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Current Pharmaceutical Biotechnology

Volume 20, 15 Issues, 2019
ISSN: 1873-4316 (Online)
ISSN: 1389-2010 (Print)
This journal supports open access

Aims & Scope

Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal includes timely in-depth/mini reviews, original research articles and letters written by leaders in the field, covering a range of current topics in scientific areas of Pharmaceutical Biotechnology. Invited and unsolicited review articles are welcome. The journal encourages contributions describing research at the interface of drug discovery and pharmacological applications, involving in vitro investigations and pre-clinical or clinical studies. Scientific areas within the scope of the journal include pharmaceutical chemistry, biochemistry and genetics, molecular and cellular biology, and polymer and materials sciences as they relate to pharmaceutical science and biotechnology. In addition, the journal also considers comprehensive studies and research advances pertaining food chemistry with pharmaceutical implication. Areas of interest include:

  • DNA/protein engineering and processing
  • Synthetic biotechnology
  • Omics (genomics, proteomics, metabolomics and systems biology)
  • Therapeutic biotechnology (gene therapy, peptide inhibitors, enzymes)
  • Drug delivery and targeting
  • Nanobiotechnology
  • Molecular pharmaceutics and molecular pharmacology
  • Analytical biotechnology (biosensing, advanced technology for detection of bioanalytes)
  • Pharmacokinetics and pharmacodynamics
  • Applied Microbiology
  • Bioinformatics (computational biopharmaceutics and modeling)
  • Environmental biotechnology
  • Regenerative medicine (stem cells, tissue engineering and biomaterials)
  • Translational immunology (cell therapies, antibody engineering, xenotransplantation)
  • Industrial bioprocesses for drug production and development
  • Biosafety
  • Biotech ethics

Special Issues devoted to crucial topics, providing the latest comprehensive information on cutting-edge areas of research and technological advances, are welcome.

Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.

Current Pharmaceutical Biotechnology

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Volume 20

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Number 3



Biography   Open Access



Perspective   Open Access



Review Article



Review Article

Phytosterols and Triterpenoids for Prevention and Treatment of Metabolicrelated Liver Diseases and Hepatocellular Carcinoma

, 20(3): 197 - 214

Isabel Sánchez-Crisóstomo, Eduardo Fernández-Martínez *, Raquel Cariño-Cortés , Gabriel Betanzos-Cabrera and Rosa A. Bobadilla-Lugo


DOI: 10.2174/1389201020666190219122357


Letter

The Combination of Dimorphandra gardneriana Galactomannan and Mangiferin Inhibits Herpes Simplex and Poliovirus

, 20(3): 215 - 221

Daniele Z. Rechenchoski, Nayara L. Samensari, Ligia C. Faccin-Galhardi, Raimundo R. de Almeida, Arcelina P. Cunha, Nágila M.P.S. Ricardo, Carlos Nozawa and Rosa E.C. Linhares*


DOI: 10.2174/1389201020666190307130431


Research Article



Research Article



Research Article   Open Access



Current Pharmaceutical Biotechnology, Volume 20 (2019) - Number 5


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Biotechnology, Volume 20 (2019) - Number 4


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Does Nimodipine, a Selective Calcium Channel Blocker, Impair Chondrocyte Proliferation or Damage Extracellular Matrix Structures?


Necati Kaplan, Ibrahim Yilmaz, Numan Karaarslan*, Yasin Emre Kaya, Duygu Yasar Sirin and Hanefi Ozbek


View Abstract View on PubMed




Tuberculosis: Current Status, Diagnosis, Treatment and Development of Novel Vaccines


Jyoti Yadav, Sonali Verma, Darshna Choudhary, Pawan K. Jaiwal and Ranjana Jaiwal


View Abstract



Healthcare-Associated Infections Due to Multidrug-Resistant Organisms: A Surveillance Study on Extra Hospital Stay and Direct Costs


Guglielmo Giraldi, Marzietta Montesano, Paola Frati, Raffaele La Russa, Alessandro Santurro, Matteo Scopetti, Christian Napoli and Giovanni Battista Orsi*


View Abstract View on PubMed


Effect of Pullulan on Physicochemical, Microbiological, and Sensory Quality of Yogurts


Anna Chlebowska-Śmigiel, Katarzyna Kycia, Katarzyna Neffe-Skocińska, Marek Kieliszek*, Małgorzata Gniewosz and Danuta Kołożyn-Krajewska


View Abstract


Evaluation of Changes in the Expression Pattern of EDIL3 in Different Grades of Endometrial Cancer


Marcin Oplawski*, Konrad Dziobek, Nikola Zmarzły, Beniamin Grabarek, Barbara Tomala, Ewa Leśniak, Iwona Adwent, Piotr Januszyk, Krzysztof Januszyk, Dariusz Dąbruś and Dariusz Boroń


View Abstract View on PubMed


Medical Records Quality as Prevention Tool for Healthcare-Associated Infections (HAIs) Related Litigation: a Case Series


Giuseppe Davide Albano, Giuseppe Bertozzi, Francesca Maglietta, Angelo Montana, Giulio Di Mizio, Massimiliano Esposito, Pietro Mazzeo, Stefano D’Errico and Monica Salerno*


View Abstract View on PubMed


Detection and Extraction of Heparin from Camel Lungs


Ahmad Almeman*, Kasem Abdulmajed and Eltayeb E Eid


View Abstract View on PubMed


Abstracts Ahead of Print

Expression profile of genes associated with the proteins degradation pathways in colorectal adenocarcinoma


Bednarczyk Martyna*, Muc-Wierzgoń Małgorzata, Zmarzły Nikola, Urszula Mazurek and Grażyna Janikowska


View Abstract


Recent Insights into Effective Nanomaterials and Biomacromolecules Conjugation in Advanced Drug Targeting


Abbas Hemati Azandaryani , Soheila Kashanian * and Tahereh Jamshidnejad Tosaramandani


View Abstract



Published Contents

Drs. Eric Betzig, Stefan W. Hell and William E. Moerner share the 2014 chemistry Nobel for the development of super-resolved fluorescence microscopy.

“The Royal Swedish Academy of Sciences has decided to award the 2014 Nobel Prize in Chemistry to Dr. Eric Betzig at Howard Hughes Medical Institute, Ashburn, U.S.A.; Professor Stefan Hell at Max Planck Institute for Biophysical Chemistry, Göttingen, and the German Cancer Research Center, Heidelberg, Germany; and Professor William Moerner at Stanford University, Stanford, U.S.A., for the development of super-resolved fluorescence microscopy.”

Much research effort was needed to realize that single-cell and single-molecule based approaches directly affect improvements in human health. However, many of these laboratory technologies are not available in a cheap and easy version. Single-molecule based fluorescence imaging and detection have the advantages of a small volume platform, digital analysis, elimination of processing steps, real-time measurements and automation of sample preparation. In 2015, Current Pharmaceutical Biotechnology will continue in this direction with quality papers that can be expected to trigger further investigations.

Drs. Eric Betzig and William E. Moerner also developed methods and biotechniques which have enabled the study of single molecules in ongoing chemical reactions in living cells. Because now it is possible to see individual macromolecules moving about in a living cell, we can study chemistry at a single-molecule level and in real life. And this is very important to chemistry because chemistry has traditionally been about studying a large number of molecules and the effect that they have. The journal Current Pharmaceutical Biotechnology has published on this research and has been at the forefront for over more than one decade. Curr. Pharm. Biotechnol. has published thematic issues, original research and review articles about the entirely new possibilities for chemistry and for biochemistry by eminent scientists from around the world, some examples:

Editor's Choice


Downregulation of TdT Expression through Splicing Modulation by Antisense Peptide Nucleic Acid (PNA)

, 2019; 20(2): 168 - 178

Soheila Montazersaheb, Masoumeh Kazemi, Elahe Nabat, Peter E. Nielsen* and Mohammad S. Hejazi*


DOI: 10.2174/1389201020666190206202650




The Role of Extracellular Nucleic Acids in Rheumatoid Arthritis

, 2018; 19(15): 1182 - 1188

Elena Neumann*, Rebecca Hasseli, Uwe Lange and Ulf Müller-Ladner


DOI: 10.2174/1389201020666190102150216







Factors Regulating Human Extravillous Trophoblast Invasion: Chemokine-peptidase and CD9-integrin Systems

, 2018; 19(10): 764 - 770

Hiroshi Fujiwara*, Hisanori Matsumoto, Yukiyasu Sato, Akihito Horie, Masanori Ono, Mitsuhiro Nakamura, Yasunari Mizumoto, Kyosuke Kagami, Tomoko Fujiwara, Akira Hattori, Yoshiko Maida, Takiko Daikoku, Kazuhiko Imakawa and Yoshihiko Araki


DOI: 10.2174/1389201019666181029164906




Open Access Articles

Expression of NRP-1 and NRP-2 in Endometrial Cancer

, 2019; 20(3): 254 - 260

Marcin Oplawski*, Konrad Dziobek, Beniamin Grabarek, Nikola Zmarzły, Dariusz Dąbruś, Piotr Januszyk, Ryszard Brus, Barbara Tomala and Dariusz Boroń




Gender Difference Response of Male and Female Immunodeficiency Rats Treated with Tissue-specific Biomolecules

, 2019; 20(3): 245 - 253

Liliya V. Fedulova, Alexandr A. Basov, Ekaterina R. Vasilevskaya and Stepan S. Dzhimak*




Effect of Powdered Activated Carbon as Advanced Step in Wastewater Treatments on Antibiotic Resistant Microorganisms

, 2019; 20(1): 63 - 75

Damiana Ravasi, Roger König, Pamela Principi, Giuseppe Perale and Antonella Demarta*




Expression Profile of Endoglin in Different Grades of Endometrial Cancer

, 2018; 19(12): 990 - 995

Marcin Opławski*, Konrad Dziobek, Iwona Adwent, Dariusz Dąbruś, Beniamin Grabarek, Nikola Zmarzły, Andrzej Plewka and Dariusz Boroń




Enzymatic Hydrolysis of Hyaluronic Layer before Drug Dosing

, 2018; 19(12): 963 - 972

Anna Trusek*, Anita Niesobska and Damian Semba





Development of MTL-CEBPA: Small Activating RNA Drug for Hepatocellular Carcinoma

, 2018; 19(8): 611 - 621

Ryan L. Setten, Helen L. Lightfoot, Nagy A. Habib and John J. Rossi*





Verification between Original and Biosimilar Therapeutic Antibody Infliximab Using nSMOL Coupled LC-MS Bioanalysis in Human Serum

, 2018; 19(6): 495 - 505

Noriko Iwamoto, Kotoko Yokoyama, Megumi Takanashi, Atsushi Yonezawa, Kazuo Matsubara and Takashi Shimada*





Collaboration of the Joint Research Centre and European Customs Laboratories for the Identification of New Psychoactive Substances

, 2018; 19(2): 91 - 98

Claude Guillou*, Fabiano Reniero, Joana Lobo Vicente, Margaret Holland, Kamil Kolar, Hubert Chassaigne, Salvatore Tirendi and Herve Schepers









Most Cited Articles

Review Article

Car T-cell therapy: A new era in cancer immunotherapy

, 2018; 19(1): 5-18.

Miliotou N. Androulla and Papadopoulou C. Lefkothea*


DOI: 10.2174/1389201019666180418095526



Review Article

Analytical approaches in fatal intoxication cases involving new synthetic opioids

, 2018; 19(2): 113-123.

Enrico Gerace*, Alberto Salomone and Marco Vincenti


DOI: 10.2174/1389201019666180405162734


Research Article

Changes in the expression profile of JAK/STAT signaling pathway genes and mirnas regulating their expression under the adalimumab therapy

, 2018; 19(7): 556-565.

Beniamin Grabarek, Dominika Wcislo-Dziadecka*, Joanna Gola, Celina Kruszniewska-Rajs, Ligia Brzezinska-Wcislo, Nikola Zmarzly and Urszula Mazurek


DOI: 10.2174/1389201019666180730094046


Review Article

Development of MTL-CEBPA: Small activating RNA drug for hepatocellular carcinoma

, 2018; 19(8): 611-621.

Ryan L. Setten, Helen L. Lightfoot, Nagy A. Habib and John J. Rossi*


DOI: 10.2174/1389201019666180611093428



Review Article

Naringenin and its nano-formulations for fatty liver: Cellular modes of action and clinical perspective

, 2018; 19(3): 196-205.

Mehdi Zobeiri, Tarun Belwal, Fatemeh Parvizi, Rozita Naseri, Mohammad H. Farzaei*, Seyed F. Nabavi, Antoni Sureda and Seyed M. Nabavi


DOI: 10.2174/1389201019666180514170122



Review Article

Intestinal crosstalk between microbiota and serotonin and its impact on gut motility

, 2018; 19(3): 190-195.

Xiaolong Ge, Junhai Pan, Yichang Liu, Hongkan Wang, Wei Zhou* and Xianfa Wang


DOI: 10.2174/1389201019666180528094202


Research Article

Detecting autologous blood transfusion in doping control: Biomarkers of blood aging and storage measured by flow cytofluorimetry

, 2018; 19(2): 124-135.

Francesco Donati, Roberta Acciarini, Ilenia De Benedittis, Xavier de la Torre, Daniela Pirri, Mariangela Prete, Alessandra Stampella, Enza Vernucci and Francesco Botre*


DOI: 10.2174/1389201019666180405165118


Review Article

Nigella sativa L. And its bioactive constituents as hepatoprotectant: A review

, 2018; 19(1): 43-67.

Heena Tabassum, Asad Ahmad and Iffat Z. Ahmad*


DOI: 10.2174/1389201019666180427110007



Research Article

Evidence for L-Dopa decarboxylase involvement in cancer cell cytotoxicity induced by docetaxel and mitoxantrone

, 2018; 19(13): 1087-1096.

Evangelos D. Kalantzis, Andreas Scorilas and Dido Vassilacopoulou*


DOI: 10.2174/1389201019666181112103637


Research Article

Effect of vinca alkaloids on the expression levels of microRNAs targeting apoptosis-related genes in breast cancer cell lines

, 2018; 19(13): 1076-1086.

Adamantios V. Mavrogiannis, Ioanna Kokkinopoulou, Christos K. Kontos and Diamantis C. Sideris*


DOI: 10.2174/1389201019666181112103204


Review Article

HELLP Syndrome: Pathophysiology and current therapies

, 2018; 19(10): 816-826.

Kedra Wallace*, Sharonda Harris, Augustina Addison and Cynthia Bean


DOI: 10.2174/1389201019666180712115215



Most Accessed Articles

CAR T-cell Therapy: A New Era in Cancer Immunotherapy

, 2018; 19(1): 5-18.

Androulla N. Miliotou and Lefkothea C. Papadopoulou*


DOI: 10.2174/1389201019666180418095526



HELLP Syndrome: Pathophysiology and Current Therapies

, 2018; 19(10): 816-826.

Kedra Wallace*, Sharonda Harris, Augustina Addison and Cynthia Bean


DOI: 10.2174/1389201019666180712115215


New Developments in Pichia pastoris Expression System, Review and Update

, 2018; 19(6): 451-467.

Roghayyeh Baghban, Safar Farajnia*, Younes Ghasemi, Mojtaba Mortazavi, Nosratollah Zarghami and Naser Samadi


DOI: 10.2174/1389201019666180718093037



Hyperglycemia and Diabetes Induced by Glucocorticoids in Nondiabetic and Diabetic Patients: Revision of Literature and Personal Considerations

, 2018; 19(15): 1210-1220.

Ceccarelli Elena*, Mattaliano Chiara, Brazzi Angelica, Marinetti A. Chiara, Nigi Laura, Chirico Chiara, Corallo Claudio, Fioravanti Antonella and Giordano Nicola


DOI: 10.2174/1389201020666190102145305




The Role of Extracellular Nucleic Acids in Rheumatoid Arthritis

, 2018; 19(15): 1182-1188.

Elena Neumann*, Rebecca Hasseli, Uwe Lange and Ulf Müller-Ladner


DOI: 10.2174/1389201020666190102150216


Preeclampsia - Current Management and Future Approach

, 2018; 19(10): 786-796.

Weronika Dymara-Konopka*, Marzena Laskowska and Jan Oleszczuk


DOI: 10.2174/1389201019666180925120109



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