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Current Molecular Medicine

Volume 19, 10 Issues, 2019
ISSN: 1875-5666 (Online)
ISSN: 1566-5240 (Print)
This journal supports open access

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  • 84th of 136 in

    Medicine, Research & Experimental

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Aims & Scope

Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews/ mini-reviews, original research articles, short communications/letters and drug clinical trial studies on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal invites guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.

Current Molecular Medicine

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Volume 19

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Number 6



Review Article



Research Article



Research Article



Research Article

Molecular Investigations of the Newly Synthesized Azomethines as Antioxidants: Theoretical and Experimental Studies

, 19(6): 419 - 433

Siyamak Shahab, Masoome Sheikhi*, Liudmila Filippovich, Evgenij Dikusar, Anhelina Pazniak, Morteza Rouhani and Rakesh Kumar


DOI: 10.2174/1566524019666190509102620


Research Article

Inhibition of Experimental Age-Related Macular Degeneration by ZQMT in Mice

, 19(6): 434 - 442

Liu Yang*, Huan Meng*, Dan Luo, Tingting Deng, Li Miao, Bin Zou, Xiaofei Ge, Xiao Hu, Yu Liu, Xifang Li, Xiuli Deng, Shixin Guo, Juanran Liang, Tingting Chen, Xiaofeng Wen, Jing Jing Li, Lai Wei and Ming Jin


DOI: 10.2174/1566524019666190425195706


Research Article



Research Article



Articles Ahead of Print

The Effect of Interleukin 38 on Inflammation-induced Corneal Neovascularization


Jiangli Zhu, Jing Zhang, Yan Wang, Jianping Chen, Xiaopeng Li, Xiangling Liu, Eryan Kong, Shao Bo Su* and Zhongjian Zhang*


DOI: 10.2174/1566524019666190627122655
View Abstract View on PubMed




Stem Cells as a Resource for Treatment of Infertility-related Diseases


Jing Wang, Chi Liu, Masayuki Fujino, Guoqing Tong, Qinxiu Zhang, Xiao-Kang Li* and Hua Yan*


DOI: 10.2174/1566524019666190709172636
View Abstract View on PubMed



Role of Polymorphisms of FAM13A, PHLDB1, and CYP24A1 in Breast Cancer Risk


Ying Wei*, Xiaolin Wang*, Zhe Zhang, Mingrui Xie, Yuyao Li, Hongxin Cao and Xinhan Zhao


DOI: 10.2174/1566524019666190619125109
View Abstract View on PubMed


Isothermal Amplification Methods for the SNP Genotyping


S. Heidari Sharafdarkolaee, P. Gill*, M. Motovali-Bashi and F. Heidari Sharafdarkolaee


DOI: 10.2174/1566524019666190527083947
View Abstract View on PubMed




Homocysteine Serum Levels as Prognostic Marker of Hepatocellular Carcinoma with Portal Vein Thrombosis


Saverio Latteri, Giulia Malaguarnera, Vito Emanuele Catania*, Gaetano La Greca, Gaetano Bertino, Antonio Maria Borzì, Filippo Drago and Michele Malaguarnera


DOI: 10.2174/1566524019666190610120416
View Abstract


Abstracts Ahead of Print

Diabetic hemodialysis: vitamin D supplementation and its related signaling pathways involved in insulin and lipid metabolism


Elahe Seyed Hosseini, Hamed Haddad Kashani, Hossein Nikzad, Alireza Soleimani, Hamed Mirzaei, Mohammd Reza Tamadon and Zatollah Asemi*


DOI: 10.2174/1566524019666190618144712
View Abstract


A Rare Variant Which Interfered with Interleukin 15 Receptor alpha Signal Transduction Exists in Schizophrenia Patients


Yanli Pan, Zhimin Wang, Guangping Zhang, Junhua Guo, Xuequan Zhu, Jia Zhou, Zhenrong Zhang, Zuoli Sun, Jian Yang, Abba J. Kastin, Weihong Pan, Xiaojun Wu, Jianliang Zhang, Xiaomin Wang, Chuanyue Wang and Yi He*


DOI: 10.2174/1566524019666190617172054
View Abstract


Published Contents

Editor's Choice


Altered Expression Patterns of the Sumoylation Enzymes E1, E2 and E3 Are Associated with Glucose Oxidase- and UVA-Induced Cataractogenesis

, 2018; 18(8): 542 - 549

Qian Nie, Ling Wang , Xiaodong Gong, Jia-Wen Xiang, Yuan Xiao, Jie Xie, Lan Yang, Huimin Chen, Yuwen Gan, Zhigang Chen and David Wan-Cheng Li*


DOI: 10.2174/1566524019666190111152324



Generation of a Primary Hyperoxaluria Type 1 Disease Model Via CRISPR/Cas9 System in Rats

, 2018; 18(7): 436 - 447

Rui Zheng, Xiaoliang Fang, Lei He, Yanjiao Shao, Nana Guo, Liren Wang, Mingyao Liu, Dali Li* and Hongquan Geng*


DOI: 10.2174/1566524019666181212092440



Digitoxin Suppresses Store Operated Calcium Entry by Modulating Phosphorylation and the Pore Region of Orai1

, 2018; 18(6): 392 - 399

Lijuan Zhou, Xiangxiang Chi, Yaping Zhu, Tian Zhang, Jindou Liu, Guolin Ma, Lian He, Shuce Zhang, Ping Gao, Yubin Zhou*, Jin Liu* and Youjun Wang


DOI: 10.2174/1566524018666181113111316



Hypoxia-Induced Caveolin-1 Expression Promotes Migration and Invasion of Tumor Cells

, 2018; 18(4): 199 - 206

J. Castillo Bennett, P. Silva, S. Martinez, V.A. Torres* and A.F.G. Quest*


DOI: 10.2174/1566524018666180926163218







Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment

, 2017; 17(10): 668 - 688

N.M. Salkho, R.Z. Turki, O. Guessoum, A.M. Martins, R.F. Vitor and G.A. Husseini*


DOI: 10.2174/1566524018666180416100142



Open Access Articles

Attenuation of Cardiac Ischaemia-reperfusion Injury by Treatment with Hydrogen-rich Water

, 2019; 19(4): 294 - 302

Xiangzi Li, Liangtong Li, Xuanchen Liu, Jiawen Wu, Xiaoyu Sun, Zhilin Li, Yong-Jian Geng, Fulin Liu* and Yujuan Zhou*




Naoxintong Retards Atherosclerosis by Inhibiting Foam Cell Formation Through Activating Pparα Pathway

, 2018; 18(10): 698 - 710

Zeng Wang, Huairui Shi, Huan Zhao, Zhen Dong, Buchang Zhao, Xinyu Weng, Rongle Liu, Xiao Li, Kai Hu, Yunzeng Zou, Aijun Sun* and Junbo Ge *







Oxidative Stress in Cerebral Small Vessel Disease Dizziness Patients, Basally and After Polyphenol Compound Supplementation

, 2018; 18(3): 160 - 165

L. Ulivi, M. Maccarrone, N. Giannini, E. Ferrari, M.C. Caselli, V. Montano, L. Chico, A. Casani, E. Navari, N. Cerchiai, G. Siciliano, U. Bonuccelli and M. Mancuso*




Decreased Expression of TIM-3 on Th17 Cells Associated with Ophthalmopathy in Patients with Graves’ Disease

, 2018; 18(2): 83 - 90

J. Zhao, B. Lin, H. Deng, X. Zhi, Y. Li, Y. Liu, P.W. Bible, Q. Li, B. Xu, L. Wei, H. Yang* and D. Huang*




ZNF424 Induces Apoptosis and Inhibits Proliferation in Lung Carcinoma Cells

, 2018; 18(2): 109 - 115

W. Liu, W. Yuan, X. Li, J. Zhuang, X. Mo, G. Dai, Y. Wang, J. Chen, Y. Wan, Y. Li, X. Zhu, Y. Chen, S. Luo, Z. Jiang, Y. Shi, F. Chen, L. Cao, X. Ye, X. Fan*, P. Zhu*, K. Zhang* and X. Wu*




Decreased Expression of MYPT1 Contributes to Tumor Angiogenesis and Poor Patient Prognosis in Human Prostate Cancer

, 2018; 18(2): 100 - 108

Y. Liang, Y. Zhuo, Z. Lin, F. Jiang, Q. Dai, J. Lu, W. Dong, X. Zhu, Z. Han* and W. Zhong*






Role of Zebrafish fhl1A in Satellite Cell and Skeletal Muscle Development

, 2017; 17(9): 627 - 636

F. Chen, W. Yuan, X. Mo, J. Zhuang, Y. Wang, J. Chen, Z. Jiang, X. Zhu, Q. Zeng, Y. Wan, F. Li, Y. Shi, L. Cao, X. Fan, S. Luo, X. Ye, Y. Chen, G. Dai, J. Gao, X. Wang, H. Xie*, P. Zhu*, Y. Li* and X. Wu*




The bHLH Protein Nulp1 is Essential for Femur Development Via Acting as a Cofactor in Wnt Signaling in Drosophila

, 2017; 17(7): 509 - 517

Q. Zeng, Y. Wan, P. Zhu, M. Zhao, F. Jiang, J. Chen, M. Tang, X. Zhu, Y. Li, H. Zha, Y. Wang, M. Hu, X. Mo, Y. Zhang, Y. Chen, Y. Chen, X. Ye, R. Bodmer, K. Ocorr, Z. Jiang*, J. Zhuang*, W. Yuan* and X. Wu*







Most Cited Articles

Review Article

Role of HIF-1 in cancer progression: Novel insights. a review

, 2018; 18(6): 343-351.

Aldo Pezzuto* and Elisabetta Carico


DOI: 10.2174/1566524018666181109121849


Research Article

Differential expression of sumoylation enzymes sae1, U BA2, UBC9, PIAS1 AND RanBP2 in major ocular tissues of mouse eye

, 2018; 18(6): 376-382.

Qian Nie*, Lan Yang*, Wenjie Qing*, Jie Xie, Xiaodong Gong, Huimin Chen, Yuwen Gan, Ling Wang, Jia-Wen Xiang, Yuan Xiao, Zhigang Chen and David Wan-Cheng Li*


DOI: 10.2174/1566524018666181116112208


Review Article

Advances in tumor targeted liposomes

, 2018; 18(1): 44-57.

A. Jain and S.K. Jain*


DOI: 10.2174/1566524018666180416101522


Research Article

Decreased expression of TIM-3 on TH17 cells associated with ophthalmopathy in patients with graves’ disease

, 2018; 18(2): 83-90.

J. Zhao, B. Lin, H. Deng, X. Zhi, Y. Li, Y. Liu, P.W. Bible, Q. Li, B. Xu, L. Wei, H. Yang* and D. Huang*


DOI: 10.2174/1566524018666180705105753


Research Article

Decreased expression of MYPT1 contributes to tumor angiogenesis and poor patient prognosis in human prostate cancer

, 2018; 18(2): 100-108.

Y. Liang, Y. Zhuo, Z. Lin, F. Jiang, Q. Dai, J. Lu, W. Dong, X. Zhu, Z. Han* and W. Zhong*


DOI: 10.2174/1566524018666180705111342



Research Article

The sumoylation modulated tumor suppressor p <sup>53</sup> regulates cell cycle checking genes to mediate lens differentiation

, 2018; 18(8): 556-565.

Xiangcheng Tang, Zhigang Chen, Mi Deng, Ling Wang, Qian Nie, Jia-Wen Xiang, Yuan Xiao, Lan Yang, Yizhi Liu* and David Wan-Cheng Li*


DOI: 10.2174/1566524019666190111154450


Research Article

Localization patterns of sumoylation enzymes e1, e2 and e3 in ocular cell lines predict their functional importance

, 2018; 18(8): 516-522.

Xiaodong Gong, Qian Nie, Yuan Xiao, Jia-Wen Xiang, Ling Wang, Fangyuan Liu, Jia-Ling Fu, Yunfei Liu, Lan Yang, Yuwen Gan, Huimin Chen, Zhongwen Luo, Ruili Qi, Zhigang Chen, Xiangcheng Tang and David Wan-Cheng Li*


DOI: 10.2174/1566524019666190112144436


Research Article

Localization analysis of seven de-sumoylation enzymes (Senps) in ocular cell lines

, 2018; 18(8): 523-532.

Yunfei Liu, Fangyuan Liu, Ling Wang, Jia-Ling Fu, Zhong-Wen Luo, Qian Nie, Xiao-Dong Gong, Jia-Wen Xiang, Yuan Xiao and David Wan-Cheng Li*


DOI: 10.2174/1566524019666190112142025


Research Article

Differential expression of seven de-sumoylation enzymes (Senps) in major ocular tissues of mouse eye

, 2018; 18(8): 533-541.

Jia-Wen Xiang, Lan Zhang, Xiangcheng Tang, Yuan Xiao, Yunfei Liu, Ling Wang, Fangyuan Liu, Xiao-Dong Gong, Jia-Ling Fu, Lan Yang, Zhongwen Luo and David Wan-Cheng Li*


DOI: 10.2174/1566524019666190112132103


Research Article

Analysis of the differential expression patterns of sumoylation enzymes e1, e2 and e3 in ocular cell lines

, 2018; 18(8): 509-515.

Qian Nie, Jie Xie, Xiaodong Gong, Zhongwen Luo, Ling Wang, Fangyuan Liu, Jia-Wen Xiang, Yuan Xiao, Jia-Ling Fu, Yunfei Liu, Zhigang Chen, Lan Yang, Huimin Chen, Yuwen Gan and David Wan-Cheng Li*


DOI: 10.2174/1566524019666190112143636


Research Article

Analysis of non-sumoylated and sumoylated isoforms of pax-6 the master regulator for eye and brain development in ocular cell lines

, 2018; 18(8): 566-573.

Fangyuan Liu, Ling Wang, Jia-Ling Fu, Yuan Xiao, Xiaodong Gong, Yunfei Liu, Qian Nie, Jia-Wen Xiang, Lan Yang, Zhigang Chen, Yizhi Liu* and David Wan-Cheng Li*


DOI: 10.2174/1566524019666190111153310


Research Article

Sodium iodate-induced mouse model of age-related macular degeneration displayed altered expression patterns of sumoylation enzymes e1, e2 and e3

, 2018; 18(8): 550-555.

Qian Nie, Xiaodong Gong, Lili Gong, Lan Zhang, Xiangcheng Tang, Ling Wang, Fangyuan Liu, Jia-ling Fu, Jia-Wen Xiang, Yuan Xiao, Zhongwen Luo, Ruili Qi, Zhigang Chen, Yunfei Liu, Qian Sun, Wenjie Qing, Lan Yang, Jie Xie, Ming Zou, Yuwen Gan, Huimin Chen and David Wan-Cheng Li*


DOI: 10.2174/1566524019666190112101147


Research Article

Altered expression patterns of the sumoylation enzymes e1, e2 and e3 are associated with glucose oxidase- and uva-induced cataractogenesis

, 2018; 18(8): 542-549.

Qian Nie, Ling Wang , Xiaodong Gong, Jia-Wen Xiang, Yuan Xiao, Jie Xie, Lan Yang, Huimin Chen, Yuwen Gan, Zhigang Chen and David Wan-Cheng Li*


DOI: 10.2174/1566524019666190111152324


Research Article

ZNF424 induces apoptosis and inhibits proliferation in lung carcinoma cells

, 2018; 18(2): 109-115.

W. Liu, W. Yuan, X. Li, J. Zhuang, X. Mo, G. Dai, Y. Wang, J. Chen, Y. Wan, Y. Li, X. Zhu, Y. Chen, S. Luo, Z. Jiang, Y. Shi, F. Chen, L. Cao, X. Ye, X. Fan*, P. Zhu*, K. Zhang* and X. Wu*


DOI: 10.2174/1566524018666180705113642



Most Accessed Articles

Blood Flow Regulates Zebrafish Caudal Vein Plexus Angiogenesis by ERK5-klf2a-nos2b Signaling

, 2018; 18(1): 3-14.

X. Xie, T. Zhou, Y. Wang, H. Chen, D. Lei, L. Huang, Y. Wang, X. Jin, T. Sun, J. Tan, T. Yin, J. Huang, H. Gregersen and G. Wang*


DOI: 10.2174/1566524018666180322153432




Negative Correlation Between Serum Levels of Homocysteine and Apolipoprotein M

, 2019; 19(2): 120-126.

J. Wei, Y. Yu, Y. Feng, J. Zhang, Q. Jiang, L. Zheng, X. Zhang, N. Xu and G. Luo*


DOI: 10.2174/1566524019666190308115624


Serotonin and Cancer: What Is the Link?

, 2015; 15(1): 62-77.

D. Sarrouilhe, J. Clarhaut, N. Defamie and M. Mesnil


DOI: 10.2174/1566524015666150114113411


Identifying the Potential Substrates of the Depalmitoylation Enzyme Acyl-protein Thioesterase 1

, 2019; 19(5): 364-375.

Huicong Liu, Peipei Yan, Junyan Ren, Can Wu, Wei Yuan, Muding Rao, Zhongjian Zhang* and Eryan Kong*


DOI: 10.2174/1566524019666190325143412


DREADD in Parvalbumin Interneurons of the Dentate Gyrus Modulates Anxiety, Social Interaction and Memory Extinction

, 2016; 16(1): 91-102.

D. Zou, L. Chen, D. Deng, D. Jiang, F. Dong, C. McSweeney, Y. Zhou, L. Liu, G. Chen, Y. Wu and Y. Mao


DOI: 10.2174/1566524016666151222150024



Stew in its Own Juice: Protein Homeostasis Machinery Inhibition Reduces Cell Viability in Multiple Myeloma Cell Lines

, 2019; 19(2): 112-119.

Mariana B. de Oliveira, Luiz F.G. Sanson, Angela I.P. Eugenio, Rebecca S.S. Barbosa-Dantas and Gisele W.B. Colleoni*


DOI: 10.2174/1566524019666190305134441




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