Drs. Eric Betzig, Stefan W. Hell and William E. Moerner share the 2014 chemistry Nobel for the development of super-resolved fluorescence microscopy.
“The Royal Swedish Academy of Sciences has decided to award the 2014 Nobel Prize in Chemistry to Dr. Eric Betzig at Howard Hughes Medical Institute, Ashburn, U.S.A.; Professor Stefan Hell at Max Planck Institute for Biophysical Chemistry, Göttingen, and the German Cancer Research Center, Heidelberg, Germany; and Professor William Moerner at Stanford University, Stanford, U.S.A., for the development of super-resolved fluorescence microscopy.”
Much research effort was needed to realize that single-cell and single-molecule based approaches directly affect improvements in human health. However, many of these laboratory technologies are not available in a cheap and easy version. Single-molecule based fluorescence imaging and detection have the advantages of a small volume platform, digital analysis, elimination of processing steps, real-time measurements and automation of sample preparation. In 2015, Current Pharmaceutical Biotechnology will continue in this direction with quality papers that can be expected to trigger further investigations.
Drs. Eric Betzig and William E. Moerner also developed methods and biotechniques which have enabled the study of single molecules in ongoing chemical reactions in living cells. Because now it is possible to see individual macromolecules moving about in a living cell, we can study chemistry at a single-molecule level and in real life. And this is very important to chemistry because chemistry has traditionally been about studying a large number of molecules and the effect that they have. The journal Current Pharmaceutical Biotechnology has published on this research and has been at the forefront for over more than one decade. Curr. Pharm. Biotechnol. has published thematic issues, original research and review articles about the entirely new possibilities for chemistry and for biochemistry by eminent scientists from around the world, some examples:
Prof. Davide Prosperi is Associate Professor in Biochemistry at the University of Milano Bicocca (Unimib), Department of Biotechnology and Bioscience. Head of the NanoBioLab of Unimib, he is devoted to biomedical and biophysical applications of nanotechnology. In particular, the research activity of Davide Prosperi involves the design, synthesis, functionalization and characterization of colloidal, polymeric and biomimetic nanoparticles for biomedical applications, with particular focus on the diagnosis and treatment of cancer and inflammatory diseases. He is author of over 100 scientific publications. He is one of the author of the patent “Nanoconstructs with pharmacological activity” (n° WO2014013473-A1), and co-founder of the spin-off company inTHEna srl, aiming to design and development of molecules, nanostructures and technologies for biomedical studies and diagnosis, prevention and therapy of human and animal diseases.