Contents

Current Pharmaceutical Design, Volume 22 - Number 5

Editorial

Editorial (Thematic Issue: Managing Strategies for Diverse Diseases: Challenges from Bench to Bedside Translation in Successful Drug Discovery and Development)

, 22(5): 515 - 517

Mohammad A. Kamal and Nigel H. Greig


DOI: 10.2174/138161282205160126151535




Interleukin-6: A Critical Cytokine in Cancer Multidrug Resistance

, 22(5): 518 - 526

Morteza Ghandadi and Amirhossein Sahebkar


DOI: 10.2174/1381612822666151124234417




Neuroprotective Mechanisms Mediated by CDK5 Inhibition

, 22(5): 527 - 534

Gohar Mushtaq, Nigel H. Greig, Firoz Anwar, Fahad A. Al-Abbasi, Mazin A. Zamzami, Hasan A. Al-Talhi and Mohammad A. Kamal


DOI: 10.2174/1381612822666151124235028




Unique Medicinal Properties of Withania somnifera: Phytochemical Constituents and Protein Component

, 22(5): 535 - 540

Parvaiz A. Dar, Laishram R. Singh, Mohammad A. Kamal and Tanveer A. Dar


DOI: 10.2174/1381612822666151125001751




Inflammatory Process in Alzheimer’s and Parkinson's Diseases: Central Role of Cytokines

, 22(5): 541 - 548

Qamre Alam, Mohammad Zubair Alam, Gohar Mushtaq, Ghazi A. Damanhouri, Mahmood Rasool, Mohammad Amjad Kamal and Absarul Haque


DOI: 10.2174/1381612822666151125000300




Polyphenols: Potential Future Arsenals in the Treatment of Diabetes

, 22(5): 549 - 565

Md. Solayman, Yousuf Ali, Fahmida Alam, Md. Asiful Islam, Nadia Alam, Md. Ibrahim Khalil and Siew Hua Gan


DOI: 10.2174/1381612822666151125001111




Current Updates on Therapeutic Advances in the Management of Cardiovascular Diseases

, 22(5): 566 - 571

Nasimudeen R. Jabir, Ali Nasir Siddiqui, Chelapram Kandy Firoz, Ghulam Md Ashraf, Syed Kashif Zaidi, Mohd Shahnawaz Khan, Shazi Shakil, Mohammed Nabil Alama, Mohammad Amjad Kamal and Shams Tabrez


DOI: 10.2174/1381612822666151125000746




Computer Aided Drug Design: Success and Limitations

, 22(5): 572 - 581

Mohammad Hassan Baig, Khurshid Ahmad, Sudeep Roy, Jalaluddin Mohammad Ashraf, Mohd Adil, Mohammad Haris Siddiqui, Saif Khan, Mohammad Amjad Kamal, Ivo Provazník and Inho Choi


DOI: 10.2174/1381612822666151125000550




Conotoxins: Structure, Therapeutic Potential and Pharmacological Applications

, 22(5): 582 - 589

Rafia Mir, Sajjad Karim, Mohammad Amjad Kamal, Cornelia M. Wilson and Zeenat Mirza


DOI: 10.2174/1381612822666151124234715




Psychopharmacology of Attention-Deficit Hyperactivity Disorder: Effects and Side Effects

, 22(5): 590 - 594

Javad Golmirzaei, Hamidreza Mahboobi, Maryam Yazdanparast, Gohar Mushtaq, Mohammad A. Kamal and Enayatollah Hamzei


DOI: 10.2174/1381612822666151124235816




Efficacy and Safety of Evacetrapib for Modifying Plasma Lipids: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

, 22(5): 595 - 608

Amirhossein Sahebkar, Luis E. Simental-Mendía, Fernando Guerrero-Romero, Jonathan Golledge and Gerald F. Watts


DOI: 10.2174/1381612822666151125000035




Manufacturing of [14C]-Labeled Drug Substance and Drug Product Utilized in Clinical Research: A Case Study of Omecamtiv Mecarbil

, 22(5): 609 - 615

Scott W. Roberts, Jeroen M. Bezemer, Michael T. Kennedy, Tiffany L. Correll, Raju Subramanian and Shawn D. Walker


DOI: 10.2174/1381612822666151228104826




Cadherins: The Superfamily Critically Involved in Breast Cancer

, 22(5): 616 - 638

Maeirah Afzal Ashaie and Ezharul Hoque Chowdhury


DOI: 10.2174/138161282205160127095338




Real-Time Polymerase Chain Reaction as a Tool for Evaluation of Magnetic Poly(Glycidyl methacrylate)-Based Microspheres in Molecular Diagnostics

, 22(5): 639 - 646

Stepanka Trachtova, Alena Spanova, Daniel Horak, Hana Kozakova and Bohuslav Rittich


DOI: 10.2174/1381612822666151228105006




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