*

DOI: 10.2174/1568026620666200110114322
View Abstract

Clinical relevance of Alternative lengthening of telomeres in cancer

Guilherme G da Silva, Karollyne S Morais, Daniel S Arcanjo and Diêgo M de Oliveira*

DOI: 10.2174/1568026620666200110112854
View Abstract

Mathematical Modeling to Address Challenges in Pancreatic Cancer

Prashant Dogra, Javier Ruiz Ramírez, María J. Peláez, Zhihui Wang, Vittorio Cristini, Gulshan Parasher and Manmeet Rawat*

DOI: 10.2174/1568026620666200101095641
View Abstract

Integrated Protocol to Design Potential Inhibitors of Dipeptidyl Peptidase-4 (DPP-4)

Simone Queiroz Pantaleão, Eric Allison Philot, Michell de Oliveira Almeida, Angelica Nakagawa Lima, Mirela Inês de Sairre, Ana Ligia Scott and Kathia Maria Honorio*

DOI: 10.2174/1568026620666191226101543
View Abstract

Synthesis, in vitro and in silico studies of indolequinone derivatives against clinically relevant bacterial pathogens

Talita Odriane Custodio Leite, Juliana Silva Novais, Beatriz Lima Cosenza de Carvalho, Vitor Francisco Ferreira, Leonardo Alves Miceli, Letícia Fraga, Bárbara Abrahim-Vieira, Carlos Rangel Rodrigues, Agnes Marie Sá Figueiredo, Helena Carla Castro and Anna Claudia Cunha*

DOI: 10.2174/1568026620666191223110518
View Abstract

Published Contents

Editor's Choice

Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*

DOI: 10.2174/1568026618666180821145215

A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*

DOI: 10.2174/1568026618666180516123229

Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*

DOI: 10.2174/1568026618666180604082610

Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao

DOI: 10.2174/1568026618666180410151518

Aurora Kinase Inhibitors in Head and Neck Cancer

, 2018; 18(3): 199 - 213

Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang* and Yasusei Kudo*

DOI: 10.2174/1568026618666180112163741

Open Access Articles

Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19(18): 1621 - 1649

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*

Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

, 2019; 19(16): 1399 - 1417

Chenyi Liao, Mathilde P. de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May* and Jianing Li*

Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity

, 2019; 19(11): 957 - 969

Ana Yisel Caballero-Alfonso, Maykel Cruz-Monteagudo, Eduardo Tejera, Emilio Benfenati, Fernanda Borges, M. Natália D.S. Cordeiro, Vinicio Armijos-Jaramillo and Yunierkis Perez-Castillo*

Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*

Mechanical Properties of Composite Hydrogels for Tissue Engineering

, 2018; 18(14): 1214 - 1223

Ramon Rial, J.F. Armando Soltero, Pedro V. Verdes, Zhen Liu and Juan M. Ruso*

Analyzing of Molecular Networks for Human Diseases and Drug Discovery

, 2018; 18(12): 1007 - 1014

Tong Hao, Qian Wang, Lingxuan Zhao, Dan Wu, Edwin Wang* and Jinsheng Sun*

Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development

, 2018; 18(11): 883 - 895

Thomas Gross, Mark Mapstone, Ricardo Miramontes, Robert Padilla, Amrita K. Cheema, Fabio Macciardi, Howard J. Federoff* and Massimo S. Fiandaca*

Ubiquitin Proteasome System as a Potential Drug Target for Malaria

, 2018; 18(5): 315 - 320

Pedro H. Scarpelli Pereira, Chiara Curra and Celia R.S. Garcia*

Metabolomics Applications in Precision Medicine: An Oncological Perspective

, 2017; 17(24): 2740 - 2751

Leonor Puchades-Carrasco and Antonio Pineda- Lucena*

InsP3 Signaling in Apicomplexan Parasites

, 2017; 17(19): 2158 - 2165

Celia R.S. Garcia*, Eduardo Alves, Pedro H. S. Pereira, Paula J. Bartlett, Andrew P. Thomas, Katsuhiko Mikoshiba, Helmut Plattner and L. David Sibley

Most Cited Articles

Review Article

Biological activities of artemisinin derivatives beyond malaria

, 2019; 19(3): 205-222.

Xiaoyan Liu, Jianguo Cao, Guozheng Huang*, Qingjie Zhao* and Jingshan Shen

DOI: 10.2174/1568026619666190122144217

Review Article

Small molecule natural products and Alzheimer’s disease

, 2019; 19(3): 187-204.

Xiaoai Wu, Huawei Cai, Lili Pan, Gang Cui, Feng Qin, YunChun Li and Zhengxin Cai*

DOI: 10.2174/1568026619666190201153257

Review Article

Zinc-depend ent deacetylase (HDAC) inhibitors with different zinc binding groups

, 2019; 19(3): 223-241.

Yan Li, Fang Wang, Xiaoxue Chen, Jie Wang, Yonglong Zhao, Yongjun Li and Bin He*

DOI: 10.2174/1568026619666190122144949

Review Article

Nanoparticle therapy for prostate cancer: Overview and perspectives

, 2019; 19(1): 57-73.

Junfu Zhang, Liying Wang, Xinru You, Tuzeng Xian, Jun Wu* and Jun Pang*

DOI: 10.2174/1568026619666190125145836

Review Article

Research advances in the use of histone deacetylase inhibitors for epigenetic targeting of cancer

, 2019; 19(12): 995-1004.

Yu Bai, Daid Ahmad, Ting Wang*, Guihua Cui and Wenliang Li*

DOI: 10.2174/1568026619666190125145110

Review Article

Protein-protein interactions and aggregation inhibitors in Alzheimer’s disease

, 2019; 19(7): 501-533.

Ankit Ganeshpurkar, Rayala Swetha, Devendra Kumar, Gore P. Gangaram, Ravi Singh, Gopichand Gutti, Srabanti Jana, Dileep Kumar, Ashok Kumar and Sushil K. Singh*

DOI: 10.2174/1568026619666190304153353

Perspectives in Medicinal Chemistry

Leishmaniasis and chagas disease – Neglected tropical diseases: Treatment updates

, 2019; 19(3): 174-177.

Leandro Stefano Sangenito, Vanessa da Silva Santos, Claudia Masini d'Avila-Levy, Marta Helena Branquinha, André Luis Souza dos Santos* and Simone S.C. de Oliveira

DOI: 10.2174/156802661903190328155136

Review Article

Recent advances in prostate-specific membrane antigen-based radiopharmaceuticals

, 2019; 19(1): 33-56.

Wei Diao, Huawei Cai, Lihong Chen, Xi Jin, Xinyang Liao and Zhiyun Jia*

DOI: 10.2174/1568026619666190201100739

Review Article

Peptide sequence-dominated enzyme-responsive nanoplatform for anticancer drug delivery

, 2019; 19(1): 74-97.

Yanan Li , Liping Du, Chunsheng Wu, Bin Yu, Hui Zhang * and Feifei An*

DOI: 10.2174/1568026619666190125144621

Perspectives in Medicinal Chemistry

Targeting histone lysine demethylase LSD1/KDM1A as a new avenue for cancer therapy

, 2019; 19(11): 889-891.

Yuan Fang, Guochao Liao* and Bin Yu*

DOI: 10.2174/156802661911190725094910

Review Article

Recent study of dual HDAC/PARP inhibitor for the treatment of tumor

, 2019; 19(12): 1041-1050.

Haiying Lu, Lan Bai, Yanping Zhou, Yongping Lu, Zhongliang Jiang* and Jianyou Shi*

DOI: 10.2174/1568026619666190603092407

Most Accessed Articles

The Present and Future of Novel Protein Degradation Technology

, 2019; 19(20): 1784-1788.

Liwen Xia, Wei Liu, Yinsen Song, Hailiang Zhu* and Yongtao Duan*

DOI: 10.2174/1568026619666191011162955

Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19(18): 1621-1649.

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*

DOI: 10.2174/1568026619666190712204603

Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

, 2019; 19(16): 1399-1417.

Chenyi Liao, Mathilde P. de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May* and Jianing Li*

DOI: 10.2174/1568026619666190709092647


Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA

Biography View Full Editorial Board

Journal History

Current Topics in Medicinal Chemistry was introduced in 2001 with the assistance of Dr. Allen B. Reitz, who is the current Editor-in-Chief serving since 2001.
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