Contents

Current Pharmaceutical Design, Volume 20 - Number 11

Editorial

Editorial (Thematic Issue: Epigenetic Regulation and Human Diseases)

, 20(11): 1595 - 1597

Shi-Wen Jiang


DOI: 10.2174/13816128113199990548




The “Methyl-CpG Binding Domain Protein 2” Plays a Repressive Role in Relation to the Promoter CpG Content in the Normal Human Cell Line MRC5

, 20(11): 1598 - 1603

Laury Perriaud, Joel Lachuer and Robert Dante


DOI: 10.2174/13816128113199990537




HDAC Inhibitor Sodium Butyrate Augments the MEF2C Enhancement of Nampt Expression under Hypoxia

, 20(11): 1604 - 1613

Shao-Fei Yan, Hong-Jie You, Tian-Yu Xing, Chen-Guang Zhang and Wei Ding


DOI: 10.2174/13816128113199990544




Sirtuins: Nodes Connecting Aging, Metabolism and Tumorigenesis

, 20(11): 1614 - 1624

Yisha Yao, Yang Yang and Wei-Guo Zhu


DOI: 10.2174/13816128113199990513




DNA Demethylation: Where Genetics Meets Epigenetics

, 20(11): 1625 - 1631

Xiaofei Zhang, Rongguo Fu, Jie Yu and Xiaosheng Wu


DOI: 10.2174/13816128113199990546




Association between MTHFR Gene Polymorphism and the Risk of Ovarian Cancer: A Meta-analysis of the Literature

, 20(11): 1632 - 1638

Danhua Pu, Shi-Wen Jiang and Jie Wu


DOI: 10.2174/13816128113199990564




Folate Deficiency and Aberrant Expression of DNA Methyltransferase 1 were Associated with Cervical Cancerization

, 20(11): 1639 - 1646

Wang Jin-tao, Ding Ling, Jiang Shi-Wen, Hao Junxia, Zhao Wei-min, Zhou Qin, Yang Zuo-kai and Zhang Li


DOI: 10.2174/13816128113199990543




Transcription Factor WT1 and Promoter CpG Hypomethylation Coactivate HOXA10 Expression in Ovarian Cancer

, 20(11): 1647 - 1654

Yi Jiang, Yongli Chu, Weiwei Tang, Yicong Wan, Lin Zhang and Wenjun Cheng


DOI: 10.2174/13816128113199990545




Utility of MLH1 Methylation Analysis in the Clinical Evaluation of Lynch Syndrome in Women with Endometrial Cancer

, 20(11): 1655 - 1663

Amanda S. Bruegl, Bojana Djordjevic, Diana L. Urbauer, Shannon N. Westin, Pamela T. Soliman, Karen H. Lu, Rajyalakshmi Luthra and Russell R. Broaddus


DOI: 10.2174/13816128113199990538




Development of an Intracellular, DNA Methyltransferase-Specific, and Gene-Specific Assay for Studying Dynamic DNA Methylation

, 20(11): 1664 - 1673

Jesus Gonzalez-Bosquet, Yongli Chu, Hai Bin Chen, Sean C. Dowdy, Karl C. Podratz, Jinping Li and Shi-Wen Jiang


DOI: 10.2174/13816128113199990539




Driven Hematopoietic Differentiation of Embryonic Stem Cells: Epigenetic Perspectives

, 20(11): 1674 - 1686

Lenka Tesarova, Stanislav Stejskal and Irena Koutna


DOI: 10.2174/13816128113199990524




Histone Modifications, Stem Cells and Prostate Cancer

, 20(11): 1687 - 1697

Francesco Crea, Pier-Luc Clermont, Antonello Mai and Cheryl D. Helgason


DOI: 10.2174/13816128113199990522




Epigenetic Regulation of EMT: The Snail Story

, 20(11): 1698 - 1705

Yiwei Lin, Chenfang Dong and Binhua P. Zhou


DOI: 10.2174/13816128113199990512




Interplay between Epigenetics & Cancer Metabolism

, 20(11): 1706 - 1714

Vibhor Gupta, P. Gopinath, Mohd Askandar Iqbal, Sybille Mazurek, Kathryn E. Wellen and Rameshwar N. K. Bamezai


DOI: 10.2174/13816128113199990536




Epigenetic Mechanism Involved in the HBV/HCV-Related Hepatocellular Carcinoma Tumorigenesis

, 20(11): 1715 - 1725

Liang Rongrui, Huang Na, Li Zongfang, Ji Fanpu and Jiang Shiwen


DOI: 10.2174/13816128113199990533




DNA Methylation, An Epigenetic Mode of Gene Expression Regulation in Reproductive Science

, 20(11): 1726 - 1750

Rosamaria Calicchio, Ludivine Doridot, Francisco Miralles, Celine Mehats and Daniel Vaiman


DOI: 10.2174/13816128113199990517




Human Imprinting Anomalies in Fetal and Childhood Growth Disorders: Clinical Implications and Molecular Mechanisms

, 20(11): 1751 - 1763

Salah Azzi, Frederic Brioude, Yves Le Bouc and Irene Netchine


DOI: 10.2174/13816128113199990525




Epigenetic Inheritance of Paternally Expressed Imprinted Genes in the Testes of ICSI Mice

, 20(11): 1764 - 1771

Xiang-Rong Xu, Rong-guo Fu, Li-Ya Wang, Ning Wang, Fan Zhang, Fang Le, Lei Li, Le-Jun Li, Xiao-Zhen Liu, Ying-Ming Zheng, Hang-Ying Lou, Shi-Wen Jiang, Xiao-Ming Zhu, Yi-Min Zhu, He-Feng Huang and Fan Jin


DOI: 10.2174/13816128113199990520




Expression of Histone Acetyltransferase GCN5 and Histone Deacetylase 1 in the Cultured Mouse Preimplantation Embryos

, 20(11): 1772 - 1777

Xiaozhen Liu, Dongmei Zhao, Yingming Zheng, Liya Wang, Yuli Qian, Chenming Xu, Hefeng Huang, Yi Lisa Hwa and Fan Jin


DOI: 10.2174/13816128113199990521




Evidence for Epigenetic Alterations in Turner Syndrome Opens up Feasibility of New Pharmaceutical Interventions

, 20(11): 1778 - 1785

Shriram N. Rajpathak and Deepti D. Deobagkar


DOI: 10.2174/13816128113199990518




Hypomethylation and Activation of Syncytin-1 Gene in Endometriotic Tissue

, 20(11): 1786 - 1795

Hongyuan Zhou, Jinping Li, Karl C. Podratz, Tracy Tipton, Susan Marzolf, Hai Bin Chen and Shi-Wen Jiang


DOI: 10.2174/13816128113199990540




Decreased Expression and Altered Methylation of Syncytin-1 Gene in Human Placentas Associated with Preeclampsia

, 20(11): 1796 - 1802

Xue-Wei Zhuang, Jinping Li, Brian C. Brost, Xi-Yan Xia, Hai Bin Chen, Chuan-Xin Wang and Shi-Wen Jiang


DOI: 10.2174/13816128113199990541




Anti-Tumoral Effect of the Non-Nucleoside DNMT Inhibitor RG108 in Human Prostate Cancer Cells

, 20(11): 1803 - 1811

Ines Graca, Elsa J. Sousa, Tiago Baptista, Mafalda Almeida, Joao Ramalho-Carvalho, Carlos Palmeira, Rui Henrique and Carmen Jeronimo


DOI: 10.2174/13816128113199990516




De Novo DNMTs and DNA Methylation: Novel Insights into Disease Pathogenesis and Therapy from Epigenomics

, 20(11): 1812 - 1818

Sylwia Leppert and Maria R. Matarazzo


DOI: 10.2174/13816128113199990534




Pharmacoepigenomics: An Interplay of Epigenetic Modulation of Drug Response and Modulation of the Epigenome by Drugs

, 20(11): 1819 - 1830

Shweta Mendiratta, Shruti Jain, Jayant Maini and Vani Brahmachari


DOI: 10.2174/13816128113199990542




Novel Therapeutic Targets in Neuropsychiatric Disorders: The Neuroepigenome

, 20(11): 1831 - 1839

Lucio Tremolizzo, Virginia Rodriguez-Menendez, Elisa Conti, Chiara Paola Zoia, Guido Cavaletti and Carlo Ferrarese


DOI: 10.2174/13816128113199990535




Epigenetic Drugs in Cognitive Disorders

, 20(11): 1840 - 1846

Jacob Peedicayil


DOI: 10.2174/13816128113199990526




HDAC as a Therapeutic Target for Treatment of Endometrial Cancers

, 20(11): 1847 - 1856

Juan Ren, Jia Zhang, Hui Cai, Yi Li, Yuelang Zhang, Xiaozhi Zhang, Dongli Zhao, Zongfang Li, Hongbing Ma, Jiansheng Wang, Yan-e Gao, Lisha Xiao, Rui Liu, Jiansheng Qian, Yan Liu, Hongxia Wei and Jinping Li


DOI: 10.2174/13816128113199990528




Epigenetic Interventions Increase the Radiation Sensitivity of Cancer Cells

, 20(11): 1857 - 1865

Juan Ren, Yongli Chu, Hongbing Ma, Yuelang Zhang, Xiaozhi Zhang, Dongli Zhao, Zongfang Li, Jiansheng Wang, Yan-e Gao, Lisha Xiao, Rui Liu, Jiansheng Qian, Yan Liu, Hongxia Wei and Shiwen Jiang


DOI: 10.2174/13816128113199990529




Comprehensive Analysis for Histone Acetylation of Human Colon Cancer Cells Treated with a novel HDAC Inhibitor

, 20(11): 1866 - 1873

Yunlong Zhao, Xiuli Fang, Ye Wang, Junmei Zhang, Sheng Jiang, Zhe Liu, Zhenyi Ma, Liyan Xu, Enmin Li and Kai Zhang


DOI: 10.2174/13816128113199990531




Epigenetic Modification Restores Functional PR Expression in Endometrial Cancer Cells

, 20(11): 1874 - 1880

Shujie Yang, Xue Xiao, Yichen Jia, Xiaoyue Liu, Yuping Zhang, Xinjun Wang, Christopher J. Winters, Eric J. Devor, Xiangbing Meng, Kristina W. Thiel and Kimberly K. Leslie


DOI: 10.2174/13816128113199990532




Cytostatic and Apoptotic Effects of DNMT and HDAC Inhibitors in Endometrial Cancer Cells

, 20(11): 1881 - 1887

Shaohua Xu, Juan Ren, Hai Bin Chen, Yanlin Wang, Qingyou Liu, Run Zhang, Shi-Wen Jiang and Jinping Li


DOI: 10.2174/13816128113199990527




The Biphasic Expression Pattern of miR-200a and E-cadherin in Epithelial Ovarian Cancer and its Correlation with Clinicopathological Features

, 20(11): 1888 - 1895

Shaohua Xu, Peizhen Xu, Wei Wu, Yangjun Ou, Juan Xu, Guanghua Zhang, Jinping Li and Guofeng Xu


DOI: 10.2174/13816128113199990523




A Family of Pleiotropically Acting MicroRNAs in Cancer Progression, miR-200: Potential Cancer Therapeutic Targets

, 20(11): 1896 - 1903

Hai-Feng Zhang, Li-Yan Xu and En-Min Li


DOI: 10.2174/13816128113199990519




Relations between GPR4 Expression, Microvascular Density (MVD) and Clinical Pathological Characteristics of Patients with Epithelial Ovarian Carcinoma (EOC)

, 20(11): 1904 - 1916

Juan Ren, Wen Jin, Yan-e Gao, Yuelang Zhang, Xiaozhi Zhang, Dongli Zhao, Hongbing Ma, Zongfang Li, Jiansheng Wang, Lisha Xiao, Rui Liu, Yuanyuan Chen, Jiansheng Qian, liying Niu, Hongxia Wei and Yan Liu


DOI: 10.2174/13816128113199990530




Oxidative Stress Upregulates PDCD4 Expression in Patients with Gastric Cancer via miR-21

, 20(11): 1917 - 1923

Honglei Tu, Haibing Sun, Yan Lin, Jie Ding, Kejun Nan, Zongfang Li, Qiang Shen and Yongchang Wei


DOI: 10.2174/13816128113199990547




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