Open Access Articles


Defense Mechanisms Against Acid Exposure by Dental Enamel Formation, Saliva and Pancreatic Juice Production

, 2018; 24(18): 2012 - 2022

Robert Racz, Akos Nagy, Zoltan Rakonczay , Erika Katalin Dunavari, Gabor Gerber and Gabor Varga*





Development of Peptide Vaccines in Dengue

, 2018; 24(11): 1157 - 1173

Kavita Reginald, Yanqi Chan, Magdalena Plebanski and Chit Laa Poh*





Virtual Screening and Statistical Analysis in the Design of New Caffeine Analogues Molecules with Potential Epithelial Anticancer Activity

, 2018; 24(5): 576 - 594

Josivan da Silva Costa*, Karina da Silva Lopes Costa, Josiane Viana Cruz, Ryan da Silva Ramos, Luciane Barros Silva, Davi Do Socorro Barros Brasil, Carlos Henrique Tomich de Paula da Silva, Cleydson Breno Rodrigues dos Santos and Williams Jorge da Cruz Macedo





Machine Learning-based Virtual Screening and Its Applications to Alzheimer’s Drug Discovery: A Review

, 2018; 24: 1 - 12 (E-Pub Ahead of Print)

Kristy A. Carpenter and Xudong Huang*




Modified LDL Particles Activate Inflammatory Pathways in Monocyte-derived Macrophages: Transcriptome Analysis

, 2018; 24: 1 - 9 (E-Pub Ahead of Print)

Alexander N. Orekhov*, Yumiko Oishi , Nikita G. Nikiforov, Andrey V. Zhelankin, Larisa Dubrovsky, Igor A. Sobenin, Alexander Kel, Daria Stelmashenko, Vsevolod J. Makeev, Kathy Foxx, Xueting Jin, Howard S. Kruth and Michael Bukrinsky




2-Hydroxypropyl-β-cyclodextrins and the Blood-Brain Barrier: Considerations for Niemann-Pick Disease Type C1

, 2017; 23(40): 6231 - 6238

Pericles Calias*




IGF-1 as a Drug for Preterm Infants: A Step-Wise Clinical Development

, 2017; 23(38): 5964 - 5970

Ann Hellstrom*, David Ley, Boubou Hallberg, Chatarina Lofqvist, Ingrid Hansen-Pupp, Luca A. Ramenghi, Jan Borg, Lois E. H. Smith and Anna-Lena Hard




A Special Focus on Selexipag - Treatment of Pulmonary Arterial Hypertension

, 2017; 23(34): 5191 - 5199

Louise M. Sorensen, Markus Wehland, Marcus Kruger, Ulf Simonsen, Mohamed Z. Nassef, Manfred Infanger and Daniela Grimm*





Ion Channel and Neurotransmitter Modulators as Electroceutical Approaches to the Control of Cancer

, 2017; 23(32): 4827 - 4841

Jack Tuszynski, Tatiana M. Tilli and Michael Levin*





Current Methods of the Circulating Tumor Cells (CTC) Analysis: A Brief Overview

, 2017; 23(32): 4726 - 4728

Natalia Dementeva, Daria Kokova and Oleg A. Mayboroda*





Role of Sulforaphane in Protection of Gastrointestinal Tract Against H. pylori and NSAID-Induced Oxidative Stress

, 2017; 23(27): 4066 - 4075

Akinori Yanaka*




Neuroprotection in Hypoxic-Ischemic Brain Injury Targeting Glial Cells

, 2017; 23(26): 3899 - 3906

Maria Ines Herrera*, Sofia Mucci*, George E. Barreto, Rodolfo Kolliker-Frers and Francisco Capani*




Hydrogel-Based Cell Therapies for Kidney Regeneration: Current Trends in Biofabrication and In Vivo Repair

, 2017; 23(26): 3845 - 3857

Katja Jansen*, Carl C.L. Schuurmans*, Jitske Jansen, Rosalinde Masereeuw* and Tina Vermonden*





Chemical Properties of Caffeic and Ferulic Acids in Biological System: Implications in Cancer Therapy. A Review

, 2017; 23(20): 3015 - 3023

Sarah S. Damasceno*, Bruna B. Dantas, Jaime Ribeiro-Filho, Demetrius Antônio M. Araújo and José Galberto M. da Costa





Macrocyclic Antimicrobial Peptides Engineered from ω-Conotoxin

, 2017; 23(14): 2131 - 2138

Xinya Hemu and James P. Tam*





Selective Inhibition of Phosphodiesterases 4A, B, C and D Isoforms in Chronic Respiratory Diseases: Current and Future Evidences

, 2017; 23(14): 2073 - 2083

Sonia Contreras*, Javier Milara*, Esteban Morcillo and Julio Cortijo




Traumatic Brain Injury: Preclinical Imaging Diagnostic(s) and Therapeutic Approaches

, 2017; 23(13): 1909 - 1915

Eric L. Kaijzel*, Ermond R. van Beek, Marieke A. Stammes, Ivo Que, Alan B. Chan, Clemens W.G.M. Lowik and Luis J. Cruz




PI3K/Akt Pathway: A Potential Therapeutic Target for Chronic Pain

, 2017; 23(12): 1860 - 1868

Shu-Ping Chen, Ya-Qun Zhou, Dai-Qiang Liu, Wen Zhang, Anne Manyande, Xue-Hai Guan, Yu-ke Tian, Da-Wei Ye* and Deeq Mohamed Omar





Inflammation: A Novel Therapeutic Target/Direction in Atherosclerosis

, 2017; 23(8): 1216 - 1227

Bin Li, Weihong Li, Xiaoli Li and Hong Zhou*




Salvia miltiorrhiza: A Potential Red Light to the Development of Cardiovascular Diseases

, 2017; 23(7): 1077 - 1097

Lili Wang, Rufeng Ma, Chenyue Liu, Haixia Liu, Ruyuan Zhu, Shuzhen Guo, Minke Tang, Yu Li, Jianzhao Niu, Min Fu, Sihua Gao* and Dongwei Zhang*




Polypharmacology in Precision Oncology: Current Applications and Future Prospects

, 2016; 22(46): 6935 - 6945

Albert A. Antolin, Paul Workman, Jordi Mestres and Bissan Al-Lazikani





Functional Foods for Health: The Interrelated Antioxidant and Anti-Inflammatory Role of Fruits, Vegetables, Herbs, Spices and Cocoa in Humans

, 2016; 22(44): 6701 - 6715

Mauro Serafini and Ilaria Peluso





Potential Pathways for CNS Drug Delivery Across the Blood-Cerebrospinal Fluid Barrier

, 2016; 22(35): 5463 - 5476

Nathalie Strazielle and Jean-François Ghersi-Egea




The Microbial Quality Aspects and Decontamination Approaches for the Herbal Medicinal Plants and Products: An in-Depth Review

, 2016; 22(27): 4264 - 4287

Daniela Dal Molim Ghisleni, Marina de Souza Braga, Irene Satiko Kikuchi, Mirela Braşoveanu, Monica R. Nemţanu, Kamal Dua and Terezinha de Jesus Andreoli Pinto




AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species

, 2016; 22(26): 3950 - 3970

Francesco Simone Ruggeri, Johnny Habchi, Andrea Cerreta and Giovanni Dietler




Miscellaneous Topics in Computer-Aided Drug Design: Synthetic Accessibility and GPU Computing, and Other Topics

, 2016; 22(23): 3555 - 3568

Yoshifumi Fukunishi, Tadaaki Mashimo, Kiyotaka Misoo, Yoshinori Wakabayashi, Toshiaki Miyaki, Seiji Ohta, Mayu Nakamura and Kazuyoshi Ikeda




Therapeutic Targets for Management of Periodontitis and Diabetes

, 2016; 22(15): 2216 - 2237

Corneliu Sima and Thomas E. Van Dyke





Evolving Drug Delivery Strategies to Overcome the Blood Brain Barrier

, 2016; 22(9): 1177 - 1193

David S. Hersh, Aniket S. Wadajkar, Nathan B. Roberts, Jimena G. Perez, Nina P. Connolly, Victor Frenkel, Jeffrey A. Winkles, Graeme F. Woodworth and Anthony J. Kim





Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational Biomarker

, 2015; 21(26): 3797 - 3806

Kenji Hashimoto





Particle Engineering in Pharmaceutical Solids Processing: Surface Energy Considerations

, 2015; 21(19): 2677 - 2694

Daryl R. Williams




Significant Differences Characterise the Correlation Coefficients between Biocide and Antibiotic Susceptibility Profiles in Staphylococcus aureus

, 2015; 21(16): 2054 - 2057

Marco R. Oggioni, Joana Rosado Coelho, Leonardo Furi, Daniel R Knight, Carlo Viti, Graziella Orefici, Jose-Luis Martinez, Ana Teresa Freitas, Teresa M. Coque, Ian Morrissey and behalf of the BIOHYPO consortium




Macrophages in Immunopathology of Atherosclerosis: A Target for Diagnostics and Therapy

, 2015; 21(9): 1172 - 1179

Alexander N. Orekhov, Igor A. Sobenin, Mikhail A. Gavrilin, Alexei Gratchev, Svetlana Y. Kotyashova, Nikita G. Nikiforov and Julia Kzhyshkowska





Antihypertensive Drugs Metabolism: An Update to Pharmacokinetic Profiles and Computational Approaches

, 2015; 21(6): 806 - 822

Aikaterini Zisaki, Ljubisa Miskovic and Vassily Hatzimanikatis





Biomarkers Predicting a Need for Intensive Treatment in Patients with Early Arthritis

, 2015; 21(2): 170 - 181

I. Gonzalez-Alvaro, A.M. Ortiz, I.V. Seoane, R. Garcia-Vicuna, C. Martinez and R.P. Gomariz




Immunotoxins Constructed with Ribosome-Inactivating Proteins and their Enhancers: A Lethal Cocktail with Tumor Specific Efficacy

, 2014; 20(42): 6584 - 6643

Roger Gilabert-Oriol, Alexander Weng, Benedicta von Mallinckrodt, Matthias F. Melzig, Hendrik Fuchs and Mayank Thakur




Tankyrases: Structure, Function and Therapeutic Implications in Cancer

, 2014; 20(41): 6472 - 6488

Teemu Haikarainen, Stefan Krauss and Lari Lehtio





Mechanisms of Action of Anesthetics for the Modulation of Perioperative Thrombosis: Evidence for Immune Mechanisms from Basic and Clinical Studies

, 2014; 20(36): 5779 - 5793

Toshiharu Azma, Florin Tuluc, Taishin Ito, Chikako Aoyama-Mani, Shinji Kawahito and Hiroyuki Kinoshita




Brain Innate Immunity in the Regulation of Neuroinflammation: Therapeutic Strategies by Modulating CD200-CD200R Interaction Involve the Cannabinoid System

, 2014; 20(29): 4707 - 4722

Miriam Hernangomez, Francisco J. Carrillo-Salinas, Miriam Mecha, Fernando Correa, Leyre Mestre, Frida Loria, Ana Feliu, Fabian Docagne and Carmen Guaza




Dipeptidyl-peptidase 4 Inhibition: Linking Metabolic Control to Cardiovascular Protection

, 2014; 20(14): 2387 - 2394

Angelo Avogaro, Saula de Kreutzenberg and Gianpaolo Fadini




Effects of Cannabis on Impulsivity: A Systematic Review of Neuroimaging Findings

, 2014; 20(13): 2126 - 2137

Johannes Wrege, Andre Schmidt, Anna Walter, Renata Smieskova, Kerstin Bendfeldt, Ernst-Wilhelm Radue, Undine E. Lang and Stefan Borgwardt




New Pharmaceutical Treatment of Gastric MALT Lymphoma: Anti-angiogenesis Treatment using VEGF Receptor Antibodies and Celecoxib

, 2014; 20(7): 1097 - 1103

Masahiko Nakamura, Tetsufumi Takahashi, Hidenori Matsui, Shinichi Takahashi, Somay Y. Murayama, Hidekazu Suzuki and Kanji Tsuchimoto





The µ Opioid Receptor and Ligands Acting at the µ Opioid Receptor, as Therapeutics and Potential Therapeutics

, 2013; 19(42): 7415 - 7434

Mariana Spetea, Muhammad Faheem Asim, Gerhard Wolber and Helmut Schmidhammer





Smart Stimuli Sensitive Nanogels in Cancer Drug Delivery and Imaging: A Review

, 2013; 19(41): 7203 - 7218

S. Maya, Bruno Sarmento, Amrita Nair, N. Sanoj Rejinold, Shantikumar V. Nair and R. Jayakumar





The Cellular Autophagy Markers Beclin-1 and LC3B-II are Increased During Reperfusion in Fibrillated Mouse Hearts

, 2013; 19(39): 6912 - 6918

Gregory Meyer, Attila Czompa, Cyril Reboul, Evelin Csepanyi, Andras Czegledi, Istvan Bak, Gyorgy Balla, Jozsef Balla, Arpad Tosaki and Istvan Lekli




Cardioprotective Effects of Sour Cherry Seed Extract (SCSE) on the Hypercholesterolemic Rabbit Heart

, 2013; 19(39): 6896 - 6905

Bela Juhasz, Attila Kertész, Jozsef Balla, Gyorgy Balla, Zoltán Szabo, Mariann Bombicz, Daniel Priksz, Rudolf Gesztelyi, Balazs Varga, David D. Haines and Arpad Tosaki




The STAT3 Inhibitor Stattic Impairs Cardiomyocyte Mitochondrial Function Through Increased Reactive Oxygen Species Formation

, 2013; 19(39): 6890 - 6895

Kerstin Boengler, Elvira Ungefug, Gerd Heusch and Rainer Schulz




Ghrelin as a Neuroprotective and Palliative Agent in Alzheimer's and Parkinson's Disease

, 2013; 19(38): 6773 - 6790

Vanessa V. dos Santos, Ana Lúcia S. Rodrigues, Thereza C. De Lima, Susana R. de Barioglio, Rita Raisman-Vozari and Rui D. Prediger




Iron Oxide Nanoparticle-induced Oxidative Stress and Genotoxicity in Human Skin Epithelial and Lung Epithelial Cell Lines

, 2013; 19(37): 6681 - 6690

Maqusood Ahamed, Hisham A. Alhadlaq, Javed Alam, M. A. Majeed Khan, Daoud Ali and Saud Alarafi





Recent Advances in Superparamagnetic Iron Oxide Nanoparticles for Cellular Imaging and Targeted Therapy Research

, 2013; 19(37): 6575 - 6593

Yi-Xiang J. Wang, Shouhu Xuan, Marc Port and Jean-Marc Idee




Immunization Against Active Ghrelin Using Virus-Like Particles for Obesity Treatment

, 2013; 19(36): 6551 - 6558

Sara Andrade, Filipa Pinho, Andreia M. Ribeiro, Marcos Carreira, Felipe F. Casanueva, Polly Roy and Mariana P. Monteiro




Diffusion Tensor Imaging to Determine Effects of Antidementive Treatment on Cerebral Structural Connectivity in Alzheimer’s Disease

, 2013; 19(36): 6416 - 6425

Ingo Kilimann, Yuttachai Likitjaroen, Harald Hampel and Stefan Teipel





Molecular Hydrogen: New Antioxidant and Anti-inflammatory Therapy for Rheumatoid Arthritis and Related Diseases

, 2013; 19(35): 6375 - 6381

Toru Ishibashi





Nanostructed Cubosomes as Advanced Drug Delivery System

, 2013; 19(35): 6290 - 6297

Xin Pan, Ke Han, Xinsheng Peng, Zhiwen Yang, Lingzhen Qin, Chune Zhu, Xintian Huang, Xuan Shi, Linghui Dian, Ming Lu and Chuanbin Wu




Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence

, 2013; 19(34): 6064 - 6093

Joao Tomé-Carneiro, Mar Larrosa, Antonio González-Sarrías, Francisco A. Tomás-Barberán, María Teresa García-Conesa and Juan Carlos Espín




Mitochondrial Mutations in Atherosclerosis: New Solutions in Research and Possible Clinical Applications

, 2013; 19(33): 5942 - 5953

Igor A. Sobenin, Dimitry A. Chistiakov, Yuri V. Bobryshev, Anton Y. Postnov and Alexander N. Orekhov





Hyperglycemia-induced Oxidative Stress and its Role in Diabetes Mellitus Related Cardiovascular Diseases

, 2013; 19(32): 5695 - 5703

Teresa Vanessa Fiorentino, Annamaria Prioletta, Pengou Zuo and Franco Folli




N-Glycosylation of Plant-produced Recombinant Proteins

, 2013; 19(31): 5503 - 5512

Dirk Bosch, Alexandra Castilho, Andreas Loos, Arjen Schots and Herta Steinkellner




Commercial Aspects of Pharmaceutical Protein Production in Plants

, 2013; 19(31): 5471 - 5477

Rainer Fischer, Stefan Schillberg, Johannes F. Buyel and Richard M. Twyman





New Molecular Targets in the Treatment of NSCLC

, 2013; 19(30): 5333 - 5343

Clorinda Schettino, Maria Anna Bareschino, Paola Claudia Sacco, Paolo Maione, Antonio Rossi, Francesca Casaluce, Assunta Sgambato and Cesare Gridelli





Cardiovascular and Systemic Risk in Nonalcoholic Fatty Liver Disease - Atherosclerosis as a Major Player in the Natural Course of NAFLD

, 2013; 19(29): 5177 - 5192

Amedeo Lonardo, Silvia Sookoian, Michel Chonchol, Paola Loria and Giovanni Targher





Lysine Acetyltransferases CBP and p300 as Therapeutic Targets in Cognitive and Neurodegenerative Disorders

, 2013; 19(28): 5051 - 5064

Luis M. Valor, Jose Viosca, Jose P. Lopez-Atalaya and Angel Barco





Treatment of Foot Disease in Patients with Type 2 Diabetes Mellitus using Human Umbilical Cord Blood Mesenchymal Stem Cells: Response and Correction of Immunological Anomalies

, 2013; 19(27): 4893 - 4899

Xiao-Yan Li, Zhao-Hui Zheng, Xue-Yi Li, Jian Guo, Yan Zhang, Hui Li, Yang-Wei Wang, Jun Ren and Zhen-Biao Wu




MicroRNA-34a Promotes Cardiomyocyte Apoptosis Post Myocardial Infarction Through Down-regulating Aldehyde Dehydrogenase 2

, 2013; 19(27): 4865 - 4873

Fan Fan, Aijun Sun, Hangtian Zhao, Xiangwei Liu, Wenbin Zhang, Xueting Jin, Cong Wang, Xin Ma, Cheng Shen, Yunzeng Zou, Kai Hu and Junbo Ge




Cardiac Dysfunction and Oxidative Stress in the Metabolic Syndrome: an Update on Antioxidant Therapies

, 2013; 19(27): 4806 - 4817

Olesya Ilkun and Sihem Boudina





Advances in Binding Free Energies Calculations: QM/MM-Based Free Energy Perturbation Method for Drug Design

, 2013; 19(26): 4674 - 4686

R.S. Rathore, M. Sumakanth, M. Siva Reddy, P. Reddanna, Allam Appa Rao, Mark D. Erion and M.R. Reddy





Role of Neurotrophins in Spinal Plasticity and Locomotion

, 2013; 19(24): 4509 - 4516

Victor Arvanian




Modulation of the Intrinsic Properties of Motoneurons by Serotonin

, 2013; 19(24): 4371 - 4384

Jean-Francois Perrier, Hanne Borger Rasmussen, Rasmus Kordt Christensen and Anders Victor Petersen




Intrinsic Disorder-based Protein Interactions and their Modulators

, 2013; 19(23): 4191 - 4213

Vladimir N. Uversky





Non-Covalent Proteasome Inhibitors

, 2013; 19(22): 4115 - 4130

Julia Kaffy, Guillaume Bernadat and Sandrine Ongeri





From Bortezomib to other Inhibitors of the Proteasome and Beyond

, 2013; 19(22): 4025 - 4038

Daniela Buac, Min Shen, Sara Schmitt, Fathima Rani Kona, Rahul Deshmukh, Zhen Zhang, Christine Neslund-Dudas, Bharati Mitra and Q. Ping Dou





PCSK9 Inhibition - A Novel Mechanism to Treat Lipid Disorders?

, 2013; 19(21): 3869 - 3877

Maciej Banach, Manfredi Rizzo, Milan Obradovic, Giuseppe Montalto, Jacek Rysz, Dimitri P. Mikhailidis and Esma R. Isenovic





Rescuing Mutant CFTR: A Multi-task Approach to a Better Outcome in Treating Cystic Fibrosis

, 2013; 19(19): 3497 - 3508

Margarida D. Amaral and Carlos M. Farinha





Cullin-RING Ligases as Attractive Anti-cancer Targets

, 2013; 19(18): 3215 - 3225

Yongchao Zhao and Yi Sun




Cdc20: A Potential Novel Therapeutic Target for Cancer Treatment

, 2013; 19(18): 3210 - 3214

Zhiwei Wang, Lixin Wan, Jiateng Zhong, Hiroyuki Inuzuka, Pengda Liu, Fazlul H. Sarkar and Wenyi Wei




Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Inhibitors in the Treatment of Hypercholesterolemia and other Pathologies

, 2013; 19(17): 3161 - 3172

Nabil G. Seidah





The Role of Fibrate Treatment in Dyslipidemia: An Overview

, 2013; 19(17): 3124 - 3131

Niki Katsiki, Dragana Nikolic, Giuseppe Montalto, Maciej Banach, Dimitri P. Mikhailidis and Manfredi Rizzo




Cell-penetrating Peptides as Nucleic Acid Delivery Systems: From Biophysics to Biological Applications

, 2013; 19(16): 2895 - 2923

Sara Trabulo, Ana L. Cardoso, Ana M. S. Cardoso, Catarina M. Morais, Amalia S. Jurado and Maria C. Pedroso de Lima




Endocytosis, Intracellular Traffic and Fate of Cell Penetrating Peptide Based Conjugates and Nanoparticles

, 2013; 19(16): 2878 - 2894

Kez Cleal, Lin He, Peter D. Watson and Arwyn T. Jones




Nuclear Translocation of Heme Oxygenase-1 Confers Resistance to Imatinib in Chronic Myeloid Leukemia Cells

, 2013; 19(15): 2765 - 2770

Daniele Tibullo, Ignazio Barbagallo, Cesarina Giallongo, Piera La Cava, Nunziatina Parrinello, Luca Vanella, Fabio Stagno, Giuseppe A. Palumbo, Giovanni Li Volti and Francesco Di Raimondo




Regulation of Autophagy in Oxygen-Dependent Cellular Stress

, 2013; 19(15): 2747 - 2756

Stefan W. Ryter and Augustine M. K. Choi




Redox Homeostasis and Epigenetics in Non-alcoholic Fatty Liver Disease (NAFLD)

, 2013; 19(15): 2737 - 2746

Christine Podrini, Michela Borghesan, Azzura Greco, Valerio Pazienza, Gianluigi Mazzoccoli and Manlio Vinciguerra




Chemical Nature and Reaction Mechanisms of the Molybdenum Cofactor of Xanthine Oxidoreductase

, 2013; 19(14): 2606 - 2614

Ken Okamoto, Teruo Kusano and Takeshi Nishino





Mesenchymal Stem/Stromal Cells: A New "Cells as Drugs" Paradigm. Efficacy and Critical Aspects in Cell Therapy

, 2013; 19(13): 2459 - 2473

Laura de Girolamo, Enrico Lucarelli, Giulio Alessandri, Maria Antonietta Avanzini, Maria Ester Bernardo, Ettore Biagi, Anna Teresa Brini, Giovanna D’Amico, Franca Fagioli, Ivana Ferrero, Franco Locatelli, Rita Maccario, Mario Marazzi, Ornella Parolini, Augusto Pessina and Maria Luisa Torre ; Italian Mesenchymal Stem Cell Group (GISM)




Chronic Hyperuricemia, Uric Acid Deposit and Cardiovascular Risk

, 2013; 19(13): 2432 - 2438

Davide Grassi, Livia Ferri, Giovambattista Desideri, Paolo Di Giosia, Paola Cheli, Rita Del Pinto, Giuliana Properzi and Claudio Ferri




Binding Site Detection and Druggability Prediction of Protein Targets for Structure- Based Drug Design

, 2013; 19(12): 2326 - 2333

Yaxia Yuan, Jianfeng Pei and Luhua Lai





Computational Approaches for Ligand Discovery and Design in Class-A G Protein- Coupled Receptors

, 2013; 19(12): 2216 - 2236

David Rodriguez and Hugo Gutierrez-de-Teran





A Review of Therapeutic Effects of Curcumin

, 2013; 19(11): 2032 - 2046

Ali Noorafshan and Soheil Ashkani-Esfahani





Pharmacological Properties of Glutamatergic Drugs Targeting NMDA Receptors and their Application in Major Depression

, 2013; 19(10): 1898 - 1922

Gianluca Serafini, Maurizio Pompili, Marco Innamorati, Yogesh Dwivedi, Goutam Brahmachari and Paolo Girardi




Molecular Aspects of the RT/drug Interactions. Perspective of Dual Inhibitors

, 2013; 19(10): 1850 - 1859

Simona Distinto, Elias Maccioni, Rita Meleddu, Angela Corona, Stefano Alcaro and Enzo Tramontano




Synthesized Peptide Inhibitors of HIV-1 gp41-dependent Membrane Fusion

, 2013; 19(10): 1800 - 1809

Yuxian He




Impact of Cellular Senescence in Aging and Cancer

, 2013; 19(9): 1699 - 1709

Mauro Provinciali, Maurizio Cardelli, Francesca Marchegiani and Elisa Pierpaoli




T Cell Replicative Senescence in Human Aging

, 2013; 19(9): 1680 - 1698

Jennifer P. Chou and Rita B. Effros




Immune System, Cell Senescence, Aging and Longevity - Inflamm-Aging Reappraised

, 2013; 19(9): 1675 - 1679

Stefano Salvioli, Daniela Monti, Catia Lanzarini, Maria Conte, Chiara Pirazzini, Maria Giulia Bacalini, Paolo Garagnani, Cristina Giuliani, Elisa Fontanesi, Rita Ostan, Laura Bucci, Federica Sevini, Stella Lukas Yani, Annalaura Barbieri, Laura Lomartire, Vincenzo Borelli, Dario Vianello, Elena Bellavista, Morena Martucci, Elisa Cevenini, Elisa Pini, Maria Scurti, Fiammetta Biondi, Aurelia Santoro, Miriam Capri and Claudio Franceschi




Human Papillomavirus DNA and E6/E7 mRNA Testing as Triage in Liquid-Based Cytology Samples from Primary Screening

, 2013; 19(8): 1508 - 1515

Sonia Andersson, Miriam Mints, Elisabete Weiderpass and Bo Johansson





The Interplay between the Gut Immune System and Microbiota in Health and Disease: Nutraceutical Intervention for Restoring Intestinal Homeostasis

, 2013; 19(7): 1329 - 1342

Thea Magrone and Emilio Jirillo





MicroRNA in the Pathogenesis and Prognosis of Esophageal Cancer

, 2013; 19(7): 1292 - 1300

Jian Gu, Yan Wang and Xifeng Wu




HtrA Protease Family as Therapeutic Targets

, 2013; 19(6): 977 - 1009

Joanna Skorko-Glonek, Dorota Zurawa-Janicka, Tomasz Koper, Miroslaw Jarzab, Donata Figaj, Przemyslaw Glaza and Barbara Lipinska




Molecular Mechanisms and Modulation of Key Pathways Underlying the Synergistic Interaction of Sorafenib with Erlotinib in Non-Small-Cell-Lung Cancer (NSCLC) Cells

, 2013; 19(5): 927 - 939

E. Giovannetti, M. Labots, H. Dekker, E. Galvani, J.S.W. Lind, R. Sciarrillo, R. Honeywell, E.F. Smit, H.M. Verheul and G.J. Peters





Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: Current Status and Future Perspectives in the Development of Novel Irreversible Inhibitors for the Treatment of Mutant Non-small Cell Lung Cancer

, 2013; 19(5): 818 - 832

Elena Galvani, Roberta Alfieri, Elisa Giovannetti, Andrea Cavazzoni, Silvia La Monica, Maricla Galetti, Claudia Fumarola, Mara Bonelli, Marco Mor, Marcello Tiseo, Godefridus J. Peters, Pier Giorgio Petronini and Andrea Ardizzoni





Rejuvenating Sirtuins: The Rise of a New Family of Cancer Drug Targets

, 2013; 19(4): 614 - 623

Santina Bruzzone, Marco Daniele Parenti, Alessia Grozio, Alberto Ballestrero, Inga Bauer, Alberto Del Rio and Alessio Nencioni





Lysosomal Rerouting of Hsp70 Trafficking as a Potential Immune Activating Tool for Targeting Melanoma

, 2013; 19(3): 430 - 440

Kata Juhasz, Roland Thuenauer, Andrea Spachinger, Ern Duda, Ibolya Horvath, Laszlo Vigh, Alois Sonnleitner and Zsolt Balogi





The Therapeutic Target Hsp90 and Cancer Hallmarks

, 2013; 19(3): 347 - 365

Yoshihiko Miyata, Hitoshi Nakamoto and Len Neckers




Hydroximic Acid Derivatives: Pleiotropic Hsp Co-Inducers Restoring Homeostasis and Robustness

, 2013; 19(3): 309 - 346

Tim Crul, Noemi Toth, Stefano Piotto, Peter Literati-Nagy, Kalman Tory, Pierre Haldimann, Bernadett Kalmar, Linda Greensmith, Zsolt Torok, Gabor Balogh, Imre Gombos, Federica Campana, Simona Concilio, Ferenc Gallyas, Gabor Nagy, Zoltan Berente, Burcin Gungor, Maria Peter, Attila Glatz, Akos Hunya, Zsuzsanna Literati-Nagy, Laszlo Vigh, Femke Hoogstra-Berends, Andre Heeres, Irma Kuipers, Lizette Loen, Jean-Paul Seerden, Deli Zhang, Roelien A M Meijering, Robert H Henning, Bianca J J M Brundel, Harm H Kampinga, Laszlo Koranyi, Zoltan Szilvassy, Jozsef Mandl, Balazs Sumegi, Mark A Febbraio, Ibolya Horvath, Philip L Hooper and Laszlo Vigh




The Rise of Carbapenem-Resistant Acinetobacter baumannii

, 2013; 19(2): 223 - 238

Benjamin A. Evans, Ahmed Hamouda and Sebastian G.B. Amyes





Non-Analgesic Effects of Opioids: Peripheral Opioid Effects on Inflammation and Wound Healing

, 2012; 18(37): 6053 - 6069

Christoph Stein and Sarah Kuchler





NF-κB as a Target for Modulating Inflammatory Responses

, 2012; 18(35): 5735 - 5745

Chiara Gasparini and Marc Feldmann




Probiotics and Oral Health

, 2012; 18(34): 5522 - 5531

Bernard Bizzini, Giuseppe Pizzo, Giovanni Scapagnini, Domenico Nuzzo and Sonya Vasto




Platelet Function Testing in Atherothrombotic Disease

, 2012; 18(33): 5379 - 5391

Erik Lerkevang Grove, Robert F. Storey and Morten Wurtz





The Role of Platelets in Athero-Thrombotic Events

, 2012; 18(33): 5197 - 5214

Matthias K. Freynhofer, Veronika Bruno, Johann Wojta and Kurt Huber




A Critical Review of the Antipsychotic Effects of Cannabidiol: 30 Years of a Translational Investigation

, 2012; 18(32): 5131 - 5140

Antonio Waldo Zuardi, Jose Alexandre S. Crippa, Jaime E.C. Hallak, Sagnik Bhattacharyya, Zerrin Atakan, Rocio Martin-Santos, Philip K. McGuire and Francisco Silveira Guimaraes




The Yin and Yang of Cannabis-induced Psychosis: the Actions of Δ 9-Tetrahydrocannabinol and Cannabidiol in Rodent Models of Schizophrenia

, 2012; 18(32): 5113 - 5130

J. C. Arnold, A. A. Boucher and T. Karl





Genetic Variation Underlying Psychosis-inducing Effects of Cannabis: Critical Review and Future Directions

, 2012; 18(32): 5015 - 5023

Jeroen Decoster, Jim van Os, Inez Myin-Germeys, Marc De Hert and Ruud van Winkel





Small-Molecule Inhibitors of Protein-Protein Interactions: How to Mimic a Protein Partner

, 2012; 18(30): 4679 - 4684

David C. Fry





Protein-protein Docking and Hot-spot Prediction for Drug Discovery

, 2012; 18(30): 4607 - 4618

Solene Grosdidier and Juan Fernandez-Recio





Inflammation in Ischemic Stroke Subtypes

, 2012; 18(28): 4289 - 4310

Antonino Tuttolomondo, Domenico Di Raimondo, Rosaria Pecoraro, Valentina Arnao, Antonio Pinto and Giuseppe Licata




Atherosclerosis as an Inflammatory Disease

, 2012; 18(28): 4266 - 4288

Antonino Tuttolomondo, Domenico Di Raimondo, Rosaria Pecoraro, Valentina Arnao, Antonio Pinto and Giuseppe Licata




Preclinical Safety and Pharmacokinetic Profile of 3K3A-APC, a Novel, Modified Activated Protein C for Ischemic Stroke

, 2012; 18(27): 4215 - 4222

Patricia D. Williams, Berislav V. Zlokovic, John H. Griffin, Kent E. Pryor and Thomas P. Davis




Cellular Players in Lung Fibrosis

, 2012; 18(27): 4093 - 4102

Annemarie N. Lekkerkerker, Jamil Aarbiou, Thomas van Es and Richard A.J. Janssen




Tobacco, Inflammation, and Respiratory Tract Cancer

, 2012; 18(26): 3901 - 3938

Javier Milara and Julio Cortijo





Molecular Link Mechanisms between Inflammation and Cancer

, 2012; 18(26): 3831 - 3852

D. B. Vendramini-Costa and J. E. Carvalho





The Role of Pericytes in Blood-Brain Barrier Function and Stroke

, 2012; 18(25): 3653 - 3662

Shuo Liu, Dritan Agalliu, Chuanhui Yu and Mark Fisher





Antimalarials in the Treatment of Schistosomiasis

, 2012; 18(24): 3531 - 3538

Jennifer Keiser and Jurg Utzinger





Choline Analogues in Malaria Chemotherapy

, 2012; 18(24): 3454 - 3466

Suzanne Peyrottes, Sergio Caldarelli, Sharon Wein, Christian Perigaud, Alain Pellet and Henri Vial





Platelet-neutrophil Interactions as a Target for Prevention and Treatment of Transfusion- related Acute Lung Injury

, 2012; 18(22): 3260 - 3266

Axelle Caudrillier and Mark R. Looney





Pharma-metabolomics in Neonatology: is it a Dream or a Fact?

, 2012; 18(21): 2996 - 3006

Vassilios Fanos, Luigi Barberini, Roberto Antonucci and Luigi Atzori





Perspective of Cyclin-dependent kinase 9 (CDK9) as a Drug Target

, 2012; 18(20): 2883 - 2890

Vladimir Krystof, Sonja Baumli and Robert Furst




Novel Drugs Targeting Microtubules: the Role of Epothilones

, 2012; 18(19): 2793 - 2803

Gabriella Ferrandina, Marisa Mariani, Mirko Andreoli, Shohreh Shahabi, Giovanni Scambia and Cristiano Ferlini




Targeting mTOR Pathways in Human Malignancies

, 2012; 18(19): 2766 - 2777

Angelica Fasolo and Cristiana Sessa





Heparin - a Key Drug in the Treatment of the Circulatory Degenerative Diseases: Controlling its Action with Polymers

, 2012; 18(18): 2591 - 2606

Krzysztof Szczubialka, Kamil Kaminski, Katarzyna Zasada, Anna Karewicz and Maria Nowakowska





Role of Wnt/β-catenin Signaling in Drug Resistance of Pancreatic Cancer

, 2012; 18(17): 2464 - 2471

Jiujie Cui, Weihua Jiang, Shuyi Wang, Liwei Wang and Keping Xie





Mast Cells in Allergic and Inflammatory Diseases

, 2012; 18(16): 2261 - 2277

Nikolaos Sismanopoulos, Danae-Anastasia Delivanis, Konstantinos-Dionysios Alysandratos, Asimenia Angelidou, Anastasia Therianou, Dimitrios Kalogeromitros and Theoharis C. Theoharides





Microbubbles as a Vehicle for Gene and Drug Delivery: Current Clinical Implications and Future Perspectives

, 2012; 18(15): 2166 - 2183

Nicolas A Geis, Hugo A Katus and Raffi Bekeredjian





G-Quadruplex as Signal Transducer for Biorecognition Events

, 2012; 18(14): 2076 - 2095

Lei Lv, Zhijun Guo, Jiahai Wang and Erkang Wang





Thrombin Binding Aptamer, More than a Simple Aptamer: Chemically Modified Derivatives and Biomedical Applications

, 2012; 18(14): 2036 - 2047

Anna Avino, Carme Fabrega, Maria Tintore and Ramon Eritja





Targeting the Cancer Initiating Cell: The Ultimate Target for Cancer Therapy

, 2012; 18(13): 1784 - 1795

James A. McCubrey, Linda S. Steelman, Stephen L. Abrams, Negin Misaghian, William H. Chappell, Jorg Basecke, Ferdinando Nicoletti, Massimo Libra, Giovanni Ligresti, Francac Stivala, Danijela Maksimovic-Ivanic, Sanja Mijatovic, Giuseppeo Montalto, Melchiorre Cervello, Piotr Laidler, Antonio Bonati, Camilla Evangelisti, Lucio Cocco and Alberto M. Martelli




Neural Stem Cell Niches in Health and Diseases

, 2012; 18(13): 1755 - 1783

Ilaria Decimo, Francesco Bifari, Mauro Krampera and Guido Fumagalli




Old Wine in a New Bottle: The Warburg Effect and Anticancer Mechanisms of Resveratrol

, 2012; 18(12): 1645 - 1654

Irfana Muqbil, Frances W.J. Beck, Bin Bao, Fazlul H. Sarkar, Ramzi M. Mohammad, S. M. Hadi and Asfar S. Azmi





Adverse Cardiovascular Effects of Antirheumatic Drugs: Implications for Clinical Practice and Research

, 2012; 18(11): 1543 - 1555

Armen Yuri Gasparyan, Lilit Ayvazyan, Giuseppe Cocco and George D. Kitas





Inflammation-Induced Thrombosis: Mechanisms, Disease Associations and Management

, 2012; 18(11): 1478 - 1493

Kenan Aksu*, Gokhan Keser and Ayhan Donmez





Physiology, Pharmacology and Pathophysiology of the pH Regulatory Transport Proteins NHE1 and NBCn1: Similarities, Differences, and Implications for Cancer Therapy

, 2012; 18(10): 1345 - 1371

E. Boedtkjer, L. Bunch and S. F. Pedersen





Multi-Parameter Optimization: Identifying High Quality Compounds with a Balance of Properties

, 2012; 18(9): 1292 - 1310

Matthew D. Segall





Transgenic Mouse Models of Alzheimer Disease: Developing a Better Model as a Tool for Therapeutic Interventions

, 2012; 18(8): 1131 - 1147

Masashi Kitazawa, Rodrigo Medeiros and Frank M. LaFerla





Drosophila Models of Proteinopathies: the Little Fly that Could

, 2012; 18(8): 1108 - 1122

Diego E. Rincon-Limas, Kurt Jensen and Pedro Fernandez-Funez*




Role of the Renin-Angiotensin-Aldosterone System in the Pathogenesis of Atherosclerosis

, 2012; 18(7): 981 - 1004

Alessandro Durante, Giovanni Peretto, Alessandra Laricchia, Francesco Ancona, Marco Spartera, Antonio Mangieri and Domenico Cianflone




The Therapeutic Potential of Sigma (σ) Receptors for the Treatment of Central Nervous System Diseases: Evaluation of the Evidence

, 2012; 18(7): 884 - 901

Samuel D. Banister and Michael Kassiou





Therapeutic Potential of Host Defense Peptides in Antibiotic-resistant Infections

, 2012; 18(6): 807 - 819

Nicole J. Afacan, Amy T.Y. Yeung, Olga M. Pena and Robert E.W. Hancock





Progress in Gene and Cell Therapy for Cystic Fibrosis Lung Disease

, 2012; 18(5): 642 - 662

Uta Griesenbach and Eric W.F.W. Alton





Neurocognition in the Psychosis Risk Syndrome: A Quantitative and Qualitative Review

, 2012; 18(4): 399 - 415

Anthony J. Giuliano, Huijun Li, Raquelle I. Mesholam-Gately, Shannon M. Sorenson, Kristen A. Woodberry and Larry J. Seidman




Rationale and First Results of Developing At-Risk (Prodromal) Criteria for Bipolar Disorder

, 2012; 18(4): 358 - 375

A. Bechdolf, A. Ratheesh, S. J. Wood, T. Tecic, P. Conus, B. Nelson, S. M. Cotton, A. M. Chanen, G. P. Amminger, S. Ruhrmann, F. Schultze-Lutter, J. Klosterkotter, P. Fusar Poli, A. R. Yung, M. Berk and P. D. McGorry




Phenotypes and Enviromental Factors: Their Influence in PCOS

, 2012; 18(3): 270 - 282

Evanthia Diamanti-Kandarakis, Charikleia Christakou and Evangelos Marinakis





GRK2 at the Control Shaft of Cellular Metabolism

, 2012; 18(2): 121 - 127

Michele Ciccarelli, Ersilia Cipolletta and Guido Iaccarino




Optimization of Cardiac Metabolism in Heart Failure

, 2011; 17(35): 3846 - 3853

Tomohisa Nagoshi, Michihiro Yoshimura, Giuseppe M. C. Rosano, Gary D. Lopaschuk and Seibu Mochizuki




The Future of Induced Pluripotent Stem Cells for Cardiac Therapy and Drug Development

, 2011; 17(30): 3258 - 3270

Lieven Thorrez and Maurilio Sampaolesi




Perinatal Gene Transfer to the Liver

, 2011; 17(24): 2528 - 2541

Tristan R. McKay, Ahad A. Rahim, Suzanne M.K. Buckley, Natalie J. Ward, Jerry K.Y.Chan, Steven J. Howe and Simon N. Waddington




Recent Progress Toward Hydrogen Medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications

, 2011; 17(22): 2241 - 2252

Shigeo Ohta





PACAP is Implicated in the Stress Axes

, 2011; 17(10): 985 - 989

Hitoshi Hashimoto, Norihito Shintani, Mamoru Tanida, Atsuko Hayata, Ryota Hashimoto and Akemichi Baba





Midkine: A Promising Molecule for Drug Development to Treat Diseases of the Central Nervous System

, 2011; 17(5): 410 - 423

Takashi Muramatsu




Herbal Medicines and Nutraceuticals for Diabetic Vascular Complications: Mechanisms of Action and Bioactive Phytochemicals

, 2010; 16(34): 3776 - 3807

Eshaifol A. Omara, Antony Kam, Ali Alqahtania, Kong M. Li, Valentina Razmovski-Naumovski, Srinivas Nammi, Kelvin Chan, Basil D Roufogalis and George Q. Li




Ligand-Based Peptide Design and Combinatorial Peptide Libraries to Target G Protein-Coupled Receptors

, 2010; 16(28): 3071 - 3088

Christian W. Gruber, Markus Muttenthaler and Michael Freissmuth





In Vivo Beta-Cell Imaging with VMAT 2 Ligands - Current State-of-the-Art and Future Perspectives

, 2010; 16(14): 1568 - 1581

Rajakrishnan Veluthakal and Paul Harris





Clinical PET Imaging of Insulinoma and Beta-Cell Hyperplasia

, 2010; 16(14): 1550 - 1560

S. Kauhanen, M. Seppanen, H. Minn and P. Nuutila





Prediction of MHC-Peptide Binding: A Systematic and Comprehensive Overview

, 2009; 15(28): 3209 - 3220

Esther M. Lafuente and Pedro A. Reche





Function and Frustration of Multi-Drug ABC Exporter Protein and Design of Model Proteins for Drug Delivery Using Protein Hydration Thermodynamics

, 2009; 15(24): 2833 - 2867

Dan W. Urry, Kelley D. Urry, Witold Szaflarski, Michal Nowicki and Maciej Zabel




The Effects of Antipsychotics on the Brain: What Have We Learnt from Structural Imaging of Schizophrenia? – A Systematic Review

, 2009; 15(22): 2535 - 2549

R. Smieskova, P. Fusar-Poli, P. Allen, K. Bendfeldt, R. D. Stieglitz, J. Drewe, E. W. Radue, P. K. McGuire, A. Riecher-Rossler and S. J. Borgwardt




Modulating Proteostasis: Peptidomimetic Inhibitors and Activators of Protein Folding

, 2009; 15(21): 2488 - 2507

Feras Hatahet and Lloyd W. Ruddock





The Role of the Gut Microbiota in Energy Metabolism and Metabolic Disease

, 2009; 15(13): 1546 - 1558

Patrice D. Cani and Nathalie M. Delzenne





Peptide-Mediated Cellular Delivery of Oligonucleotide-Based Therapeutics In Vitro: Quantitative Evaluation of Overall Efficacy Employing Easy to Handle Reporter Systems

, 2008; 14(34): 3637 - 3655

S. D. Laufer and T. Restle





The Use of Growth Factors in Hematopoietic Stem Cell Transplantation

, 2008; 14(20): 1950 - 1961

I. Pusic and J. F. DiPersio





Apoptosis in the Homeostasis of the Immune System and in Human Immune Mediated Diseases

, 2008; 14(3): 253 - 268

R. Paganelli, A. Giovannetti, M. Pierdominici, A. Di Iorio, R. Cianci, G. Murdaca, F. Puppo and F. Pandolfi





Advances in Asthma and COPD Treatment: Combination Therapy with Inhaled Corticosteroids and Long-Acting β2-Agonists.

, 2006; 12(25): 3261 - 3279

A. Miller-Larsson and O. Selroos






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