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Current Pharmaceutical Biotechnology

Volume 20, 15 Issues, 2019
ISSN: 1873-4316 (Online)
ISSN: 1389-2010 (Print)
This journal supports open access

Aims & Scope

Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal includes timely in-depth/mini reviews, original research articles and letters written by leaders in the field, covering a range of current topics in scientific areas of Pharmaceutical Biotechnology. Invited and unsolicited review articles are welcome. The journal encourages contributions describing research at the interface of drug discovery and pharmacological applications, involving in vitro investigations and pre-clinical or clinical studies. Scientific areas within the scope of the journal include pharmaceutical chemistry, biochemistry and genetics, molecular and cellular biology, and polymer and materials sciences as they relate to pharmaceutical science and biotechnology. In addition, the journal also considers comprehensive studies and research advances pertaining food chemistry with pharmaceutical implication. Areas of interest include:

  • DNA/protein engineering and processing
  • Synthetic biotechnology
  • Omics (genomics, proteomics, metabolomics and systems biology)
  • Therapeutic biotechnology (gene therapy, peptide inhibitors, enzymes)
  • Drug delivery and targeting
  • Nanobiotechnology
  • Molecular pharmaceutics and molecular pharmacology
  • Analytical biotechnology (biosensing, advanced technology for detection of bioanalytes)
  • Pharmacokinetics and pharmacodynamics
  • Applied Microbiology
  • Bioinformatics (computational biopharmaceutics and modeling)
  • Environmental biotechnology
  • Regenerative medicine (stem cells, tissue engineering and biomaterials)
  • Translational immunology (cell therapies, antibody engineering, xenotransplantation)
  • Industrial bioprocesses for drug production and development
  • Biosafety
  • Biotech ethics

Special Issues devoted to crucial topics, providing the latest comprehensive information on cutting-edge areas of research and technological advances, are welcome.

Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.

Current Pharmaceutical Biotechnology

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Volume 19

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Number 15



Biography   Open Access



Editorial   Open Access



Review Article



Review Article



Review Article



Review Article



General Review Article

Hyperglycemia and Diabetes Induced by Glucocorticoids in Nondiabetic and Diabetic Patients: Revision of Literature and Personal Considerations

, 19(15): 1210 - 1220

Ceccarelli Elena*, Mattaliano Chiara, Brazzi Angelica, Marinetti A. Chiara, Nigi Laura, Chirico Chiara, Corallo Claudio, Fioravanti Antonella and Giordano Nicola


DOI: 10.2174/1389201020666190102145305


General Research Article



Current Pharmaceutical Biotechnology, Volume 20 (2019) - Number 1


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print





The Combination of Dimorphandra gardneriana Galactomannan and Mangiferin Inhibits Herpes Simplex and Poliovirus


Daniele Zendrini Rechenchoski, Nayara Lopes Samensari, Ligia Carla Faccin-Galhardi, Raimundo Rafael de Almeida, Arcelina Pacheco Cunha, Nágila Maria Pontes Silva Ricardo, Carlos Nozawa and Rosa Elisa Carvalho Linhares*


View Abstract View on PubMed



Sodium Oleate Increases Ampicillin Sensitivity in Methylophilus quaylei Biofilms on Teflon and Polypropylene


Abir M.H.A. Mohamed*, Shevlyagina N. Vladimirovna, Zhukhovitsky V. Grigorievich, Pshenichnikova A. Borisovna and Shvets V. Ivanovich


View Abstract View on PubMed


Phytosterols and Triterpenoids for Prevention and Treatment of Metabolic- related Liver Diseases and Hepatocellular Carcinoma


Sánchez-Crisóstomo Isabel, Fernández-Martínez Eduardo*, Cariño-Cortés Raquel, Betanzos-Cabrera Gabriel and Bobadilla-Lugo A. Rosa


View Abstract View on PubMed




Abstracts Ahead of Print


Vancomycin Therapeutic Regime Adjustment In Newborn And Infant With Bacterial Infection: Case Series


Nadielle Silva Bidu, Bruno José Dumêt Fernandes, Eduardo Jorge Cavalvante Dias, Jucelino Nery Conceição Filho, Regina Eunice de Andrade Bastos, Ana Leonor Pardo Campos Godoy, Francine Johansson Azeredo, Joice Neves Reis Pedreira and Ricardo David Couto*


View Abstract







Drs. Eric Betzig, Stefan W. Hell and William E. Moerner share the 2014 chemistry Nobel for the development of super-resolved fluorescence microscopy.

“The Royal Swedish Academy of Sciences has decided to award the 2014 Nobel Prize in Chemistry to Dr. Eric Betzig at Howard Hughes Medical Institute, Ashburn, U.S.A.; Professor Stefan Hell at Max Planck Institute for Biophysical Chemistry, Göttingen, and the German Cancer Research Center, Heidelberg, Germany; and Professor William Moerner at Stanford University, Stanford, U.S.A., for the development of super-resolved fluorescence microscopy.”

Much research effort was needed to realize that single-cell and single-molecule based approaches directly affect improvements in human health. However, many of these laboratory technologies are not available in a cheap and easy version. Single-molecule based fluorescence imaging and detection have the advantages of a small volume platform, digital analysis, elimination of processing steps, real-time measurements and automation of sample preparation. In 2015, Current Pharmaceutical Biotechnology will continue in this direction with quality papers that can be expected to trigger further investigations.

Drs. Eric Betzig and William E. Moerner also developed methods and biotechniques which have enabled the study of single molecules in ongoing chemical reactions in living cells. Because now it is possible to see individual macromolecules moving about in a living cell, we can study chemistry at a single-molecule level and in real life. And this is very important to chemistry because chemistry has traditionally been about studying a large number of molecules and the effect that they have. The journal Current Pharmaceutical Biotechnology has published on this research and has been at the forefront for over more than one decade. Curr. Pharm. Biotechnol. has published thematic issues, original research and review articles about the entirely new possibilities for chemistry and for biochemistry by eminent scientists from around the world, some examples:

Editor's Choice

Establishment of Novel Cells Stably Secreting Various Human IL-18 Recombinant Proteins

, 2019; 20(1): 47 - 55

Asuka Kumagai , Kenji Shimizu, Riho Kurata , Xiaofeng Cui, Takayuki Isagawa, Masamitsu Harada, Jun Nagai, Yasuhiro Yoshida , Kei-ichi Ozaki , Norihiko Takeda and Tomo Yonezawa*


DOI: 10.2174/1389201020666190206203640



The Role of Extracellular Nucleic Acids in Rheumatoid Arthritis

, 2018; 19(15): 1182 - 1188

Elena Neumann*, Rebecca Hasseli, Uwe Lange and Ulf Müller-Ladner


DOI: 10.2174/1389201020666190102150216







Factors Regulating Human Extravillous Trophoblast Invasion: Chemokine-peptidase and CD9-integrin Systems

, 2018; 19(10): 764 - 770

Hiroshi Fujiwara*, Hisanori Matsumoto, Yukiyasu Sato, Akihito Horie, Masanori Ono, Mitsuhiro Nakamura, Yasunari Mizumoto, Kyosuke Kagami, Tomoko Fujiwara, Akira Hattori, Yoshiko Maida, Takiko Daikoku, Kazuhiko Imakawa and Yoshihiko Araki


DOI: 10.2174/1389201019666181029164906






Open Access Articles

Expression Profile of Endoglin in Different Grades of Endometrial Cancer

, 2018; 19(12): 990 - 995

Marcin Opławski*, Konrad Dziobek, Iwona Adwent, Dariusz Dąbruś, Beniamin Grabarek, Nikola Zmarzły, Andrzej Plewka and Dariusz Boroń




Enzymatic Hydrolysis of Hyaluronic Layer before Drug Dosing

, 2018; 19(12): 963 - 972

Anna Trusek*, Anita Niesobska and Damian Semba





Development of MTL-CEBPA: Small Activating RNA Drug for Hepatocellular Carcinoma

, 2018; 19(8): 611 - 621

Ryan L. Setten, Helen L. Lightfoot, Nagy A. Habib and John J. Rossi*





Verification between Original and Biosimilar Therapeutic Antibody Infliximab Using nSMOL Coupled LC-MS Bioanalysis in Human Serum

, 2018; 19(6): 495 - 505

Noriko Iwamoto, Kotoko Yokoyama, Megumi Takanashi, Atsushi Yonezawa, Kazuo Matsubara and Takashi Shimada*





Collaboration of the Joint Research Centre and European Customs Laboratories for the Identification of New Psychoactive Substances

, 2018; 19(2): 91 - 98

Claude Guillou*, Fabiano Reniero, Joana Lobo Vicente, Margaret Holland, Kamil Kolar, Hubert Chassaigne, Salvatore Tirendi and Herve Schepers









Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells

, 2015; 16(9): 782 - 792

Pier M. Biava, Silvia Canaider, Federica Facchin, Eva Bianconi, Liza Ljungberg, Domenico Rotilio, Fabio Burigana and Carlo Ventura






Most Cited Articles


Novel Therapeutic Targets for Phosphodiesterase 5 Inhibitors: current state-of-the-art on systemic arterial hypertension and atherosclerosis

, 2016; 17(4): 347-364.

Elisardo C. Vasquez, Agata L. Gava, Jones B. Graceli, Camille M. Balarini, Bianca P. Campagnaro, Thiago de Melo C. Pereira and Silvana S. Meyrelles


DOI: 10.2174/1389201017666151223123904



Harnessing Bioinformatics for Designing a Novel Multiepitope Peptide Vaccine Against Breast Cancer

, 2016; 17(12): 1100-1114.

Shirin Mahmoodi, Navid Nezafat, Abolfazl Barzegar, Manica Negahdaripour, Ali R. Nikanfar, Nosratollah Zarghami and Younes Ghasemi


DOI: 10.2174/1389201017666160914191106






Ovarian Stimulation Protocol in IVF: An Up-to-Date Review of the Literature

, 2016; 17(4): 303-315.

Alessandro Pacchiarotti, Helmy Selman, Claudia Valeri, Simona Napoletano, Marco Sbracia, Gabriele Antonini, Giulio Biagiotti and Arianna Pacchiarotti


DOI: 10.2174/1389201017666160118103147




Most Accessed Articles

CAR T-cell Therapy: A New Era in Cancer Immunotherapy

, 2018; 19(1): 5-18.

Androulla N. Miliotou and Lefkothea C. Papadopoulou*


DOI: 10.2174/1389201019666180418095526




Phage Therapy in Clinical Practice: Treatment of Human Infections

, 2010; 11(1): 69-86.

Elizabeth Kutter, Daniel De Vos, Guram Gvasalia, Zemphira Alavidze, Lasha Gogokhia, Sarah Kuhl and Stephen T. Abedon


DOI: 10.2174/138920110790725401


New Developments in Pichia pastoris Expression System, Review and Update

, 2018; 19(6): 451-467.

Roghayyeh Baghban, Safar Farajnia*, Younes Ghasemi, Mojtaba Mortazavi, Nosratollah Zarghami and Naser Samadi


DOI: 10.2174/1389201019666180718093037



HELLP Syndrome: Pathophysiology and Current Therapies

, 2018; 19(10): 816-826.

Kedra Wallace*, Sharonda Harris, Augustina Addison and Cynthia Bean


DOI: 10.2174/1389201019666180712115215



The Impact of Antiepileptic Drugs on Vitamin Levels in Epileptic Patients

, 2018; 19(8): 674-681.

Abdul S. Shaikh, Xi Guo, Yi Li, Lili Cao, Xuewu Liu, Pingli Li, Rui Zhang and Ruichen Guo*


DOI: 10.2174/1389201019666180816104716




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