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Current Molecular Pharmacology

Volume 14, 6 Issues, 2021
ISSN: 1874-4702 (Online)
ISSN: 1874-4672 (Print)
This journal supports open access

Aims & Scope

Current Molecular Pharmacology aims to publish the latest developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of novel drugs under development, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, proteomics, and metabonomics applications to drug action. An additional focus will be the way in which normal biological function is illuminated by knowledge of the action of drugs at the cellular and molecular level. The journal publishes full-length/mini reviews, original research articles and thematic issues on molecular pharmacology.

Current Molecular Pharmacology is an essential journal for every scientist who is involved in drug design and discovery, target identification, target validation, preclinical and clinical development of drugs therapeutically useful in human disease.

Current Molecular Pharmacology

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Volume 14

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Number 2







Review Article (Mini-Review)





Review Article (Mini-Review)









Articles Ahead of Print




Curcumin Efficacy in a Serum/glucose Deprivation-induced Neuronal PC12 Injury Model


Tahereh Farkhondeh, Milad Ashrafizadeh, Mohsen Azimi-Nezhad, Fariborz Samini, Micheal Aschenr and Saeed Samarghandian*


DOI: 10.2174/1874467214666210203211312
View Abstract View on PubMed


Chlorpyrifos with Age-dependent Effects in Cardiac Tissue of Male Rats


Behzad Mesbahzadeh, Hossein Salarjavan, Saeed Samarghandian* and Tahereh Farkhondeh*


DOI: 10.2174/1874467214666210111105321
View Abstract View on PubMed





Intrathecal Administration of Melatonin Ameliorates the Neuroinflammation- mediated Sensory and Motor Dysfunction in A Rat Model of Compression Spinal Cord Injury


Sajad Fakhri*, Amir Kiani, Cyrus Jalili, Fatemeh Abbaszadeh, Sana Piri, Mohammad Hosein Farzaei, Mohsen Rastegari-Pouyani, Ehsan Mohammadi-Noori and Haroon Khan*


DOI: 10.2174/1874467213666201230101811
View Abstract View on PubMed


Hypoxia-inducible factor (HIF): Fuel for Cancer Progression


Saurabh Satija*, Harpreet Kaur*, Murtaza M. Tambuwala, Prabal Sharma, Manish Vyas, Navneet Khurana, Neha Sharma, Hamid A. Bakshi, Nitin B. Charbe, Flavia C Zacconi, Alaa A. Aljabali, Srinivas Nammi, Harish Dureja, Thakur Gurjeet Singh, Gaurav Gupta, Daljeet S. Dhanjal, Kamal Dua, Dinesh Kumar Chellappan* and Meenu Mehta*


DOI: 10.2174/1874467214666210120154929
View Abstract View on PubMed


Abstracts Ahead of Print

Thioacetamide-induced norepinephrine production by hepatocytes is associated with hepatic stellate cell activation and liver fibrosis


Wei-Chien Tang, Ya-Wen Tang, Mingtian Che, Mei-Hui Wang, Keith K. Lai, Patrick T. Fueger, Wendong Huang, Shwu-Bin Lin* and Keane K. Y. Lai*


DOI: 10.2174/1874467214666210412144416
View Abstract


Harnessing the natural pool of polyketide and non-ribosomal peptide family: A route map towards novel drug development


Aiswarya Girija, Mallika Vijayanathan*, Sweda Sreekumar , Jasim Basheer , Tara G Menon, Radhakrishnan Edayileveetil Krishnankutty and Eppurathu Vasudevan Soniya*


DOI: 10.2174/1874467214666210319145816
View Abstract



Nutraceuticals and their Derived Nano-formulations for the Prevention and Treatment of Alzheimer's disease


Ashif Iqubal, Mohammad Kashif Iqubal, Syed Abul Fazal, Faheem Hyder Pottoo and Syed Ehtaishamul Haque*


DOI: 10.2174/1874467214666210309115605
View Abstract


Anticancer Effects of Ginsenoside Rh2: A Systematic Review


Xin-Ling He, Xiao-Huang Xu, Jia-Jie Shi, Mingqing Huang, Yitao Wang, Xiuping Chen and Jin-Jian Lu*


DOI: 10.2174/1874467214666210309115105
View Abstract




Assessment of Antioxidant Effect of Beta-Glucan on the Whole Blood Oxidative DNA Damage with the Comet Assay in Colorectal Cancer


Necla Benlier, Nilay Uçar, Eda Öğüt, Havva Yeşil Çinkir, Mustafa Yildirim, Pınar Günel Karadeniz, Esra Küpeli Akkol*, Haroon Khan and Eyüp Ilker Saygili*


DOI: 10.2174/1874467214666210219145445
View Abstract




Published Contents

Editor's Choice

TRPC3-Based Protein Signaling Complex as a Therapeutic Target of Myocardial Atrophy

, 2021; 14(2): 123 - 131

Kazuhiro Nishiyama, Tomohiro Tanaka, Akiyuki Nishimura and Motohiro Nishida*


DOI: 10.2174/1874467213666200407090121



Molecular Mechanisms Involved in the Progression and Protection of Osteoarthritis

, 2021; 14(2): 165 - 169

Yoshifumi Takahata*, Tomohiko Murakami, Kenji Hata and Riko Nishimura


DOI: 10.2174/1874467213666200417122933




Hepatic Stellate Cell: A Potential Target for Hepatocellular Carcinoma

, 2020; 13(4): 261 - 272

Mengna Wu, Huajie Miao, Rong Fu, Jie Zhang* and Wenjie Zheng *


DOI: 10.2174/1874467213666200224102820




Characterization of a New Positive Allosteric Modulator of AMPA Receptors - PAM-43: Specific Binding of the Ligand and its Ability to Potentiate AMPAR Currents

, 2020; 13(3): 216 - 223

Tatiana V. Vyunova*, Lioudmila A. Andreeva, Konstantin V. Shevchenko, Vladimir V. Grigoriev, Vladimir A. Palyulin, Mstislav I. Lavrov, Ekaterina V. Bondarenko, Elena E. Kalashnikova and Nikolay F. Myasoedov


DOI: 10.2174/1874467213666200303140834



Discovering Therapeutic Protein Targets for Bladder Cancer Using Proteomic Data Analysis

, 2020; 13(2): 150 - 172

Samira Bahrami, Bahram Kazemi*, Hakimeh Zali, Peter C. Black, Abbas Basiri, Mojgan Bandehpour, Mehdi Hedayati and Amirhossein Sahebkar


DOI: 10.2174/1874467212666191016124935






Open Access Articles

Lactoferrin Suppresses Decreased Locomotor Activities by Improving Dopamine and Serotonin Release in the Amygdala of Ovariectomized Rats

, 2021; 14(2): 245 - 252

Nobuo Izumo*, Ishibashi Yukiko, Nobuharu Kagaya, Megumi Furukawa, Rina Iwasaki, Akihide Sumino, Kohsuke Hayamizu, Makoto Nakano, Tatsuo Hoshino, Haruna Kurono, Yasuo Watanabe and Takayuki Manabe*





Nuezhenide Exerts Anti-Inflammatory Activity through the NF-κB Pathway

, 2021; 14(1): 101 - 111

Qin-Qin Wang, Shan Han, Xin-Xing Li, Renyikun Yuan, Youqiong Zhuo, Xinxin Chen, Chenwei Zhang, Yangling Chen, Hongwei Gao*, Li-Chun Zhao* and Shilin Yang




New Insights in Cannabinoid Receptor Structure and Signaling

, 2019; 12(3): 239 - 248

Lingyan Ye, Zheng Cao, Weiwei Wang and Naiming Zhou*





Targeting Chromatin Remodeling for Cancer Therapy

, 2019; 12(3): 215 - 229

Jasmine Kaur, Abdelkader Daoud and Scott T. Eblen*




Mitochondria-Targeted Drugs

, 2019; 12(3): 202 - 214

Roman A. Zinovkin* and Andrey A. Zamyatnin*




A Contemporary Overview of PPARα/γ Dual Agonists for the Management of Diabetic Dyslipidemia

, 2019; 12(3): 195 - 201

Pitchai Balakumar*, Nanjaian Mahadevan and Ramanathan Sambathkumar




Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions

, 2019; 12(3): 184 - 194

Ricardo Jorge Dinis-Oliveira*, Carolina Lança Pereira and Diana Dias da Silva




Anticancer Mechanism of Lobaplatin as Monotherapy and in Combination with Paclitaxel in Human Gastric Cancer

, 2018; 11(4): 316 - 325

Suhang Hua, Xiangyu Kong, Binbin Chen, Wenxin Zhuang, Qian Sun, Wei Yang, Wenzhi Liu* and Yongxing Zhang*





Decoding Corticotropin-Releasing Factor Receptor Type 1 Crystal Structures

, 2017; 10(4): 334 - 344

Andrew S. Dore, Andrea Bortolato, Kaspar Hollenstein, Robert K.Y. Cheng, Randy J. Read and Fiona H. Marshall*






Pharmacology of L-type Calcium Channels: Novel Drugs for Old Targets?

, 2015; 8(2): 110 - 122

Jorg Striessnig, Nadine J. Ortner and Alexandra Pinggera





Most Cited Articles

Research Article

Mir-4319 suppresses the growth of esophageal squamous cell carcinoma via targeting NLRC5

, 2020; 13(2): 144-149.

Xiao Hu, Min Wang, Lei Cao, Li Cong, Yujie Gao, Jianwei Lu, Jifeng Feng, Bo Shen and Delin Liu*


DOI: 10.2174/1874467212666191119094636


Review Article

Melatonin receptor as a drug target for neuroprotection

, 2021; 14(2): 150-164.

Pawaris Wongprayoon and Piyarat Govitrapong*


DOI: 10.2174/1874467213666200421160835


Review Article

Recent updates in the alzheimer’s disease etiopathology and possible treatment approaches: A narrative review of current clinical trials

, 2020; 13(4): 273-294.

Elahe Zarini-Gakiye, Javad Amini, Nima Sanadgol*, Gholamhassan Vaezi and Kazem Parivar


DOI: 10.2174/1874467213666200422090135


Research Article

Discovering therapeutic protein targets for bladder cancer using proteomic data analysis

, 2020; 13(2): 150-172.

Samira Bahrami, Bahram Kazemi*, Hakimeh Zali, Peter C. Black, Abbas Basiri, Mojgan Bandehpour, Mehdi Hedayati and Amirhossein Sahebkar


DOI: 10.2174/1874467212666191016124935



Review Article

The role of autophagy in cancer radiotherapy

, 2020; 13(1): 31-40.

Lei Li, Wen-Ling Liu, Lei Su, Zhou-Cheng Lu and Xiu-Sheng He*


DOI: 10.2174/1874467212666190809154518


Research Article

Oral administration of the food-derived hydrophilic antioxidant ergothioneine enhances object recognition memory in mice

, 2021; 14(2): 220-233.

Noritaka Nakamichi, Shunsuke Nakao, Misa Nishiyama, Yuka Takeda, Takahiro Ishimoto, Yusuke Masuo, Satoshi Matsumoto, Makoto Suzuki and Yukio Kato*


DOI: 10.2174/1874467213666200212102710


Review Article

Hepatic stellate cell: A potential target for hepatocellular carcinoma

, 2020; 13(4): 261-272.

Mengna Wu, Huajie Miao, Rong Fu, Jie Zhang* and Wenjie Zheng *


DOI: 10.2174/1874467213666200224102820


Review Article

Therapeutic promises of chlorogenic acid with special emphasis on its anti-obesity property

, 2020; 13(1): 7-16.

Rajnish Kumar, Anju Sharma, Mohammed Shariq Iqbal and Janmejai K. Srivastava*


DOI: 10.2174/1874467212666190716145210



Research Article

Circrna 001418 promoted cell growth and metastasis of bladder carcinoma via epha2 by mir-1297

, 2021; 14(1): 68-78.

Guorui Peng, Hongxue Meng, Hongxin Pan and Wentao Wang*


DOI: 10.2174/1874467213666200505093815



Review Article

2-aminoethyldiphenyl borinate: A multitarget compound with potential as a drug precursor

, 2020; 13(1): 57-75.

Melvin N. Rosalez, Elizabeth Estevez-Fregoso, Alberto Alatorre, Antonio Abad-García* and Marvin A. Soriano-Ursúa*


DOI: 10.2174/1874467212666191025145429


Review Article (Mini-Review)

TRPC3-based protein signaling complex as a therapeutic target of myocardial atrophy

, 2021; 14(2): 123-131.

Kazuhiro Nishiyama, Tomohiro Tanaka, Akiyuki Nishimura and Motohiro Nishida*


DOI: 10.2174/1874467213666200407090121


Review Article (Mini-Review)

Actions of alcohol in brain: Genetics, metabolomics, gaba receptors, proteomics and glutamate transporter glast/eaat1

, 2021; 14(2): 138-149.

Mohammed Abul Kashem, Omar Šerý, David V. Pow, Benjamin D. Rowlands, Caroline D. Rae and Vladimir J. Balcar*


DOI: 10.2174/1874467213666200424155244



Most Accessed Articles




Nuezhenide Exerts Anti-Inflammatory Activity through the NF-κB Pathway

, 2021; 14(1): 101-111.

Qin-Qin Wang, Shan Han, Xin-Xing Li, Renyikun Yuan, Youqiong Zhuo, Xinxin Chen, Chenwei Zhang, Yangling Chen, Hongwei Gao*, Li-Chun Zhao* and Shilin Yang


DOI: 10.2174/1874467213666200611141337


FAT10: Function and Relationship with Cancer

, 2020; 13(3): 182-191.

Senfeng Xiang, Xuejing Shao, Ji Cao, Bo Yang, Qiaojun He* and Meidan Ying*


DOI: 10.2174/1874467212666191113130312


Protective Potential of Ginkgo biloba Against an ADHD-like Condition

, 2021; 14(2): 200-209.

Garima Sharma, Naveen Sharma, Bao Trong Nguyen, Ji Hoon Jeong, Seung-Yeol Nah, Yukio Yoneda, Eun-Joo Shin and Hyoung-Chun Kim*


DOI: 10.2174/1874467213666200424152454


miR-18a-3p Encourages Apoptosis of Chondrocyte in Osteoarthritis via HOXA1 Pathway

, 2020; 13(4): 328-341.

Baiyang Ding, Shujuan Xu, Xiumin Sun, Jianming Gao, Wenlei Nie and Hongguang Xu *


DOI: 10.2174/1874467213666200204143740


Lactoferrin Suppresses Decreased Locomotor Activities by Improving Dopamine and Serotonin Release in the Amygdala of Ovariectomized Rats

, 2021; 14(2): 245-252.

Nobuo Izumo*, Ishibashi Yukiko, Nobuharu Kagaya, Megumi Furukawa, Rina Iwasaki, Akihide Sumino, Kohsuke Hayamizu, Makoto Nakano, Tatsuo Hoshino, Haruna Kurono, Yasuo Watanabe and Takayuki Manabe*


DOI: 10.2174/1570163817666200430002937



Valproic acid, A Potential Inducer of Osteogenesis in Mouse Mesenchymal Stem Cells

, 2021; 14(1): 27-35.

Narayanan Akshaya, Prakash Prasith, Balakrishnan Abinaya, Badrinath Ashwin, S.V. Chandran and Nagarajan Selvamurugan*


DOI: 10.2174/1874467213666200713102410


Interleukin-19 as an Immunoregulatory Cytokine

, 2021; 14(2): 191-199.

Yasuyuki Fujimoto, Nobuyuki Kuramoto, Masanori Yoneyama and Yasu-Taka Azuma*


DOI: 10.2174/1874467213666200424151528



Evaluation of the Effects of 1,25 Vitamin D3 on Regulatory T Cells and T Helper 17 Cells in Vitamin D-deficient Women with Unexplained Recurrent Pregnancy Loss

, 2020; 13(4): 306-317.

Elham Abdollahi, Seyed Abdolrahim Rezaee, Nafiseh Saghafi, Maryam Rastin, Vicki Clifton, Amirhossein Sahebkar and Houshang Rafatpanah*


DOI: 10.2174/1874467213666200303130153





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