Contents

Current Pharmaceutical Biotechnology, Volume 12 - Number 12

Editorial [Hot Topic: Relevance of Pharmacokinetics to Antibiotic Dosing in Critically Ill Patients (Guest Editor: Jason A. Roberts)]

, 12(12): 1981 - 1982

Jason A. Roberts


DOI: 10.2174/138920111798808310




Pharmacokinetic Concepts Revisited - Basic and Applied

, 12(12): 1983 - 1990

Kashyap Patel and Carl M.J. Kirkpatrick


DOI: 10.2174/138920111798808400




Physiological Changes in the Critically Ill Patient with Sepsis

, 12(12): 1991 - 1995

Shaun Hosein, Andrew A. Udy and Jeffrey Lipman


DOI: 10.2174/138920111798808248




The Relevance of Drug Volume of Distribution in Antibiotic Dosing

, 12(12): 1996 - 2001

Marta Ulldemolins and Jordi Rello


DOI: 10.2174/138920111798808365




The Relevance of Drug Clearance to Antibiotic Dosing in Critically Ill Patients

, 12(12): 2002 - 2014

Darren M. Roberts


DOI: 10.2174/138920111798808374




Dosing of Antibiotics in Critically Ill Patients Undergoing Renal Replacement Therapy

, 12(12): 2015 - 2019

Jan T. Kielstein and Olaf Burkhardt


DOI: 10.2174/138920111798808275




ARC - Augmented Renal Clearance

, 12(12): 2020 - 2029

Andrew A. Udy, Michael T. Putt, Robert J. Boots and Jeffrey Lipman


DOI: 10.2174/138920111798808446




The Effect of Critical Illness on Drug Distribution

, 12(12): 2030 - 2036

Daniel Gonzalez, Daniela J Conrado, Ursula Theuretzbacher and Hartmut Derendorf


DOI: 10.2174/138920111798808211




How to Measure Pharmacokinetics in Critically Ill Patients?

, 12(12): 2037 - 2043

Xin Liu, Peter S. Kruger and Michael S. Roberts


DOI: 10.2174/138920111798808239




Relevance of Pharmacokinetic and Pharmacodynamic Modeling to Clinical Care of Critically Ill Patients

, 12(12): 2044 - 2061

Jurgen B. Bulitta, Cornelia B. Landersdorfer, Alan Forrest, Silvia V. Brown, Michael N. Neely, Brian T. Tsuji and Arnold Louie


DOI: 10.2174/138920111798808428




Reducing the Development of Antibiotic Resistance in Critical Care Units

, 12(12): 2062 - 2069

Marjolein P.D. Deege and David L. Paterson


DOI: 10.2174/138920111798808301




Using PK/PD to Optimize Antibiotic Dosing for Critically Ill Patients

, 12(12): 2070 - 2079

Jason A. Roberts


DOI: 10.2174/138920111798808329




Editorial [Hot Topic: TGF-β As Target in Oncology (Guest Editor: Karl-Hermann Schlingensiepen)]

, 12(12): 2080

Karl-Hermann Schlingensiepen


DOI: 10.2174/138920111798808220




Structures of TGF-β Receptor Complexes: Implications for Function and Therapeutic Intervention Using Ligand Traps

, 12(12): 2081 - 2098

Andrew P. Hinck and Maureen D. O'Connor-McCourt


DOI: 10.2174/138920111798808383




Biology of Transforming Growth Factor-β Signaling

, 12(12): 2099 - 2107

Hiroaki Ikushima and Kohei Miyazono


DOI: 10.2174/138920111798808419




TGF-β Receptor Signaling Pathways in Angiogenesis; Emerging Targets for Anti-Angiogenesis Therapy

, 12(12): 2108 - 2120

Laurens A. van Meeteren, Marie-Jose Goumans and Peter ten Dijke


DOI: 10.2174/138920111798808338




Therapeutic Strategies to Target TGF-β in the Treatment of Bone Metastases

, 12(12): 2121 - 2137

Jeroen T. Buijs, Patricia Juarez and Theresa A. Guise


DOI: 10.2174/138920111798808293




The Complexities of TGF-β Action During Mammary and Squamous Cell Carcinogenesis

, 12(12): 2138 - 2149

Erin C. Connolly and Rosemary J. Akhurst


DOI: 10.2174/138920111798808284




TGF-β2 Signaling in High-Grade Gliomas

, 12(12): 2150 - 2157

Peter Hau, Piotr Jachimczak, Jurgen Schlaier and Ulrich Bogdahn


DOI: 10.2174/138920111798808347




Transforming Growth Factor Beta in Pancreatic Cancer

, 12(12): 2158 - 2164

Andreas Hilbig and Helmut Oettle


DOI: 10.2174/138920111798808356




Role of TGF-β in Melanoma

, 12(12): 2165 - 2175

A. Busse and U. Keilholz


DOI: 10.2174/138920111798808437




Antibody Targeting of TGF-β in Cancer Patients

, 12(12): 2176 - 2189

Scott Lonning, Joan Mannick and John M. McPherson


DOI: 10.2174/138920111798808392




TGF-Beta Type I Receptor (Alk5) Kinase Inhibitors in Oncology

, 12(12): 2190 - 2202

Leona E. Ling and Wen-Cherng Lee


DOI: 10.2174/138920111798808257




The Antisense Oligonucleotide Trabedersen (AP 12009) for the Targeted Inhibition of TGF-β2

, 12(12): 2203 - 2213

Frank Jaschinski, Tanja Rothhammer, Piotr Jachimczak, Christian Seitz, Anneliese Schneider and Karl-Hermann Schlingensiepen


DOI: 10.2174/138920111798808266




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