Contents

Current Pharmaceutical Design, Volume 12 - Number 8

Editorial [Hot Topic: Latest Developments in Pharmaceutical Design of Arachidonic Acid Metabolites: Prostaglandins, Thromboxanes, Hepoxilins and Isoprostanes (Executive Editors: J.-M. Dogne and K.-H. Ruan )]

, 12(8): 893 - 894

Jean-Michel Dogne and Ke-He Ruan


DOI: 10.2174/138161206776055976




The Isoprostanes - Unique Products of Arachidonate Peroxidation: Their Role as Mediators of Oxidant Stress

, 12(8): 895 - 902

Jason D. Morrow


DOI: 10.2174/138161206776055985




From the Design to the Clinical Application of Thromboxane Modulators

, 12(8): 903 - 923

Jean-Michel Dogne, Julien Hanson, Xavier de Leval, Domenico Pratico, Cecil R. Pace-Asciak, Pierre Drion, Bernard Pirotte and Ke-He Ruan


DOI: 10.2174/138161206776055921




Implications of the Molecular Basis of Prostacyclin Biosynthesis and Signaling in Pharmaceutical Designs

, 12(8): 925 - 941

Ke-He Ruan and Jean-Michel Dogne


DOI: 10.2174/138161206776055994




Prostaglandin E Synthase: A Novel Drug Target for Inflammation and Cancer

, 12(8): 943 - 954

Makoto Murakami and Ichiro Kudo


DOI: 10.2174/138161206776055912




NAD+-Linked 15-Hydroxyprostaglandin Dehydrogenase: Structure and Biological Functions

, 12(8): 955 - 962

H- H. Tai, H. Cho, M. Tong and Y. Ding


DOI: 10.2174/138161206776055958




Hepoxilin Analogs, Potential New Therapeutics in Disease

, 12(8): 963 - 969

C. R. Pace-Asciak, X. Li, N. Qiao, D. Reynaud, P. Demin and M. Abdelhaleem


DOI: 10.2174/138161206776055903




Coxibs and Cardiovascular Side-Effects: From Light to Shadow

, 12(8): 971 - 975

Jean-Michel Dogne, Julien Hanson, Claudiu Supuran and Domenico Pratico


DOI: 10.2174/138161206776055949




The Role of Unbound Drug in Pharmacokinetics/Pharmacodynamics and in Therapy

, 12(8): 977 - 987

Rosario Calvo, John C. Lukas, Monica Rodriguez, Nerea Leal and Elena Suarez


DOI: 10.2174/138161206776055967




Biologicals Dramatic Advances in the Treatment of Psoriasis

, 12(8): 989 - 999

Dagmar Wilsmann-Theis, Saskia Martin, Michael Reber, Bartlomiej Kwiek, Thomas Bieber and Natalija Novak


DOI: 10.2174/138161206776055930




Role of Opioid Antagonists in the Treatment of Women with Glucoregulation Abnormalities

, 12(8): 1001 - 1012

M. Guido, D. Romualdi and A. Lanzone


DOI: 10.2174/138161206776055895




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