Contents

Current Pharmaceutical Design, Volume 21 - Number 3

Editorial (Thematic Issue: Targeting Phosphodiesterases (PDEs) for Treatment of CNS Diseases)

, 21(3): 271 - 273

Han-Ting Zhang


DOI: 10.2174/138161282103141125124920




The Roles of Phosphodiesterase 2 in the Central Nervous and Peripheral Systems

, 21(3): 274 - 290

Chong Zhang, Yingcong Yu, Lina Ruan, Chuang Wang, Jianchun Pan, Jonathan Klabnik, Lindsay Lueptow, Han-Ting Zhang, James M. O’Donnell and Ying Xu


DOI: 10.2174/1381612820666140826115245




Phosphodiesterase-4 Modulation as a Potential Therapeutic for Cognitive Loss in Pathological and Non-Pathological Aging: Possibilities and Pitfalls

, 21(3): 291 - 302

Rolf T. Hansen III and Han-Ting Zhang


DOI: 10.2174/1381612820666140826114208




Phosphodiesterase: An Interface Connecting Cognitive Deficits to Neuropsychiatric and Neurodegenerative Diseases

, 21(3): 303 - 316

Zhen-Zhen Wang, Yi Zhang, Han-Ting Zhang and Yun-Feng Li


DOI: 10.2174/1381612820666140826115559




Phosphodiesterase Inhibitors as a Target for Cognition Enhancement in Aging and Alzheimer’s Disease: A Translational Overview

, 21(3): 317 - 331

P.R.A. Heckman, C. Wouters and J. Prickaerts


DOI: 10.2174/1381612820666140826114601




Phosphodiesterase Inhibitors as Therapeutics for Traumatic Brain Injury

, 21(3): 332 - 342

David J. Titus, Anthony A. Oliva, Nicole M. Wilson and Coleen M. Atkins


DOI: 10.2174/1381612820666140826113731




Genetic Signatures in the Treatment of Stroke

, 21(3): 343 - 354

Anjana Munshi and Vandana Sharma


DOI: 10.2174/1381612820666140826113502




Role of Phosphodiesterase 4-Mediated Cyclic AMP Signaling in Pharmacotherapy for Substance Dependence

, 21(3): 355 - 364

Rui-Ting Wen, Wan-Yu Feng, Jian-Hui Liang and Han-Ting Zhang


DOI: 10.2174/1381612820666140826114412




Phosphodiesterases as Therapeutic Targets for Huntington’s Disease

, 21(3): 365 - 377

Francesca R. Fusco and Carmela Giampa


DOI: 10.2174/1381612820666140826113957




Emerging Biology of PDE10A

, 21(3): 378 - 388

Lindsay S. Wilson and Nicholas J. Brandon


DOI: 10.2174/1381612820666140826114744




Does Phosphodiesterase 11A (PDE11A) Hold Promise as a Future Therapeutic Target?

, 21(3): 389 - 416

Michy P. Kelly


DOI: 10.2174/1381612820666140826114941




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