Open Access Articles

Serotonin Receptor Binding Characteristics of Geissoschizine Methyl Ether, an Indole Alkaloid in Uncaria Hook

, 2018; 25(9): 1036 - 1045

Yasushi Ikarashi, Kyoji Sekiguchi and Kazushige Mizoguchi*




NGS Technologies as a Turning Point in Rare Disease Research , Diagnosis and Treatment

, 2018; 25(3): 404 - 432

Ana Fernandez-Marmiesse*, Sofia Gouveia and Maria L. Couce *




The Interplay between G-quadruplex and Transcription

, 2018; 25: 1 - 19 (E-Pub Ahead of Print)

Nayun Kim*




Common Aspects Influencing the Translocation of SERS to Biomedicine

, 2018; 25: 1 - 15 (E-Pub Ahead of Print)

Dionysia Tsoutsi, Marcos Sanles-Sobrido, Andreu Cabo and Pilar Rivera Gil*




Vitamin D Receptor: A Novel Therapeutic Target for Kidney Diseases

, 2018; 25: 1 - 16 (E-Pub Ahead of Print)

Shikun Yang , Aimei Li , JianWen Wang , Jun Liu , Yachun Han , Wei Zhang, Yan Chun Li and Hao Zhang*




Immunocontraception: Filamentous Bacteriophage as a Platform for Vaccine Development

, 2017; 24(35): 3907 - 3920

Tatiana I. Samoylova*, Timothy D. Braden, Jennifer A. Spencer and Frank F. Bartol




A Therapeutic Connection between Dietary Phytochemicals and ATP Synthase

, 2017; 24(35): 3894 - 3906

Zulfiqar Ahmad*, Sherif S. Hassan and Sofiya Azim




A Systematic Analysis of Physicochemical and ADME Properties of All Small Molecule Kinase Inhibitors Approved by US FDA from January 2001 to October 2015

, 2017; 24(29): 3159 - 3184

Zhihong O`Brien and Mehran F. Moghaddam*




Major Developments in the Design of Inhibitors along the Kynurenine Pathway

, 2017; 24(23): 2471 - 2495

Kelly R. Jacobs, Gloria Castellano-Gonzalez , Gilles J. Guillemin * and David B. Lovejoy *




Therapeutic Strategies of Plant-derived Compounds for Diabetes Via Regulation of Monocyte Chemoattractant Protein-1

, 2017; 24(14): 1453 - 1468

Magdalena Czemplik*, Anna Kulma, Yu Fu Wang and Jan Szopa




Recent Advances of Graphene-based Hybrids with Magnetic Nanoparticles for Biomedical Applications

, 2017; 24(5): 529 - 536

Nuria Alegret, Alejandro Criado and Maurizio Prato*




Mycosporine-Like Amino Acids for Skin Photoprotection

, 2017; 24: 1 - 16 (E-Pub Ahead of Print)

Karl P Lawrence, Paul F Long and Antony R Young*




Fighting Type-2 Diabetes: Present and Future Perspectives

, 2017; 24: 1 - 17 (E-Pub Ahead of Print)

Cai-Guo Yu , Ying Fu, Yuan Fang , Ning Zhang, Rong-Xin Sun , Dong Zhao, Ying-Mei Feng and Bao-Yu Zhang*




Untargeted Metabolomics Provides Insight into the Mechanisms Underlying Resistant Hypertension

, 2017; 24: 1 - 12 (E-Pub Ahead of Print)

Renata Bujak, Arlette Yumba-Mpanga, Wiktoria Struck-Lewicka, Marta Kordalewska, Katarzyna Polonis, Małgorzata Patejko, Monika Mironiuk, Anna Szyndle, Marzena Chrostowska, Michał Hoffmann, Ryszard T. Smoleński, Roman Kaliszan, Krzysztof Narkiewicz and Michał J. Markuszewski*




Xanthine Oxidoreductase in Drug Metabolism: Beyond a Role as a Detoxifying Enzyme

, 2016; 23(35): 4027 - 4036

Maria Giulia Battelli, Letizia Polito, Massimo Bortolotti and Andrea Bolognesi




Osteoimmunology and Beyond

, 2016; 23(33): 3754 - 3774

Lia Ginaldi and Massimo De Martinis




Targeting the Microglial Signaling Pathways: New Insights in the Modulation of Neuropathic Pain

, 2016; 23(26): 2908 - 2928

Katarzyna Popiolek-Barczyk and Joanna Mika




Why Antidiabetic Vanadium Complexes are Not in the Pipeline of “Big Pharma” Drug Research? A Critical Review

, 2016; 23(25): 2874 - 2891

Thomas Scior, Jose Antonio Guevara-Garcia, Quoc-Tuan Do, Philippe Bernard and Stefan Laufer




A Compendium of Volatile Organic Compounds (VOCs) Released By Human Cell Lines

, 2016; 23(20): 2112 - 2131

Wojciech Filipiak, Pawel Mochalski, Anna Filipiak, Clemens Ager, Raquel Cumeras, Cristina E. Davis, Agapios Agapiou, Karl Unterkofler and Jakob Troppmair




Structure and Expression of Different Serum Amyloid A (SAA) Variants and their Concentration-Dependent Functions During Host Insults

, 2016; 23(17): 1725 - 1755

Mieke De Buck, Mieke Gouwy, Ji Ming Wang, Jacques Van Snick, Ghislain Opdenakker, Sofie Struyf and Jo Van Damme




Current Advances in Developing Inhibitors of Bacterial Multidrug Efflux Pumps

, 2016; 23(10): 1062 - 1081

Hannah Y. Mahmood, Shirin Jamshidi, J. Mark Sutton and Khondaker M. Rahman




Food Proteins as Source of Opioid Peptides-A Review

, 2016; 23(9): 893 - 910

Swati Garg, Kulmira Nurgali and Vijay Kumar Mishra




Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases

, 2016; 23(8): 792 - 815

Marisa Cabeza, Araceli Sánchez-Márquez, Mariana Garrido, Aylín Silva and Eugene Bratoeff




Serotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson’s Disease

, 2016; 23(7): 686 - 700

Ikuko Miyazaki and Masato Asanuma




Role of Tyrosine Isomers in Acute and Chronic Diseases Leading to Oxidative Stress - A Review

, 2016; 23(7): 667 - 685

Gergő A. Molnár, Szilárd Kun, Eszter Sélley, Melinda Kertész, Lívia Szélig, Csaba Csontos, Katalin Böddi, Lajos Bogár, Attila Miseta and István Wittmann




Eosinophils in Cancer: Favourable or Unfavourable?

, 2016; 23(7): 650 - 666

Samy Sakkal, Sarah Miller, Vasso Apostolopoulos and Kulmira Nurgali




A “Double-Edged” Scaffold: Antitumor Power within the Antibacterial Quinolone

, 2016; 23(6): 520 - 577

Gregory S. Bisacchi and Michael R. Hale




Action of Nanoparticles on Platelet Activation and Plasmatic Coagulation

, 2016; 23(5): 408 - 430

Eleonore Fröhlich




Lipoprotein-Related and Apolipoprotein-Mediated Delivery Systems for Drug Targeting and Imaging

, 2015; 22(31): 3631 - 3651

Gunter Almer, Harald Mangge, Andreas Zimmer and Ruth Prassl




Non-Traditional Systemic Treatments for Diabetic Retinopathy: An Evidence-Based Review

, 2015; 22(21): 2580 - 2589

Rafael Simo, Stefania Ballarini, Jose Cunha-Vaz, Linong Ji, Hermann Haller, Paul Zimmet and Tien Y Wong




Bacteriophages and Phage-Derived Proteins – Application Approaches

, 2015; 22(14): 1757 - 1773

Zuzanna Drulis-Kawa, Grazyna Majkowska-Skrobek and Barbara Maciejewska




Key Sites for P2X Receptor Function and Multimerization: Overview of Mutagenesis Studies on a Structural Basis

, 2015; 22(7): 799 - 818

Ralf Hausmann, Achim Kless and Gunther Schmalzing




Recent Development of Multifunctional Agents as Potential Drug Candidates for the Treatment of Alzheimer’s Disease

, 2015; 22(3): 373 - 404

Natalia Guzior, Anna Wi eckowska, Dawid Panek and Barbara Malawska




Novel Strategies for Preventing Diabetes and Obesity Complications with Natural Polyphenols

, 2015; 22(1): 150 - 164

C. Carpene, S. Gomez-Zorita, S. Deleruyelle and M.A. Carpene




Interactions Between Nanosized Materials and the Brain

, 2014; 21(37): 4200 - 4214

M. Simko and Mats-Olof Mattsson




A Common Molecular Motif Characterizes Extracellular Allosteric Enhancers of GPCR Aminergic Receptors and Suggests Enhancer Mechanism of Action

, 2014; 21(32): 3673 - 3686

Robert Root-Bernstein and Patrick F. Dillon




Atrial Natriuretic Peptide: A Magic Bullet for Cancer Therapy Targeting Wnt Signaling and Cellular pH Regulators

, 2014; 21(21): 2401 - 2409

A. Serafino and P. Pierimarchi




In Vitro and In Vivo Models for Analysis of Resistance to Anticancer Molecular Therapies

, 2014; 21(14): 1595 - 1606

Roberta Rosa, Francesca Monteleone, Nicola Zambrano and Roberto Bianco




Histopathological Determinants of Tumor Resistance: A Special Look to the Immunohistochemical Expression of Carbonic Anhydrase IX in Human Cancers

, 2014; 21(14): 1569 - 1582

G. Ilardi, N. Zambrano, F. Merolla, M. Siano, S. Varricchio, M. Vecchione, G. De Rosa, M. Mascolo and S. Staibano




Exogenous Hormonal Regulation in Breast Cancer Cells by Phytoestrogens and Endocrine Disruptors

, 2014; 21(9): 1129 - 1145

A. Albini, C. Rosano, G. Angelini, A. Amaro, A.I. Esposito, S. Maramotti, D.M. Noonan and U. Pfeffer




Pathophysiogenesis of Mesial Temporal Lobe Epilepsy: Is Prevention of Damage Antiepileptogenic?

, 2014; 21(6): 663 - 688

G. Curia, C. Lucchi, J. Vinet, F. Gualtieri, C. Marinelli, A. Torsello, L. Costantino and G. Biagini




Phytoestrogens in Postmenopause: The State of the Art from a Chemical, Pharmacological and Regulatory Perspective

, 2014; 21(4): 417 - 436

Elisabetta Poluzzi, Carlo Piccinni, Emanuel Raschi, Angela Rampa, Maurizio Recanatini and Fabrizio De Ponti




An Update on Autoinflammatory Diseases

, 2014; 21(3): 261 - 269

F. Ciccarelli, M. De Martinis and L. Ginaldi




An Up-date of Olive Oil Phenols in Inflammation and Cancer: Molecular Mechanisms and Clinical Implications

, 2013; 20(37): 4758 - 4776

A. Cárdeno, M. Sánchez-Hidalgo and C. Alarcón-de-la-Lastra




Reduction of Breast Cancer Relapses with Perioperative Non-Steroidal Anti-Inflammatory Drugs: New Findings and a Review

, 2013; 20(33): 4163 - 4176

Michael Retsky, Romano Demicheli, William J.M. Hrushesky, Patrice Forget, Marc De Kock, Isaac Gukas, Rick A Rogers, Michael Baum, Vikas Sukhatme and Jayant S. Vaidya




Medicinal Chemistry of the Epigenetic Diet and Caloric Restriction

, 2013; 20(32): 4050 - 4059

S. L. Martin, T. M. Hardy and T. O. Tollefsbol




Neuroprotective Properties of Curcumin in Alzheimer’s Disease – Merits and Limitations

, 2013; 20(32): 3955 - 3985

Dawn Chin, Patricia Huebbe, Kathrin Pallauf and Gerald Rimbach




Free Fatty Acids-Sensing G Protein-Coupled Receptors in Drug Targeting and Therapeutics

, 2013; 20(31): 3855 - 3871

Tomo Yonezawa, Riho Kurata, Kaori Yoshida, Masanori A. Murayama, Xiaofeng Cui and Akihiko Hasegawa




Tuberculosis Clinical Trial Update and the Current Anti-Tuberculosis Drug Portfolio

, 2013; 20(30): 3785 - 3796

Juan Carlos Palomino and Anandi Martin




A Novel Promising Therapeutic Option Against Hepatitis C Virus: An Oral Nucleotide NS5B Polymerase Inhibitor Sofosbuvir

, 2013; 20(30): 3733 - 3742

I. Gentile, F. Borgia, A. R. Buonomo, G. Castaldo and G. Borgia




Reactive Oxygen Species in Cancer Biology and Anticancer Therapy

, 2013; 20(30): 3677 - 3692

Y. Yang, S. Karakhanova, J. Werner and A. V. Bazhin




MicroRNAs and Cancer Therapy – From Bystanders to Major Players

, 2013; 20(29): 3561 - 3573

Cornelia Braicu, George A. Calin and Ioana Berindan-Neagoe




Neurodegeneration in the Pathogenesis of Diabetic Retinopathy: Molecular Mechanisms and Therapeutic Implications

, 2013; 20(26): 3241 - 3250

Maxwell S. Stem and Thomas W. Gardner




Mitochondria Damage in the Pathogenesis of Diabetic Retinopathy and in the Metabolic Memory Associated with its Continued Progression

, 2013; 20(26): 3226 - 3233

Renu A. Kowluru




Calpains: Potential Targets for Alternative Chemotherapeutic Intervention Against Human Pathogenic Trypanosomatids

, 2013; 20(25): 3174 - 3185

M. H. Branquinha, F. A. Marinho, L. S. Sangenito, S. S.C. Oliveira, K. C. Goncalves, V. Ennes-Vidal, C. M. d’Avila-Levy and A. L.S. Santos




Aspartic Peptidases of Human Pathogenic Trypanosomatids: Perspectives and Trends for Chemotherapy

, 2013; 20(25): 3116 - 3133

L. O. Santos, A. S. Garcia-Gomes, M. Catanho, C. L. Sodre, A. L.S. Santos, M. H. Branquinha and C. M. d’Avila-Levy




Parasite Prolyl Oligopeptidases and the Challenge of Designing Chemotherapeuticals for Chagas Disease, Leishmaniasis and African Trypanosomiasis

, 2013; 20(25): 3103 - 3115

I. M.D. Bastos, F. N. Motta, P. Grellier and J. M. Santana




Synthetic and Natural Protease Inhibitors Provide Insights into Parasite Development, Virulence and Pathogenesis

, 2013; 20(25): 3078 - 3102

A. A. Rascon and J. H. McKerrow




n-3 Fatty Acids: Role in Neurogenesis and Neuroplasticity

, 2013; 20(24): 2953 - 2963

R. Crupi, A. Marino and S. Cuzzocrea




An Overview on Natural Polysaccharides with Antioxidant Properties

, 2013; 20(23): 2899 - 2913

H. Wang, Y. M. Liu, Z. M. Qi, S. Y. Wang, S. X. Liu, X. Li, H. J. Wang and X. C. Xia




Virtual Screening Strategies in Drug Discovery: A Critical Review

, 2013; 20(23): 2839 - 2860

A. Lavecchia and C. Di Giovanni




Trypanosomatidae Diseases: From the Current Therapy to the Efficacious Role of Trypanothione Reductase in Drug Discovery

, 2013; 20(21): 2673 - 2696

L.S.C. Bernardes, C.L. Zani and I. Carvalho




Flavonoids in Atherosclerosis: An Overview of Their Mechanisms of Action

, 2013; 20(21): 2641 - 2660

G. Siasos, D. Tousoulis, V. Tsigkou, E. Kokkou, E. Oikonomou, M. Vavuranakis, E.K. Basdra, A.G. Papavassiliou and C. Stefanadis




Bioavailability of Quercetin: Problems and Promises

, 2013; 20(20): 2572 - 2582

X. Cai, Z. Fang, J. Dou, A. Yu and G. Zhai




Clinical and Marketed Proteasome Inhibitors for Cancer Treatment

, 2013; 20(20): 2537 - 2551

Jiankang Zhang, Peng Wu and Yongzhou Hu




Piroxicam-β-Cyclodextrin: A GI Safer Piroxicam

, 2013; 20(19): 2415 - 2437

C. Scarpignato




Insulin Secretion and Interleukin-1β Dependent Mechanisms in Human Diabetes Remission After Metabolic Surgery

, 2013; 20(18): 2374 - 2388

Chih-Yen Chen, Wei-Jei Lee, A. Asakawa, N. Fujitsuka, Keong Chong, Shu-Chun Chen, Shou-Dong Lee and A. Inui




1,2,4-Oxadiazoles Identified by Virtual Screening and their Non-Covalent Inhibition of the Human 20S Proteasome

, 2013; 20(18): 2351 - 2362

X. Maréchal, E. Genin, L. Qin, O. Sperandio, M. Montes, N. Basse, N. Richy, M.A. Miteva, M. Reboud-Ravaux, J. Vidal and B.O. Villoutreix




Luminescent Silica Nanoparticles for Cancer Diagnosis

, 2013; 20(17): 2195 - 2211

W. Arap, R. Pasqualini, M. Montalti, L. Petrizza, L. Prodi, E. Rampazzo, N. Zaccheroni and S. Marchio




Computational Peptidology: A New and Promising Approach to Therapeutic Peptide Design

, 2013; 20(15): 1985 - 1996

P. Zhou, C. Wang, Y. Ren, C. Yang and F. Tian




Targeting the Akt Kinase to Modulate Survival, Invasiveness and Drug Resistance of Cancer Cells

, 2013; 20(15): 1923 - 1945

Giuliana Cassinelli, Valentina Zuco, Laura Gatti, Cinzia Lanzi, Nadia Zaffaroni, Diego Colombo and Paola Perego




Histone Deacetylase Inhibitors: An Attractive Strategy for Cancer Therapy

, 2013; 20(14): 1858 - 1886

Jiyang Li, Guangqiang Li and Wenqing Xu




RNAi in Clinical Studies

, 2013; 20(14): 1801 - 1816

P. Kubowicz, D. Zelaszczyk and E. Pekala




Multi-Target Compounds Acting in the Central Nervous System Designed From Natural Products

, 2013; 20(13): 1673 - 1685

X. Chen and M. Decker




Rationally Designed Multi-Targeted Agents Against Neurodegenerative Diseases

, 2013; 20(13): 1662 - 1672

W. J. Geldenhuys and C. J. Van der Schyf




The Economics of Polypharmacology: Fixed Dose Combinations and Drug Cocktails

, 2013; 20(13): 1635 - 1638

A. I. Wertheimer




Camptothecin Resistance in Cancer: Insights into the Molecular Mechanisms of a DNA-Damaging Drug

, 2013; 20(12): 1541 - 1565

G. L. Beretta, L. Gatti, P. Perego and N. Zaffaroni




Long-Acting Beta-Agonists and their Association with Inhaled Corticosteroids in COPD

, 2013; 20(12): 1477 - 1495

L. Fuso, N. Mores, S. Valente, M. Malerba and P. Montuschi




Anti-Inflammatory and Antioxidant Effects of Resveratrol in Healthy Smokers A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial

, 2013; 20(10): 1323 - 1331

S. Bo, G. Ciccone, A. Castiglione, R. Gambino, F. De Michieli, P. Villois, M. Durazzo, P. Cavallo-Perin and M. Cassader




Serenoa Repens, Lycopene and Selenium: A Triple Therapeutic Approach to Manage Benign Prostatic Hyperplasia

, 2013; 20(10): 1306 - 1312

L. Minutoli, A. Bitto, F. Squadrito, H. Marini, N. Irrera, G. Morgia, A. Passantino and D. Altavilla




Ion Channels as Drug Targets in Central Nervous System Disorders

, 2013; 20(10): 1241 - 1285

A. M. Waszkielewicz, A. Gunia, N. Szkaradek, K. Sloczynska, S. Krupinska and H. Marona




Plant Metabolomics: From Holistic Data to Relevant Biomarkers

, 2013; 20(8): 1056 - 1090

Jean-Luc Wolfender, Serge Rudaz, Young Hae Choi and Hye Kyong Kim




From Resveratrol to Its Derivatives: New Sources of Natural Antioxidant

, 2013; 20(8): 1005 - 1017

Shan He and Xiaojun Yan




Antimicrobial Plant Metabolites: Structural Diversity and Mechanism of Action

, 2013; 20(7): 932 - 952

N.S. Radulovic, P.D. Blagojevic, Z.Z. Stojanovic-Radic and N.M. Stojanovic




The Pentacyclic Triterpenoids in Herbal Medicines and Their Pharmacological Activities in Diabetes and Diabetic Complications

, 2013; 20(7): 908 - 931

A. Alqahtani, K. Hamid, A. Kam, K.H. Wong, Z. Abdelhak, V. Razmovski-Naumovski, K. Chan, K.M. Li, P.W. Groundwater and G.Q. Li




Survey of Recent Literature Related to the Biologically Active 4(3H)-Quinazolinones Containing Fused Heterocycles

, 2013; 20(6): 794 - 814

Martine Demeunynck and Isabelle Baussanne




Glyconanoparticles-An Update

, 2013; 20(6): 782 - 788

Gangliang Huang




Honey as a Source of Dietary Antioxidants: Structures, Bioavailability and Evidence of Protective Effects Against Human Chronic Diseases

, 2013; 20(5): 621 - 638

Josè M. Alvarez-Suarez, Francesca Giampieri and Maurizio Battino




Treatment of Estrogen Receptor-Positive Breast Cancer

, 2013; 20(5): 596 - 604

F. Lumachi, A. Brunello, M. Maruzzo, U. Basso and S. M.M. Basso




The Current Status of Sweat Testing For Drugs of Abuse: A Review

, 2013; 20(4): 545 - 561

N. De Giovanni and N. Fucci




New Chemotherapeutic Strategies Against Malaria, Leishmaniasis and Trypanosomiases

, 2013; 20(4): 502 - 526

M. Zucca, S. Scutera and D. Savoia




Do Subjects at Clinical High Risk for Psychosis Differ from those with a Genetic High Risk? - A Systematic Review of Structural and Functional Brain Abnormalities

, 2013; 20(3): 467 - 481

R. Smieskova, J. Marmy, A. Schmidt, K. Bendfeldt, A. Riecher-Rossler, M. Walter, U. E. Lang and S. Borgwardt




Volumetric Changes in the Basal Ganglia After Antipsychotic Monotherapy: A Systematic Review

, 2013; 20(3): 438 - 447

B. H. Ebdrup, H. Norbak, S. Borgwardt and B. Glenthoj




Transcranial Brain Stimulation in Schizophrenia: Targeting Cortical Excitability, Connectivity and Plasticity

, 2013; 20(3): 405 - 413

A. Hasan, P. Falkai and T. Wobrock




Abnormal Striatal Dopamine Transmission in Schizophrenia

, 2013; 20(3): 397 - 404

Jerome Brunelin, Shirley Fecteau and Marie-Francoise Suaud-Chagny




Serotonin Receptors of Type 6 (5-HT6): From Neuroscience to Clinical Pharmacology

, 2013; 20(3): 371 - 377

Donatella Marazziti, Stefano Baroni, Franco Borsini, Michela Picchetti, Elena Vatteroni, Valentina Falaschi and Mario Catena-Dell’Osso




Metabolomics Analysis for Biomarker Discovery: Advances and Challenges

, 2013; 20(2): 257 - 271

M.S. Monteiro, M. Carvalho, M.L. Bastos and P. Guedes de Pinho




Histone Methyltransferase Inhibitors: Novel Epigenetic Agents for Cancer Treatment

, 2013; 20(2): 167 - 185

C. Zagni, U. Chiacchio and A. Rescifina




Polymer Nanoparticles - A Novel Strategy for Administration of Paclitaxel in Cancer Chemotherapy

, 2012; 19(36): 6207 - 6213

G. Deepa, N. Ashwanikumar, J. J. Pillai and G. S.V. Kumar




Recent Lipase-Catalyzed Hydrolytic Approaches to Pharmacologically Important β-and λ-Amino Acids

, 2012; 19(36): 6178 - 6187

E. Forro and F. Fulop




Alveolar Epithelial Stem and Progenitor Cells: Emerging Evidence for their Role in Lung Regeneration

, 2012; 19(35): 6003 - 6008

A. M. Hoffman and E. P. Ingenito




Stem Cells, Self-Renewal and Cancer of the Gastric Epithelium

, 2012; 19(35): 5975 - 5983

Werner Hoffmann




Store-Dependent Ca2+ Entry in Endothelial Progenitor Cells As a Perspective Tool to Enhance Cell-Based Therapy and Adverse Tumour Vascularization

, 2012; 19(34): 5802 - 5818

F. Moccia, S. Dragoni, F. Lodola, E. Bonetti, C. Bottino, G. Guerra, U. Laforenza, V. Rosti and F. Tanzi




Polarization of Calcium Signaling and Fluid Secretion in Salivary Gland Cells

, 2012; 19(34): 5774 - 5781

I. S. Ambudkar




Signal Transduction Pathways of the Epidermal Growth Factor Receptor in Colorectal Cancer and their Inhibition by Small Molecules

, 2012; 19(33): 5735 - 5744

T. Efferth




Contribution of Oxidative Metabolism to Cocaine-Induced Liver and Kidney Damage

, 2012; 19(33): 5601 - 5606

M.J. Valente, F. Carvalho, M.d.L. Bastos, P.G. de Pinho and M. Carvalho




Adiponectin: Key Player in the Adipose Tissue-Liver Crosstalk

, 2012; 19(32): 5467 - 5473

A. R. Moschen, V. Wieser and H. Tilg




Protective Role of Adiponectin in Cardiovascular Disease

, 2012; 19(32): 5459 - 5466

R. Shibata, T. Murohara and N. Ouchi




A Targeted Therapy for Protein and Lipid Kinases in Chronic Lymphocytic Leukemia

, 2012; 19(31): 5294 - 5318

P. Robak and T. Robak




Immunoliposomes

, 2012; 19(31): 5239 - 5277

E. Paszko and M.O. Senge




Glutamate Transporter 1: Target for the Treatment of Alcohol Dependence

, 2012; 19(30): 5148 - 5156

P.S.S. Rao and Y. Sari




Fragment Based Drug Design: From Experimental to Computational Approaches

, 2012; 19(30): 5128 - 5147

A. Kumar, A. Voet and K.Y.J. Zhang




From Metallodrugs to Metallodendrimers for Nanotherapy in Oncology: A Concise Overview

, 2012; 19(29): 4995 - 5010

S. El Kazzouli, N. El Brahmi, S. Mignani, M. Bousmina, M. Zablocka and J. -P. Majoral




Fluorescent Dendrimers As Sensors for Biologically Important Metal Cations

, 2012; 19(29): 4976 - 4983

I. Grabchev, D. Staneva and R. Betcheva




Role of Oxidative Stress and Molecular Changes in Liver Fibrosis: A Review

, 2012; 19(28): 4850 - 4860

V. Sanchez-Valle, N. C. Chavez-Tapia, M. Uribe and N. Mendez-Sanchez




Recent Advances in Receptor-Targeted Fluorescent Probes for In Vivo Cancer Imaging

, 2012; 19(28): 4742 - 4758

M. Bai and D. J. Bornhop




New Strategies Against Prostate Cancer – Pt(II)-Based Chemotherapy

, 2012; 19(27): 4678 - 4687

C. S. Matos, A. L.M.B. de Carvalho, R. P. Lopes and M. P.M. Marques




Review Metabolomics: A New Approach to Drug Delivery in Perinatology

, 2012; 19(27): 4654 - 4661

L. Atzori, J. L. Griffin, A. Noto and V. Fanos




Peptides As Therapeutics with Enhanced Bioactivity

, 2012; 19(26): 4451 - 4461

D. Goodwin, P. Simerska and I. Toth




Biology and Clinical Management of Myeloproliferative Neoplasms and Development of the JAK Inhibitor Ruxolitinib

, 2012; 19(26): 4399 - 4413

J. Mascarenhas, T. I. Mughal and S. Verstovsek




Insights into Targeting Colon Cancer Cell Fate at the Level of Proteoglycans / Glycosaminoglycans

, 2012; 19(25): 4247 - 4258

D. Nikitovic, G. Chatzinikolaou, J. Tsiaoussis, A. Tsatsakis, N. K. Karamanos and G. N. Tzanakakis




The Synergistic Effects of DNA-Targeted Chemotherapeutics and Histone Deacetylase Inhibitors As Therapeutic Strategies for Cancer Treatment

, 2012; 19(25): 4218 - 4238

M. Stiborova, T. Eckschlager, J. Poljakova, J. Hrabeta, V. Adam, R. Kizek and E. Frei




Physicochemical Strategies for Inhibition of Amyloid Fibril Formation: An Overview of Recent Advances

, 2012; 19(24): 4157 - 4174

R. Liu, R. Su, M. Liang, R. Huang, M. Wang, W. Qi and Z. He




Chromogranin-A: A Multifaceted Cardiovascular Role in Health and Disease

, 2012; 19(24): 4042 - 4050

T. Angelone, R. Mazza and M. C. Cerra




Glutathione-Related Factors and Oxidative Stress in Autism, A Review

, 2012; 19(23): 4000 - 4005

A. Ghanizadeh, S. Akhondzadeh, M. Hormozi, A. Makarem, M. Abotorabi-Zarchi and A. Firoozabadi




Role of PARP Inhibitors in Cancer Biology and Therapy

, 2012; 19(23): 3907 - 3921

D. Davar, J. H. Beumer, L. Hamieh and H. Tawbi




Structure and Ligand Based Drug Design Strategies in the Development of Novel 5- LOX Inhibitors

, 2012; 19(22): 3763 - 3778

Polamarasetty Aparoy, Kakularam Kumar Reddy and Pallu Reddanna




Homeostasis and the Importance for a Balance Between AKT/mTOR Activity and Intracellular Signaling

, 2012; 19(22): 3748 - 3762

D. A. Altomare and A. R. Khaled




Combinatorial Nanoparticles for Cancer Diagnosis and Therapy

, 2012; 19(22): 3714 - 3721

A. Mukerjee, A. P. Ranjan and J. K. Vishwanatha




Survivin as a Prognostic/Predictive Marker and Molecular Target in Cancer Therapy

, 2012; 19(22): 3679 - 3688

F. Rodel, T. Sprenger, B. Kaina, T. Liersch, C. Rodel, S. Fulda and S. Hehlgans




Antimicrobial and Biofilm Inhibiting Diketopiperazines

, 2012; 19(21): 3564 - 3577

M. P. de Carvalho and W.-R. Abraham




Recent Progress in the Development of Agonists and Antagonists for Melatonin Receptors

, 2012; 19(21): 3532 - 3549

D. P. Zlotos




Designed Multiple Ligands: Basic Research vs Clinical Outcomes

, 2012; 19(20): 3353 - 3387

L. Costantino and D. Barlocco




Radiolabelled Agents for PET Imaging of Tumor Hypoxia

, 2012; 19(20): 3282 - 3289

H. Kurihara, N. Honda, Y. Kono and Y. Arai




Drug Targeting to Cancer by Nanoparticles Surface Functionalized with Special Biomolecules

, 2012; 19(19): 3188 - 3195

M. A. Holgado, L. Martin-Banderas, J. Alvarez-Fuentes, M. Fernandez-Arevalo and J. L. Arias




Drug-Loaded Nanocarriers: Passive Targeting and Crossing of Biological Barriers

, 2012; 19(19): 3070 - 3102

J. M. Rabanel, V. Aoun, I. Elkin, M. Mokhtar and P. Hildgen




Recent Progress and Future Potential for Metal Complexes as Anticancer Drugs Targeting G-quadruplex DNA

, 2012; 19(18): 2957 - 2975

J. Zhang, F. Zhang, H. Li, C. Liu, J. Xia, L. Ma, W. Chu, Z. Zhang, C. Chen, S. Li and S. Wang




Protocatechuic Acid and Human Disease Prevention: Biological Activities and Molecular Mechanisms

, 2012; 19(18): 2901 - 2917

R. Masella, C. Santangelo, M. D’Archivio, G. LiVolti, C. Giovannini and F. Galvano




Chelating Agents for the Treatment of Systemic Iron Overload

, 2012; 19(17): 2816 - 2827

Y. Ma, T. Zhou, X. Kong and R. C. Hider




Iron Chelators for the Treatment of Cancer

, 2012; 19(17): 2689 - 2702

Y. Yu, E. Gutierrez, Z. Kovacevic, F. Saletta, P. Obeidy, Y. Suryo Rahmanto and D. R. Richardson




The Role of microRNAs in Cardiovascular Disease

, 2012; 19(16): 2605 - 2610

N. Papageorgiou, D. Tousoulis, E. Androulakis, G. Siasos, A. Briasoulis, G. Vogiatzi, A.-M. Kampoli, E. Tsiamis, C. Tentolouris and C. Stefanadis




Evaluating Oxidative Stress in Human Cardiovascular Disease: Methodological Aspects and Considerations

, 2012; 19(16): 2504 - 2520

R. Lee, M. Margaritis, K. M. Channon and C. Antoniades




Role of microRNAs in Gynecological Pathology

, 2012; 19(15): 2406 - 2413

J. Gilabert-Estelles, A. Braza-Boils, L. A. Ramon, E. Zorio, P. Medina, F. Espana and A. Estelles




CuAAC Click Chemistry Accelerates the Discovery of Novel Chemical Scaffolds as Promising Protein Tyrosine Phosphatases Inhibitors

, 2012; 19(15): 2399 - 2405

X. -P. He, J. Xie, Y. Tang, J. Li and G. -R. Chen




The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases - Part II

, 2012; 19(14): 2176 - 2228

T.J. Schmidt, S.A. Khalid, A.J. Romanha, T.MA. Alves, M.W. Biavatti, R. Brun, F.B. Da Costa, S.L. de Castro, V.F. Ferreira, M.V.G. de Lacerda, J.H.G. Lago, L.L. Leon, N.P. Lopes, R.C. das Neves Amorim, M. Niehues, I.V. Ogungbe, A.M. Pohlit, M.T. Scotti, W.N. Setzer, M. de N.C. Soeiro and M. Steindel and A.G. Tempone




Anti-Inflammatory Iridoids of Botanical Origin

, 2012; 19(14): 2104 - 2127

A. Viljoen, N. Mncwangi and I. Vermaak




Anti-Inflammatory Agents from Plants: Progress and Potential

, 2012; 19(14): 2088 - 2103

M.C. Recio, I. Andujar and J.L. Rios




Activity of Epiisopiloturine Against Schistosoma mansoni

, 2012; 19(13): 2051 - 2058

L. M. Veras, M. A. Guimaraes, Y. D. Campelo, M. M. Vieira, C. Nascimento, D. F. Lima, L. Vasconcelos, E. Nakano, S. S. Kuckelhaus, M. C. Batista, J. R. Leite and J. Moraes




Three Decades of P-gp Inhibitors: Skimming Through Several Generations and Scaffolds

, 2012; 19(13): 1946 - 2025

A. Palmeira, E. Sousa, M. H. Vasconcelos and M. M. Pinto




Induction of Abscopal Anti-Tumor Immunity and Immunogenic Tumor Cell Death by Ionizing Irradiation - Implications for Cancer Therapies

, 2012; 19(12): 1751 - 1764

B. Frey, Y. Rubner, R. Wunderlich, E.-M. Weiss, A.G. Pockley, R. Fietkau and U.S. Gaipl




Modulation of Inflammatory Immune Reactions by Low-Dose Ionizing Radiation: Molecular Mechanisms and Clinical Application

, 2012; 19(12): 1741 - 1750

F. Rodel, B. Frey, U. Gaipl, L. Keilholz, C. Fournier, K. Manda, H. Schollnberger, G. Hildebrandt and C. Rodel




In Vitro - In Vivo Correlation of Gene Expression Alterations Induced by Liver Carcinogens

, 2012; 19(11): 1721 - 1730

T. Heise, M. Schug, D. Storm, H. Ellinger-Ziegelbauer, H. J. Ahr, B. Hellwig, J. Rahnenführer, A. Ghallab, G. Guenther, J. Sisnaiske, R. Reif, P. Godoy, H. Mielke, U. Gundert-Remy, A. Lampen, A. Oberemm and J. G. Hengstler




Resveratrol in Medicinal Chemistry: A Critical Review of its Pharmacokinetics, Drug-Delivery, and Membrane Interactions

, 2012; 19(11): 1663 - 1681

A. R. Neves, M. Lucio, J. L.C. Lima and S. Reis




Granulocytes in Helminth Infection - Who is Calling the Shots?

, 2012; 19(10): 1567 - 1586

B. L. Makepeace, C. Martin, J. D. Turner and S. Specht




Current Advances in Detection and Treatment of Babesiosis

, 2012; 19(10): 1504 - 1518

J. Mosqueda, A. Olvera-Ramirez, G. Aguilar-Tipacamu and G. J. Canto




Leishmaniasis: Prevention, Parasite Detection and Treatment

, 2012; 19(10): 1443 - 1474

T. Kobets, I. Grekov and M. Lipoldova




Glutamate in CNS Neurodegeneration and Cognition and its Regulation by GCPII Inhibition

, 2012; 19(9): 1335 - 1345

K. A. Rahn, B. S. Slusher and A. I. Kaplin