Open Access Articles

Peptide Mediated Brain Delivery of Nano- and Submicroparticles: A Synergistic Approach

, 2018; 24: 1 - 11 (E-Pub Ahead of Print)

Mark McCully, Macarena Sanchez-Navarro , Meritxell Teixido* and Ernest Giralt*




2-Hydroxypropyl-β-cyclodextrins and the Blood-Brain Barrier: Considerations for Niemann-Pick Disease Type C1

, 2017; 23(40): 6231 - 6238

Pericles Calias*




IGF-1 as a Drug for Preterm Infants: A Step-Wise Clinical Development

, 2017; 23(38): 5964 - 5970

Ann Hellström*, David Ley, Boubou Hallberg, Chatarina Löfqvist, Ingrid Hansen-Pupp, Luca A. Ramenghi, Jan Borg, Lois E. H. Smith and Anna-Lena Hard




A Special Focus on Selexipag - Treatment of Pulmonary Arterial Hypertension

, 2017; 23(34): 5191 - 5199

Louise M. Sorensen, Markus Wehland, Marcus Kruger, Ulf Simonsen, Mohamed Z. Nassef, Manfred Infanger and Daniela Grimm*




Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress

, 2017; 23(27): 4066 - 4075

Akinori Yanaka*




Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates

, 2017; 23(15): 2276 - 2286

Ulviye Acar Cevik, Begum Nurpelin Saglik, Yusuf Ozkay*, Zerrin Canturk, Juan Bueno, Fatih Demirci and Ali Savas Koparal




Macrocyclic Antimicrobial Peptides Engineered from ω-Conotoxin

, 2017; 23(14): 2131 - 2138

Xinya Hemu and James P. Tam*




Anti-EGFRvIII Chimeric Antigen Receptor-Modified T Cells for Adoptive Cell Therapy of Glioblastoma

, 2017; 23(14): 2113 - 2116

Pei-pei Ren, Ming Li, Tian-fang Li and Shuang-yin Han*




Neural Circuits Underlying Fly Larval Locomotion

, 2017; 23(12): 1722 - 1733

Hiroshi Kohsaka*, Pierre A. Guertin and Akinao Nose




Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases

, 2017; 23(7): 1077 - 1097

Lili Wang, Rufeng Ma, Chenyue Liu, Haixia Liu, Ruyuan Zhu, Shuzhen Guo, Minke Tang, Yu Li, Jianzhao Niu, Min Fu, Sihua Gao* and Dongwei Zhang*




Virtual Screening and Statistical Analysis in the Design of New Caffeine Analogues Molecules with Potential Epithelial Anticancer Activity

, 2017; 23: 1 - 19 (E-Pub Ahead of Print)

Josivan da Silva Costa*, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macêdo




Polypharmacology in Precision Oncology: Current Applications and Future Prospects

, 2016; 22(46): 6935 - 6945

Albert A. Antolin, Paul Workman, Jordi Mestres and Bissan Al-Lazikani




From PK/PD to QSP: Understanding the Dynamic Effect of Cholesterol-Lowering Drugs on Atherosclerosis Progression and Stratified Medicine

, 2016; 22(46): 6903 - 6910

Cesar Pichardo-Almarza and Vanessa Diaz-Zuccarini




Functional Foods for Health: The Interrelated Antioxidant and Anti-Inflammatory Role of Fruits, Vegetables, Herbs, Spices and Cocoa in Humans

, 2016; 22(44): 6701 - 6715

Mauro Serafini and Ilaria Peluso




Enteric Ecosystem Disruption in Autism Spectrum Disorder: Can the Microbiota and Macrobiota be Restored?

, 2016; 22(40): 6107 - 6121

John Slattery, Derrick F. MacFabe, Stephen G. Kahler and Richard E. Frye




Potential Pathways for CNS Drug Delivery Across the Blood-Cerebrospinal Fluid Barrier

, 2016; 22(35): 5463 - 5476

Nathalie Strazielle and Jean-François Ghersi-Egea




The Microbial Quality Aspects and Decontamination Approaches for the Herbal Medicinal Plants and Products: An in-Depth Review

, 2016; 22(27): 4264 - 4287

Daniela Dal Molim Ghisleni, Marina de Souza Braga, Irene Satiko Kikuchi, Mirela Braşoveanu, Monica R. Nemţanu, Kamal Dua and Terezinha de Jesus Andreoli Pinto




AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species

, 2016; 22(26): 3950 - 3970

Francesco Simone Ruggeri, Johnny Habchi, Andrea Cerreta and Giovanni Dietler




Miscellaneous Topics in Computer-Aided Drug Design: Synthetic Accessibility and GPU Computing, and Other Topics

, 2016; 22(23): 3555 - 3568

Yoshifumi Fukunishi, Tadaaki Mashimo, Kiyotaka Misoo, Yoshinori Wakabayashi, Toshiaki Miyaki, Seiji Ohta, Mayu Nakamura and Kazuyoshi Ikeda




Therapeutic Targets for Management of Periodontitis and Diabetes

, 2016; 22(15): 2216 - 2237

Corneliu Sima and Thomas E. Van Dyke




The Therapeutic Aspects of the Endocannabinoid System (ECS) for Cancer and their Development: From Nature to Laboratory

, 2016; 22(12): 1756 - 1766

Mohammed I. Khan, Anna A. Sobocińska, Anna M. Czarnecka, Magdalena Król, Bruno Botta and Cezary Szczylik




Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier

, 2016; 22(9): 1177 - 1193

David S. Hersh, Aniket S. Wadajkar, Nathan B. Roberts, Jimena G. Perez, Nina P. Connolly, Victor Frenkel, Jeffrey A. Winkles, Graeme F. Woodworth and Anthony J. Kim




Recent advances in the fundamental understanding of adhesive mixtures for inhalation

, 2015; 21(40): 5900 - 5914

Floris Grasmeijer, Niels Grasmeijer, Paul Hagedoorn, Henderik Willem Frijlink and Anne Haaije de Boer




Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker

, 2015; 21(26): 3797 - 3806

Kenji Hashimoto




Lipid-Based Nanocarriers for RNA Delivery

, 2015; 21(22): 3140 - 3147

Hui Yi Xue, Pengbo Guo, Wu-Cheng Wen and Ho Lun Wong




Particle Engineering in Pharmaceutical Solids Processing: Surface Energy Considerations

, 2015; 21(19): 2677 - 2694

Daryl R. Williams




Significant Differences Characterise the Correlation Coefficients between Biocide and Antibiotic Susceptibility Profiles in Staphylococcus aureus

, 2015; 21(16): 2054 - 2057

Marco R. Oggioni, Joana Rosado Coelho, Leonardo Furi, Daniel R Knight, Carlo Viti, Graziella Orefici, Jose-Luis Martinez, Ana Teresa Freitas, Teresa M. Coque, Ian Morrissey and behalf of the BIOHYPO consortium




Macrophages in Immunopathology of Atherosclerosis: A Target for Diagnostics and Therapy

, 2015; 21(9): 1172 - 1179

Alexander N. Orekhov, Igor A. Sobenin, Mikhail A. Gavrilin, Alexei Gratchev, Svetlana Y. Kotyashova, Nikita G. Nikiforov and Julia Kzhyshkowska




Assessment and Relevance of Carotid Intima-Media Thickness (C-IMT) in Primary and Secondary Cardiovascular Prevention

, 2015; 21(9): 1164 - 1171

Alessio Ravani, Jose Pablo Werba, Beatrice Frigerio, Daniela Sansaro, Mauro Amato, Elena Tremoli and Damiano Baldassarre




Antihypertensive Drugs Metabolism: An Update to Pharmacokinetic Profiles and Computational Approaches

, 2015; 21(6): 806 - 822

Aikaterini Zisaki, Ljubisa Miskovic and Vassily Hatzimanikatis




Targeting Cardiomyocyte Ca2+ Homeostasis in Heart Failure

, 2015; 21(4): 431 - 448

Asmund T. Roe, Michael Frisk and William E. Louch




Biomarkers Predicting a Need for Intensive Treatment in Patients with Early Arthritis

, 2015; 21(2): 170 - 181

I. Gonzalez-Alvaro, A.M. Ortiz, I.V. Seoane, R. Garcia-Vicuna, C. Martinez and R.P. Gomariz




Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy

, 2014; 20(42): 6584 - 6643

Roger Gilabert-Oriol, Alexander Weng, Benedicta von Mallinckrodt, Matthias F. Melzig, Hendrik Fuchs and Mayank Thakur




Tankyrases: Structure, Function and Therapeutic Implications in Cancer

, 2014; 20(41): 6472 - 6488

Teemu Haikarainen, Stefan Krauss and Lari Lehtio




Telomere Maintenance Mechanisms in Cancer: Clinical Implications

, 2014; 20(41): 6361 - 6374

Roger R. Reddel




Mechanisms of Action of Anesthetics for the Modulation of Perioperative Thrombosis: Evidence for Immune Mechanisms from Basic and Clinical Studies

, 2014; 20(36): 5779 - 5793

Toshiharu Azma, Florin Tuluc, Taishin Ito, Chikako Aoyama-Mani, Shinji Kawahito and Hiroyuki Kinoshita




Brain Innate Immunity in the Regulation of Neuroinflammation: Therapeutic Strategies by Modulating CD200-CD200R Interaction Involve the Cannabinoid System

, 2014; 20(29): 4707 - 4722

Miriam Hernangomez, Francisco J. Carrillo-Salinas, Miriam Mecha, Fernando Correa, Leyre Mestre, Frida Loria, Ana Feliu, Fabian Docagne and Carmen Guaza




Dipeptidyl-peptidase 4 Inhibition: Linking Metabolic Control to Cardiovascular Protection

, 2014; 20(14): 2387 - 2394

Angelo Avogaro, Saula de Kreutzenberg and Gianpaolo Fadini




Effects of Cannabis on Impulsivity: A Systematic Review of Neuroimaging Findings

, 2014; 20(13): 2126 - 2137

Johannes Wrege, Andre Schmidt, Anna Walter, Renata Smieskova, Kerstin Bendfeldt, Ernst-Wilhelm Radue, Undine E. Lang and Stefan Borgwardt




New Pharmaceutical Treatment of Gastric MALT Lymphoma: Anti-angiogenesis Treatment using VEGF Receptor Antibodies and Celecoxib

, 2014; 20(7): 1097 - 1103

Masahiko Nakamura, Tetsufumi Takahashi, Hidenori Matsui, Shinichi Takahashi, Somay Y. Murayama, Hidekazu Suzuki and Kanji Tsuchimoto




Network Pharmacology Strategies Toward Multi-Target Anticancer Therapies: From Computational Models to Experimental Design Principles

, 2014; 20(1): 23 - 36

Jing Tang and Tero Aittokallio




The µ Opioid Receptor and Ligands Acting at the µ Opioid Receptor, as Therapeutics and Potential Therapeutics

, 2013; 19(42): 7415 - 7434

Mariana Spetea, Muhammad Faheem Asim, Gerhard Wolber and Helmut Schmidhammer




Functionalization of the Carbonyl Group in Position 6 of Morphinan-6-ones. Development of Novel 6-Amino and 6-Guanidino Substituted 14-Alkoxymorphinans

, 2013; 19(42): 7391 - 7399

Helmut Schmidhammer, Mariana Spetea, Petra Windisch, Johannes Schütz, Pal Riba, Mahmoud Al-Khrasani and Susanna Furst




Smart Stimuli Sensitive Nanogels in Cancer Drug Delivery and Imaging: A Review

, 2013; 19(41): 7203 - 7218

S. Maya, Bruno Sarmento, Amrita Nair, N. Sanoj Rejinold, Shantikumar V. Nair and R. Jayakumar




Mechanisms of Drug Resistance in Cancer Chemotherapy: Coordinated Role and Regulation of Efflux Transporters and Metabolizing Enzymes

, 2013; 19(40): 7126 - 7140

Ramya Krishna Vadlapatla, Aswani Dutt Vadlapudi, Dhananjay Pal and Ashim K. Mitra




The Cellular Autophagy Markers Beclin-1 and LC3B-II are Increased During Reperfusion in Fibrillated Mouse Hearts

, 2013; 19(39): 6912 - 6918

Gregory Meyer, Attila Czompa, Cyril Reboul, Evelin Csepanyi, Andras Czegledi, Istvan Bak, Gyorgy Balla, Jozsef Balla, Arpad Tosaki and Istvan Lekli




Cardioprotective Effects of Sour Cherry Seed Extract (SCSE) on the Hypercholesterolemic Rabbit Heart

, 2013; 19(39): 6896 - 6905

Bela Juhasz, Attila Kertész, Jozsef Balla, Gyorgy Balla, Zoltán Szabo, Mariann Bombicz, Daniel Priksz, Rudolf Gesztelyi, Balazs Varga, David D. Haines and Arpad Tosaki




The STAT3 Inhibitor Stattic Impairs Cardiomyocyte Mitochondrial Function Through Increased Reactive Oxygen Species Formation

, 2013; 19(39): 6890 - 6895

Kerstin Boengler, Elvira Ungefug, Gerd Heusch and Rainer Schulz




Ghrelin as a Neuroprotective and Palliative Agent in Alzheimer's and Parkinson's Disease

, 2013; 19(38): 6773 - 6790

Vanessa V. dos Santos, Ana Lúcia S. Rodrigues, Thereza C. De Lima, Susana R. de Barioglio, Rita Raisman-Vozari and Rui D. Prediger




Iron Oxide Nanoparticle-induced Oxidative Stress and Genotoxicity in Human Skin Epithelial and Lung Epithelial Cell Lines

, 2013; 19(37): 6681 - 6690

Maqusood Ahamed, Hisham A. Alhadlaq, Javed Alam, M. A. Majeed Khan, Daoud Ali and Saud Alarafi




Nanomaterials for Photohyperthermia: A Review

, 2013; 19(37): 6622 - 6634

Jonathan Fang and Yu-Chie Chen




Recent Advances in Superparamagnetic Iron Oxide Nanoparticles for Cellular Imaging and Targeted Therapy Research

, 2013; 19(37): 6575 - 6593

Yi-Xiang J. Wang, Shouhu Xuan, Marc Port and Jean-Marc Idee




Immunization Against Active Ghrelin Using Virus-Like Particles for Obesity Treatment

, 2013; 19(36): 6551 - 6558

Sara Andrade, Filipa Pinho, Andreia M. Ribeiro, Marcos Carreira, Felipe F. Casanueva, Polly Roy and Mariana P. Monteiro




Diffusion Tensor Imaging to Determine Effects of Antidementive Treatment on Cerebral Structural Connectivity in Alzheimer’s Disease

, 2013; 19(36): 6416 - 6425

Ingo Kilimann, Yuttachai Likitjaroen, Harald Hampel and Stefan Teipel




Anti-miRNA-23a Oligonucleotide Suppresses Glioma Cells Growth by Targeting Apoptotic Protease Activating Factor-1

, 2013; 19(35): 6382 - 6389

Shizhong Lian, Ruyi Shi, Tao Bai, Yang Liu, Wang Miao, Hongqin Wang, Xiaodong Liu and Yimin Fan




Molecular Hydrogen: New Antioxidant and Anti-inflammatory Therapy for Rheumatoid Arthritis and Related Diseases

, 2013; 19(35): 6375 - 6381

Toru Ishibashi




The Smart Targeting of Nanoparticles

, 2013; 19(35): 6315 - 6329

Adam D. Friedman, Sarah E. Claypool and Rihe Liu




Nanostructed Cubosomes as Advanced Drug Delivery System

, 2013; 19(35): 6290 - 6297

Xin Pan, Ke Han, Xinsheng Peng, Zhiwen Yang, Lingzhen Qin, Chune Zhu, Xintian Huang, Xuan Shi, Linghui Dian, Ming Lu and Chuanbin Wu




Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence

, 2013; 19(34): 6064 - 6093

Joao Tomé-Carneiro, Mar Larrosa, Antonio González-Sarrías, Francisco A. Tomás-Barberán, María Teresa García-Conesa and Juan Carlos Espín




Mitochondrial Mutations in Atherosclerosis: New Solutions in Research and Possible Clinical Applications

, 2013; 19(33): 5942 - 5953

Igor A. Sobenin, Dimitry A. Chistiakov, Yuri V. Bobryshev, Anton Y. Postnov and Alexander N. Orekhov




Role of Adiponectin in the Metabolic Syndrome: Current Perspectives on its Modulation as a Treatment Strategy

, 2013; 19(32): 5755 - 5763

Indira Padmalayam and Mark Suto




Hyperglycemia-induced Oxidative Stress and its Role in Diabetes Mellitus Related Cardiovascular Diseases

, 2013; 19(32): 5695 - 5703

Teresa Vanessa Fiorentino, Annamaria Prioletta, Pengou Zuo and Franco Folli




N-Glycosylation of Plant-produced Recombinant Proteins

, 2013; 19(31): 5503 - 5512

Dirk Bosch, Alexandra Castilho, Andreas Loos, Arjen Schots and Herta Steinkellner




Commercial Aspects of Pharmaceutical Protein Production in Plants

, 2013; 19(31): 5471 - 5477

Rainer Fischer, Stefan Schillberg, Johannes F. Buyel and Richard M. Twyman




The Culture-Repopulating Ability Assays and Incubation in Low Oxygen: A Simple Way to Test Drugs on Leukaemia Stem or Progenitor Cells

, 2013; 19(30): 5374 - 5383

Maria Grazia Cipolleschi, Elisabetta Rovida and Persio Dello Sbarba




New Molecular Targets in the Treatment of NSCLC

, 2013; 19(30): 5333 - 5343

Clorinda Schettino, Maria Anna Bareschino, Paola Claudia Sacco, Paolo Maione, Antonio Rossi, Francesca Casaluce, Assunta Sgambato and Cesare Gridelli




Genetic Predisposition in NAFLD and NASH: Impact on Severity of Liver Disease and Response to Treatment

, 2013; 19(29): 5219 - 5238

Paola Dongiovanni, Quentin M. Anstee and Luca Valenti




Cardiovascular and Systemic Risk in Nonalcoholic Fatty Liver Disease - Atherosclerosis as a Major Player in the Natural Course of NAFLD

, 2013; 19(29): 5177 - 5192

Amedeo Lonardo, Silvia Sookoian, Michel Chonchol, Paola Loria and Giovanni Targher




Epidemiology and Natural History of Patients with NAFLD

, 2013; 19(29): 5169 - 5176

Neeraj Bhala, Ramy Ibrahim Kamal Jouness and Elisabetta Bugianesi




Lysine Acetyltransferases CBP and p300 as Therapeutic Targets in Cognitive and Neurodegenerative Disorders

, 2013; 19(28): 5051 - 5064

Luis M. Valor, Jose Viosca, Jose P. Lopez-Atalaya and Angel Barco




Histone Acetylation: From Code to Web and Router Via Intrinsically Disordered Regions

, 2013; 19(28): 5019 - 5042

Masami Horikoshi




Treatment of Foot Disease in Patients with Type 2 Diabetes Mellitus using Human Umbilical Cord Blood Mesenchymal Stem Cells: Response and Correction of Immunological Anomalies

, 2013; 19(27): 4893 - 4899

Xiao-Yan Li, Zhao-Hui Zheng, Xue-Yi Li, Jian Guo, Yan Zhang, Hui Li, Yang-Wei Wang, Jun Ren and Zhen-Biao Wu




MicroRNA-34a Promotes Cardiomyocyte Apoptosis Post Myocardial Infarction Through Down-regulating Aldehyde Dehydrogenase 2

, 2013; 19(27): 4865 - 4873

Fan Fan, Aijun Sun, Hangtian Zhao, Xiangwei Liu, Wenbin Zhang, Xueting Jin, Cong Wang, Xin Ma, Cheng Shen, Yunzeng Zou, Kai Hu and Junbo Ge




Cardiac Dysfunction and Oxidative Stress in the Metabolic Syndrome: an Update on Antioxidant Therapies

, 2013; 19(27): 4806 - 4817

Olesya Ilkun and Sihem Boudina




Genomes to Hits In Silico - A Country Path Today, A Highway Tomorrow: A Case Study of Chikungunya

, 2013; 19(26): 4687 - 4700

Anjali Soni, Khushhali M. Pandey, Pratima Ray and B. Jayaram




Advances in Binding Free Energies Calculations: QM/MM-Based Free Energy Perturbation Method for Drug Design

, 2013; 19(26): 4674 - 4686

R.S. Rathore, M. Sumakanth, M. Siva Reddy, P. Reddanna, Allam Appa Rao, Mark D. Erion and M.R. Reddy




Cardioprotection Techniques: Preconditioning, Postconditioning and Remote Con-ditioning (Basic Science)

, 2013; 19(25): 4544 - 4563

Derek J. Hausenloy




Role of Neurotrophins in Spinal Plasticity and Locomotion

, 2013; 19(24): 4509 - 4516

Victor Arvanian




Modulation of the Intrinsic Properties of Motoneurons by Serotonin

, 2013; 19(24): 4371 - 4384

Jean-Francois Perrier, Hanne Borger Rasmussen, Rasmus Kordt Christensen and Anders Victor Petersen




Intrinsic Disorder-based Protein Interactions and their Modulators

, 2013; 19(23): 4191 - 4213

Vladimir N. Uversky




The Role of Protonation States in Ligand-Receptor Recognition and Binding

, 2013; 19(23): 4182 - 4190

Marharyta Petukh, Shannon Stefl and Emil Alexov




Non-Covalent Proteasome Inhibitors

, 2013; 19(22): 4115 - 4130

Julia Kaffy, Guillaume Bernadat and Sandrine Ongeri




Deubiquitinating Enzymes as Therapeutic Targets in Cancer

, 2013; 19(22): 4039 - 4052

Key-Hwan Lim and Kwang-Hyun Baek




From Bortezomib to other Inhibitors of the Proteasome and Beyond

, 2013; 19(22): 4025 - 4038

Daniela Buac, Min Shen, Sara Schmitt, Fathima Rani Kona, Rahul Deshmukh, Zhen Zhang, Christine Neslund-Dudas, Bharati Mitra and Q. Ping Dou




Current Developments of Coumarin Compounds in Medicinal Chemistry

, 2013; 19(21): 3884 - 3930

Xin-Mei Peng, Guri L.V. Damu and Cheng- He Zhou




PCSK9 Inhibition - A Novel Mechanism to Treat Lipid Disorders?

, 2013; 19(21): 3869 - 3877

Maciej Banach, Manfredi Rizzo, Milan Obradovic, Giuseppe Montalto, Jacek Rysz, Dimitri P. Mikhailidis and Esma R. Isenovic




Invasive Aspergillosis: New Insights into Disease, Diagnostic and Treatment

, 2013; 19(20): 3569 - 3594

Meinolf Karthaus and Dieter Buchheidt




Rescuing Mutant CFTR: A Multi-task Approach to a Better Outcome in Treating Cystic Fibrosis

, 2013; 19(19): 3497 - 3508

Margarida D. Amaral and Carlos M. Farinha




Combined Angiogenic and Osteogenic Factor Delivery for Bone Regenerative Engineering

, 2013; 19(19): 3374 - 3383

Quanjun Cui, Abhijit S. Dighe and James N. Irvine Jr




Cullin-RING Ligases as Attractive Anti-cancer Targets

, 2013; 19(18): 3215 - 3225

Yongchao Zhao and Yi Sun




Cdc20: A Potential Novel Therapeutic Target for Cancer Treatment

, 2013; 19(18): 3210 - 3214

Zhiwei Wang, Lixin Wan, Jiateng Zhong, Hiroyuki Inuzuka, Pengda Liu, Fazlul H. Sarkar and Wenyi Wei




Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Inhibitors in the Treatment of Hypercholesterolemia and other Pathologies

, 2013; 19(17): 3161 - 3172

Nabil G. Seidah




The Promise of Cholesteryl Ester Transfer Protein (CETP) Inhibition in the Treatment of Cardiovascular Disease

, 2013; 19(17): 3143 - 3149

A.E. Bochem, J.A. Kuivenhoven and E.S.G. Stroes




The Role of Fibrate Treatment in Dyslipidemia: An Overview

, 2013; 19(17): 3124 - 3131

Niki Katsiki, Dragana Nikolic, Giuseppe Montalto, Maciej Banach, Dimitri P. Mikhailidis and Manfredi Rizzo




Cell-penetrating Peptides as Nucleic Acid Delivery Systems: From Biophysics to Biological Applications

, 2013; 19(16): 2895 - 2923

Sara Trabulo, Ana L. Cardoso, Ana M. S. Cardoso, Catarina M. Morais, Amalia S. Jurado and Maria C. Pedroso de Lima




Endocytosis, Intracellular Traffic and Fate of Cell Penetrating Peptide Based Conjugates and Nanoparticles

, 2013; 19(16): 2878 - 2894

Kez Cleal, Lin He, Peter D. Watson and Arwyn T. Jones




Nuclear Translocation of Heme Oxygenase-1 Confers Resistance to Imatinib in Chronic Myeloid Leukemia Cells

, 2013; 19(15): 2765 - 2770

Daniele Tibullo, Ignazio Barbagallo, Cesarina Giallongo, Piera La Cava, Nunziatina Parrinello, Luca Vanella, Fabio Stagno, Giuseppe A. Palumbo, Giovanni Li Volti and Francesco Di Raimondo




Regulation of Autophagy in Oxygen-Dependent Cellular Stress

, 2013; 19(15): 2747 - 2756

Stefan W. Ryter and Augustine M. K. Choi




Redox Homeostasis and Epigenetics in Non-alcoholic Fatty Liver Disease (NAFLD)

, 2013; 19(15): 2737 - 2746

Christine Podrini, Michela Borghesan, Azzura Greco, Valerio Pazienza, Gianluigi Mazzoccoli and Manlio Vinciguerra




Chemical Nature and Reaction Mechanisms of the Molybdenum Cofactor of Xanthine Oxidoreductase

, 2013; 19(14): 2606 - 2614

Ken Okamoto, Teruo Kusano and Takeshi Nishino




Targeting UDP-Galactopyranose Mutases from Eukaryotic Human Pathogens

, 2013; 19(14): 2561 - 2573

Karina Kizjakina, John J. Tanner and Pablo Sobrado




Mesenchymal Stem/Stromal Cells: A New "Cells as Drugs" Paradigm. Efficacy and Critical Aspects in Cell Therapy

, 2013; 19(13): 2459 - 2473

Laura de Girolamo, Enrico Lucarelli, Giulio Alessandri, Maria Antonietta Avanzini, Maria Ester Bernardo, Ettore Biagi, Anna Teresa Brini, Giovanna D’Amico, Franca Fagioli, Ivana Ferrero, Franco Locatelli, Rita Maccario, Mario Marazzi, Ornella Parolini, Augusto Pessina and Maria Luisa Torre ; Italian Mesenchymal Stem Cell Group (GISM)




Chronic Hyperuricemia, Uric Acid Deposit and Cardiovascular Risk

, 2013; 19(13): 2432 - 2438

Davide Grassi, Livia Ferri, Giovambattista Desideri, Paolo Di Giosia, Paola Cheli, Rita Del Pinto, Giuliana Properzi and Claudio Ferri




Binding Site Detection and Druggability Prediction of Protein Targets for Structure- Based Drug Design

, 2013; 19(12): 2326 - 2333

Yaxia Yuan, Jianfeng Pei and Luhua Lai




Targeting the Nuclear Transport Machinery by Rational Drug Design

, 2013; 19(12): 2318 - 2325

Lei Mao and Yongliang Yang




Computational Approaches for Ligand Discovery and Design in Class-A G Protein- Coupled Receptors

, 2013; 19(12): 2216 - 2236

David Rodriguez and Hugo Gutierrez-de-Teran




Perspectives on New Synthetic Curcumin Analogs and their Potential Anticancer Properties

, 2013; 19(11): 2047 - 2069

Alok Vyas, Prasad Dandawate, Subhash Padhye, Aamir Ahmad and Fazlul Sarkar




A Review of Therapeutic Effects of Curcumin

, 2013; 19(11): 2032 - 2046

Ali Noorafshan and Soheil Ashkani-Esfahani




The Clinical Applications of Curcumin: Current State and the Future

, 2013; 19(11): 2011 - 2031

Xia Fan, Chun Zhang, Dong-bo Liu, Jun Yan and Hua-ping Liang




Pharmacological Properties of Glutamatergic Drugs Targeting NMDA Receptors and their Application in Major Depression

, 2013; 19(10): 1898 - 1922

Gianluca Serafini, Maurizio Pompili, Marco Innamorati, Yogesh Dwivedi, Goutam Brahmachari and Paolo Girardi




Molecular Aspects of the RT/drug Interactions. Perspective of Dual Inhibitors

, 2013; 19(10): 1850 - 1859

Simona Distinto, Elias Maccioni, Rita Meleddu, Angela Corona, Stefano Alcaro and Enzo Tramontano




Synthesized Peptide Inhibitors of HIV-1 gp41-dependent Membrane Fusion

, 2013; 19(10): 1800 - 1809

Yuxian He




Impact of Cellular Senescence in Aging and Cancer

, 2013; 19(9): 1699 - 1709

Mauro Provinciali, Maurizio Cardelli, Francesca Marchegiani and Elisa Pierpaoli




T Cell Replicative Senescence in Human Aging

, 2013; 19(9): 1680 - 1698

Jennifer P. Chou and Rita B. Effros




Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised

, 2013; 19(9): 1675 - 1679

Stefano Salvioli, Daniela Monti, Catia Lanzarini, Maria Conte, Chiara Pirazzini, Maria Giulia Bacalini, Paolo Garagnani, Cristina Giuliani, Elisa Fontanesi, Rita Ostan, Laura Bucci, Federica Sevini, Stella Lukas Yani, Annalaura Barbieri, Laura Lomartire, Vincenzo Borelli, Dario Vianello, Elena Bellavista, Morena Martucci, Elisa Cevenini, Elisa Pini, Maria Scurti, Fiammetta Biondi, Aurelia Santoro, Miriam Capri and Claudio Franceschi




Human Papillomavirus DNA and E6/E7 mRNA Testing as Triage in Liquid-Based Cytology Samples from Primary Screening

, 2013; 19(8): 1508 - 1515

Sonia Andersson, Miriam Mints, Elisabete Weiderpass and Bo Johansson




Human Papillomavirus (HPV) Vaccines as an Option for Preventing Cervical Malignancies: (How) Effective and Safe?

, 2013; 19(8): 1466 - 1487

Lucija Tomljenovic, Jean Pierre Spinosa and Christopher A. Shaw




The Interplay between the Gut Immune System and Microbiota in Health and Disease: Nutraceutical Intervention for Restoring Intestinal Homeostasis

, 2013; 19(7): 1329 - 1342

Thea Magrone and Emilio Jirillo




Glycine Reuptake Inhibition as a New Therapeutic Approach in Schizophrenia: Focus on the Glycine Transporter 1 (GlyT1)

, 2013; 19(7): 1311 - 1320

Pierre Chue




MicroRNA in the Pathogenesis and Prognosis of Esophageal Cancer

, 2013; 19(7): 1292 - 1300

Jian Gu, Yan Wang and Xifeng Wu




HtrA Protease Family as Therapeutic Targets

, 2013; 19(6): 977 - 1009

Joanna Skorko-Glonek, Dorota Zurawa-Janicka, Tomasz Koper, Miroslaw Jarzab, Donata Figaj, Przemyslaw Glaza and Barbara Lipinska




Molecular Mechanisms and Modulation of Key Pathways Underlying the Synergistic Interaction of Sorafenib with Erlotinib in Non-Small-Cell-Lung Cancer (NSCLC) Cells

, 2013; 19(5): 927 - 939

E. Giovannetti, M. Labots, H. Dekker, E. Galvani, J.S.W. Lind, R. Sciarrillo, R. Honeywell, E.F. Smit, H.M. Verheul and G.J. Peters




PI3K Pathway Inhibitors: Better Not Left Alone

, 2013; 19(5): 895 - 906

Ben Markman, Jessica J. Tao and Maurizio Scaltriti




Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: Current Status and Future Perspectives in the Development of Novel Irreversible Inhibitors for the Treatment of Mutant Non-small Cell Lung Cancer

, 2013; 19(5): 818 - 832

Elena Galvani, Roberta Alfieri, Elisa Giovannetti, Andrea Cavazzoni, Silvia La Monica, Maricla Galetti, Claudia Fumarola, Mara Bonelli, Marco Mor, Marcello Tiseo, Godefridus J. Peters, Pier Giorgio Petronini and Andrea Ardizzoni




Wnt/beta-Catenin Signaling and Small Molecule Inhibitors

, 2013; 19(4): 634 - 664

Andrey Voronkov and Stefan Krauss




Rejuvenating Sirtuins: The Rise of a New Family of Cancer Drug Targets

, 2013; 19(4): 614 - 623

Santina Bruzzone, Marco Daniele Parenti, Alessia Grozio, Alberto Ballestrero, Inga Bauer, Alberto Del Rio and Alessio Nencioni




Modulation of Epigenetic Targets for Anticancer Therapy: Clinicopathological Relevance, Structural Data and Drug Discovery Perspectives

, 2013; 19(4): 578 - 613

Federico Andreoli, Armenio Jorge Moura Barbosa, Marco Daniele Parenti and Alberto Del Rio




Lysosomal Rerouting of Hsp70 Trafficking as a Potential Immune Activating Tool for Targeting Melanoma

, 2013; 19(3): 430 - 440

Kata Juhasz, Roland Thuenauer, Andrea Spachinger, Ern Duda, Ibolya Horvath, Laszlo Vigh, Alois Sonnleitner and Zsolt Balogi




Hsp90 Inhibitors as Anti-Cancer Agents, from Basic Discoveries to Clinical Development

, 2013; 19(3): 366 - 376

Shiro Soga, Shiro Akinaga and Yukimasa Shiotsu




The Therapeutic Target Hsp90 and Cancer Hallmarks

, 2013; 19(3): 347 - 365

Yoshihiko Miyata, Hitoshi Nakamoto and Len Neckers




Hydroximic Acid Derivatives: Pleiotropic Hsp Co-Inducers Restoring Homeostasis and Robustness

, 2013; 19(3): 309 - 346

Tim Crul, Noemi Toth, Stefano Piotto, Peter Literati-Nagy, Kalman Tory, Pierre Haldimann, Bernadett Kalmar, Linda Greensmith, Zsolt Torok, Gabor Balogh, Imre Gombos, Federica Campana, Simona Concilio, Ferenc Gallyas, Gabor Nagy, Zoltan Berente, Burcin Gungor, Maria Peter, Attila Glatz, Akos Hunya, Zsuzsanna Literati-Nagy, Laszlo Vigh, Femke Hoogstra-Berends, Andre Heeres, Irma Kuipers, Lizette Loen, Jean-Paul Seerden, Deli Zhang, Roelien A M Meijering, Robert H Henning, Bianca J J M Brundel, Harm H Kampinga, Laszlo Koranyi, Zoltan Szilvassy, Jozsef Mandl, Balazs Sumegi, Mark A Febbraio, Ibolya Horvath, Philip L Hooper and Laszlo Vigh




The Rise of Carbapenem-Resistant Acinetobacter baumannii

, 2013; 19(2): 223 - 238

Benjamin A. Evans, Ahmed Hamouda and Sebastian G.B. Amyes




Statin Therapy

, 2012; 18(38): 6284 - 6290

Colleen G. Koch




Non-Analgesic Effects of Opioids: Peripheral Opioid Effects on Inflammation and Wound Healing

, 2012; 18(37): 6053 - 6069

Christoph Stein and Sarah Kuchler




The Role of Oxidative Stress in Depressive Disorders

, 2012; 18(36): 5890 - 5899

Tanja Maria Michel, Dietrich Pulschen and Johannes Thome




NF-κB as a Target for Modulating Inflammatory Responses

, 2012; 18(35): 5735 - 5745

Chiara Gasparini and Marc Feldmann




Probiotics and Oral Health

, 2012; 18(34): 5522 - 5531

Bernard Bizzini, Giuseppe Pizzo, Giovanni Scapagnini, Domenico Nuzzo and Sonya Vasto




Platelet Function Testing in Atherothrombotic Disease

, 2012; 18(33): 5379 - 5391

Erik Lerkevang Grove, Robert F. Storey and Morten Wurtz




Interindividual Variability in the Efficacy of Oral Antiplatelet Drugs: Definitions, Mechanisms and Clinical Importance

, 2012; 18(33): 5344 - 5361

Morten Wurtz and Erik Lerkevang Grove




The Role of Platelets in Athero-Thrombotic Events

, 2012; 18(33): 5197 - 5214

Matthias K. Freynhofer, Veronika Bruno, Johann Wojta and Kurt Huber




A Critical Review of the Antipsychotic Effects of Cannabidiol: 30 Years of a Translational Investigation

, 2012; 18(32): 5131 - 5140

Antonio Waldo Zuardi, Jose Alexandre S. Crippa, Jaime E.C. Hallak, Sagnik Bhattacharyya, Zerrin Atakan, Rocio Martin-Santos, Philip K. McGuire and Francisco Silveira Guimaraes




The Yin and Yang of Cannabis-induced Psychosis: the Actions of Δ 9-Tetrahydrocannabinol and Cannabidiol in Rodent Models of Schizophrenia

, 2012; 18(32): 5113 - 5130

J. C. Arnold, A. A. Boucher and T. Karl




Effects of Cannabis Use on Human Brain Structure in Psychosis: A Systematic Review Combining In Vivo Structural Neuroimaging and Post Mortem Studies

, 2012; 18(32): 5070 - 5080

Charlotte Rapp, Hilal Bugra, Anita Riecher-Rossler, Corinne Tamagni and Stefan Borgwardt




Genetic Variation Underlying Psychosis-inducing Effects of Cannabis: Critical Review and Future Directions

, 2012; 18(32): 5015 - 5023

Jeroen Decoster, Jim van Os, Inez Myin-Germeys, Marc De Hert and Ruud van Winkel




Ghrelin and Motilin in the Gastrointestinal System

, 2012; 18(31): 4755 - 4765

Chih-Yen Chen and Chang-Youh Tsai




Small-Molecule Inhibitors of Protein-Protein Interactions: How to Mimic a Protein Partner

, 2012; 18(30): 4679 - 4684

David C. Fry