Contents

Current Medicinal Chemistry, Volume 22 - Number 4

Meet the Editorial Board

, 22(4): 405

Vito Ferro


DOI: 10.2174/092986732204141226144632




Editorial

Editorial (Thematic Issue: Bioactivation of Drugs: Enzymes, Reactive Metabolites and Adverse Reactions)

, 22(4): 406 - 407

Hilmi Orhan


DOI: 10.2174/092986732204141226144740




Extrahepatic Targets and Cellular Reactivity of Drug Metabolites

, 22(4): 408 - 437

Hilmi Orhan


DOI: 10.2174/0929867321666140826113716




Should the Incorporation of Structural Alerts be Restricted in Drug Design? An Analysis of Structure-Toxicity Trends with Aniline-Based Drugs

, 22(4): 438 - 464

A.S. Kalgutkar


DOI: 10.2174/0929867321666141112122118




Gauging Reactive Metabolites in Drug-Induced Toxicity

, 22(4): 465 - 489

Marsha R. Eno and Michael D. Cameron


DOI: 10.2174/0929867321666140826113520




Melatonin, its Metabolites and its Synthetic Analogs as Multi-Faceted Compounds: Antioxidant, Prooxidant and Inhibitor of Bioactivation Reactions

, 22(4): 490 - 499

Hande Gurer-Orhan and Sibel Suzen


DOI: 10.2174/0929867321666141215095259




Biotransformation of Endocrine Disrupting Compounds by Selected Phase I and Phase II Enzymes – Formation of Estrogenic and Chemically Reactive Metabolites by Cytochromes P450 and Sulfotransferases

, 22(4): 500 - 527

J. Reinen and N.P.E. Vermeulen


DOI: 10.2174/0929867321666140916123022




Idiosyncratic Drug Hepatotoxicity: Strategy for Prevention and Proposed Mechanism

, 22(4): 528 - 537

Toshihiko Ikeda


DOI: 10.2174/0929867321666140916122628




Reactive Metabolites in Early Drug Development: Predictive In vitro Tools

, 22(4): 538 - 550

Olavi Pelkonen, Markku Pasanen, Ari Tolonen, Mikko Koskinen, Jukka Hakkola, Khaled Abass, Jaana Laine, Merja Hakkinen, Risto Juvonen, Seppo Auriola, Markus Storvik, Pasi Huuskonen, Timo Rousu and Maiju Rahikkala


DOI: 10.2174/0929867321666141012175543




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