Contents

Current Pharmaceutical Design, Volume 20 - Number 15

Editorial

Editorial (Thematic issue: Soluble Beta Amyloid in a Continuum from Physiology to Pathology: Searching the Determinants of its Effects and Designing New Pharmacological Treatments)

, 20(15): 2457

Luigia Trabace


DOI: 10.2174/13816128113199990511




Getting Rid of Intracellular Aβ - Loss of Cellular Degradation Leads to Transfer Between Connected Neurons

, 20(15): 2458 - 2468

Lotta Agholme and Martin Hallbeck


DOI: 10.2174/13816128113199990501




Disrupting Self-Assembly and Toxicity of Amyloidogenic Protein Oligomers by “ Molecular Tweezers” - from the Test Tube to Animal Models

, 20(15): 2469 - 2483

Aida Attar and Gal Bitan


DOI: 10.2174/13816128113199990496




Characterization of the Effect of a Novel γ-secretase Modulator on Aβ: A Clinically Translatable Model

, 20(15): 2484 - 2490

Erik Portelius, Paulina Appelkvist, Kia Stromberg and Kina Hoglund


DOI: 10.2174/13816128113199990499




In Vivo Application of beta Amyloid Oligomers: A Simple Tool to Evaluate Mechanisms of Action and New Therapeutic Approaches

, 20(15): 2491 - 2505

Claudia Balducci and Gianluigi Forloni


DOI: 10.2174/13816128113199990497




The Effects of Soluble A β Oligomers on Neurodegeneration in Alzheimer's Disease

, 20(15): 2506 - 2519

Jonathan Brouillette


DOI: 10.2174/13816128113199990498




Disruption of Zinc Neuromodulation by Aß Oligomers : Therapeutic Implications

, 20(15): 2520 - 2524

Emily C. Vogler and Jorge Busciglio


DOI: 10.2174/13816128113199990510




Dangerous Liaisons between Beta-Amyloid and Cholinergic Neurotransmission

, 20(15): 2525 - 2538

Stefano Govoni, Elisa Mura, Stefania Preda, Marco Racchi, Cristina Lanni, Massimo Grilli, Stefania Zappettini, Alessia Salamone, Guendalina Olivero, Anna Pittaluga and Mario Marchi


DOI: 10.2174/13816128113199990503




Modulatory Activity of Soluble Beta Amyloid on HPA Axis Function in Rats

, 20(15): 2539 - 2546

Maria Grazia Morgese, Paolo Tucci, Marilena Colaianna, Margherita Zotti, Vincenzo Cuomo, Stefania Schiavone and Luigia Trabace


DOI: 10.2174/13816128113199990500




Soluble Amyloid-β Levels and Late-Life Depression

, 20(15): 2547 - 2554

Ricardo S. Osorio, Tyler Gumb and Nunzio Pomara


DOI: 10.2174/13816128113199990502




Editorial

Editorial Targeting the Metabolism of Cancer Cells- A Foreword

, 20(15): 2555 - 2556

Miguel Angel Medina


DOI: 10.2174/13816128113199990491




Glutamine, Glucose and other Fuels for Cancer

, 20(15): 2557 - 2579

Maria Victoria Ruiz-Perez, Francisca Sanchez-Jimenez, Francisco J. Alonso, Juan A. Segura, Javier Marquez and Miguel Angel Medina


DOI: 10.2174/13816128113199990482




Reprogrammed Metabolism of Cancer Cells as a Potential Therapeutic Target

, 20(15): 2580 - 2594

Jaap Keijer and Dorien A.M. van Dartel


DOI: 10.2174/13816128113199990483




Pyruvate Kinase M2: Regulatory Circuits and Potential for Therapeutic Intervention

, 20(15): 2595 - 2606

Vibhor Gupta, Kathryn E. Wellen, Sybille Mazurek and Rameshwar N. K. Bamezai


DOI: 10.2174/13816128113199990484




AMPK as a Potential Anticancer Target - Friend or Foe?

, 20(15): 2607 - 2618

Hsiao-Ching Chuang, Chih-Chien Chou, Samuel K. Kulp and Ching-Shih Chen


DOI: 10.2174/13816128113199990485




Targeting SREBP-1-driven Lipid Metabolism to Treat Cancer

, 20(15): 2619 - 2626

Deliang Guo, Erica Hlavin Bell, Paul Mischel and Arnab Chakravarti


DOI: 10.2174/13816128113199990486




Acetylation Control of Cancer Cell Metabolism

, 20(15): 2627 - 2633

Ruiting Lin, Xin Zhou, Wei Huang, Di Zhao, Lei Lv, Yue Xiong, Kun-Liang Guan and Qun-Ying Lei


DOI: 10.2174/13816128113199990487




A Dual Role for Sirtuin 1 in Tumorigenesis

, 20(15): 2634 - 2636

Yujiang Fang and Michael B. Nicholl


DOI: 10.2174/13816128113199990488




Targeted Cancer Therapeutics: Biosynthetic and Energetic Pathways Characterized by Metabolomics and the Interplay with Key Cancer Regulatory Factors

, 20(15): 2637 - 2647

Ngoc-Ha T. Dang, Arvind K. Singla, Emily M. Mackay, Frank R. Jirik and Aalim M. Weljie


DOI: 10.2174/13816128113199990489




A Systems Biology Road Map for the Discovery of Drugs Targeting Cancer Cell Metabolism

, 20(15): 2648 - 2666

Lilia Alberghina, Daniela Gaglio, Rosa Maria Moresco, Maria Carla Gilardi, Cristina Messa and Marco Vanoni


DOI: 10.2174/13816128113199990490




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