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Current Pharmaceutical Biotechnology

Volume 21, 15 Issues, 2020
ISSN: 1873-4316 (Online)
ISSN: 1389-2010 (Print)
This journal supports open access
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Aims & Scope

Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal includes timely in-depth/mini reviews, original research articles and letters written by leaders in the field, covering a range of current topics in scientific areas of Pharmaceutical Biotechnology. Invited and unsolicited review articles are welcome. The journal encourages contributions describing research at the interface of drug discovery and pharmacological applications, involving in vitro investigations and pre-clinical or clinical studies. Scientific areas within the scope of the journal include pharmaceutical chemistry, biochemistry and genetics, molecular and cellular biology, and polymer and materials sciences as they relate to pharmaceutical science and biotechnology. In addition, the journal also considers comprehensive studies and research advances pertaining food chemistry with pharmaceutical implication. Areas of interest include:

  • DNA/protein engineering and processing
  • Synthetic biotechnology
  • Omics (genomics, proteomics, metabolomics and systems biology)
  • Therapeutic biotechnology (gene therapy, peptide inhibitors, enzymes)
  • Drug delivery and targeting
  • Nanobiotechnology
  • Molecular pharmaceutics and molecular pharmacology
  • Analytical biotechnology (biosensing, advanced technology for detection of bioanalytes)
  • Pharmacokinetics and pharmacodynamics
  • Applied Microbiology
  • Bioinformatics (computational biopharmaceutics and modeling)
  • Environmental biotechnology
  • Regenerative medicine (stem cells, tissue engineering and biomaterials)
  • Translational immunology (cell therapies, antibody engineering, xenotransplantation)
  • Industrial bioprocesses for drug production and development
  • Biosafety
  • Biotech ethics

Special Issues devoted to crucial topics, providing the latest comprehensive information on cutting-edge areas of research and technological advances, are welcome.

Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.

Current Pharmaceutical Biotechnology

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Volume 21

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Number 8



Biography   Open Access



Review Article (Mini-Review)

The Physiologic Activity and Mechanism of Quercetin-Like Natural Plant Flavonoids

, 21(8): 654 - 658

Wujun Chen, Shuai Wang, Yudong Wu, Xin Shen, Shutan Xu, Zhu Guo*, Renshuai Zhang* and Dongming Xing*


DOI: 10.2174/1389201021666200212093130


Research Article   Open Access



Research Article

Saponins of Panax japonicus Confer Neuroprotection against Brain Aging through Mitochondrial Related Oxidative Stress and Autophagy in Rats

, 21(8): 667 - 680

Jing-zhi Wan, Rui Wang, Zhi-yong Zhou, Li-li Deng, Chang-cheng Zhang, Chao-qi Liu, Hai-xia Zhao, Cheng-fu Yuan, Yu-min He, Yao-yan Dun, Ding Yuan* and Ting Wang*


DOI: 10.2174/1389201021666191216114815


Research Article



Research Article

Protective Effect of Paeoniflorin on Acute Cerebral Infarction in Rats

, 21(8): 702 - 709

Weilin Wu, Chenfeng Qiu, Xuewen Feng, Xiaoxiao Tao, Qian Zhu, Zhengjun Chen, Xiaomin Ma, Jinwei Yang and Xianjun Bao*


DOI: 10.2174/1389201021666191224151634


Research Article

The Anti-Inflammatory Effects of Anacardic Acid on a TNF-α - Induced Human Saphenous Vein Endothelial Cell Culture Model

, 21(8): 710 - 719

Burak Önal*, Deniz Özen, Bülent Demir, Duygu Gezen Ak, Erdinç Dursun, Caner Demir, Ahmet Gökhan Akkan and Sibel Özyazgan


DOI: 10.2174/1389201020666191105154619


Research Article



Current Pharmaceutical Biotechnology, Volume 21 (2020) - Number 10


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Biotechnology, Volume 21 (2020) - Number 9


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print


Novel Therapeutic Approaches and Targets for Treatment of Psoriasis


Giulia Radi, Anna Campanati*, Federico Diotallevi, Tommaso Bianchelli and Annamaria Offidani


DOI: 10.2174/1389201021666200629150231
View Abstract View on PubMed





Novel Therapeutic Approaches and Targets for the Treatment of Atopic Dermatitis


Pescitelli Leonardo, Rosi Elia, Ricceri Federica, Pimpinelli Nicola and Prignano Francesca*


DOI: 10.2174/1389201021666200611112755
View Abstract View on PubMed






Published Contents

Drs. Eric Betzig, Stefan W. Hell and William E. Moerner share the 2014 chemistry Nobel for the development of super-resolved fluorescence microscopy.

“The Royal Swedish Academy of Sciences has decided to award the 2014 Nobel Prize in Chemistry to Dr. Eric Betzig at Howard Hughes Medical Institute, Ashburn, U.S.A.; Professor Stefan Hell at Max Planck Institute for Biophysical Chemistry, Göttingen, and the German Cancer Research Center, Heidelberg, Germany; and Professor William Moerner at Stanford University, Stanford, U.S.A., for the development of super-resolved fluorescence microscopy.”

Much research effort was needed to realize that single-cell and single-molecule based approaches directly affect improvements in human health. However, many of these laboratory technologies are not available in a cheap and easy version. Single-molecule based fluorescence imaging and detection have the advantages of a small volume platform, digital analysis, elimination of processing steps, real-time measurements and automation of sample preparation. In 2015, Current Pharmaceutical Biotechnology will continue in this direction with quality papers that can be expected to trigger further investigations.

Drs. Eric Betzig and William E. Moerner also developed methods and biotechniques which have enabled the study of single molecules in ongoing chemical reactions in living cells. Because now it is possible to see individual macromolecules moving about in a living cell, we can study chemistry at a single-molecule level and in real life. And this is very important to chemistry because chemistry has traditionally been about studying a large number of molecules and the effect that they have. The journal Current Pharmaceutical Biotechnology has published on this research and has been at the forefront for over more than one decade. Curr. Pharm. Biotechnol. has published thematic issues, original research and review articles about the entirely new possibilities for chemistry and for biochemistry by eminent scientists from around the world, some examples:

Editor's Choice

The Physiologic Activity and Mechanism of Quercetin-Like Natural Plant Flavonoids

, 2020; 21(8): 654 - 658

Wujun Chen, Shuai Wang, Yudong Wu, Xin Shen, Shutan Xu, Zhu Guo*, Renshuai Zhang* and Dongming Xing*


DOI: 10.2174/1389201021666200212093130




Feasibility Study for Bedside Production of Recombinant Human Acid α-Glucosidase: Technical and Financial Considerations

, 2020; 21(6): 467 - 479

Mohammed H. Aldosari*, Marcel den Hartog, Hubertina Ganizada, Martijn J.W. Evers, Enrico Mastrobattista and Huub Schellekens


DOI: 10.2174/1389201021666200217113049



Active Targeting Towards and Inside the Brain based on Nanoparticles: A Review

, 2020; 21(5): 374 - 383

Morteza Rabiei, Soheila Kashanian*, Seyedeh S. Samavati, Shahriar Jamasb and Steven J.P. McInnes


DOI: 10.2174/1389201020666191203094057







Biotechnological Production of Statins: Metabolic Aspects and Genetic Approaches

, 2019; 20(15): 1244 - 1259

Roberval N.M. Neto , Edelvio de Barros Gomes , Lucas Weba-Soares , Léo R.L. Dias, Luís C.N. da Silva * and Rita de C.M. de Miranda


DOI: 10.2174/1389201020666190718165746




Open Access Articles


Development of Formulation Methods and Physical Characterization of Injectable Sodium Selenite Nanoparticles for the Delivery of Sorafenib tosylate

, 2020; 21(8): 659 - 666

Sivakumar S. Moni*, Mohammad F. Alam*, Mohammed M. Safhi , Muhammad H. Sultan, Hafiz A. Makeen and Mohamed E. Elmobark




Assessment of Expression of Homeobox A5 in Endometrial Cancer on the mRNA and Protein Level

, 2020; 21(7): 635 - 641

Konrad Dziobek*, Marcin Oplawski, Nikola Zmarzły, Beniamin O. Gabarek, Robert Kiełbasiński, Kamil Kiełbasiński, Przemysław Kieszkowski, Karol Talkowski and Dariusz Boroń




Relationship between SNP rs1764391 and Susceptibility, Risk Factors, Gene-environment Interactions of Acute Myocardial Infarction in Guangxi Han Chinese Population

, 2020; 21(1): 79 - 88

Jun Li, Rui Qin, Wei Wang*, Zhou Huang, Dong-Ling Huang, Tian Li, Fan Wang, Xiang-tao Zeng, Zhong-yi Sun, Xue-feng Liu, Feng Huang and Tao Guo




Variances in the Level of COX-2 and iNOS in Different Grades of Endometrial Cancer

, 2020; 21(1): 52 - 59

Marcin Oplawski*, Konrad Dziobek, Nikola Zmarzły, Beniamin O. Grabarek, Robert Kiełbasiński, Przemysław Kieszkowski, Piotr Januszyk, Karol Talkowski, Michał Schweizer, Piotr Kras, Andrzej Plewka and Dariusz Boroń




The Influence of Salinomycin on the Expression Profile of mRNAs Encoding Selected Caspases and MiRNAs Regulating their Expression in Endometrial Cancer Cell Line

, 2020; 21: 1 - 11 (E-Pub Ahead of Print)

Krzysztof Januszyk*, Piotr Januszyk, Beniamin Oskar Grabarek, Dariusz Boroń and Marcin Oplawski




Salinomycin Modulates the Expression of mRNAs and miRNAs Related to Stemness in Endometrial Cancer

, 2020; 21: 1 - 10 (E-Pub Ahead of Print)

Karol Talkowski*, Kamil Kiełbasiński, Wojciech Peszek, Beniamin Oskar Grabarek, Dariusz Boroń and Marcin Oplawski




Plant Phenolics and Lectins as Vaccine Adjuvants

, 2019; 20(15): 1236 - 1243

Hernández-Ramos Reyna-Margarita, Castillo-Maldonado Irais*, Rivera-Guillén Mario-Alberto, Ramírez-Moreno Agustina, Serrano-Gallardo Luis-Benjamín and Pedroza-Escobar David*




Preparation of Chitosan/Alginate-ellagic Acid Sustained-release Microspheres and their Inhibition of Preadipocyte Adipogenic Differentiation

, 2019; 20(14): 1213 - 1222

Chengshi Ding, Haidan Bi, Deya Wang, Meiling Kang, Zhongjing Tian, Yingxia Zhang, Hongkai Wang, Tianshun Zhu* and Jing Ma*




Changes in the Density of Corneal Endothelial Cells in Elderly Diabetic Patients After Combined Phacovitrectomy and Ex-PRESS Glaucoma Implants

, 2019; 20(12): 1037 - 1043

Anita Lyssek-Boroń*, Katarzyna Krysik, Magdalena Kijonka, Mateusz Osuch, Beniamin O. Grabarek and Dariusz Dobrowolski




Changes in the Expression Profile of VEGF-A, VEGF-B, VEGFR-1, VEGFR-2 in Different Grades of Endometrial Cancer

, 2019; 20(11): 955 - 963

Konrad Dziobek*, Marcin Opławski, Beniamin Oskar Grabarek, Nikola Zmarzły, Barbara Tomala, Tomasz Halski, Ewa Leśniak, Krzysztof Januszyk, Ryszard Brus, Robert Kiełbasiński and Dariusz Boroń




Changes in Expression Pattern of SEMA3F Depending on Endometrial Cancer Grade - Pilot Study

, 2019; 20(9): 727 - 732

Konrad Dziobek*, Marcin Opławski, Beniamin Grabarek, Nikola Zmarzły, Robert Kiełbasiński, Ewa Leśniak, Piotr Januszyk, Krzysztof Januszyk, Iwona Adwent, Dariusz Dąbruś, Przemysław Kieszkowski, Kamil Kiełbasiński, Agnieszka Kuś-Kierach and Dariusz Boroń




Does Nimodipine, a Selective Calcium Channel Blocker, Impair Chondrocyte Proliferation or Damage Extracellular Matrix Structures?

, 2019; 20(6): 517 - 524

Necati Kaplan, Ibrahim Yilmaz, Numan Karaarslan*, Yasin E. Kaya, Duygu Y. Sirin and Hanefi Ozbek




Evaluation of Changes in the Expression Pattern of EDIL3 in Different Grades of Endometrial Cancer

, 2019; 20(6): 483 - 488

Marcin Oplawski*, Konrad Dziobek, Nikola Zmarzły, Beniamin Grabarek, Barbara Tomala, Ewa Leśniak, Iwona Adwent, Piotr Januszyk, Dariusz Dąbruś and Dariusz Boroń




Fenoldopam Mesylate: A Narrative Review of Its Use in Acute Kidney Injury

, 2019; 20(5): 366 - 375

Annalisa Noce*, Giulia Marrone, Valentina Rovella, Andrea Busca, Caterina Gola, Michele Ferrannini and Nicola Di Daniele*





Most Cited Articles


Review Article

Functional biomolecule delivery systems and bioengineering in cartilage regeneration

, 2019; 20(1): 32-46.

Marta A. Szychlinska, Ugo D'Amora, Silvia Ravalli, Luigi Ambrosio, Michelino Di Rosa and Giuseppe Musumeci*


DOI: 10.2174/1389201020666190206202048


Research Article

Effect of pullulan on physicochemical, microbiological, and sensory quality of yogurts

, 2019; 20(6): 489-496.

Anna Chlebowska-Śmigiel, Katarzyna Kycia, Katarzyna Neffe-Skocińska, Marek Kieliszek*, Małgorzata Gniewosz and Danuta Kołożyn-Krajewska


DOI: 10.2174/1389201020666190416151129


Research Article

Healthcare-associated infections due to multidrug-resistant organisms: A surveillance study on extra hospital stay and direct costs

, 2019; 20(8): 643-652.

Guglielmo Giraldi, Marzietta Montesano, Christian Napoli, Paola Frati, Raffaele La Russa, Alessandro Santurro, Matteo Scopetti and Giovanni B. Orsi*


DOI: 10.2174/1389201020666190408095811


Review Article

Antibiotics application strategies to control biofilm formation in pathogenic bacteria

, 2020; 21(4): 270-286.

Fazlurrahman Khan, Dung T.N. Pham, Sandra F. Oloketuyi and Young-Mog Kim*


DOI: 10.2174/1389201020666191112155905



Research Article

New rules on patient’s safety and professional liability for the Italian health service

, 2019; 20(8): 615-624.

Sara Albolino, Tommaso Bellandi, Simone Cappelletti, Marco Di Paolo, Vittorio Fineschi*, Paola Frati, Caterina Offidani, Michela Tanzini, Riccardo Tartaglia and Emanuela Turillazzi


DOI: 10.2174/1389201020666190408094016


Review Article

Recent insights into effective nanomaterials and biomacromolecules conjugation in advanced drug targeting

, 2019; 20(7): 526-541.

Abbas H. Azandaryani , Soheila Kashanian * and Tahereh Jamshidnejad-Tosaramandani


DOI: 10.2174/1389201020666190417125101


Research Article

Tanshinone IIA promotes macrophage cholesterol efflux and attenuates atherosclerosis of apoE-/- mice by omentin-1/ABCA1 pathway

, 2019; 20(5): 422-432.

Yu-lin Tan, Han-xiao Ou, Min Zhang, Duo Gong, Zhen-wang Zhao, Ling-yan Chen, Xiao-dan Xia, Zhong-cheng Mo* and Chao-ke Tang*


DOI: 10.2174/1389201020666190404125213



General Review Article

Role of probiotics in prophylaxis of Helicobacter pylori infection

, 2019; 20(2): 137-145.

Kashyapi Chakravarty and Smriti Gaur*


DOI: 10.2174/1389201020666190227203107




Research Article

Changes in the expression profile of VEGF-A, VEGF-B, VEGFR-1, VEGFR-2 in different grades of endometrial cancer

, 2019; 20(11): 955-963.

Konrad Dziobek*, Marcin Opławski, Beniamin Oskar Grabarek, Nikola Zmarzły, Barbara Tomala, Tomasz Halski, Ewa Leśniak, Krzysztof Januszyk, Ryszard Brus, Robert Kiełbasiński and Dariusz Boroń


DOI: 10.2174/1389201020666190717092448


Review Article

Valorization of fruits by-products to unconventional sources of additives, oil, biomolecules and innovative functional foods

, 2019; 20(10): 776-786.

Charalampia Dimou, Haralabos C. Karantonis, Dimitrios Skalkos and Antonios E. Koutelidakis*


DOI: 10.2174/1389201020666190405181537



Most Accessed Articles

CAR T-cell Therapy: A New Era in Cancer Immunotherapy

, 2018; 19(1): 5-18.

Androulla N. Miliotou and Lefkothea C. Papadopoulou*


DOI: 10.2174/1389201019666180418095526





Phage Therapy in Clinical Practice: Treatment of Human Infections

, 2010; 11(1): 69-86.

Elizabeth Kutter, Daniel De Vos, Guram Gvasalia, Zemphira Alavidze, Lasha Gogokhia, Sarah Kuhl and Stephen T. Abedon


DOI: 10.2174/138920110790725401


Variances in the Level of COX-2 and iNOS in Different Grades of Endometrial Cancer

, 2020; 21(1): 52-59.

Marcin Oplawski*, Konrad Dziobek, Nikola Zmarzły, Beniamin O. Grabarek, Robert Kiełbasiński, Przemysław Kieszkowski, Piotr Januszyk, Karol Talkowski, Michał Schweizer, Piotr Kras, Andrzej Plewka and Dariusz Boroń


DOI: 10.2174/1389201020666190918104105


Relationship between SNP rs1764391 and Susceptibility, Risk Factors, Gene-environment Interactions of Acute Myocardial Infarction in Guangxi Han Chinese Population

, 2020; 21(1): 79-88.

Jun Li, Rui Qin, Wei Wang*, Zhou Huang, Dong-Ling Huang, Tian Li, Fan Wang, Xiang-tao Zeng, Zhong-yi Sun, Xue-feng Liu, Feng Huang and Tao Guo


DOI: 10.2174/1389201019666191003150015


A Review of Gene Therapy Delivery Systems for Intervertebral Disc Degeneration

, 2020; 21(3): 194-205.

Songfeng Chen, Ming Luo, Hongwei Kou, Guowei Shang, Yanhui Ji and Hongjian Liu*


DOI: 10.2174/1389201020666191024171618


Reversing Breast Cancer Stem Cell into Breast Somatic Stem Cell

, 2011; 12(2): 189-195.

L. Wijaya, D. Agustina, A. O. Lizandi, M. M. Kartawinata and F. Sandra


DOI: 10.2174/138920111794295819


The Use of Biomarkers in Sepsis: A Systematic Review

, 2017; 18(6): 499-507.

Konstantinos Giannakopoulos*, Ursula Hoffmann, Uzair Ansari, Thomas Bertsch, Martin Borggrefe, Ibrahim Akin and Michael Behnes


DOI: 10.2174/1389201018666170601080111



Editor-in-Chief

Nikolaos Labrou
Department of Biotechnology
Agricultural University of Athens
Athens
(Greece)
Biography View Full Editorial Board

Journal History

Current Pharmaceutical Biotechnology was launched in 2000. Dr. Nikolaos Labrou serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 1.97

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