Contents

Current Pharmaceutical Design, Volume 22 - Number 21

Editorial

Editorial (Thematic Issue: Polypharmacology in Drug Discovery)

, 22(21): 3071 - 3072

Luciana Scotti and Marcus T. Scotti


DOI: 10.2174/1381612822999160405113658




Drugs Polypharmacology by In Silico Methods: New Opportunities in Drug Discovery

, 22(21): 3073 - 3081

Antonino Lauria, Riccardo Bonsignore, Roberta Bartolotta, Ugo Perricone, Annamaria Martorana and Carla Gentile


DOI: 10.2174/1381612822666160224142323




Ligand-Based Virtual Screening Using Tailored Ensembles: A Prioritization Tool for Dual A2A Adenosine Receptor Antagonists / Monoamine Oxidase B Inhibitors

, 22(21): 3082 - 3096

Aliuska Morales Helguera, Yunierkis Perez-Castillo, M. Natália D.S. Cordeiro, Eduardo Tejera, César Paz-y-Miño, Aminael Sánchez-Rodríguez, Marta Teijeira, Evys Ancede-Gallardo, Fernando Cagide, Fernanda Borges and Maykel Cruz-Monteagudo


DOI: 10.2174/1381612822666160302103542




Harnessing Polypharmacology with Computer-Aided Drug Design and Systems Biology

, 22(21): 3097 - 3108

Henri Wathieu, Naiem T. Issa, Stephen W. Byers and Sivanesan Dakshanamurthy


DOI: 10.2174/1381612822666160224141930




Exploring Polypharmacology in Drug Discovery and Repurposing Using the CANDO Platform

, 22(21): 3109 - 3123

Gaurav Chopra and Ram Samudrala


DOI: 10.2174/1381612822666160325121943




Computational Drug Repositioning by Target Hopping: A Use Case in Chagas Disease

, 22(21): 3124 - 3134

V. Joachim Haupt, Jesús E. Aguilar Uvalle, Sebastian Salentin, Simone Daminelli, Franziska Leonhardt, Janez Konc and Michael Schroeder


DOI: 10.2174/1381612822666160224143008




Multi-Target Drugs for Neglected Diseases

, 22(21): 3135 - 3163

Luciana Scotti, Francisco J.B.M. Filho, Ricardo O. de Moura, Frederico F. Ribeiro, Hamilton Ishiki, Marcelo S. da Silva, José M.B. Filho and Marcus T. Scotti


DOI: 10.2174/1381612822666160224142552




Tailored Multi-Target Agents. Applications and Design Considerations

, 22(21): 3164 - 3170

Alan Talevi


DOI: 10.2174/1381612822666160308141203




Polypharmacology in Drug Discovery: A Review from Systems Pharmacology Perspective

, 22(21): 3171 - 3181

Wenjuan Zhang, Yaofei Bai, Yonghua Wang and Wei Xiao


DOI: 10.2174/1381612822666160224142812




Progress in the Rational Design for Polypharmacology Drug

, 22(21): 3182 - 3189

Jinming Zhou, Quanjie Li, Meng Wu, Chao Chen and Shan Cen


DOI: 10.2174/1381612822666160224125121




Label-Free Cell Phenotypic Assays for Assessing Drug Polypharmacology

, 22(21): 3190 - 3200

Jixia Wang, Xiuli Zhang, Ye Fang and Xinmiao Liang


DOI: 10.2174/1381612822666160224142048




1, 2-Benzisoxazole: A Privileged Structure with a Potential for Polypharmacology

, 22(21): 3201 - 3211

Yoshikazu Uto


DOI: 10.2174/1381612822666160224142648




Polypharmacological Drugs in the Treatment of Epilepsy: The Comprehensive Review of Marketed and New Emerging Molecules

, 22(21): 3212 - 3225

Shikha Kumari, Chandra Bhushan Mishra and Manisha Tiwari


DOI: 10.2174/1381612822666160226144200




Epidermal Growth Factor Receptor (EGFR) and its Cross-Talks with Topoisomerases: Challenges and Opportunities for Multi-Target Anticancer Drugs

, 22(21): 3226 - 3236

Monika Chauhan, Gourav Sharma, Gaurav Joshi and Raj Kumar


DOI: 10.2174/1381612822666160224142200




Polypharmacological Properties and Therapeutic Potential of β-Caryophyllene: A Dietary Phytocannabinoid of Pharmaceutical Promise

, 22(21): 3237 - 3264

Charu Sharma, Juma M. Al Kaabi, Syed M. Nurulain, Sameer N. Goyal, Mohammad Amjad Kamal and Shreesh Ojha


DOI: 10.2174/1381612822666160311115226




Imidazole Derivatives as Potential Therapeutic Agents

, 22(21): 3265 - 3301

Archana Sharma, Vipin Kumar, Rajeev Kharb, Sunil Kumar, Prabodh Chander Sharma and Dharam Pal Pathak


DOI: 10.2174/1381612822666160226144333




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