Contents

Current Pharmaceutical Biotechnology, Volume 10 - Number 4

Editorial [Hot Topic: Aggregation Detection and Removal Biopharmaceutical Proteins (Guest Editors: Pete Gagnon & Tsutomu Arakawa)]

, 10(4): 347

Pete Gagnon and Tsutomu Arakawa


DOI: 10.2174/138920109788488923




Mechanisms of Protein Aggregation

, 10(4): 348 - 351

John S. Philo and Tsutomu Arakawa


DOI: 10.2174/138920109788488932




Immunogenicity Assessment of Therapeutic Proteins and Peptides

, 10(4): 352 - 358

Arunan Kaliyaperumal and Shuqian Jing


DOI: 10.2174/138920109788488860




A Critical Review of Methods for Size Characterization of Non-Particulate Protein Aggregates

, 10(4): 359 - 372

John S. Philo


DOI: 10.2174/138920109788488815




A Critical Review of Analytical Methods for Subvisible and Visible Particles

, 10(4): 373 - 381

Linda O. Narhi, Yijia Jiang, Shawn Cao, Kalman Benedek and Deborah Shnek


DOI: 10.2174/138920109788488905




Separation and Characterization of Protein Aggregates and Particles by Field Flow Fractionation

, 10(4): 382 - 390

Shawn Cao, Joey Pollastrini and Yijia Jiang


DOI: 10.2174/138920109788488978




Application of Vibrational Spectroscopy to the Structural Characterization of Monoclonal Antibody and its Aggregate

, 10(4): 391 - 399

Cynthia H. Li and Tiansheng Li


DOI: 10.2174/138920109788488950




Effect of Additives on Protein Aggregation

, 10(4): 400 - 407

Hiroyuki Hamada, Tsutomu Arakawa and Kentaro Shiraki


DOI: 10.2174/138920109788488941




Suppression of Protein Aggregation by L-Arginine

, 10(4): 408 - 414

Christian Lange and Rainer Rudolph


DOI: 10.2174/138920109788488851




To be Excluded or to Bind, that is the Question: Arginine Effects on Proteins

, 10(4): 415 - 420

Makoto Nakakido, Motonori Kudou, Tsutomu Arakawa and Kouhei Tsumoto


DOI: 10.2174/138920109788488824




Ion Exchange Chromatography of Proteins and Clearance of Aggregates

, 10(4): 421 - 426

Y. Yigzaw, P. Hinckley, A. Hewig and G. Vedantham


DOI: 10.2174/138920109788488842




Recent Advancement in Application of Hydrophobic Interaction Chromatography for Aggregate Removal in Industrial Purification Process

, 10(4): 427 - 433

Yuefeng Lu, Brian Williamson and Ronald Gillespie


DOI: 10.2174/138920109788488897




IgG Aggregate Removal by Charged-Hydrophobic Mixed Mode Chromatography

, 10(4): 434 - 439

Pete Gagnon


DOI: 10.2174/138920109788488888




Antibody Aggregate Removal by Hydroxyapatite Chromatography

, 10(4): 440 - 446

Pete Gagnon and Kevin Beam


DOI: 10.2174/138920109788488833




Application of High Hydrostatic Pressure to Dissociate Aggregates and Refold Proteins

, 10(4): 447 - 455

Matthew B. Seefeldt, Mary S. Rosendahl, Jeffrey L. Cleland and Lyndal K. Hesterberg


DOI: 10.2174/138920109788488914




Stress-Free Chromatography: Affinity Chromatography

, 10(4): 456 - 460

Tsutomu Arakawa, Yoshiko Kita, Haruna Sato and Daisuke Ejima


DOI: 10.2174/138920109788488969




Stress-Free Chromatography: IEC and HIC

, 10(4): 461 - 463

Tsutomu Arakawa, Yoshiko Kita and Daisuke Ejima


DOI: 10.2174/138920109788488879




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