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Current Molecular Medicine

Volume 19, 10 Issues, 2019
ISSN: 1875-5666 (Online)
ISSN: 1566-5240 (Print)
This journal supports open access

Aims & Scope

Current Molecular Medicine is an interdisciplinary journal focused on providing the readership with current and comprehensive reviews/ mini-reviews, original research articles, short communications/letters and drug clinical trial studies on fundamental molecular mechanisms of disease pathogenesis, the development of molecular-diagnosis and/or novel approaches to rational treatment. The reviews should be of significant interest to basic researchers and clinical investigators in molecular medicine. Periodically the journal invites guest editors to devote an issue on a basic research area that shows promise to advance our understanding of the molecular mechanism(s) of a disease or has potential for clinical applications.

Current Molecular Medicine

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Volume 19

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Number 2



Review Article



Research Article



Research Article

Diagnostic Value of Non-Invasive Prenatal Screening of β-thalassemia by Cell Free Fetal DNA and Fetal NRBC

, 19(2): 105 - 111

Nadia Shafei, Mohammad Saeed Hakhamaneshi*, Massoud Houshmand, Siavash Gerayeshnejad, Fardin Fathi and Sardar Sharifzadeh


DOI: 10.2174/1566524019666190226124135


Research Article

Stew in its Own Juice: Protein Homeostasis Machinery Inhibition Reduces Cell Viability in Multiple Myeloma Cell Lines

, 19(2): 112 - 119

Mariana B. de Oliveira, Luiz F.G. Sanson, Angela I.P. Eugenio, Rebecca S.S. Barbosa-Dantas and Gisele W.B. Colleoni*


DOI: 10.2174/1566524019666190305134441


Research Article

Negative Correlation Between Serum Levels of Homocysteine and Apolipoprotein M

, 19(2): 120 - 126

J. Wei, Y. Yu, Y. Feng, J. Zhang, Q. Jiang, L. Zheng, X. Zhang, N. Xu and G. Luo*


DOI: 10.2174/1566524019666190308115624


Research Article



Research Article



Research Article



Current Molecular Medicine, Volume 19 (2019) - Number 4


This issue is in progress but contains articles that are final and fully citable.

Current Molecular Medicine, Volume 19 (2019) - Number 3


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Molecular and Clinical Investigations on Portuguese Patients with Multiple acyl-CoA Dehydrogenase Deficiency


Bárbara J. Henriques, Tânia G. Lucas, Esmeralda Martins, Ana Gaspar, Anabela Bandeira, Célia Nogueira, Otilia Brandão, Hugo Rocha, Laura Vilarinho* and Cláudio M. Gomes


View Abstract




Inhibition of Experimental Age-Related Macular Degeneration by ZQMT in Mice


Liu Yang, H. Meng, T. Deng, L. Miao, B. Zou, X. Ge, X. Hu, Y. Liu, X. Li, X. Deng, S. Guo, J. Liang, T. Chen, X. Wen, J. J. Li, L. Wei* and M. Jin


View Abstract



Inhibition of SOX15 Sensitizes Esophageal Squamous Carcinoma Cells to Paclitaxel


Ming Zhang, Jianying Wang, Tianwei Gao, Xin Chen, Yan Xu, Xiaoting Yu, Xianyang Guo, Rong Zhuang, Ziwei Li, Hongjin Wu* and Juehua Yu*


View Abstract View on PubMed


FoxF1 is Required for Ciliogenesis and Distribution of Sonic Hedgehog Signaling Components in Cilium


Lu Huang, Marco Tjakra, Desha Luo, Lin Wen, Daoxi Lei, Jinxuan Wang, Tieying Yin, Xiaojuan Zhang, Junli Huang, Yeqi Wang* and Guixue Wang*


View Abstract View on PubMed


Assessment of the Effect of Baicalin on Duck Virus Hepatitis


Yun Chen, Fangke Yao, Ke Ming, Jintong Shi, Ling Zeng, Deyun Wang, Yi Wu, Yuanliang Hu and Jiaguo Liu*


View Abstract View on PubMed



Identifying the Potential Substrates of the Depalmitoylation Enzyme Acyl-protein Thioesterase 1


Huicong Liu, Peipei Yan, Junyan Ren, Can Wu, Wei Yuan, Muding Rao, Zhongjian Zhang* and Eryan Kong*


View Abstract View on PubMed


Abstracts Ahead of Print

Molecular Investigations of the New Synthesized Azomethines as Antioxidants: Theoretical and Experimental Studies


Siyamak Shahab, Masoome Sheikhi, Liudmila Filippovich, Evgenij Dikusar, Morteza Rouhani, Anhelina Pazniak and Rakesh Kumar


View Abstract




Dopaminergic genes polymorphisms and prefrontal cortex efficiency among obese people - whether gender is a differentiating factor?


Maciej Bieliński*, Natalia Lesiewska, Roman Junik, Anna Kamińska, Andrzej Tretyn and Alina Borkowska


View Abstract


Published Contents

Editor's Choice


Altered Expression Patterns of the Sumoylation Enzymes E1, E2 and E3 Are Associated with Glucose Oxidase- and UVA-Induced Cataractogenesis

, 2018; 18(8): 542 - 549

Qian Nie, Ling Wang , Xiaodong Gong, Jia-Wen Xiang, Yuan Xiao, Jie Xie, Lan Yang, Huimin Chen, Yuwen Gan, Zhigang Chen and David Wan-Cheng Li*


DOI: 10.2174/1566524019666190111152324



Generation of a Primary Hyperoxaluria Type 1 Disease Model Via CRISPR/Cas9 System in Rats

, 2018; 18(7): 436 - 447

Rui Zheng, Xiaoliang Fang, Lei He, Yanjiao Shao, Nana Guo, Liren Wang, Mingyao Liu, Dali Li* and Hongquan Geng*


DOI: 10.2174/1566524019666181212092440



Digitoxin Suppresses Store Operated Calcium Entry by Modulating Phosphorylation and the Pore Region of Orai1

, 2018; 18(6): 392 - 399

Lijuan Zhou, Xiangxiang Chi, Yaping Zhu, Tian Zhang, Jindou Liu, Guolin Ma, Lian He, Shuce Zhang, Ping Gao, Yubin Zhou*, Jin Liu* and Youjun Wang


DOI: 10.2174/1566524018666181113111316



Hypoxia-Induced Caveolin-1 Expression Promotes Migration and Invasion of Tumor Cells

, 2018; 18(4): 199 - 206

J. Castillo Bennett, P. Silva, S. Martinez, V.A. Torres* and A.F.G. Quest*


DOI: 10.2174/1566524018666180926163218







Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment

, 2017; 17(10): 668 - 688

N.M. Salkho, R.Z. Turki, O. Guessoum, A.M. Martins, R.F. Vitor and G.A. Husseini*


DOI: 10.2174/1566524018666180416100142



Open Access Articles

Naoxintong Retards Atherosclerosis by Inhibiting Foam Cell Formation Through Activating Pparα Pathway

, 2018; 18(10): 698 - 710

Zeng Wang, Huairui Shi, Huan Zhao, Zhen Dong, Buchang Zhao, Xinyu Weng, Rongle Liu, Xiao Li, Kai Hu, Yunzeng Zou, Aijun Sun* and Junbo Ge *






Oxidative Stress in Cerebral Small Vessel Disease Dizziness Patients, Basally and After Polyphenol Compound Supplementation

, 2018; 18(3): 160 - 165

L. Ulivi, M. Maccarrone, N. Giannini, E. Ferrari, M.C. Caselli, V. Montano, L. Chico, A. Casani, E. Navari, N. Cerchiai, G. Siciliano, U. Bonuccelli and M. Mancuso*




Decreased Expression of TIM-3 on Th17 Cells Associated with Ophthalmopathy in Patients with Graves’ Disease

, 2018; 18(2): 83 - 90

J. Zhao, B. Lin, H. Deng, X. Zhi, Y. Li, Y. Liu, P.W. Bible, Q. Li, B. Xu, L. Wei, H. Yang* and D. Huang*




ZNF424 Induces Apoptosis and Inhibits Proliferation in Lung Carcinoma Cells

, 2018; 18(2): 109 - 115

W. Liu, W. Yuan, X. Li, J. Zhuang, X. Mo, G. Dai, Y. Wang, J. Chen, Y. Wan, Y. Li, X. Zhu, Y. Chen, S. Luo, Z. Jiang, Y. Shi, F. Chen, L. Cao, X. Ye, X. Fan*, P. Zhu*, K. Zhang* and X. Wu*




Decreased Expression of MYPT1 Contributes to Tumor Angiogenesis and Poor Patient Prognosis in Human Prostate Cancer

, 2018; 18(2): 100 - 108

Y. Liang, Y. Zhuo, Z. Lin, F. Jiang, Q. Dai, J. Lu, W. Dong, X. Zhu, Z. Han* and W. Zhong*






Role of Zebrafish fhl1A in Satellite Cell and Skeletal Muscle Development

, 2017; 17(9): 627 - 636

F. Chen, W. Yuan, X. Mo, J. Zhuang, Y. Wang, J. Chen, Z. Jiang, X. Zhu, Q. Zeng, Y. Wan, F. Li, Y. Shi, L. Cao, X. Fan, S. Luo, X. Ye, Y. Chen, G. Dai, J. Gao, X. Wang, H. Xie*, P. Zhu*, Y. Li* and X. Wu*




The bHLH Protein Nulp1 is Essential for Femur Development Via Acting as a Cofactor in Wnt Signaling in Drosophila

, 2017; 17(7): 509 - 517

Q. Zeng, Y. Wan, P. Zhu, M. Zhao, F. Jiang, J. Chen, M. Tang, X. Zhu, Y. Li, H. Zha, Y. Wang, M. Hu, X. Mo, Y. Zhang, Y. Chen, Y. Chen, X. Ye, R. Bodmer, K. Ocorr, Z. Jiang*, J. Zhuang*, W. Yuan* and X. Wu*






Proteotoxic Stress Desensitizes TGF-beta Signaling Through Receptor Downregulation in Retinal Pigment Epithelial Cells

, 2017; 17(3): 189 - 199

X. Tan, C. Chen, Y. Zhu, J. Deng, X. Qiu, S. Huang, F. Shang, B. Cheng* and Y. Liu*






Most Cited Articles

Research Article

Differential expression of sumoylation enzymes sae1, U BA2, UBC9, PIAS1 AND RanBP2 in major ocular tissues of mouse eye

, 2018; 18(6): 376-382.

Qian Nie*, Lan Yang*, Wenjie Qing*, Jie Xie, Xiaodong Gong, Huimin Chen, Yuwen Gan, Ling Wang, Jia-Wen Xiang, Yuan Xiao, Zhigang Chen and David Wan-Cheng Li*


DOI: 10.2174/1566524018666181116112208


Review Article

Advances in tumor targeted liposomes

, 2018; 18(1): 44-57.

A. Jain and S.K. Jain*


DOI: 10.2174/1566524018666180416101522


Review Article

Role of HIF-1 in cancer progression: Novel insights. a review

, 2018; 18(6): 343-351.

Aldo Pezzuto* and Elisabetta Carico


DOI: 10.2174/1566524018666181109121849


Research Article

Decreased expression of TIM-3 on TH17 cells associated with ophthalmopathy in patients with graves’ disease

, 2018; 18(2): 83-90.

J. Zhao, B. Lin, H. Deng, X. Zhi, Y. Li, Y. Liu, P.W. Bible, Q. Li, B. Xu, L. Wei, H. Yang* and D. Huang*


DOI: 10.2174/1566524018666180705105753




Research Article

Decreased expression of MYPT1 contributes to tumor angiogenesis and poor patient prognosis in human prostate cancer

, 2018; 18(2): 100-108.

Y. Liang, Y. Zhuo, Z. Lin, F. Jiang, Q. Dai, J. Lu, W. Dong, X. Zhu, Z. Han* and W. Zhong*


DOI: 10.2174/1566524018666180705111342


Research Article

Genetic modifiers of fetal haemoglobin (HbF) and phenotypic severity in β-thalassemia patients

, 2018; 18(5): 295-305.

S.A.A. Razak, N.A.A. Murad*, F. Masra, D.L.S. Chong, N. Abdullah, N. Jalil, H. Alauddin, R.Z.A.R. Sabudin, A. Ithnin, L.C. Khai, N.A. Aziz, Z. Muda, H. Ibrahim and Z.A. Latiff*


DOI: 10.2174/1566524018666181004121604




Research Article

Blood flow regulates zebrafish caudal vein plexus angiogenesis by ERK5-klf2a-nos2b signaling

, 2018; 18(1): 3-14.

X. Xie, T. Zhou, Y. Wang, H. Chen, D. Lei, L. Huang, Y. Wang, X. Jin, T. Sun, J. Tan, T. Yin, J. Huang, H. Gregersen and G. Wang*


DOI: 10.2174/1566524018666180322153432




Research Article

The sumoylation modulated tumor suppressor p <sup>53</sup> regulates cell cycle checking genes to mediate lens differentiation

, 2018; 18(8): 556-565.

Xiangcheng Tang, Zhigang Chen, Mi Deng, Ling Wang, Qian Nie, Jia-Wen Xiang, Yuan Xiao, Lan Yang, Yizhi Liu* and David Wan-Cheng Li*


DOI: 10.2174/1566524019666190111154450


Research Article

Cystathionine β-synthase induces multidrug resistance and metastasis in hepatocellular carcinoma

, 2018; 18(7): 496-506.

Lupeng Wang, Huanxiao Hannawi, Ya Liu, Xiuli Zhang, Xiaoyan Shi and Tianxiao Wang*


DOI: 10.2174/1566524019666181211162754



Most Accessed Articles

Spinal Muscular Atrophy: More than a Disease of Motor Neurons?

, 2016; 16(9): 779-792.

L. A. Nash, J. K. Burns, J. Warman Chardon, R. Kothary and R. J. Parks


DOI: 10.2174/1566524016666161128113338


Serotonin and Cancer: What Is the Link?

, 2015; 15(1): 62-77.

D. Sarrouilhe, J. Clarhaut, N. Defamie and M. Mesnil


DOI: 10.2174/1566524015666150114113411


VEGFR2 and VEGF-C Suppresses the Epithelial-Mesenchymal Transition Via YAP in Retinal Pigment Epithelial Cells

, 2018; 18(5): 273-286.

Y. Du, Q. Chen, L. Huang, S. Wang, X. Yin, L. Zhou, Z. Ye, X. Ren, Y. Cai, X. Ding, H. Ouyang, X. Li* and R. Ju*


DOI: 10.2174/1566524018666181004115304


Blood Flow Regulates Zebrafish Caudal Vein Plexus Angiogenesis by ERK5-klf2a-nos2b Signaling

, 2018; 18(1): 3-14.

X. Xie, T. Zhou, Y. Wang, H. Chen, D. Lei, L. Huang, Y. Wang, X. Jin, T. Sun, J. Tan, T. Yin, J. Huang, H. Gregersen and G. Wang*


DOI: 10.2174/1566524018666180322153432


DREADD in Parvalbumin Interneurons of the Dentate Gyrus Modulates Anxiety, Social Interaction and Memory Extinction

, 2016; 16(1): 91-102.

D. Zou, L. Chen, D. Deng, D. Jiang, F. Dong, C. McSweeney, Y. Zhou, L. Liu, G. Chen, Y. Wu and Y. Mao


DOI: 10.2174/1566524016666151222150024


Establishment of Retinal Degeneration Model in Rat and Monkey by Intravitreal Injection of Sodium Iodate

, 2018; 18(6): 352-364.

Qingjian Ou, Tong Zhu, Peng Li, Zongyi Li, Li Wang, Chunpin Lian, Hua Xu, Caixia Jin, Furong Gao, Jing-Ying Xu, Juan Wang, Jieping Zhang, Weiye Li, Haibin Tian*, Lixia Lu* and Guo-Tong Xu*


DOI: 10.2174/1566524018666181113104023


Genetic Modifiers of Fetal Haemoglobin (HbF) and Phenotypic Severity in β-Thalassemia Patients

, 2018; 18(5): 295-305.

S.A.A. Razak, N.A.A. Murad*, F. Masra, D.L.S. Chong, N. Abdullah, N. Jalil, H. Alauddin, R.Z.A.R. Sabudin, A. Ithnin, L.C. Khai, N.A. Aziz, Z. Muda, H. Ibrahim and Z.A. Latiff*


DOI: 10.2174/1566524018666181004121604






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