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Current Pharmaceutical Design

Volume 25, 46 Issues, 2019
ISSN: 1873-4286 (Online)
ISSN: 1381-6128 (Print)
This journal supports open access

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    Pharmacology & Pharmacy

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Open Access Articles

Nanomedicines to Treat Skin Pathologies with Natural Molecules

, 2019; 25(21): 2323 - 2337

Elisabetta Esposito*, Claudio Nastruzzi, Maddalena Sguizzato and Rita Cortesi






Effects of As2O3 and Resveratrol on the Proliferation and Apoptosis of Colon Cancer Cells and the hERG-mediated Potential Mechanisms

, 2019; 25(12): 1385 - 1391

Caichuan Yan*, Fengmei Li*, Yuhao Zhang, Yang Li, Mingzhu Li, Fang Wang, Guocui Zhang, Yuexin Li, Baoxin Li and Xin Zhao











Modified LDL Particles Activate Inflammatory Pathways in Monocyte-derived Macrophages: Transcriptome Analysis

, 2018; 24(26): 3143 - 3151

Alexander N. Orekhov*, Yumiko Oishi , Nikita G. Nikiforov, Andrey V. Zhelankin, Larisa Dubrovsky, Igor A. Sobenin, Alexander Kel, Daria Stelmashenko, Vsevolod J. Makeev, Kathy Foxx, Xueting Jin, Howard S. Kruth and Michael Bukrinsky












Virtual Screening and Statistical Analysis in the Design of New Caffeine Analogues Molecules with Potential Epithelial Anticancer Activity

, 2018; 24(5): 576 - 594

Josivan da Silva Costa*, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macedo






IGF-1 as a Drug for Preterm Infants: A Step-Wise Clinical Development

, 2017; 23(38): 5964 - 5970

Ann Hellstrom*, David Ley, Boubou Hallberg, Chatarina Lofqvist, Ingrid Hansen-Pupp, Luca A. Ramenghi, Jan Borg, Lois E. H. Smith and Anna-Lena Hard




A Special Focus on Selexipag - Treatment of Pulmonary Arterial Hypertension

, 2017; 23(34): 5191 - 5199

Louise M. Sorensen, Markus Wehland, Marcus Kruger, Ulf Simonsen, Mohamed Z. Nassef, Manfred Infanger and Daniela Grimm*














Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases

, 2017; 23(7): 1077 - 1097

Lili Wang, Rufeng Ma, Chenyue Liu, Haixia Liu, Ruyuan Zhu, Shuzhen Guo, Minke Tang, Yu Li, Jianzhao Niu, Min Fu, Sihua Gao* and Dongwei Zhang*









The Microbial Quality Aspects and Decontamination Approaches for the Herbal Medicinal Plants and Products: An in-Depth Review

, 2016; 22(27): 4264 - 4287

Daniela Dal Molim Ghisleni, Marina de Souza Braga, Irene Satiko Kikuchi, Mirela Braşoveanu, Monica R. Nemţanu, Kamal Dua and Terezinha de Jesus Andreoli Pinto





Miscellaneous Topics in Computer-Aided Drug Design: Synthetic Accessibility and GPU Computing, and Other Topics

, 2016; 22(23): 3555 - 3568

Yoshifumi Fukunishi, Tadaaki Mashimo, Kiyotaka Misoo, Yoshinori Wakabayashi, Toshiaki Miyaki, Seiji Ohta, Mayu Nakamura and Kazuyoshi Ikeda






Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier

, 2016; 22(9): 1177 - 1193

David S. Hersh, Aniket S. Wadajkar, Nathan B. Roberts, Jimena G. Perez, Nina P. Connolly, Victor Frenkel, Jeffrey A. Winkles, Graeme F. Woodworth and Anthony J. Kim








Significant Differences Characterise the Correlation Coefficients between Biocide and Antibiotic Susceptibility Profiles in Staphylococcus aureus

, 2015; 21(16): 2054 - 2057

Marco R. Oggioni, Joana Rosado Coelho, Leonardo Furi, Daniel R Knight, Carlo Viti, Graziella Orefici, Jose-Luis Martinez, Ana Teresa Freitas, Teresa M. Coque, Ian Morrissey and behalf of the BIOHYPO consortium




Macrophages in Immunopathology of Atherosclerosis: A Target for Diagnostics and Therapy

, 2015; 21(9): 1172 - 1179

Alexander N. Orekhov, Igor A. Sobenin, Mikhail A. Gavrilin, Alexei Gratchev, Svetlana Y. Kotyashova, Nikita G. Nikiforov and Julia Kzhyshkowska








Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy

, 2014; 20(42): 6584 - 6643

Roger Gilabert-Oriol, Alexander Weng, Benedicta von Mallinckrodt, Matthias F. Melzig, Hendrik Fuchs and Mayank Thakur







Brain Innate Immunity in the Regulation of Neuroinflammation: Therapeutic Strategies by Modulating CD200-CD200R Interaction Involve the Cannabinoid System

, 2014; 20(29): 4707 - 4722

Miriam Hernangomez, Francisco J. Carrillo-Salinas, Miriam Mecha, Fernando Correa, Leyre Mestre, Frida Loria, Ana Feliu, Fabian Docagne and Carmen Guaza





Effects of Cannabis on Impulsivity: A Systematic Review of Neuroimaging Findings

, 2014; 20(13): 2126 - 2137

Johannes Wrege, Andre Schmidt, Anna Walter, Renata Smieskova, Kerstin Bendfeldt, Ernst-Wilhelm Radue, Undine E. Lang and Stefan Borgwardt




New Pharmaceutical Treatment of Gastric MALT Lymphoma: Anti-angiogenesis Treatment using VEGF Receptor Antibodies and Celecoxib

, 2014; 20(7): 1097 - 1103

Masahiko Nakamura, Tetsufumi Takahashi, Hidenori Matsui, Shinichi Takahashi, Somay Y. Murayama, Hidekazu Suzuki and Kanji Tsuchimoto









The Cellular Autophagy Markers Beclin-1 and LC3B-II are Increased During Reperfusion in Fibrillated Mouse Hearts

, 2013; 19(39): 6912 - 6918

Gregory Meyer, Attila Czompa, Cyril Reboul, Evelin Csepanyi, Andras Czegledi, Istvan Bak, Gyorgy Balla, Jozsef Balla, Arpad Tosaki and Istvan Lekli




Cardioprotective Effects of Sour Cherry Seed Extract (SCSE) on the Hypercholesterolemic Rabbit Heart

, 2013; 19(39): 6896 - 6905

Bela Juhasz, Attila Kertész, Jozsef Balla, Gyorgy Balla, Zoltán Szabo, Mariann Bombicz, Daniel Priksz, Rudolf Gesztelyi, Balazs Varga, David D. Haines and Arpad Tosaki





Ghrelin as a Neuroprotective and Palliative Agent in Alzheimer's and Parkinson's Disease

, 2013; 19(38): 6773 - 6790

Vanessa V. dos Santos, Ana Lúcia S. Rodrigues, Thereza C. De Lima, Susana R. de Barioglio, Rita Raisman-Vozari and Rui D. Prediger







Immunization Against Active Ghrelin Using Virus-Like Particles for Obesity Treatment

, 2013; 19(36): 6551 - 6558

Sara Andrade, Filipa Pinho, Andreia M. Ribeiro, Marcos Carreira, Felipe F. Casanueva, Polly Roy and Mariana P. Monteiro








Nanostructed Cubosomes as Advanced Drug Delivery System

, 2013; 19(35): 6290 - 6297

Xin Pan, Ke Han, Xinsheng Peng, Zhiwen Yang, Lingzhen Qin, Chune Zhu, Xintian Huang, Xuan Shi, Linghui Dian, Ming Lu and Chuanbin Wu




Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence

, 2013; 19(34): 6064 - 6093

Joao Tomé-Carneiro, Mar Larrosa, Antonio González-Sarrías, Francisco A. Tomás-Barberán, María Teresa García-Conesa and Juan Carlos Espín







N-Glycosylation of Plant-produced Recombinant Proteins

, 2013; 19(31): 5503 - 5512

Dirk Bosch, Alexandra Castilho, Andreas Loos, Arjen Schots and Herta Steinkellner






New Molecular Targets in the Treatment of NSCLC

, 2013; 19(30): 5333 - 5343

Clorinda Schettino, Maria Anna Bareschino, Paola Claudia Sacco, Paolo Maione, Antonio Rossi, Francesca Casaluce, Assunta Sgambato and Cesare Gridelli










MicroRNA-34a Promotes Cardiomyocyte Apoptosis Post Myocardial Infarction Through Down-regulating Aldehyde Dehydrogenase 2

, 2013; 19(27): 4865 - 4873

Fan Fan, Aijun Sun, Hangtian Zhao, Xiangwei Liu, Wenbin Zhang, Xueting Jin, Cong Wang, Xin Ma, Cheng Shen, Yunzeng Zou, Kai Hu and Junbo Ge









Modulation of the Intrinsic Properties of Motoneurons by Serotonin

, 2013; 19(24): 4371 - 4384

Jean-Francois Perrier, Hanne Borger Rasmussen, Rasmus Kordt Christensen and Anders Victor Petersen








From Bortezomib to other Inhibitors of the Proteasome and Beyond

, 2013; 19(22): 4025 - 4038

Daniela Buac, Min Shen, Sara Schmitt, Fathima Rani Kona, Rahul Deshmukh, Zhen Zhang, Christine Neslund-Dudas, Bharati Mitra and Q. Ping Dou





PCSK9 Inhibition - A Novel Mechanism to Treat Lipid Disorders?

, 2013; 19(21): 3869 - 3877

Maciej Banach, Manfredi Rizzo, Milan Obradovic, Giuseppe Montalto, Jacek Rysz, Dimitri P. Mikhailidis and Esma R. Isenovic








Cdc20: A Potential Novel Therapeutic Target for Cancer Treatment

, 2013; 19(18): 3210 - 3214

Zhiwei Wang, Lixin Wan, Jiateng Zhong, Hiroyuki Inuzuka, Pengda Liu, Fazlul H. Sarkar and Wenyi Wei






The Role of Fibrate Treatment in Dyslipidemia: An Overview

, 2013; 19(17): 3124 - 3131

Niki Katsiki, Dragana Nikolic, Giuseppe Montalto, Maciej Banach, Dimitri P. Mikhailidis and Manfredi Rizzo




Cell-penetrating Peptides as Nucleic Acid Delivery Systems: From Biophysics to Biological Applications

, 2013; 19(16): 2895 - 2923

Sara Trabulo, Ana L. Cardoso, Ana M. S. Cardoso, Catarina M. Morais, Amalia S. Jurado and Maria C. Pedroso de Lima





Nuclear Translocation of Heme Oxygenase-1 Confers Resistance to Imatinib in Chronic Myeloid Leukemia Cells

, 2013; 19(15): 2765 - 2770

Daniele Tibullo, Ignazio Barbagallo, Cesarina Giallongo, Piera La Cava, Nunziatina Parrinello, Luca Vanella, Fabio Stagno, Giuseppe A. Palumbo, Giovanni Li Volti and Francesco Di Raimondo





Redox Homeostasis and Epigenetics in Non-alcoholic Fatty Liver Disease (NAFLD)

, 2013; 19(15): 2737 - 2746

Christine Podrini, Michela Borghesan, Azzura Greco, Valerio Pazienza, Gianluigi Mazzoccoli and Manlio Vinciguerra






Mesenchymal Stem/Stromal Cells: A New "Cells as Drugs" Paradigm. Efficacy and Critical Aspects in Cell Therapy

, 2013; 19(13): 2459 - 2473

Laura de Girolamo, Enrico Lucarelli, Giulio Alessandri, Maria Antonietta Avanzini, Maria Ester Bernardo, Ettore Biagi, Anna Teresa Brini, Giovanna D’Amico, Franca Fagioli, Ivana Ferrero, Franco Locatelli, Rita Maccario, Mario Marazzi, Ornella Parolini, Augusto Pessina and Maria Luisa Torre ; Italian Mesenchymal Stem Cell Group (GISM)




Chronic Hyperuricemia, Uric Acid Deposit and Cardiovascular Risk

, 2013; 19(13): 2432 - 2438

Davide Grassi, Livia Ferri, Giovambattista Desideri, Paolo Di Giosia, Paola Cheli, Rita Del Pinto, Giuliana Properzi and Claudio Ferri











Molecular Aspects of the RT/drug Interactions. Perspective of Dual Inhibitors

, 2013; 19(10): 1850 - 1859

Simona Distinto, Elias Maccioni, Rita Meleddu, Angela Corona, Stefano Alcaro and Enzo Tramontano





Impact of Cellular Senescence in Aging and Cancer

, 2013; 19(9): 1699 - 1709

Mauro Provinciali, Maurizio Cardelli, Francesca Marchegiani and Elisa Pierpaoli





Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised

, 2013; 19(9): 1675 - 1679

Stefano Salvioli, Daniela Monti, Catia Lanzarini, Maria Conte, Chiara Pirazzini, Maria Giulia Bacalini, Paolo Garagnani, Cristina Giuliani, Elisa Fontanesi, Rita Ostan, Laura Bucci, Federica Sevini, Stella Lukas Yani, Annalaura Barbieri, Laura Lomartire, Vincenzo Borelli, Dario Vianello, Elena Bellavista, Morena Martucci, Elisa Cevenini, Elisa Pini, Maria Scurti, Fiammetta Biondi, Aurelia Santoro, Miriam Capri and Claudio Franceschi









HtrA Protease Family as Therapeutic Targets

, 2013; 19(6): 977 - 1009

Joanna Skorko-Glonek, Dorota Zurawa-Janicka, Tomasz Koper, Miroslaw Jarzab, Donata Figaj, Przemyslaw Glaza and Barbara Lipinska






Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: Current Status and Future Perspectives in the Development of Novel Irreversible Inhibitors for the Treatment of Mutant Non-small Cell Lung Cancer

, 2013; 19(5): 818 - 832

Elena Galvani, Roberta Alfieri, Elisa Giovannetti, Andrea Cavazzoni, Silvia La Monica, Maricla Galetti, Claudia Fumarola, Mara Bonelli, Marco Mor, Marcello Tiseo, Godefridus J. Peters, Pier Giorgio Petronini and Andrea Ardizzoni





Rejuvenating Sirtuins: The Rise of a New Family of Cancer Drug Targets

, 2013; 19(4): 614 - 623

Santina Bruzzone, Marco Daniele Parenti, Alessia Grozio, Alberto Ballestrero, Inga Bauer, Alberto Del Rio and Alessio Nencioni





Lysosomal Rerouting of Hsp70 Trafficking as a Potential Immune Activating Tool for Targeting Melanoma

, 2013; 19(3): 430 - 440

Kata Juhasz, Roland Thuenauer, Andrea Spachinger, Ern Duda, Ibolya Horvath, Laszlo Vigh, Alois Sonnleitner and Zsolt Balogi






Hydroximic Acid Derivatives: Pleiotropic Hsp Co-Inducers Restoring Homeostasis and Robustness

, 2013; 19(3): 309 - 346

Tim Crul, Noemi Toth, Stefano Piotto, Peter Literati-Nagy, Kalman Tory, Pierre Haldimann, Bernadett Kalmar, Linda Greensmith, Zsolt Torok, Gabor Balogh, Imre Gombos, Federica Campana, Simona Concilio, Ferenc Gallyas, Gabor Nagy, Zoltan Berente, Burcin Gungor, Maria Peter, Attila Glatz, Akos Hunya, Zsuzsanna Literati-Nagy, Laszlo Vigh, Femke Hoogstra-Berends, Andre Heeres, Irma Kuipers, Lizette Loen, Jean-Paul Seerden, Deli Zhang, Roelien A M Meijering, Robert H Henning, Bianca J J M Brundel, Harm H Kampinga, Laszlo Koranyi, Zoltan Szilvassy, Jozsef Mandl, Balazs Sumegi, Mark A Febbraio, Ibolya Horvath, Philip L Hooper and Laszlo Vigh









Probiotics and Oral Health

, 2012; 18(34): 5522 - 5531

Bernard Bizzini, Giuseppe Pizzo, Giovanni Scapagnini, Domenico Nuzzo and Sonya Vasto






The Role of Platelets in Athero-Thrombotic Events

, 2012; 18(33): 5197 - 5214

Matthias K. Freynhofer, Veronika Bruno, Johann Wojta and Kurt Huber




A Critical Review of the Antipsychotic Effects of Cannabidiol: 30 Years of a Translational Investigation

, 2012; 18(32): 5131 - 5140

Antonio Waldo Zuardi, Jose Alexandre S. Crippa, Jaime E.C. Hallak, Sagnik Bhattacharyya, Zerrin Atakan, Rocio Martin-Santos, Philip K. McGuire and Francisco Silveira Guimaraes












Inflammation in Ischemic Stroke Subtypes

, 2012; 18(28): 4289 - 4310

Antonino Tuttolomondo, Domenico Di Raimondo, Rosaria Pecoraro, Valentina Arnao, Antonio Pinto and Giuseppe Licata




Atherosclerosis as an Inflammatory Disease

, 2012; 18(28): 4266 - 4288

Antonino Tuttolomondo, Domenico Di Raimondo, Rosaria Pecoraro, Valentina Arnao, Antonio Pinto and Giuseppe Licata





Cellular Players in Lung Fibrosis

, 2012; 18(27): 4093 - 4102

Annemarie N. Lekkerkerker, Jamil Aarbiou, Thomas van Es and Richard A.J. Janssen












Choline Analogues in Malaria Chemotherapy

, 2012; 18(24): 3454 - 3466

Suzanne Peyrottes, Sergio Caldarelli, Sharon Wein, Christian Perigaud, Alain Pellet and Henri Vial










Novel Drugs Targeting Microtubules: the Role of Epothilones

, 2012; 18(19): 2793 - 2803

Gabriella Ferrandina, Marisa Mariani, Mirko Andreoli, Shohreh Shahabi, Giovanni Scambia and Cristiano Ferlini










Mast Cells in Allergic and Inflammatory Diseases

, 2012; 18(16): 2261 - 2277

Nikolaos Sismanopoulos, Danae-Anastasia Delivanis, Konstantinos-Dionysios Alysandratos, Asimenia Angelidou, Anastasia Therianou, Dimitrios Kalogeromitros and Theoharis C. Theoharides











Targeting the Cancer Initiating Cell: The Ultimate Target for Cancer Therapy

, 2012; 18(13): 1784 - 1795

James A. McCubrey, Linda S. Steelman, Stephen L. Abrams, Negin Misaghian, William H. Chappell, Jorg Basecke, Ferdinando Nicoletti, Massimo Libra, Giovanni Ligresti, Francac Stivala, Danijela Maksimovic-Ivanic, Sanja Mijatovic, Giuseppeo Montalto, Melchiorre Cervello, Piotr Laidler, Antonio Bonati, Camilla Evangelisti, Lucio Cocco and Alberto M. Martelli




Neural Stem Cell Niches in Health and Diseases

, 2012; 18(13): 1755 - 1783

Ilaria Decimo, Francesco Bifari, Mauro Krampera and Guido Fumagalli




Old Wine in a New Bottle: The Warburg Effect and Anticancer Mechanisms of Resveratrol

, 2012; 18(12): 1645 - 1654

Irfana Muqbil, Frances W.J. Beck, Bin Bao, Fazlul H. Sarkar, Ramzi M. Mohammad, S. M. Hadi and Asfar S. Azmi
















Role of the Renin-Angiotensin-Aldosterone System in the Pathogenesis of Atherosclerosis

, 2012; 18(7): 981 - 1004

Alessandro Durante, Giovanni Peretto, Alessandra Laricchia, Francesco Ancona, Marco Spartera, Antonio Mangieri and Domenico Cianflone










Neurocognition in the Psychosis Risk Syndrome: A Quantitative and Qualitative Review

, 2012; 18(4): 399 - 415

Anthony J. Giuliano, Huijun Li, Raquelle I. Mesholam-Gately, Shannon M. Sorenson, Kristen A. Woodberry and Larry J. Seidman




Rationale and First Results of Developing At-Risk (Prodromal) Criteria for Bipolar Disorder

, 2012; 18(4): 358 - 375

A. Bechdolf, A. Ratheesh, S. J. Wood, T. Tecic, P. Conus, B. Nelson, S. M. Cotton, A. M. Chanen, G. P. Amminger, S. Ruhrmann, F. Schultze-Lutter, J. Klosterkotter, P. Fusar Poli, A. R. Yung, M. Berk and P. D. McGorry




Phenotypes and Enviromental Factors: Their Influence in PCOS

, 2012; 18(3): 270 - 282

Evanthia Diamanti-Kandarakis, Charikleia Christakou and Evangelos Marinakis






Optimization of Cardiac Metabolism in Heart Failure

, 2011; 17(35): 3846 - 3853

Tomohisa Nagoshi, Michihiro Yoshimura, Giuseppe M. C. Rosano, Gary D. Lopaschuk and Seibu Mochizuki





Perinatal Gene Transfer to the Liver

, 2011; 17(24): 2528 - 2541

Tristan R. McKay, Ahad A. Rahim, Suzanne M.K. Buckley, Natalie J. Ward, Jerry K.Y.Chan, Steven J. Howe and Simon N. Waddington






PACAP is Implicated in the Stress Axes

, 2011; 17(10): 985 - 989

Hitoshi Hashimoto, Norihito Shintani, Mamoru Tanida, Atsuko Hayata, Ryota Hashimoto and Akemichi Baba






Herbal Medicines and Nutraceuticals for Diabetic Vascular Complications: Mechanisms of Action and Bioactive Phytochemicals

, 2010; 16(34): 3776 - 3807

Eshaifol A. Omar, Antony Kam, Ali Alqahtani, Kong M. Li, Valentina Razmovski-Naumovski, Srinivas Nammi, Kelvin Chan, Basil D Roufogalis and George Q. Li













The Effects of Antipsychotics on the Brain: What Have We Learnt from Structural Imaging of Schizophrenia? – A Systematic Review

, 2009; 15(22): 2535 - 2549

R. Smieskova, P. Fusar-Poli, P. Allen, K. Bendfeldt, R. D. Stieglitz, J. Drewe, E. W. Radue, P. K. McGuire, A. Riecher-Rossler and S. J. Borgwardt












Apoptosis in the Homeostasis of the Immune System and in Human Immune Mediated Diseases

, 2008; 14(3): 253 - 268

R. Paganelli, A. Giovannetti, M. Pierdominici, A. Di Iorio, R. Cianci, G. Murdaca, F. Puppo and F. Pandolfi









Editor-in-Chief

William A. Banks
(29546 citations)
Seattle VA Puget Sound Health Care System
Room 810C, Building 1
1660 S. Columbian Way
Seattle, WA 98108
USA

Biography View Full Editorial Board

Journal History

Current Pharmaceutical Design was introduced in 1995 with the assistance of Dr. William A. Banks, who is the current Editor-in-Chief serving since 1995.
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