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Current Topics in Medicinal Chemistry

Volume 19, 32 Issues, 2019
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

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  • 20th of 61 in

    Chemistry, Medicinal

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Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Current Topics in Medicinal Chemistry

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Volume 19

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Number 24



Editorial   Open Access



Review Article



Review Article



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Review Article



Current Topics in Medicinal Chemistry, Volume 19 (2019) - Number 26


This issue is in progress but contains articles that are final and fully citable.

Current Topics in Medicinal Chemistry, Volume 19 (2019) - Number 25


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print



Cytotoxicity of Anchusa arvensis Against HepG-2 Cell Lines: Mechanistic and Computational Approaches


Sajid Hussain *, Farhat Ullah, Abdul Sadiq , Muhammad Ayaz , Azhar-ul-Haq Ali Shah, Syed Adnan Ali Shah , Syed Majid Shah , Akhtar Nadhman, Farman Ullah , Abdul Wadood and Mohamed El-Shazly


DOI: 10.2174/1568026619666191105103801
View Abstract View on PubMed




Emerging Complexity and the Need for Advanced Drug Delivery in Targeting Candida Species


Ridhima Wadhwa, Parijat Pandey, Gaurav Gupta, Taru Aggarwal, Nitesh Kumar, Meenu Mehta, Saurabh Satija, Monica Gulati, Jyotsna Madan, Harish Dureja, Sri Renukadevi Balusamy, Haribalan Perumalsamy, Pawan K Maurya, Trudi Collet, Murtaza Tambuwala, Philip M. Hansbro, Dinesh Kumar Chellappan and Kamal Dua*


DOI: 10.2174/1568026619666191026105308
View Abstract


The Patenting and Technological Trends in Candidiasis Treatment: A Systematic Review (2014-2018)


Izabel Almeida Alves, Flávia Medeiros Savi, Juliana de Vasconcelos C. Braz, Lucindo José Quintans Junior and Mairim Russo Serafini*


DOI: 10.2174/1568026619666191030091211
View Abstract View on PubMed




A Paradigm Shift in the Development of Anti-Candida Drugs


DV Gowda*, Afrasim Moin, Meenakshi S, Manohar M, Hemalatha S, Siddaramaiah, Sathish Babu P, Syed Mohd Danish Rizvi, Talib Hussain and Mohammad Amjad Kamal*


DOI: 10.2174/1568026619666191029145209
View Abstract View on PubMed


Abstracts Ahead of Print

The Association of Sleep Disorders, Obesity, and Sleep-Related Hypoxia with Cancer


Anna Brzecka, Karolina Sarul, Tomasz Dyła, Marco Avila-Rodriguez, Ricardo Cabezas-Perez, Vladimir N. Chubarev, Nina N. Minyaeva, Sergey G. Klochkov, Margarita E. Neganova, Liudmila M. Mikhaleva, Siva G. Somasundaram, Cecil E. Kirkland, Vadim V. Tarasov and Gjumrakch Aliev*


DOI: 10.2174/1568026619666191118110155
View Abstract



Pharmacophore Modeling, Synthesis, Scaffold hopping And Biological β-Hematin Inhibition Interaction Studies for Anti-malaria Compounds


Neda Fayyazi, Somayeh Esmaeili, Salman Taheri, Frederico F. Ribeiro, Marcus T. Scotti, Luciana Scotti, Jahan B. Ghasemi*, Lotfollah Saghaei and Afshin Fassihi


DOI: 10.2174/1568026619666191116160326
View Abstract


Spiro-Lactams as Novel Antimicrobial Agents


Américo J. S. Alves, Nuno G. Alves, Cátia C. Caratão, Margarida I. M. Esteves, Diana Fontinha, Inês Bártolo, Maria I. L. Soares, Susana M. M. Lopes, Miguel Prudêncio, Nuno Taveira and Teresa M. V. D. Pinho e Melo*


DOI: 10.2174/1568026619666191105110049
View Abstract


ORO-DENTAL MANIFESTATIONS IN WEST SYNDROME


Fedora della Vella*, Maria Contaldo , Renato Fucile, Francesco Panza, Vittorio Dibello, Zamira Kalemaj, Rossella Ninivaggi, Massimo Petruzzi and Rosario Serpico


DOI: 10.2174/1568026619666191114122732
View Abstract


A chlorhexidine-containing brush-on gel as adjuvant treatment for plaque induced gingivitis.


Gianna Maria Nardi , Roberta Grassi, Guglielmo Campus, Maria Letizia Pareti , Dario Di Stasio and Fedora della Vella*


DOI: 10.2174/1568026619666191114120218
View Abstract


Updated Understanding of the Degenerative Disc Diseases - Causes versus Effects - Treatments, Studies and Hypothesis


Cristian Muresanu, Siva G. Somasundaram, Margarita E. Neganova, Elena V. Bovina, Sergey V. Vissarionov, Okom N. F. C. Ofodile, Vladimir P. Fisenko, Valentin Bragin, Nina N. Minyaeva, Vladimir N. Chubarev, Sergey G. Klochkov, Vadim V. Tarasov, Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1568026619666191114113048
View Abstract


The Long-Term Effect of Medically Enhancing Melanin Intrinsic Bioenergetics Capacity in Prematurity


Arturo Solís Herrera, Paola E. Solís Arias, María del Carmen Arias Esparza, Luis Fernando Torres Bernal, Andrey D. Bondarev, Vladimir P. Fisenko, Vladimir N. Chubarev, Nina N. Minyaeva, Lyudmila M. Mikhaleva, Vadim V. Tarasov, Siva G. Somasundaram, Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1568026619666191114110928
View Abstract



Marine Actinomycetes-derived Natural Products


Chengfang Yang, Rui Qian, Yao Xu, Junxi Yi, Yiwen Gu, Xiaoyu Liu, Haobing Yu, Binghua Jiao, Xiaoling Lu and Wei Zhang*


DOI: 10.2174/1568026619666191114102359
View Abstract


Published Contents

Editor's Choice

Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*


DOI: 10.2174/1568026618666180821145215




A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*


DOI: 10.2174/1568026618666180516123229




Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610






Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao


DOI: 10.2174/1568026618666180410151518



Aurora Kinase Inhibitors in Head and Neck Cancer

, 2018; 18(3): 199 - 213

Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang* and Yasusei Kudo*


DOI: 10.2174/1568026618666180112163741



Open Access Articles


Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19(18): 1621 - 1649

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*




Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

, 2019; 19(16): 1399 - 1417

Chenyi Liao, Mathilde P. de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May* and Jianing Li*




Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity

, 2019; 19(11): 957 - 969

Ana Yisel Caballero-Alfonso, Maykel Cruz-Monteagudo, Eduardo Tejera, Emilio Benfenati, Fernanda Borges, M. Natália D.S. Cordeiro, Vinicio Armijos-Jaramillo and Yunierkis Perez-Castillo*






Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*




Mechanical Properties of Composite Hydrogels for Tissue Engineering

, 2018; 18(14): 1214 - 1223

Ramon Rial, J.F. Armando Soltero, Pedro V. Verdes, Zhen Liu and Juan M. Ruso*





Analyzing of Molecular Networks for Human Diseases and Drug Discovery

, 2018; 18(12): 1007 - 1014

Tong Hao, Qian Wang, Lingxuan Zhao, Dan Wu, Edwin Wang* and Jinsheng Sun*




Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development

, 2018; 18(11): 883 - 895

Thomas Gross, Mark Mapstone, Ricardo Miramontes, Robert Padilla, Amrita K. Cheema, Fabio Macciardi, Howard J. Federoff* and Massimo S. Fiandaca*





Ubiquitin Proteasome System as a Potential Drug Target for Malaria

, 2018; 18(5): 315 - 320

Pedro H. Scarpelli Pereira, Chiara Curra and Celia R.S. Garcia*




Metabolomics Applications in Precision Medicine: An Oncological Perspective

, 2017; 17(24): 2740 - 2751

Leonor Puchades-Carrasco and Antonio Pineda- Lucena*




InsP3 Signaling in Apicomplexan Parasites

, 2017; 17(19): 2158 - 2165

Celia R.S. Garcia*, Eduardo Alves, Pedro H. S. Pereira, Paula J. Bartlett, Andrew P. Thomas, Katsuhiko Mikoshiba, Helmut Plattner and L. David Sibley





Most Cited Articles

Review Article

Coumarin compounds in medicinal chemistry: Some important examples from the last years

, 2018; 18(2): 124-148.

Thiago Moreira Pereira, Daiana Portella Franco, Felipe Vitorio and Arthur Eugen Kummerle*


DOI: 10.2174/1568026618666180329115523


Perspectives in Medicinal Chemistry

Perspectives in medicinal chemistry

, 2018; 18(23): 2000-2001.

Dorina Lauritano


DOI: 10.2174/156802661823190110112258


Review Article

Bis-coumarin derivatives and their biological activities

, 2018; 18(2): 101-113.

Qing-Cheng Ren, Chuan Gao , Zhi Xu , Lian-Shun Feng, Ming-liang Liu*, Xiang Wu* and Feng Zhao*


DOI: 10.2174/1568026618666180221114515



Review Article

Recent development of small molecule glutaminase inhibitors

, 2018; 18(6): 432-443.

Minsoo Song*, Soong-Hyun Kim, Chun Young Im and Hee-Jong Hwang


DOI: 10.2174/1568026618666180525100830


Review Article

Recent development of coumarin derivatives as potential antiplasmodial and antimalarial agents

, 2018; 18(2): 114-123.

Xin-Liang Hu, Chuan Gao, Zhi Xu, Ming-Liang Liu, Lian-Shun Feng and Guang-De Zhang*


DOI: 10.2174/1568026618666171215101158



Research Article

Structure-based virtual screening for the identification of high affinity compounds as potent VEGFR2 inhibitors for the treatment of renal cell carcinoma

, 2018; 18(25): 2174-2185.

Khushboo Sharma, Khushboo Patidar, Meer Asif Ali, Pravin Patil, Himshikha Goud, Tajamul Hussain, Anuraj Nayarisseri* and Sanjeev Kumar Singh*


DOI: 10.2174/1568026619666181130142237



Review Article

Ubiquitin proteasome system as a potential drug target for malaria

, 2018; 18(5): 315-320.

Pedro H. Scarpelli Pereira, Chiara Curra and Celia R. S. Garcia*


DOI: 10.2174/1568026618666180427145308



Research Article

New benzothiazole-based thiazolidinones as potent antimicrobial agents. Design, synthesis and biological evaluation

, 2018; 18(1): 75-87.

Michelyne Haroun*, Christophe Tratrat, Katerina Kositzi, Evangelia Tsolaki, Anthi Petrou, Bandar Aldhubiab, Mahesh Attimarad, Sree Harsha, Athina Geronikaki*, Katharigatta N. Venugopala, Heba S. Elsewedy, Marina Sokovic, Jasna Glamoclija and Ana Ciric


DOI: 10.2174/1568026618666180206101814


Review Article

Applications of machine learning methods in drug toxicity prediction

, 2018; 18(12): 987-997.

Li Zhang, Hui Zhang, Haixin Ai, Huan Hu, Shimeng Li, Jian Zhao and Hongsheng Liu*


DOI: 10.2174/1568026618666180727152557


Review Article

Prediction and targeting of interaction interfaces in G-protein coupled receptor oligomers

, 2018; 18(8): 714-746.

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610


Review Article

Backbone-cyclized peptides: A critical review

, 2018; 18(7): 526-555.

Samuel J.S. Rubin and Nir Qvit*


DOI: 10.2174/1568026618666180518092333



Most Accessed Articles




3D-QSAR in Drug Design - A Review

, 2010; 10(1): 95-115.

Jitender Verma, Vijay M. Khedkar and Evans C. Coutinho


DOI: 10.2174/156802610790232260


The Present and Future of Novel Protein Degradation Technology

, 2019; 19(20): 1784-1788.

Liwen Xia, Wei Liu, Yinsen Song, Hailiang Zhu* and Yongtao Duan*


DOI: 10.2174/1568026619666191011162955


An Overview on the Potential Antimycobacterial Agents Targeting Serine/Threonine Protein Kinases from Mycobacterium tuberculosis

, 2019; 19(9): 646-661.

Matteo Mori, José Camilla Sammartino, Luca Costantino, Arianna Gelain, Fiorella Meneghetti, Stefania Villa and Laurent Roberto Chiarelli*


DOI: 10.2174/1568026619666190227182701


Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

, 2019; 19(16): 1399-1417.

Chenyi Liao, Mathilde P. de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May* and Jianing Li*


DOI: 10.2174/1568026619666190709092647



In Vitro, In Silico and Ex Vivo Studies of Dihydroartemisinin Derivatives as Antitubercular Agents

, 2019; 19(8): 633-644.

Komal Kalani, Sarfaraz Alam, Vinita Chaturvedi, Shyam Singh, Feroz Khan and Santosh Kumar Srivastava*


DOI: 10.2174/1568026619666190305131425





Editor-in-Chief

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
USA

Biography View Full Editorial Board

Journal History

Current Topics in Medicinal Chemistry was introduced in 2001 with the assistance of Dr. Allen B. Reitz, who is the current Editor-in-Chief serving since 2001.
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Scopus CiteScore Metrics: 2.42


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