Contents

Current Pharmaceutical Design, Volume 20 - Number 1

Foreword

, 20(1): 1

William A. Banks


DOI: 10.2174/138161282001140113121900




Editorial (Thematic Issue: Systems and Network Biology in Pharmaceutical Drug Discovery)

, 20(1): 2 - 3

Asfar S. Azmi


DOI: 10.2174/138161282001140113122054




Differential Network Analysis in Human Cancer Research

, 20(1): 4 - 10

Ryan Gill, Somnath Datta and Susmita Datta


DOI: 10.2174/138161282001140113122316




Novel Next-Generation Sequencing and Networks-Based Therapeutic Targets: Realistic and More Effective Drug Design and Discovery

, 20(1): 11 - 22

Dimitrios H. Roukos, Giannis G. Baltogiannis, Christos S. Katsouras, Aris Bechlioulis, Katerina K. Naka, Charalambos Batsis, Theodore Liakakos and Lampros K. Michalis


DOI: 10.2174/138161282001140113122438




Network Pharmacology Strategies Toward Multi-Target Anticancer Therapies: From Computational Models to Experimental Design Principles

, 20(1): 23 - 36

Jing Tang and Tero Aittokallio


DOI: 10.2174/13816128113199990470




Physiologically Based Mathematical Models to Optimize Therapies Against Metastatic Colorectal Cancer: A Mini-Review

, 20(1): 37 - 48

Annabelle Ballesta and Jean Clairambault


DOI: 10.2174/138161282001140113123441




Protein Microarrays for Studies of Drug Mechanisms and Biomarker Discovery in the Era of Systems Biology

, 20(1): 49 - 55

Shun Tu, He-Wei Jiang, Cheng-Xi Liu, Shu-Min Zhou and Sheng-Ce Tao


DOI: 10.2174/138161282001140113123707




Understanding XPO1 Target Networks Using Systems Biology and Mathematical Modeling

, 20(1): 56 - 65

Irfana Muqbil, Michael Kauffman, Sharon Shacham, Ramzi M. Mohammad and Asfar S. Azmi


DOI: 10.2174/13816128113199990611




Lessons we Learned from High-Throughput and Top-Down Systems Biology Analyses about Glioma Stem Cells

, 20(1): 66 - 72

Andreas Mock, Sara Chiblak and Christel Herold-Mende


DOI: 10.2174/138161282001140113124343




Systems Biology Approaches to Pancreatic Cancer Detection, Prevention and Treatment

, 20(1): 73 - 80

Osama M. Alian, Philip A. Philip, Fazlul H. Sarkar and Asfar S. Azmi


DOI: 10.2174/138161282001140113124643




Proteomic-based Analysis for Identification of Proteins Involved in 5-fluorouracil Resistance in Hepatocellular Carcinoma

, 20(1): 81 - 87

Yi Tan, Shukui Qin, Xin Hou, Xiujuan Qian, Jun Xia, Yumei Li, Rui Wang, Changjie Chen, Qingling Yang, Lucio Miele, Qiong Wu and Zhiwei Wang


DOI: 10.2174/138161282001140113125143




Deciphering the Systems Biology of mTOR Inhibition by Integrative Transcriptome Analysis

, 20(1): 88 - 100

Sophie Domhan, Christian Schwager, Quanxiang Wei, Stefan Muschal, Claudia Sommerer, Christian Morath, Wolfgang Wick, Christian Maercker, Jurgen Debus, Martin Zeier, Peter E. Huber and Amir Abdollahi


DOI: 10.2174/138161282001140113125549




The Critical Roles of HSC70 in Physiological and Pathological Processes

, 20(1): 101 - 107

Yi Liao and Liling Tang


DOI: 10.2174/13816128113199990585




Inflammasome and Atherogenesis

, 20(1): 108 - 124

Xinjie Lu and Vijay Kakkar


DOI: 10.2174/13816128113199990586




The mTOR Signaling Pathway is an Emerging Therapeutic Target in Multiple Myeloma

, 20(1): 125 - 135

Jie Li, Jingyu Zhu, Biyin Cao and Xinliang Mao


DOI: 10.2174/13816128113199990638




Leptin and the Ob-Receptor as Anti-Obesity Target: Recent In Silico Advances in the Comprehension of the Protein-Protein Interaction and Rational Drug Design of Anti- Obesity Lead Compounds

, 20(1): 136 - 145

Marco Tutone, Antonino Lauria and Anna Maria Almerico


DOI: 10.2174/13816128113196660743




Comparison of Two Molecular Scaffolds, 5-Methylisoxazole-3-Carboxamide and 5-Methylisoxazole-4-Carboxamide

, 20(1): 146 - 152

Yaoming Song, Yiguan Zhang, An-Rong Lee, Wen-Hsin Huang, Ben Chen, Bruce Palfey and Jiajiu Shaw


DOI: 10.2174/13816128113199990584




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