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Current Pharmaceutical Biotechnology

Volume 22, 15 Issues, 2021
ISSN: 1873-4316 (Online)
ISSN: 1389-2010 (Print)
This journal supports open access

Aims & Scope

Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal includes timely in-depth/mini reviews, original research articles and letters written by leaders in the field, covering a range of current topics in scientific areas of Pharmaceutical Biotechnology. Invited and unsolicited review articles are welcome. The journal encourages contributions describing research at the interface of drug discovery and pharmacological applications, involving in vitro investigations and pre-clinical or clinical studies. Scientific areas within the scope of the journal include pharmaceutical chemistry, biochemistry and genetics, molecular and cellular biology, and polymer and materials sciences as they relate to pharmaceutical science and biotechnology. In addition, the journal also considers comprehensive studies and research advances pertaining food chemistry with pharmaceutical implication. Areas of interest include:

  • DNA/protein engineering and processing
  • Synthetic biotechnology
  • Omics (genomics, proteomics, metabolomics and systems biology)
  • Therapeutic biotechnology (gene therapy, peptide inhibitors, enzymes)
  • Drug delivery and targeting
  • Nanobiotechnology
  • Molecular pharmaceutics and molecular pharmacology
  • Analytical biotechnology (biosensing, advanced technology for detection of bioanalytes)
  • Pharmacokinetics and pharmacodynamics
  • Applied Microbiology
  • Bioinformatics (computational biopharmaceutics and modeling)
  • Environmental biotechnology
  • Regenerative medicine (stem cells, tissue engineering and biomaterials)
  • Translational immunology (cell therapies, antibody engineering, xenotransplantation)
  • Industrial bioprocesses for drug production and development
  • Biosafety
  • Biotech ethics

Special Issues devoted to crucial topics, providing the latest comprehensive information on cutting-edge areas of research and technological advances, are welcome.

Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.

Current Pharmaceutical Biotechnology

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Volume 22

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Number 4



Biography   Open Access





Review Article

Matrix Metalloproteinase Inspired Therapeutic Strategies for Bone Diseases

, 22(4): 451 - 467

Longfa Kou, Xinyu Jiang, Xinlu Lin, Huirong Huang, Jun Wang, Qing Yao* and Ruijie Chen*


DOI: 10.2174/1389201021666200630140735




Review Article







Research Article

The P-MAPA Immunomodulator Partially Prevents Apoptosis Induced by Zika Virus Infection in THP-1 Cells

, 22(4): 514 - 522

Morganna C. Lima, Elisa A.N. Azevedo, Clarice N.L. de Morais, Larissa I.O. de Sousa, Bruno M. Carvalho, Iseu N. da Silva and Rafael F.O. Franca*


DOI: 10.2174/1389201021666200602140005


Current Pharmaceutical Biotechnology, Volume 22 (2021) - Number 8


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Biotechnology, Volume 22 (2021) - Number 7


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Biotechnology, Volume 22 (2021) - Number 6


This issue is in progress but contains articles that are final and fully citable.

Current Pharmaceutical Biotechnology, Volume 22 (2021) - Number 5


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print


Unravelling the Immune Modulatory Effect of Indian Spices to Impede the Transmission of COVID-19: A Promising Approach


Aswathy R Devan, Bhagyalakshmi Nair, Ayana R Kumar, Jaggaiah N Gorantla Gorantla, T. S. Aishwarya and Lekshmi R Nath*


DOI: 10.2174/1389201022666210216144917
View Abstract View on PubMed



The Role of Hypoxia in Endometrial Cancer


Yarely M. Salinas-Vera, Dolores Gallardo-Rincón, Erika Ruíz-García, Macrina B. Silva-Cázares, Carmen Sol de la Peña-Cruz and César López-Camarillo*


DOI: 10.2174/1389201022666210224130022
View Abstract View on PubMed




Evaluation of Decontamination Efficacy of Electrolytically Generated Hypochlorous Acid for the Vesicating Agent: A Multimodel Study


Ajay Kumar Sharma, Sandeep Kumar Shukla*, Aman Kalonia, Priyanka Shaw, Kushagra Khanna, Richa Gupta, M. H. Yashavarddhan and Aseem Bhatnagar


DOI: 10.2174/1389201022666210311140922
View Abstract View on PubMed





Abstracts Ahead of Print


Nanotechnology Enabled Solutions to Combat Covid-19: Prevention, Treatment and Diagnosis


Pankaj Musyuni, Manju Nagpal, Manjinder Singh, Ramesh K. Goyal and Geeta Aggarwal*


DOI: 10.2174/1389201022666210122124311
View Abstract


Bacteriophages: from isolation to application


Abdallah S. Abdelsattar, Alyaa Dawoud, Salsabil Makky , Rana Nofal, Ramy K. Aziz and Ayman El-Shibiny*


DOI: 10.2174/1389201022666210426092002
View Abstract



Cytotoxicity, Anti-diabetic, and hepato-protective potential of Ajuga bracteosa-conjugated silver nanoparticles in Balb/c mice


Sadia Nazer, Saiqa Andleeb*, Shaukat Ali, Nazia Gulzar, Abida Raza, Habib Khan, Kalsoom Akhtar and Muhammad Naeem Ahmed


DOI: 10.2174/1389201022666210421101837
View Abstract


Olive oil consumption can prevent non-communicable diseases and COVID-19 : Review


Debabrata Majumder, Mousumi Debnath*, Kamal Nayan Sharma, Surinder Singh Shekhawat, G.B.K.S Prasad, Debasish Maiti and Seeram Ramakrishna


DOI: 10.2174/1389201022666210412143553
View Abstract



The Beneficial Effects of QIAPI 1® against Pentavalent Arsenic-Induced Lung Toxicity a Hypothetical Model for SARS CoV2-Induced Lung Toxicity


Arturo Solís Herrera, Narasimha M. Beeraka, Mikhail Y Sinelnikov, Vladimir N. Nikolenko, Dimitry B. Giller, Luis Fernando Torres Solis, Liudmila M. Mikhaleva, Siva G. Somasundaram*, Cecil E. Kirkland and Gjumrakch Aliev*


DOI: 10.2174/1389201022666210412142230
View Abstract



The Rhodamine B-encrypted vipericidin peptide, RhoB-Ctn[1-9], displays in vitro antimicrobial activity against opportunistic bacteria and yeasts


Hilania Valeria Doudou Lima, Thales Márcio Cabral dos Santos, Mirelly Mirna Alves de Sousa Silva, João Victor da Silva Albuquerque, Luciana Magalhães Melo, Vicente José de Figueirêdo Freitas* and Gandhi Rádis-Baptista*


DOI: 10.2174/1389201022666210322123903
View Abstract


Published Contents

Drs. Eric Betzig, Stefan W. Hell and William E. Moerner share the 2014 chemistry Nobel for the development of super-resolved fluorescence microscopy.

“The Royal Swedish Academy of Sciences has decided to award the 2014 Nobel Prize in Chemistry to Dr. Eric Betzig at Howard Hughes Medical Institute, Ashburn, U.S.A.; Professor Stefan Hell at Max Planck Institute for Biophysical Chemistry, Göttingen, and the German Cancer Research Center, Heidelberg, Germany; and Professor William Moerner at Stanford University, Stanford, U.S.A., for the development of super-resolved fluorescence microscopy.”

Much research effort was needed to realize that single-cell and single-molecule based approaches directly affect improvements in human health. However, many of these laboratory technologies are not available in a cheap and easy version. Single-molecule based fluorescence imaging and detection have the advantages of a small volume platform, digital analysis, elimination of processing steps, real-time measurements and automation of sample preparation. In 2015, Current Pharmaceutical Biotechnology will continue in this direction with quality papers that can be expected to trigger further investigations.

Drs. Eric Betzig and William E. Moerner also developed methods and biotechniques which have enabled the study of single molecules in ongoing chemical reactions in living cells. Because now it is possible to see individual macromolecules moving about in a living cell, we can study chemistry at a single-molecule level and in real life. And this is very important to chemistry because chemistry has traditionally been about studying a large number of molecules and the effect that they have. The journal Current Pharmaceutical Biotechnology has published on this research and has been at the forefront for over more than one decade. Curr. Pharm. Biotechnol. has published thematic issues, original research and review articles about the entirely new possibilities for chemistry and for biochemistry by eminent scientists from around the world, some examples:

Editor's Choice




Potential Pharmaceutical and Food Applications of Postbiotics: A Review

, 2020; 21(15): 1576 - 1587

Aziz H. Rad, Amin Abbasi*, Hossein S. Kafil* and Khudaverdi Ganbarov


DOI: 10.2174/1389201021666200516154833



Roles and Biomedical Applications of Haemolymph Lectin

, 2020; 21(14): 1444 - 1450

Rana Kamei, Oinam S. Devi, Sorokhaibam J. Singh and Senjam S. Singh*


DOI: 10.2174/1389201021666200730123330



Screening of an Alkaline CMCase-Producing Strain and the Optimization of its Fermentation Condition

, 2020; 21(13): 1304 - 1315

Junmei Zhou, Lianghong Yin*, Chenbin Wu, Sijia Wu, Jidong Lu, Hailing Fang and Yongchang Qian*


DOI: 10.2174/1389201021666200129123818




Curcumin Therapeutic Modulation of the Wnt Signaling Pathway

, 2020; 21(11): 1006 - 1015

Milad Ashrafizadeh, Zahra Ahmadi, Reza Mohamamdinejad, Habib Yaribeygi*, Maria-Corina Serban , Hossein M. Orafai and Amirhossein Sahebkar*


DOI: 10.2174/1389201021666200305115101



Current Prospects of Nutraceuticals: A Review

, 2020; 21(10): 884 - 896

Vedant Sachdeva, Arpita Roy and Navneeta Bharadvaja*


DOI: 10.2174/1389201021666200130113441




Open Access Articles

Investigation on the Antibacterial Activity of Electronic Cigarette Liquids (ECLs): A Proof of Concept Study

, 2021; 22(7): 975 - 986

Virginia Fuochi, Massimo Caruso , Rosalia Emma, Aldo Stivala, Riccardo Polosa, Alfio Distefano and Pio Maria Furneri *





Synthesis and Biological Evaluation of Amoxicillin Loaded Hybrid Material Composite Spheres Against Methicillin-Resistant Staphylococcus aureus

, 2021; 22(5): 678 - 688

Muhammad A. Yameen*, Amir Zeb, Raza E. Mustafa, Sana Mushtaq, Nargis Aman, Muhammad Samie, Khizar H. Shah and Jamshed Iqbal




Analysis of the Differences in the Expression of mRNAs and miRNAs Associated with Drug Resistance in Endometrial Cancer Cells Treated with Salinomycin

, 2021; 22(4): 541 - 548

Piotr Januszyk*, Krzysztof Januszyk, Magdalena Wierzbik-Strońska, Dariusz Boroń and Beniamin Grabarek




Leaf and Fruit Methanolic Extracts of Azadirachta indica Exhibit Antifertility Activity on Rats’ Sperm Quality and Testicular Histology

, 2021; 22(3): 400 - 407

Castillo-Maldonado Irais, Borjón-Ríos Claudia, Pedroza-Escobar David*, Sharma Ashutosh, García-Garza Rubén, Ramírez-Moreno Agustina, Vega-Menchaca M. del Carmen, Rivera-Guillén Mario-Alberto and Serrano-Gallardo Luis-Benjamín*




Salinomycin Modulates the Expression of mRNAs and miRNAs Related to Stemness in Endometrial Cancer

, 2021; 22(2): 317 - 326

Karol Talkowski*, Kamil Kiełbasiński, Wojciech Peszek, Beniamin O. Grabarek, Dariusz Boroń and Marcin Oplawski




Development and Characteristics of Novel PLGA-chitosan as a New Nano-carrier for Pentavalent Vaccine Delivery

, 2021; 22: 1 - 13 (E-Pub Ahead of Print)

Zahra Alikhani, Nadia Kazemi-Pour*, Mehdi Shafieeardestani* and Mojtaba Noofeli




Expression Profile of EMT-related Genes and miRNAs Involved in Signal Transduction via the Wnt Pathway and Cadherins in Endometrial Cancer

, 2021; 22: 1 - 9 (E-Pub Ahead of Print)

Nikola Zmarzły, Ewelina Hermyt, Celina Kruszniewska-Rajs, Joanna Gola, Andrzej Witek, Urszula Mazurek, Aleksander Ostenda and Dariusz Boroń




Effect of TRAF1 on Phenotypic Changes of Kupffer Cells in Liver Transplantation Ischemic-Reperfusion

, 2021; 22: 1 - 10 (E-Pub Ahead of Print)

Zhen Zhang, KeTing Que, Yu You, XiaoPing Zhao, DiGuang Wen, ZhiHao Feng and ZuoJin Liu*






Effect of Salinomycin on Expression Pattern of Genes Associated with Apoptosis in Endometrial Cancer Cell Line

, 2020; 21(12): 1269 - 1277

Kamil Kiełbasiński*, Wojciech Peszek, Beniamin O. Grabarek, Dariusz Boroń, Magdalena Wierzbik-Strońska and Marcin Oplawski





Differences in the Expression Pattern of mRNA Protein SEMA3F in Endometrial Cancer in vitro under Cisplatin Treatment

, 2020; 21(11): 1119 - 1128

Przemysław Kieszkowski*, Dariusz Dąbruś, Beniamin O. Grabarek and Dariusz Boroń




Analysis of the Clinical Diagnostic Value of GMFB in Cerebral Infarction

, 2020; 21(10): 955 - 963

Zhaohu Yuan*, Zhiwu Yu, Yiyu Zhang and Huikuan Yang





Most Cited Articles




Review Article

Current prospects of nutraceuticals: A review

, 2020; 21(10): 884-896.

Vedant Sachdeva, Arpita Roy and Navneeta Bharadvaja*


DOI: 10.2174/1389201021666200130113441



Review Article (Mini-Review)

Effect of the phytochemical agents against the SARS-CoV and some of them selected for application to COVID-19: A mini-review

, 2021; 22(4): 444-450.

Muhammad Idrees, Shamshad Khan, Nazakat H. Memon and Zhiyong Zhang*


DOI: 10.2174/1389201021666200703201458


Review Article

Potential pharmaceutical and food applications of postbiotics: A review

, 2020; 21(15): 1576-1587.

Aziz H. Rad, Amin Abbasi*, Hossein S. Kafil* and Khudaverdi Ganbarov


DOI: 10.2174/1389201021666200516154833


Research Article

Enhancing the antibacterial activity of erythromycin with titanium dioxide nanoparticles against MRSA

, 2020; 21(10): 948-954.

Kaleem Ullah, Shujaat A. Khan, Abdul Mannan, Romana Khan, Ghulam Murtaza* and Muhammad A. Yameen*


DOI: 10.2174/1389201021666200128124142


Review Article (Mini-Review)

A review of gene therapy delivery systems for intervertebral disc degeneration

, 2020; 21(3): 194-205.

Songfeng Chen, Ming Luo, Hongwei Kou, Guowei Shang, Yanhui Ji and Hongjian Liu*


DOI: 10.2174/1389201020666191024171618


Research Article

Design of experiment, preparation, and in vitro biological assessment of human amniotic membrane extract loaded nanoparticles

, 2020; 21(3): 256-267.

Avishan Shabani, Fatemeh Atyabi, Mohammad R. Khoshayand, Reza Mahbod, Reza A. Cohan, Iman Akbarzadeh and Haleh Bakhshandeh*


DOI: 10.2174/1389201020666191019122130


Research Article

New folate-modified human serum albumin conjugated to cationic lipid carriers for dual targeting of mitoxantrone against breast cancer

, 2020; 21(4): 305-315.

Abbas A. Ridha, Soheila Kashanian*, Abbas H. Azandaryani, Ronak Rafipour and Elahe Mahdavian


DOI: 10.2174/1389201020666191114113022


Review Article (Mini-Review)

The physiologic activity and mechanism of quercetin-like natural plant flavonoids

, 2020; 21(8): 654-658.

Wujun Chen, Shuai Wang, Yudong Wu, Xin Shen, Shutan Xu, Zhu Guo*, Renshuai Zhang* and Dongming Xing*


DOI: 10.2174/1389201021666200212093130




Review Article

Antibiotics application strategies to control biofilm formation in pathogenic bacteria

, 2020; 21(4): 270-286.

Fazlurrahman Khan, Dung T.N. Pham, Sandra F. Oloketuyi and Young-Mog Kim*


DOI: 10.2174/1389201020666191112155905



Most Accessed Articles



Novel Therapeutic Approaches and Targets for the Treatment of Atopic Dermatitis

, 2021; 22(1): 73-84.

Leonardo Pescitelli, Elia Rosi, Federica Ricceri , Nicola Pimpinelli and Francesca Prignano *


DOI: 10.2174/1389201021666200611112755


Novel Therapeutic Approaches and Targets for the Treatment of Hidradenitis Suppurativa

, 2021; 22(1): 59-72.

Roberta Giuffrida, Serafinella Patrizia Cannavò, Marialorena Coppola and Claudio Guarneri*


DOI: 10.2174/1389201021666200505100556





Potential Pharmaceutical and Food Applications of Postbiotics: A Review

, 2020; 21(15): 1576-1587.

Aziz H. Rad, Amin Abbasi*, Hossein S. Kafil* and Khudaverdi Ganbarov


DOI: 10.2174/1389201021666200516154833



Curcumin Therapeutic Modulation of the Wnt Signaling Pathway

, 2020; 21(11): 1006-1015.

Milad Ashrafizadeh, Zahra Ahmadi, Reza Mohamamdinejad, Habib Yaribeygi*, Maria-Corina Serban , Hossein M. Orafai and Amirhossein Sahebkar*


DOI: 10.2174/1389201021666200305115101



Proteomics Analysis of Trastuzumab Toxicity in the H9c2 Cardiomyoblast Cell Line and its Inhibition by Carvedilol

, 2020; 21(13): 1377-1385.

Elham Beiranvand, Fatemeh Torkashvand, Seyed N. Ostad, Mehdi Mirzaie, Esmat M. Ardakani, Fatemeh Zandi, Soroush Sardari, Ghasem H. Salekdeh, Mohammad A. Shokrgozar and Behrouz Vaziri*


DOI: 10.2174/1389201021666200515135548







Editor-in-Chief

graphic
Nikolaos Labrou
Department of Biotechnology
Agricultural University of Athens
Athens
(Greece)
Biography
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Journal History

Current Pharmaceutical Biotechnology was launched in 2000. Dr. Nikolaos Labrou serves as the Editor-in-Chief of the journal.

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