Contents

Current Pharmaceutical Design, Volume 19 - Number 42

Editorial (Thematic Issue: Current Perspectives and Challenges in Design, Chemistry and Pharmacology of Opioids)

, 19(42): 7331 - 7332

Mariana Spetea and Helmut Schmidhammer


DOI: 10.2174/138161281942140105160158




Opioid Receptor Interacting Proteins and the Control of Opioid Signaling

, 19(42): 7333 - 7347

Jennifer T. Lamberts and John R. Traynor


DOI: 10.2174/138161281942140105160625




Lack of Regulatory Changes of µ-Opioid Receptors by 14-Methoxymetopon Treatment in Rat Brain. Further Evidence for Functional Selectivity

, 19(42): 7348 - 7354

Resat Cinar, Orsolya Kekesi, Erika Birkas, Gabriella Fabian, Helmut Schmidhammer and Maria Szucs


DOI: 10.2174/138161281942140105161245




Microglia Activation Precedes the Anti-Opioid BDNF and NMDA Receptor Mechanisms Underlying Morphine Analgesic Tolerance

, 19(42): 7355 - 7361

Yosuke Matsushita, Idowu O. Omotuyi, Takehiro Mukae and Hiroshi Ueda


DOI: 10.2174/138161281942140105161733




Current κ Opioid Receptor Ligands and Discovery of a New Molecular Scaffold as a κ Opioid Receptor Antagonist Using Pharmacophore-Based Virtual Screening

, 19(42): 7362 - 7372

Mariana Spetea, Muhammad Faheem Asim, Stefan Noha, Gerhard Wolber and Helmut Schmidhammer


DOI: 10.2174/138161281942140105162601




Opiate-Induced Analgesia: Contributions From Mu, Delta and Kappa Opioid Receptors Mouse Mutants

, 19(42): 7373 - 7381

Claire Gaveriaux-Ruff


DOI: 10.2174/138161281942140105163727




Opioid Receptors and Their Ligands in the Musculoskeletal System and Relevance for Pain Control

, 19(42): 7382 - 7390

Mariana Spetea


DOI: 10.2174/13816128113199990363




Functionalization of the Carbonyl Group in Position 6 of Morphinan-6-ones. Development of Novel 6-Amino and 6-Guanidino Substituted 14-Alkoxymorphinans

, 19(42): 7391 - 7399

Helmut Schmidhammer, Mariana Spetea, Petra Windisch, Johannes Schütz, Pal Riba, Mahmoud Al-Khrasani and Susanna Furst


DOI: 10.2174/138161281942140105164804




Essential Structure of the κ Opioid Receptor Agonist Nalfurafine for Binding to the κ Receptor

, 19(42): 7400 - 7414

Hiroshi Nagase and Hideaki Fujii


DOI: 10.2174/138161281942140105165011




The µ Opioid Receptor and Ligands Acting at the µ Opioid Receptor, as Therapeutics and Potential Therapeutics

, 19(42): 7415 - 7434

Mariana Spetea, Muhammad Faheem Asim, Gerhard Wolber and Helmut Schmidhammer


DOI: 10.2174/13816128113199990362




Hybrid Opioid/Non-Opioid Ligands in Pain Research

, 19(42): 7435 - 7450

Patrycja Kleczkowska, Andrzej W. Lipkowski, Dirk Tourwe and Steven Ballet


DOI: 10.2174/138161281942140105165646




The Use of Bifunctional NOP/Mu and NOP Receptor Selective Compounds for the Treatment of Pain, Drug Abuse, and Psychiatric Disorders

, 19(42): 7451 - 7460

Lawrence Toll


DOI: 10.2174/13816128113199990354




Tritiated Opioid Receptor Ligands as Radiotracers

, 19(42): 7461 - 7472

Geza Toth and Jayapal Reddy Mallareddy


DOI: 10.2174/138161281942140105170259




Inhibitory Effects of Water Caltrop Pericarps on the Growth of Human Gastric Cancer Cells In Vitro

, 19(42): 7473 - 7478

Qiusheng Lin, Junhui Shen, Ying Ning, Shengrong Shen and Undurti N. Das


DOI: 10.2174/138161281942140105170451




Phase 1 Safety, Tolerability and Pharmacokinetics of 3K3A-APC in Healthy Adult Volunteers

, 19(42): 7479 - 7485

Patrick Lyden, Howard Levy, Sara Weymer, Kent Pryor, William Kramer, John H. Griffin, Thomas P. Davis and Berislav Zlokovic


DOI: 10.2174/1381612819666131230131454




Acknowledgement to Reviewers:

, 19(42): 7486


DOI: 10.2174/138161281942140105171000




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