Contents

Current Medicinal Chemistry, Volume 18 - Number 18

Editorial [Hot Topic: Phosphoinositide 3-Kinase Pathway Inhibitors: Pharmacology, Metabolism & Drug Development (Guest Editor: Marco Falasca)]

, 18(18): 2673

Marco Falasca


DOI: 10.2174/092986711796011210




Present and Future of PI3K Pathway Inhibition in Cancer: Perspectives and Limitations

, 18(18): 2674 - 2685

E. Ciraolo, F. Morello and E. Hirsch


DOI: 10.2174/092986711796011193




Progress in the Preclinical Discovery and Clinical Development of Class I and Dual Class I/IV Phosphoinositide 3-Kinase (PI3K) Inhibitors

, 18(18): 2686 - 2714

S. J. Shuttleworth, F. A. Silva, A. R.L. Cecil, C. D. Tomassi, T. J. Hill, F. I. Raynaud, P. A. Clarke and P. Workman


DOI: 10.2174/092986711796011229




Targeting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cells

, 18(18): 2715 - 2726

A. M. Martelli, C. Evangelisti, M. Y. Follo, G. Ramazzotti, M. Fini, R. Giardino, L. Manzoli, J. A. McCubrey and L. Cocco


DOI: 10.2174/092986711796011201




Novel Inhibitors of AKT: Assessment of a Different Approach Targeting the Pleckstrin Homology Domain

, 18(18): 2727 - 2742

E. J. Meuillet


DOI: 10.2174/092986711796011292




mTOR Inhibitors: Facing New Challenges Ahead

, 18(18): 2743 - 2762

I. Mavrommati and T. Maffucci


DOI: 10.2174/092986711796011247




Targeting PDK1 in Cancer

, 18(18): 2763 - 2769

C. Raimondi and M. Falasca


DOI: 10.2174/092986711796011238




Novel Circular, Cyclic and Acyclic ψ(CH2O) Containing Peptide Inhibitors of SKI- 1/S1P: Synthesis, Kinetic and Biochemical Evaluations

, 18(18): 2770 - 2782

S. Majumdar, A. Chen, H. Palmer-Smith and A. Basak


DOI: 10.2174/092986711796011265




Serotonin Receptors of Type 6 (5-HT6): What can we Expect from them?

, 18(18): 2783 - 2790

D. Marazziti, S. Baroni, M. Catena Dell'Osso, F. Bordi and F. Borsini


DOI: 10.2174/092986711796011283




Adenosine in the Inflamed Gut: A Janus Faced Compound

, 18(18): 2791 - 2815

A. B. Estrela and W.-R. Abraham


DOI: 10.2174/092986711796011274




Molecular Chaperone Hsp90 as a Target for Oxidant-Based Anticancer Therapies

, 18(18): 2816 - 2825

R. Beck, N. Dejeans, C. Glorieux, R. C. Pedrosa, D. Vasquez, J. A. Valderrama, P. B. Calderon and J. Verrax


DOI: 10.2174/092986711796011256




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