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Current Pharmaceutical Biotechnology

Volume 23, 15 Issues, 2022
ISSN: 1873-4316 (Online)
ISSN: 1389-2010 (Print)
This journal supports open access

Aims & Scope

Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal includes timely in-depth/mini reviews, original research articles and letters written by leaders in the field, covering a range of current topics in scientific areas of Pharmaceutical Biotechnology. Invited and unsolicited review articles are welcome. The journal encourages contributions describing research at the interface of drug discovery and pharmacological applications, involving in vitro investigations and pre-clinical or clinical studies. Scientific areas within the scope of the journal include pharmaceutical chemistry, biochemistry and genetics, molecular and cellular biology, and polymer and materials sciences as they relate to pharmaceutical science and biotechnology. In addition, the journal also considers comprehensive studies and research advances pertaining food chemistry with pharmaceutical implication. Areas of interest include:

  • DNA/protein engineering and processing
  • Synthetic biotechnology
  • Omics (genomics, proteomics, metabolomics and systems biology)
  • Therapeutic biotechnology (gene therapy, peptide inhibitors, enzymes)
  • Drug delivery and targeting
  • Nanobiotechnology
  • Molecular pharmaceutics and molecular pharmacology
  • Analytical biotechnology (biosensing, advanced technology for detection of bioanalytes)
  • Pharmacokinetics and pharmacodynamics
  • Applied Microbiology
  • Bioinformatics (computational biopharmaceutics and modeling)
  • Environmental biotechnology
  • Regenerative medicine (stem cells, tissue engineering and biomaterials)
  • Translational immunology (cell therapies, antibody engineering, xenotransplantation)
  • Industrial bioprocesses for drug production and development
  • Biosafety
  • Biotech ethics

Special Issues devoted to crucial topics, providing the latest comprehensive information on cutting-edge areas of research and technological advances, are welcome.

Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.

Current Pharmaceutical Biotechnology

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Volume 23

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Number 4




Review Article (Mini-Review)

The Role of Lectin as Potential Biomarker in Ovarian Cancer

, 23(4): 478 - 485

Sangita Devi Oinam, Sunil Sing Senjam*, Rana Kamei and Joykishan Sharma Hanjabam


DOI: 10.2174/1389201022666210625125506


Review Article (Mini-Review)



Review Article

Recent Advances in the Discovery of Antiviral Metabolites from Fungi

, 23(4): 495 - 537

Sunil K. Deshmukh*, Shivankar Agrawal, Manish Kumar Gupta, Rajesh K. Patidar and Nihar Ranjan


DOI: 10.2174/1389201022666210615120720




Review Article

Recent Advances in siRNA Delivery Systems for Prostate Cancer Therapy

, 23(4): 579 - 593

Shahin Aghamiri*, Pourya Raee, Shiva Shahmohamadnejad, Sasan Shabani, Jaber Ghorbani, Marzieh Sameni and Mohammad Taha Ebrahimi


DOI: 10.2174/1389201022666210615123211


Research Article

Variances in the Expression Profile of the EMT-Related Genes in Endometrial Cancer Lines <i>In Vitro</i> Study

, 23(4): 594 - 608

Robert Nowakowski*, Beniamin Grabarek, Anna Burnat-Olech, Dariusz Boroń and Monika Paul-Samojedny


DOI: 10.2174/1389201022666210702153919


Articles Ahead of Print

Anti-anxiety Properties of Selected Medicinal Plants


Asmatullah Khan, Muhammad Akram, Muthu Thiruvengadam*, Muhammad Daniyal, Shahbaz Ahmad Zakki, Naveed Munir, Rida Zainab*, Mojtaba Heydari, Seyed Hamdollah Mosavat, Maksim Rebezov and Mohammad Ali Shariati


DOI: 10.2174/1389201022666210122125131
View Abstract View on PubMed



Protective Effects of Curcumin Against Iron-Induced Toxicity


Nastaran Moinipour, Mahdi Barati, Amirhosein Sahebkar*, Milad Iranshahy and Abolfazl Shakeri


DOI: 10.2174/1389201022666210914122846
View Abstract View on PubMed


Rational Design and Evaluation of the Recombinant Multiepitope Protein for Serodiagnosis of Rubella


Marilen Souza, Juliana Machado, Jonatas da Silva, Luana Ramos, Lais Nogueira, Patrícia Ribeiro, Daniel Dias, Josiane Santos, José Carlos Santos, Yanna Nóbrega, Amanda Souza, Sonia Freitas, Mariana Campos da Paz, Maria Felipe, Fernando Torres and Alexsandro Galdino*


DOI: 10.2174/1389201022666210907170921
View Abstract View on PubMed






Polymer-Based Nanotherapeutics for Burn Wounds


Rewati Raman Ujjwal, Awesh Yadav*, Shourya Tripathi and S.T.V. Sai Krishna


DOI: 10.2174/1389201022666210927103755
View Abstract View on PubMed


Escherichia coli and Colorectal Cancer: Unfolding the Enigmatic Relationship


Rogayeh Nouri, Alka Hasani, Kourosh Masnadi Shirazi, Mohammad Reza Alivand, Bita Sepehri, Simin Sotoodeh, Fatemeh Hemmati and Mohammad Ahangarzadeh Rezaee*


DOI: 10.2174/1389201022666210910094827
View Abstract View on PubMed


Abstracts Ahead of Print

Antisense agents against antibiotic-resistant bacteria


Javad Nezhadi, Sepehr Taghizadeh, Ehsaneh Khodadadi, Mehdi Yousefi, Khudaverdi Ganbarov, Bahman Yousefi, Hamed Ebrahimzadeh Leylabadlo, Mohammad Asgharzadeh, Asghar Tanomand, Fahimeh Kazeminava and Hossein Samadi Kafil


DOI: 10.2174/1389201023666220114160216
View Abstract







Promising Applications of Nanotechnology in Cancer Diagnostics and Therapeutics


Neelam Yadav*, Twinkle Dahiya, Anil Kumar Chhillar, Jogender Singh Rana* and Hari Mohan


DOI: 10.2174/1389201023666211222165508
View Abstract




Synthesis, Characterization, Antiproliferative Activity of Galloyl Derivatives and Investigation of Cytotoxic Properties in HepG2/C3A cells


Rafael Claudino dos Santos, Raquel Oliveira Nascimento de Freitas, Mary Ann Foglio, João Ernesto de Carvalho, Ana Lucia Tasca Góes Ruiz, Lucas Roberto Pessatto, Rodrigo Juliano Oliveira*, Adrivanio Baranoski, Bruna Isabela Biazi, Mário Sérgio Mantovani, Candida Aparecida Leite Kassuya, Pedro Cruz de Oliveira Junior and Anelise Samara Nazari Formagio*


DOI: 10.2174/1389201023666211217150837
View Abstract


Published Contents

Drs. Eric Betzig, Stefan W. Hell and William E. Moerner share the 2014 chemistry Nobel for the development of super-resolved fluorescence microscopy.

“The Royal Swedish Academy of Sciences has decided to award the 2014 Nobel Prize in Chemistry to Dr. Eric Betzig at Howard Hughes Medical Institute, Ashburn, U.S.A.; Professor Stefan Hell at Max Planck Institute for Biophysical Chemistry, Göttingen, and the German Cancer Research Center, Heidelberg, Germany; and Professor William Moerner at Stanford University, Stanford, U.S.A., for the development of super-resolved fluorescence microscopy.”

Much research effort was needed to realize that single-cell and single-molecule based approaches directly affect improvements in human health. However, many of these laboratory technologies are not available in a cheap and easy version. Single-molecule based fluorescence imaging and detection have the advantages of a small volume platform, digital analysis, elimination of processing steps, real-time measurements and automation of sample preparation. In 2015, Current Pharmaceutical Biotechnology will continue in this direction with quality papers that can be expected to trigger further investigations.

Drs. Eric Betzig and William E. Moerner also developed methods and biotechniques which have enabled the study of single molecules in ongoing chemical reactions in living cells. Because now it is possible to see individual macromolecules moving about in a living cell, we can study chemistry at a single-molecule level and in real life. And this is very important to chemistry because chemistry has traditionally been about studying a large number of molecules and the effect that they have. The journal Current Pharmaceutical Biotechnology has published on this research and has been at the forefront for over more than one decade. Curr. Pharm. Biotechnol. has published thematic issues, original research and review articles about the entirely new possibilities for chemistry and for biochemistry by eminent scientists from around the world, some examples:

Editor's Choice




Green Synthesis and Applications of Nanomaterials

, 2021; 22(13): 1705 - 1747

N.B. Singh*, Preeti Jain, Anindita De and Richa Tomar


DOI: 10.2174/1389201022666210412142734



Recent Advances in Clinical Utility of Probiotics in Gastrointestinal Tract Disorders

, 2021; 22(12): 1559 - 1573

Prativa Biswasroy, Deepak Pradhan, Dipak K. Sahu, Amita Sahu, Goutam Ghosh and Goutam Rath*


DOI: 10.2174/1389201021666201029154239




Is Biotechnological Next-Generation Therapeutics Promising Enough in Clinical Development to Treat Advanced Colon Cancer?

, 2021; 22(10): 1287 - 1301

Sarubala Malayaperumal, Sushmitha Sriramulu, Antara Banerjee, M.K. Makalakshmi and Surajit Pathak*


DOI: 10.2174/1389201021666201126142716



Targeted Delivery of CRISPR/Cas13 as a Promising Therapeutic Approach to Treat SARS-CoV-2

, 2021; 22(9): 1149 - 1155

Kazem Abbaszadeh-Goudarzi, Mohammad H. Nematollahi, Hashem Khanbabaei, Hossein H. Nave, Hamid R. Mirzaei, Hossein Pourghadamyari* and Amirhossein Sahebkar *


DOI: 10.2174/1389201021666201009154517



Growing Preferences towards Analog-based Drug Discovery

, 2021; 22(8): 1030 - 1045

Mehak Dangi, Alka Khichi, Ritu Jakhar and Anil K. Chhillar*


DOI: 10.2174/1389201021666200908121409



Recent Advances in the Scaffold Engineering of Protein Binders

, 2021; 22(7): 878 - 891

Mohammad K.B. Ahmadi, Seyed A. Mohammadi, Manoochehr Makvandi, Morteza Mamouei, Mohammad Rahmati*, Hesam Dehghani and David W. Wood


DOI: 10.2174/1389201021999200824101035



Open Access Articles


Investigation on the Antibacterial Activity of Electronic Cigarette Liquids (ECLs): A Proof of Concept Study

, 2021; 22(7): 983 - 994

Virginia Fuochi, Massimo Caruso , Rosalia Emma, Aldo Stivala, Riccardo Polosa, Alfio Distefano and Pio M. Furneri *




Analysis of the Differences in the Expression of mRNAs and miRNAs Associated with Drug Resistance in Endometrial Cancer Cells Treated with Salinomycin

, 2021; 22(4): 541 - 548

Piotr Januszyk*, Krzysztof Januszyk, Magdalena Wierzbik-Strońska, Dariusz Boroń and Beniamin Grabarek




Leaf and Fruit Methanolic Extracts of <i>Azadirachta indica</i> Exhibit Antifertility Activity on Rats’ Sperm Quality and Testicular Histology

, 2021; 22(3): 400 - 407

Castillo-Maldonado Irais, Borjón-Ríos Claudia, Pedroza-Escobar David*, Sharma Ashutosh, García-Garza Rubén, Ramírez-Moreno Agustina, Vega-Menchaca M. del Carmen, Rivera-Guillén Mario-Alberto and Serrano-Gallardo Luis-Benjamín*




Salinomycin Modulates the Expression of mRNAs and miRNAs Related to Stemness in Endometrial Cancer

, 2021; 22(2): 317 - 326

Karol Talkowski*, Kamil Kiełbasiński, Wojciech Peszek, Beniamin O. Grabarek, Dariusz Boroń and Marcin Oplawski




Scutellaria baicalensis Extract-Phospholipid Complex: Preparation and Initial Pharmacodynamics Research in Rats

, 2021; 22: 1 - 14 (E-Pub Ahead of Print)

Shibin Chen*, Qiujie Xie, Ming Yang, Yajun Shi, Junhui Shi and Xiaobin Zeng*






Cisplatin Changes Expression of SEMA3B in Endometrial Cancer

, 2020; 21(13): 1368 - 1376

Wojciech Peszek*, Piotr Kras, Beniamin O. Grabarek, Dariusz Boroń and Marcin Oplawski




Effect of Salinomycin on Expression Pattern of Genes Associated with Apoptosis in Endometrial Cancer Cell Line

, 2020; 21(12): 1269 - 1277

Kamil Kiełbasiński*, Wojciech Peszek, Beniamin O. Grabarek, Dariusz Boroń, Magdalena Wierzbik-Strońska and Marcin Oplawski





Differences in the Expression Pattern of mRNA Protein SEMA3F in Endometrial Cancer <i>in vitro</i> under Cisplatin Treatment

, 2020; 21(11): 1119 - 1128

Przemysław Kieszkowski*, Dariusz Dąbruś, Beniamin O. Grabarek and Dariusz Boroń




Analysis of the Clinical Diagnostic Value of GMFB in Cerebral Infarction

, 2020; 21(10): 955 - 963

Zhaohu Yuan*, Zhiwu Yu, Yiyu Zhang and Huikuan Yang




Plant Phenolics as Pathogen-Carrier Immunogenicity Modulator Haptens

, 2020; 21(10): 897 - 905

Castillo-Maldonado Irais, Sevilla-González María-de-la-Luz, Delgadillo-Guzmán Dealmy, Ramírez-Moreno Agustina, Cabral-Hipólito Nidia, Rivera-Guillén Mario-Alberto, Serrano-Gallardo Luis-Benjamín*, Vega-Menchaca María-del-Carmen and Pedroza-Escobar David*






Most Cited Articles


Review Article

Current prospects of nutraceuticals: A review

, 2020; 21(10): 884-896.

Vedant Sachdeva, Arpita Roy and Navneeta Bharadvaja*


DOI: 10.2174/1389201021666200130113441





Research Article

Healthcare-associated infections due to multidrug-resistant organisms: A surveillance study on extra hospital stay and direct costs

, 2019; 20(8): 643-652.

Guglielmo Giraldi, Marzietta Montesano, Christian Napoli, Paola Frati, Raffaele La Russa, Alessandro Santurro, Matteo Scopetti and Giovanni B. Orsi*


DOI: 10.2174/1389201020666190408095811



Review Article

Ginger: A novel strategy to battle cancer through modulating cell signalling pathways: A review

, 2019; 20(1): 5-16.

Ahmad Almatroudi, Mohammed A. Alsahli, Faris Alrumaihi, Khaled S. Allemailem and Arshad H. Rahmani*


DOI: 10.2174/1389201020666190119142331


Research Article

Advanced loss eventuality assessment and technical estimates: An integrated approach for management of healthcare-associated infections

, 2019; 20(8): 625-634.

Vittorio Gatto, Matteo Scopetti, Raffaele La Russa*, Alessandro Santurro, Luigi Cipolloni, Rocco V. Viola, Mariantonia Di Sanzo, Paola Frati and Vittorio Fineschi


DOI: 10.2174/1389201020666190408095050


Research Article

New rules on patient’s safety and professional liability for the Italian health service

, 2019; 20(8): 615-624.

Sara Albolino, Tommaso Bellandi, Simone Cappelletti, Marco Di Paolo, Vittorio Fineschi*, Paola Frati, Caterina Offidani, Michela Tanzini, Riccardo Tartaglia and Emanuela Turillazzi


DOI: 10.2174/1389201020666190408094016


Review Article

Functional biomolecule delivery systems and bioengineering in cartilage regeneration

, 2019; 20(1): 32-46.

Marta A. Szychlinska, Ugo D'Amora, Silvia Ravalli, Luigi Ambrosio, Michelino Di Rosa and Giuseppe Musumeci*


DOI: 10.2174/1389201020666190206202048




Review Article

Potential pharmaceutical and food applications of postbiotics: A review

, 2020; 21(15): 1576-1587.

Aziz H. Rad, Amin Abbasi*, Hossein S. Kafil* and Khudaverdi Ganbarov


DOI: 10.2174/1389201021666200516154833


Review Article

Blood brain barrier permeability prediction using machine learning techniques: An update

, 2019; 20(14): 1163-1171.

Deeksha Saxena, Anju Sharma, Mohammed H. Siddiqui and Rajnish Kumar*


DOI: 10.2174/1389201020666190821145346



Most Accessed Articles

Targeting Macrophages in Atherosclerosis

, 2021; 22(15): 2008-2018.

Dan Hu, Zengyan Wang, Yuzhong Wang* and Caihong Liang*


DOI: 10.2174/1389201022666210122142233



Synthesis of Silymarin-Gold Nanoparticle Conjugate and Analysis of its Liver-Protecting Activity

, 2021; 22(15): 2001-2007.

Sergey Staroverov, Sergey Kozlov, Alexander Fomin, Konstantin Gabalov, Alexey Volkov, Ivan Domnitsky, Lev Dykman and Olga Guliy*


DOI: 10.2174/1389201022666210101163734


Is Hospital Autopsy Auditing Suitable for Clinical Risk Manage ment? Actualities and Perspectives of Auditing in the Autopsy Room Following Italian Law 24/2017 on Patient Safety

, 2021; 22(15): 1964-1970.

Martina Zanon, Eleonora Valentinuz, Martina Montanaro, Davide Radaelli, Alessandro Manfredi, Diana Bonuccelli, Massimo Martelloni and Stefano D’Errico*


DOI: 10.2174/1389201021666201208115525





The Role of Hypoxia in Endometrial Cancer

, 2022; 23(2): 230-243.

Yarely M. Salinas-Vera, Dolores Gallardo-Rincón, Erika Ruíz-García, Macrina B. Silva-Cázares, Carmen Sol de la Peña-Cruz and César López-Camarillo*


DOI: 10.2174/1389201022666210224130022


Gut Microbiota and Human Body Interactions; Its Impact on Health: A Review

, 2022; 23(1): 4-14.

Mahdyeh Neghabi Hajiagha, Sepehr Taghizadeh, Mohammad Asgharzadeh, Sounkalo Dao, Khudaverdi Ganbarov, Şükran Köse and Hossein Samadi Kafil*


DOI: 10.2174/1389201022666210104115836



Resveratrol and Cardiac Fibrosis Prevention and Treatment

, 2022; 23(2): 199-209.

Parinaz Zivarpour, Željko Reiner, Jamal Hallajzadeh* and Liaosadat Mirsafaei


DOI: 10.2174/1389201022666210212125003


Engineered Probiotic and Prebiotic Nutraceutical Supplementations in Combating Non-communicable Disorders: A Review

, 2022; 23(1): 72-97.

Rout George Kerry, Gitishree Das, Upendarrao Golla, Maria del Pilar Rodriguez-Torres, Han-Seung Shin and Jayanta Kumar Patra*


DOI: 10.2174/1389201021666201013153142



Unravelling the Immune Modulatory Effect of Indian Spices to Impede the Transmission of COVID-19: A Promising Approach

, 2022; 23(2): 210-229.

Aswathy R. Devan, Bhagyalakshmi Nair, Ayana R Kumar, Jaggaiah N. Gorantla, Aishwarya T. S. and Lekshmi R. Nath*


DOI: 10.2174/1389201022666210216144917


Nanotechnology Enabled Solutions to Combat Covid-19: Prevention, Treatment, and Diagnosis

, 2022; 23(1): 98-111.

Pankaj Musyuni, Manju Nagpal, Manjinder Singh, Ramesh K. Goyal and Geeta Aggarwal*


DOI: 10.2174/1389201022666210122124311




Editor-in-Chief

graphic
Nikolaos Labrou
School of Food, Biotechnology and Development
Department of Biotechnology
Agricultural University of Athens
Athens
(Greece)
Biography
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Journal History

Current Pharmaceutical Biotechnology was launched in 2000. Dr. Nikolaos Labrou serves as the Editor-in-Chief of the journal.

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