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Current Topics in Medicinal Chemistry

Volume 21, 32 Issues, 2021
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Current Topics in Medicinal Chemistry

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Volume 21

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Number 3



Editorial   Open Access



Review Article



Review Article (Mini-Review)



Review Article



Review Article (Mini-Review)



Review Article

ENTPDases from Pathogenic Trypanosomatids and Purinergic Signaling: Shedding Light towards Biotechnological Applications

, 21(3): 213 - 226

Walmir da Silva, Nancy da Rocha Torres, Joice de Melo Agripino, Victor Hugo Ferraz da Silva, Anna Cláudia Alves de Souza, Isadora Cunha Ribeiro, Tatiana Aparecida de Oliveira, Luciana Angelo de Souza, Lethicia Kelly Ramos Andrade, João Victor Badaró de Moraes, Marcel Arruda Diogo, Raíssa Barbosa de Castro, Marcelo Depolo Polêto, Luis Carlos Crocco Afonso and Juliana Lopes Rangel Fietto*


DOI: 10.2174/1568026620666201005125146


Review Article



Articles Ahead of Print



Tuberculosis: An Update on Pathophysiology, Molecular Mechanisms of Drug Resistance, Newer Anti-TB Drugs, Treatment Regimens and Host- Directed Therapies


Pobitra Borah, Pran Kishore Deb*, Katharigatta N. Venugopala, Nizar A. Al-Shar’i, Vinayak Singh, Satyendra Deka, Amavya Srivastava, Vinod Tiwari and Raghu Prasad Mailavaram


DOI: 10.2174/1568026621999201211200447
View Abstract View on PubMed



Role of Extracellular Vesicles in Glioma Progression: Deciphering Cellular Biological Processes to Clinical Applications


Rashmi Rana, Shikha Joon, Kirti Chauhan, Vaishnavi Rathi, Nirmal Kumar Ganguly, Chandni Kumari and Dharmendra Kumar Yadav*


DOI: 10.2174/1568026620666201207100139
View Abstract View on PubMed







Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Published Contents

Editor's Choice

Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*


DOI: 10.2174/1568026618666180821145215




A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*


DOI: 10.2174/1568026618666180516123229




Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610






Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao


DOI: 10.2174/1568026618666180410151518



Aurora Kinase Inhibitors in Head and Neck Cancer

, 2018; 18(3): 199 - 213

Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang* and Yasusei Kudo*


DOI: 10.2174/1568026618666180112163741



Open Access Articles

Beyond DNA-targeting in Cancer Chemotherapy. Emerging Frontiers - A Review

, 2021; 21(1): 28 - 47

Simon N. Mbugua, Lydia W. Njenga, Ruth A. Odhiambo, Shem O. Wandiga and Martin O. Onani*




Peptide Receptor Radionuclide Therapy: Looking Back, Looking Forward

, 2020; 20(32): 2959 - 2969

Danny Feijtel, Marion de Jong and Julie Nonnekens*




Learning the Edit Costs of Graph Edit Distance Applied to Ligand-Based Virtual Screening

, 2020; 20(18): 1582 - 1592

Carlos Garcia-Hernandez, Alberto Fernández* and Francesc Serratosa




Telomere-related Markers for Cancer

, 2020; 20(6): 410 - 432

Xiaotian Yuan*, Mingkai Dai and Dawei Xu*






Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19(18): 1621 - 1649

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*




Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

, 2019; 19(16): 1399 - 1417

Chenyi Liao, Mathilde P. de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May* and Jianing Li*




Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity

, 2019; 19(11): 957 - 969

Ana Yisel Caballero-Alfonso, Maykel Cruz-Monteagudo, Eduardo Tejera, Emilio Benfenati, Fernanda Borges, M. Natália D.S. Cordeiro, Vinicio Armijos-Jaramillo and Yunierkis Perez-Castillo*





Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*




Mechanical Properties of Composite Hydrogels for Tissue Engineering

, 2018; 18(14): 1214 - 1223

Ramon Rial, J.F. Armando Soltero, Pedro V. Verdes, Zhen Liu and Juan M. Ruso*





Analyzing of Molecular Networks for Human Diseases and Drug Discovery

, 2018; 18(12): 1007 - 1014

Tong Hao, Qian Wang, Lingxuan Zhao, Dan Wu, Edwin Wang* and Jinsheng Sun*




Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development

, 2018; 18(11): 883 - 895

Thomas Gross, Mark Mapstone, Ricardo Miramontes, Robert Padilla, Amrita K. Cheema, Fabio Macciardi, Howard J. Federoff* and Massimo S. Fiandaca*





Most Cited Articles

Review Article

Biological signatures of alzheimer’s disease

, 2020; 20(9): 770-781.

Poornima Sharma, Anjali Sharma, Faizana Fayaz, Sharad Wakode* and Faheem H. Pottoo


DOI: 10.2174/1568026620666200228095553



Review Article

Emerging proof of protein misfolding and interactions in multifactorial alzheimer's disease

, 2020; 20(26): 2380-2390.

Md. Sahab Uddin*, Abdullah Al Mamun, Md. Ataur Rahman, Tapan Behl, Asma Perveen, Abdul Hafeez, May N. Bin-Jumah, Mohamed M. Abdel-Daim and Ghulam Md Ashraf*


DOI: 10.2174/1568026620666200601161703


Review Article

Emerging promise of immunotherapy for alzheimer’s disease: A new hope for the development of alzheimer’s vaccine

, 2020; 20(13): 1214-1234.

Md. Tanvir Kabir, Md. Sahab Uddin*, Bijo Mathew, Pankoj Kumar Das, Asma Perveen and Ghulam Md. Ashraf*


DOI: 10.2174/1568026620666200422105156




Review Article

Telomerase-based cancer therapeutics: A review on their clinical trials

, 2020; 20(6): 433-457.

Nicola Relitti*, Akella P. Saraswati, Stefano Federico, Tuhina Khan, Margherita Brindisi, Daniela Zisterer, Simone Brogi, Sandra Gemma, Stefania Butini and Giuseppe Campiani*


DOI: 10.2174/1568026620666200102104930


Review Article

Telomere-related markers for cancer

, 2020; 20(6): 410-432.

Xiaotian Yuan*, Mingkai Dai and Dawei Xu*


DOI: 10.2174/1568026620666200106145340


Systematic Review Article

An update on glutamatergic system in suicidal depression and on the role of esketamine

, 2020; 20(7): 554-584.

Domenico De Berardis*, Carmine Tomasetti, Maurizio Pompili, Gianluca Serafini, Federica Vellante, Michele Fornaro, Alessandro Valchera, Giampaolo Perna, Umberto Volpe, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio, Yong-Ku Kim and Laura Orsolini


DOI: 10.2174/1568026620666200131100316


Current Frontiers

Novel drugs targeting the SARS-CoV-2/COVID-19 machinery

, 2020; 20(16): 1423-1433.

Ariane Sternberg, Dwight L. McKee and Cord Naujokat*


DOI: 10.2174/1568026620999200517043137



Review Article

Peptide receptor radionuclide therapy: Looking back, looking forward

, 2020; 20(32): 2959-2969.

Danny Feijtel, Marion de Jong and Julie Nonnekens*


DOI: 10.2174/1568026620666200226104652


Current Frontiers

Exploring the potential of neuroproteomics in Alzheimer's disease

, 2020; 20(25): 2263-2278.

Md. Sahab Uddin*, Md. Tanvir Kabir, Md. Jakaria, Eduardo Sobarzo-Sánchez, George E. Barreto, Asma Perveen, Abdul Hafeez, May N. Bin-Jumah, Mohamed M. Abdel-Daim and Ghulam M. Ashraf*


DOI: 10.2174/1568026620666200603112030



Research Article

Construction of a neuro-immune-cognitive pathway-phenotype underpinning the phenome of deficit schizophrenia

, 2020; 20(9): 747-758.

Hussein K. Al-Hakeim, Abbas F. Almulla, Arafat H. Al-Dujaili and Michael Maes*


DOI: 10.2174/1568026620666200128143948



Most Accessed Articles


Akt Pathway Inhibitors

, 2020; 20(10): 883-900.

Nne E. Uko, Osman F. Güner, Diane F. Matesic and J. Phillip Bowen*


DOI: 10.2174/1568026620666200224101808





Computer-Aided Drug Design Applied to Secondary Metabolites as Anticancer Agents

, 2020; 20(19): 1677-1703.

Rodrigo Santos Aquino de Araújo, Edeildo Ferreira da Silva-Junior, Thiago Mendonça de Aquino, Marcus Tullius Scotti, Hamilton M. Ishiki, Luciana Scotti and Francisco Jaime Bezerra Mendonça-Junior*


DOI: 10.2174/1568026620666200607191838


Fungal Infections in COVID-19-Positive Patients: A Lack of Optimal Treatment Options

, 2020; 20(22): 1951-1957.

Laura Nunes Silva, Thaís Pereira de Mello, Lívia de Souza Ramos, Marta Helena Branquinha, Maryam Roudbary and André Luis Souza dos Santos*


DOI: 10.2174/156802662022200917110102



Small Molecule CDK Inhibitors for the Therapeutic Management of Cancer

, 2020; 20(17): 1535-1563.

Bharat Goel, Nancy Tripathi, Nivedita Bhardwaj and Shreyans K. Jain*


DOI: 10.2174/1568026620666200516152756







Computational Modeling of Environmental Co-exposure on Oil-Derived Hydrocarbon Overload by Using Substrate-Specific Transport Protein (TodX) with Graphene Nanostructures

, 2020; 20(25): 2308-2325.

Patrícia Viera de Oliveira*, Luiza Goulart, Cláudia Lange dos Santos, Jussane Rossato, Solange Binotto Fagan*, Ivana Zanella, M. Natália D.S. Cordeiro, Juan M. Ruso and Michael González-Durruthy*


DOI: 10.2174/1568026620666200820145412



Editor-in-Chief

Jia Zhou
Chemical Biology Program
Department of Pharmacology and Toxicology
University of Texas Medical Branch
Galveston, TX
(USA)
Biography
View Full Editorial Board

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Journal History

Current Topics in Medicinal Chemistry was introduced in 2001 with the assistance of Dr. Allen B. Reitz, who is the current Editor-in-Chief serving since 2001.

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