Articles Ahead of Print
Inhibitors of ER Aminopeptidase 1 and 2: From Design to Clinical Application
Dimitris Georgiadis, Anastasia Mpakali, Despoina Koumantou and Efstratios Stratikos*
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Diagnoses of Pathological States Based on Acetylcholinesterase and Butyrylcholinesterase
Miroslav Pohanka*
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Therapeutic Options for Homozygous Familial Hypercholesterolemia: the Role of Lomitapide
Antonina Giammanco, Angelo B. Cefalù, Davide Noto and Maurizio R. Averna*
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The Glycogen Synthase Kinase-3 in the Regulation of Ion Channels and Cellular Carriers
Mentor Sopjani, Lulzim Millaku, Dashnor Nebija, Merita Emini, Arleta Rifati-Nixha and Miribane Dermaku-Sopjani*
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Oxidative Status in Multiple Sclerosis and Off-Targets of Antioxidants: The Case of Edaravone
Cristina Agresti, Rosella Mechelli, Stefania Olla, Caterina Veroni, Cecilia Eleuteri, Giovanni Ristori and Marco Salvetti*
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Editorial: Novel Therapeutic Strategies for the Treatment of Chronic Diseases
Gianluca Testa, Fabiana Passaro, Aldo Cinquegrana, Melania Palma, Pasquale Abete and Carlo Gabriele Tocchetti*
Endothelium as a Therapeutic Target in Diabetes Mellitus: From Basic Mechanisms to Clinical Practice
Anastasios Tentolouris, Ioanna Eleftheriadou, Evangelia Tzeravini, Dimitrios Tsilingiris, Stavroula A. Paschou, Gerasimos Siasos and Nikolaos Tentolouris*
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How to Fluorescently Label the Potassium Channel: A Case in hERG
Xiaomeng Zhang, Beilei Wang, Zhenzhen Liu, Yubin Zhou and Lupei Du*
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Management of Peripheral Neuropathy Induced by Chemotherapy
Maayan Fradkin*, Ron Batash*, Shiran Elamleh*, Ronen Debi , Pamela Schaffer , Moshe Schaffer and Noam Asna
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Therapeutic Targeting of the Soluble Guanylate Cyclase
Garyfallia I Makrynitsa, Aikaterini A Zompra, Aikaterini I Argyriou, Georgios A Spyroulias and Stavros Topouzis*
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Small Molecules Targeting Mutant P53: A Promising Approach for Cancer Treatment
Elizabeth A. Lopes, Sara Gomes, Lucília Saraiva and Maria Santos*
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Rho-kinase (ROCK) Inhibitors - A Neuroprotective Therapeutic Paradigm with a Focus on Ocular Utility
Vasudha Abbhi and Poonam Piplani*
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Nano-biofilm Arrays as a Novel Universal Platform for Microscale Microbial Culture and High-Throughput Downstream Applications
Anand Srinivasan , Anand K. Ramasubramanian and José L. Lopez-Ribot*
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The Mycobacterial HBHA Protein: A Promising Biomarker for Tuberculosis
Flavio De Maio, Flavia Squeglia, Delia Goletti and Giovanni Delogu*
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Ionic Liquids for Topical Delivery in Cancer
Ana Rita Dias, João Costa-Rodrigues, Cátia Teixeira, Paula Gomes, Cristina Prudêncio* and Ricardo Ferraz
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Computational Approaches for the Design of Mosquito Repellent Chemicals
Subhash C. Basak* and Apurba K. Bhattacharjee
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Autophagy Modulators and Neuroinflammation
Kyoung Sang Cho, Jang Ho Lee, Jeiwon Cho, Guang-Ho Cha* and Gyun Jee Song*
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Small Peptides as Modulators of Serine Proteases
Peng Xu and Mingdong Huang*
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Proteomic and Glycomic Markers to Differentiate Lung Adenocarcinoma from COPD
Miklos Szabo, Laszlo Hajba, Renáta Kun, András Guttman* and Eszter Csánky
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Mechanistic Insights of Soluble Uric Acid-related Kidney Disease
Jing Pan, Min Shi, Liang Ma* and Ping Fu*
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Perioperative Heart-Brain Axis Protection in Obese Surgical Patients: The Nutrigenomic Approach
Jacopo Agrimi, Carlotta Baroni, Ekene Anakor and Vincenzo Lionetti*
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NADPH Producing Enzymes as Promising Drug Targets for Chagas Disease
Artur T. Cordeiro*
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Goniothalamin-Related Styryl Lactones. Isolation, Synthesis, Biological Activity and Mode of Action
Ronaldo Aloise Pilli*, Ian de Toledo, Matheus Andrade Meirelles and Thiago Augusto Grigolo
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Current Challenges in the Development of Vaccines and Drugs Against Emerging Vector-borne Diseases
Kwang-sun Kim*
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Nanoparticle-plasma Membrane Interactions: Thermodynamics, Toxicity and Cellular Response
A. G. Rodríguez-Hernández , R. Vazquez-Duhalt and A. Huerta-Saquero *
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Healthy Diet and Reduction of Chronic Disease Risks of Night Shift Workers
Giovanni M. Ferri*, Domenica Cavone, Graziana Intranuovo and Linda Macinagrossa
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Graphene and Graphene Oxide Applications for SERS Sensing and Imaging
Anna Jablonska, Alekdandra Jaworska, Mateusz Kasztelan , Sylwia Berbec and Barbara Palys *
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Flavonoids as P-gp Inhibitors: A Systematic Review of SARs
Jiahua Cui*, Xiaoyang Liu and Larry M. C. Chow
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Targeting Kinetoplastid and Apicomplexan Thymidylate Biosynthesis as an Antiprotozoal Strategy
Maria Valente, Antonio E. Vidal and Dolores Gonzalez Pacanowska*
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Anesthetic-induced Myocardial Conditioning: Molecular Fundamentals and Scope
Jose Luis Guerrero Orriach*, Juan Jose Escalona Belmonte , Marta Ramirez-Aliaga, Alicia Ramirez-Fernandez , Aida Raigon-Ponferrada , Manuel Rubio-Navarro and Jose Cruz-Manas
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Chitosan-based Polymer Matrix for Pharmaceutical Excipients and Drug Delivery
Md. Iqbal Hassan Khan , Xingye An, Lei Dai , Hailong Li, Avik Khan and Yonghao Ni*
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The Role of Mitochondria in Systemic Lupus Erythematosus: A Glimpse of Various Pathogenetic Mechanisms
Shi-kun Yang, Hao-ran Zhang, Shu-peng Shi, Ying-qiu Zhu, Na Song, Qing Dai, Wei Zhang, Ming Gui and Hao Zhang*
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The Role of TRP Channels in Allergic Inflammation and its Clinical Relevance
Woo Kyung Kim* and Joo Hyun Nam
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Nanocarriers: A Successful Tool to Increase Solubility, Stability and Optimise Bioefficacy of Natural Constituents
Anna Rita Bilia*, Vieri Piazzini, Laura Risaliti, Giulia Vanti, Marta Casamonti, Meng Wang and Maria Camilla Bergonzi
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Sugars and Sweeteners: Structure, Properties and In Silico Modeling
Dusanka Janezic, Lorentz Jantschi* and Sorana D. Bolboaca
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Development of Health Products from Natural Sources
Francesca Sansone, Teresa Mencherini, Patrizia Picerno, Maria Rosaria Lauro, Michele Cerrato and Rita Patrizia Aquino*
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Agronomic Cultivation, Chemical Composition, Functional Activities and Applications of Pereskia Species – A Mini Review
Vinicius B.V. Maciel, Cristiana M.P. Yoshida and Francisco Goycoolea*
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Implantable Medical Devices and Tissue Engineering: An Overview of Manufacturing Processes and the Use of Polymeric Matrices for Manufacturing and Coating their Surfaces
Gabriel Victor Simoes Dutra, Weslany Silverio Neto, Joao Paulo Simoes Dutra and Fabricio Machado*
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A Systematic Review on Anti-diabetic Properties of Chalcones
Sonia Rocha, Daniela Ribeiro, Eduarda Fernandes* and Marisa Freitas*
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The Mechanism of Action of Praziquantel: Can New Drugs Exploit Similar Mechanisms?
Charlotte M. Thomas and David Timson*
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Recent Advances and Challenges of the Drugs Acting on Monoamine Transporters
Weiwei Xue*, Tingting Fu, Guoxun Zheng, Gao Tu, Yang Zhang, Fengyuan Yang, Lin Tao, Lixia Yao and Feng Zhu*
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Drug Target Selection for Trypanosoma cruzi Metabolism by Metabolic Control Analysis and Kinetic Modeling
Emma Saavedra*, Zabdi Gonzalez-Chavez, Rafael Moreno-Sanchez and Paul A. M. Michels
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Complex Signaling Networks Controlling Dynamic Molecular Changes in Pseudomonas aeruginosa Biofilm
Grzegorz Gula, Agata Dorotkiewicz-Jach, Kamila Korzekwa, Miguel Angel Valvano and Zuzanna Drulis-Kawa*
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An Update on the Neurochemistry of Essential Tremor
Félix Javier Jiménez-Jiménez *, Hortensia Alonso-Navarro, Elena García-Martín and José A.G. Agúndez
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The ERM Complex: A New Player Involved in Diabetes-induced Vascular Leakage
Olga Simo-Servat, Cristina Hernández and Rafael Simó*
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Biopolymer Substrates in Buccal Drug Delivery: Current Status and Future Trend
Bo Sun, Weijun Wang, Zhibin He, Min Zhang, Fangong Kong and Mohini Sain*
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Targeting Nodal and Cripto-1: Perspectives Inside Dual Potential Theranostic Cancer Biomarkers
Annamaria Sandomenico* and Menotti Ruvo
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Sulfur-containing Secondary Metabolites as Neuroprotective Agents
Alessandro Venditti* and Armandodoriano Bianco
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Trends in Diagnosis for Active Tuberculosis Using Nanomaterials
Le Mihn Tu Phan, Lemma Teshome Tufa, Hwa-Jung Kim, Jaebeom Lee and Tae Jung Park*
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Sam Domains in Multiple Diseases
Marian Vincenzi, Flavia Anna Mercurio and Marilisa Leone*
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Stimuli-responsive Drug Delivery Nanocarriers in the Treatment of Breast Cancer
Joao A. Oshiro-Junior , Renata Carolina Alves, Gilmar Hanck-Silva , Mariana R. Sato, Camila Rodero, Josimar O. Eloy* and Marlus Chorilli*
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Pyridine and Pyrimidine Derivatives as Privileged Scaffolds in Biologically Active Agents
Maria Assunta Chiacchio , Daniela Iannazzo , Roberto Romeo, Salvatore V. Giofrè and Laura Legnani*
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A Review of Drug Repositioning Based Chemical-induced Cell Line Expression Data
Fei Wang, Xiujuan Lei and Fang-Xiang Wu*
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Lipids as Activators of Innate Immunity in Peptide Vaccine Delivery
Stacey Bartlett, M. Skwarczynski * and Istvan Toth
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Structural and Molecular Tear Film Changes in Glaucoma
Rodolfo Mastropasqua*, Luca Agnifili and Leonardo Mastropasqua
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Manipulation of the Immune System for Cancer Defeat: A Focus on the T Cell Inhibitory Checkpoint Molecules
Paolo D’Arrigo, Martina Tufano, Anna Rea, Vincenza Vigorito, Nunzia Novizio, Salvatore Russo, Maria Fiammetta Romano and Simona Romano*
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Development of Pin1 Inhibitors and their Potential as Therapeutic Agents
Yusuke Nakatsu, Yasuka Matsunaga, Koji Ueda, Takeshi Yamamotoya, Yuki Inoue, Masa-ki Inoue, Yu Mizuno, Akifumi Kushiyama, Hiraku Ono, Midori Fujishiro, Hisanaka Ito, Takayoshi Okabe and Tomoichiro Asano*
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Pharmacological Management of Chronic Obstructive Lung Disease (COPD). Evidence from a Real-World Perspective
Aliaksei Kisialiou, Giulia Prinzi, Palma Lamonaca, Vittorio Cardaci, Massimo Fini, Stefano Bonassi and Patrizia Russo *
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Peripheral Immunity, Immunoaging and Neuroinflammation in Parkinson’s Disease
Kustrimovic Natasa, Marino Franca and Marco Cosentino*
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Therapeutic Approaches for the Management of Sleep Disorders in Geriatric Population
Mireille Salas-Crisostomo, Pablo Torterolo , André Barciela Veras, Nuno Barbosa Rocha, Sérgio Machado and Eric Murillo-Rodríguez§*
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Bacterial Lipoprotein Biosynthetic Pathway as a Potential Target for Structure-based Design of Antibacterial Agents
Jie Xia*, Bo Feng, Gang Wen, Wenjie Xue, Guixing Ma, Hongmin Zhang and Song Wu*
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Role of Fatty Acid Binding Protein 4 (FABP4) in Kidney Disease
Min Shi, Liang Ma* and Ping Fu
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Aptamer-Based Targeted Drug Delivery Systems: Current Potential and Challenges
Fen He, Nachuan Wen, Daipeng Xiao, Jianhua Yan, Hongjie Xiong, Shundong Cai, Zhenbao Liu* and Yanfei Liu*
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Antimicrobial Capacity of Plant Polyphenols against Gram-positive Bacteria: A Comprehensive Review
Francisco Javier Alvarez-Martinez, Enrique Barrajon-Catalan*, Jose Antonio Encinar, Juan Carlos Rodriguez-Diaz and Vicente Micol
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An Overview of Antiretroviral Agents for Treating HIV Infection in Paediatric Population
Rita Melo, Agostinho Lemos, António J. Preto, Beatriz Bueschell, Pedro Matos-Filipe, Carlos Barreto, José G. Almeida, Rúben D.M. Silva, João D. G. Correia and Irina Moreira*
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The Close Interplay of Nitro-Oxidative Stress, Advanced Glycation end Products and Inflammation in Inflammatory Bowel Diseases
Fabiana Andrea Moura, Marília Oliveira Fonseca Goulart*, Amylly Sanuelly da Paz Martins and Samara Bonfim Gomes Campos
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Prognostic Impact of Tissue Inhibitor of Metalloproteinase-1 in Non- Small Cell Lung Cancer: Systematic Review and Meta-Analysis
Gurudeeban Selvaraj*, Satyavani Kaliamurthi, Shuhuang Lin, Keren Gu and Dong-Qing Wei
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Five Years of the KNIME Vernalis Cheminformatics Community Contribution
Stephen Roughley*
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Can We Extrapolate Data from One Immune-Mediated Inflammatory Disease to Another One?
Fernando Magro*, Rosa Coelho and Armando Peixoto
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Advances in the Understanding of the Cannabinoid Receptor 1 – Focusing on the Inverse Agonists Interactions
Silvana Russo and Walter Filgueira De Azevedo*
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Tumor Vasculature Targeted TNFα Therapy: Reversion of Microenvironment Anergy and Enhancement of the Anti-tumor Efficiency
Enrica Balza, Barbara Carnemolla, Paola Orecchia, Anna Rubartelli, Alessandro Poggi and Lorenzo Mortara*
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Metabolomics of Exhaled Breath Condensate by Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry: A Methodological Approach
Mauro Maniscalco*, Adele Cutignano, Debora Paris, Dominique J. Melck, Antonio Molino, Salvatore Fuschillo and Andrea Motta*
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Cubilin, the Intrinsic Factor-vitamin B12 Receptor in Development and Disease
Renata Kozyraki * and Olivier Cases
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From Levinthal’s Paradox to the Effects of Cell Environmental Perturbation on Protein Folding
Juan Zeng* and Zunnan Huang*
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The Thiol-polyamine Metabolism of Trypanosoma cruzi: Molecular Targets and Drug Repurposing Strategies
Alan Talevi, Carolina Carrillo and Marcelo A Comini*
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Hydrogel-clay Nanocomposites as Carriers for Controlled Release
Raluca Ianchis, Claudia Ninciuleanu*, Ioana Catalina Gifu, Elvira Alexandrescu, Cristina Lavinia Nistor, Sabina Georgiana Nitu and Cristian Petcu
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Recent Progress in Histone Deacetylase Inhibitors as Anticancer Agents
Loredana Cappellacci*, Diego R. Perinelli, Filippo Maggi, Mario Grifantini and Riccardo Petrelli*
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Electronic Noses in Medical Diagnostics
Wojciech Wojnowski*, Tomasz Dymerski, Jacek Gębicki and Jacek Namieśnik
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Phenylboronic Acid-polymers for Biomedical Applications
Ji Hyun Ryu, Gyeong Jin Lee, Yu-Ru V Shih, Tae-il Kim* and Shyni Varghese*
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Cordycepin in Anticancer Research: Molecular Mechanism of Therapeutic Effects
Md. Asaduzzaman Khan* and Mousumi Tania
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A Review: The Anti-inflammatory, Anticancer, Antibacterial Properties of Four Kinds of Licorice Flavonoids Isolated from Licorice
Ze-Feng Wang, Jia Liu, Yong-An Yang and Hai-Liang Zhu*
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Omega-3 Polyunsaturated Fatty Acid Derived Lipid Mediators and their Application in Drug Discovery
Curtis W. Pazderka, Brian Oliver, Michael Murray and Tristan Rawling*
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The Current Status and Perspectives of Delivery Strategy for Boronbased Drugs
Zhu Yinghuai*, Xinglong Lin, Hongming Xie, Jianlin Li, Narayan S. Hosmane and Yingjun Zhang
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Streptococcal Collagen-like Protein 1 Binds Wound Fibronectin: Implications in Pathogen Targeting
Dudley H McNitt, Livingston Van De Water, Daniela Marasco, Rita Berisio and Slawomir Lukomski*
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Targeting Long Non-Coding RNAs in Nervous System Cancers: New Insights in Prognosis, Diagnosis and Therapy
Nikos Malissovas, Elpinickie Ninou , Artemis Michail and Panagiotis K Politis*
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Plant-Derived Products as Antibacterial and Antifungal Agents in Human Health Care
Ladislav Kokoska*, Pavel Kloucek , Olga Leuner and Pavel Novy
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Advances in Docking
Vladimir B Sulimov*, Danil C Kutov and Alexey V Sulimov
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Exosome-like Nanovectors for Drug Delivery in Cancer
Noemi Arrighetti, Claudia Corbo, Michael Evangelopoulos, Anna Pasto, Valentina Zuco and Ennio Tasciotti*
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Fructose-1,6-bisphosphatase Inhibitors: A Review of Recent (2000– 2017) Advances and Structure-Activity Relationship Studies
Sarbjit Singh, Dipesh S. Harmalkar , Yongseok Choi* and Kyeong Lee*
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T-type Calcium Channels in Health and Disease
Dan Wang, Lotten Ragnarsson and Richard J. Lewis*
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Ocular Ciliopathies: Genetic and Mechanistic Insights into Developing Therapies
Mahesh Shivanna, Manisha Anand, Subhabrata Chakrabarti and Hemant Khanna*
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Lithium – Pharmacological and Toxicological Aspects: The Current State of the Art
Branislava Medić*, Marko Stojanović, Bojan Štimec, Nevena Divac, Katarina Savić Vujović, Radan Stojanović, Mirjana Čolović, Danijela Z. Krstić and Milica Prostran
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Novel Diagnostic Biomarkers of Prostate Cancer: An Update
Umberto Anceschi*, Gabriele Tuderti, Franco Lugnani, Pier Mario Biava, Gianni Malossini, Lorenzo Luciani, Tommaso Cai, Davide Marsiliani, Alessio Filianoti, Daniele Mattevi, Manuela Costantini, Leonardo Misuraca and Giuseppe Simone
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Lipids as Biomarkers of Cancer and Bacterial Infections
Gerald Larrouy-Maumus *
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Carbohydrates: Potential Sweet Tools Against Cancer
Oscar Lopez*, Antonio Franconetti and Jose G. Fernandez-Bolanos
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Migraine: Genetic Variants and Clinical Phenotypes
Innocenzo Rainero*, Alessandro Vacca, Flora Govone, Annalisa Gai, Lorenzo Pinessi and Elisa Rubino
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Structural and Biological Overview of Boron-containing Amino Acids in the Medicinal Chemistry Field
Antonio Abad Garcia, Alexey Rayevski, Erik Andrade-Jorge and Jose G. Trujillo-Ferrara*
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The Healing Effects of Spices in Chronic Diseases
Danka Bukvicki*, Davide Gottardi, Sahdeo Prasad, Miroslav Novakovic, Petar Marin and Amit Kumar Tyagi
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Circulating Biomarkers for Tumor Angiogenesis: Where Are We?
Virginia Di Paolo, Marta Colletti, Valentina Ferruzzi, Ida Russo, Angela Galardi, Iside Alessi , Giuseppe Maria Milano and Angela Di Giannatale*
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Xanthine Derivatives as Agents Affecting Non-dopaminergic Neuroprotection in Parkinson`s Disease
Alexandra Kasabova-Angelova, Diana Tzankova, Javor Mitkov, Maya Georgieva, Virginia Tzankova, Alexander Zlatkov and Magdalena Kondeva-Burdina*
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Cancer Biomarker Discovery for Precision Medicine: New Progress
Jinfeng Zou and Edwin Wang*
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Silver Nanomaterials in Contemporary Molecular Physiology Research
Igor Pantic*, David Sarenac, Mila Cetkovic, Milan Milisavljevic, Rastko Rakocevic and Sandor Kasas
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Hybrid Compounds & Oxidative Stress Induced Apoptosis in Cancer Therapy
Aysegul Hanikoglu, Hakan Ozben, Ferhat Hanikoglu and Tomris Ozben*
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Methodological Aspects of Phytosterol Measurements in Biological Samples
Helena Gylling*, Piia Simonen, Leena Kaipiainen and Ingmar Wester
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Therapeutic Macromolecular Iron Chelators
Upendra Bulbake, Alka Singh, Avi Domb* and Wahid Khan
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The Neurokinins: Peptidomimetic Ligand Design and Therapeutic Applications
Charlene Gadais and Steven Ballet*
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In Silico Prediction of P-glycoprotein Binding: Insights from Molecular Docking Studies
Santiago Vilar*, Eduardo Sobarzo-Sanchez and Eugenio Uriarte
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Non-Steroidal Androgen Receptor Antagonists and Prostate Cancer: A Survey on Chemical Structures Binding this Fast-Mutating Target
Claudia Ferroni* and Greta Varchi*
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C-cinnamoyl Glycosides: An Emerging “Tail” for the Development of Selective Carbonic Anhydrase Inhibitors
Helberth Llantén Martínez, Leonardo E. Riafrecha and Pedro Alfonso Colinas*
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The Role of Adipokines in the Establishment and Progression of Head and Neck Neoplasms
Theodora Tzanavari, Jason Tasoulas*, Chrysoula Vakaki , Chrysovalantou Mihailidou , Gerasimos Tsourouflis and Stamatios Theocharis
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Cellular Communication in Bone Homeostasis and the Related Antiosteoporotic Drug Development
Yi Zhang, Guojing Luo and Xijie Yu*
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Antimicrobial Peptides: Amphibian Host Defense Peptides
Jiri Patocka, Eugenie Nepovimova , Blanka Klimova, Qinghua Wu and Kamil Kuca*
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Calcium Channel Blockers in Restoration of Endothelial Function: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Miroslav Radenkovic*, Marko Stojanovic and Milica Prostran
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Quercetin and its Natural Sources in Wound Healing Management
Nicoletta Polera , Mariateresa Badolato , Filomena Perri , Gabriele Carullo and Francesca Aiello*
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A Walk in Nature. Sesquiterpene Lactones as Multi-Target Agents Involved in Inflammatory Pathways
Adriana Coricello, James David Adams*, Eric Lien, Christopher Nguyen, Filomena Perri, Travis J. Williams and Francesca Aiello
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Recent Drug-Repurposing-Driven Advances in the Discovery of Novel Antibiotics
Ananda Kumar Konreddy, Grandhe Usha Rani, Kyeong Lee and Yongseok Choi*
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Electrophysiological Characteristics of the Migraine Brain: Current Knowledge and Perspectives
Erica Marucco, Marco Lisicki and Delphine Magis*
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Pharmacological Management of Chronic Obstructive Lung Disease (COPD). Focus on Mutations
Patrizia Russo, Filippo Lococco, Aliaksei Kisialiou*, Giulia Prinzi, Palma Lamonaca, Vittorio Cardaci and Massimo Fini
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Latest Updates in Dengue Fever Therapeutics: Natural, Marine and Synthetic Drugs
Samira Hosseini*, Rodrigo B. Munoz-Soto, Jacqueline Oliva-Ramirez, Patricia Vazquez-Villegas, Nasrin Aghamohammadi, Aida Rodriguez-Garcia and Sergio O. Martinez-Chapa
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Could Flavonoids Compete with Synthetic Azoles in Diminishing Candida albicans Infections? A Comparative Review Based on In Vitro Studies
Marija Smiljkovic*, Marina Kostic, Dejan Stojkovic, Jasmina Glamoclija and Marina Sokovic
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Synthetic Peptide Libraries. From Random Mixtures to In Vivo Testing
Annamaria Sandomenico, Andrea Caporale, Nunzianna Doti, Simon Cross, Gabriele Cruciani, Angela Chambery, Sandro De Falco and Menotti Ruvo*
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Cancer-associated Cachexia, Reactive Oxygen Species, and Nutrition Therapy
Geir Bjorklund*, Maryam Dadar , Jan Aaseth , Salvatore Chirumbolo and Joeri J. Pen
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Impact of Natural Dietary Agents on Multiple Myeloma Prevention and Treatment: Molecular Insights and Potential for Clinical Translation
Lavinia Raimondi, Angela De Luca, Gianluca Giavaresi, Agnese Barone, Pierosandro Tagliaferri, Pierfrancesco Tassone and Nicola Amodio*
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Rational Drug Design Approach of Receptor Tyrosine Kinase Type III Inhibitors
Eunae Kim* and Cheolhee Kim
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Dual Inhibitors as a New Challenge for Cancer Multidrug Resistance Treatment
Tijana Stankovic, Jelena Dinic, Ana Podolski-Renic, Loana Musso, Sonja Stojkovic Buric, Sabrina Dallavalle* and Milica Pesic
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Signal Transducer and Activator of Transcription Protein 3 (STAT3): An Update on its Direct Inhibitors as Promising Anticancer Agents
Arianna Gelain , Matteo Mori , Fiorella Meneghetti and Stefania Villa*
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Genetic Polymorphisms within Interferon-λ Region and Interferon-λ3 in the Human Pathophysiology: Their Contribution to Outcome, Treatment, and Prevention of Infections with Hepatotropic Viruses
Alicja E. Grzegorzewska *
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Focusing on the Influenza Virus Polymerase Complex: Recent Progress in Drug Discovery and Assay Development
Jiantao Zhang, Yanmei Hu, Rami Ghassan Musharrafieh, Hang Yin and Jun Wang*
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Porous Inorganic and Hybrid Systems for Drug Delivery: Future Promise in Combatting Drug Resistance and Translation to Botanical Applications
Junling Guo, Bruno D. Mattos, Blaise L. Tardy, Vanessa M. Moody, Gao Xiao, Hirotaka Ejima, Jiwei Cui, Kang Liang and Joseph Jacob Richardson*
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Advances in the Prediction of Protein Aggregation Propensity
Irantzu Pallarès* and Salvador Ventura
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The Mechanisms Behind the Biological Activity of Flavonoids
Ana M. Gonzalez-Paramas, Begona Ayuda-Duran, Sofia Martinez, Susana Gonzalez-Manzano and Celestino Santos-Buelga*
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Cysteine-targeted Irreversible Inhibitors of Tyrosine Kinases and Key Interactions
Chunqi Hu* and Xiaowu Dong
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Pharmacokinetic and Pharmacogenetic Markers of Irinotecan Toxicity
Roberta Zilles Hahn, Marina Venzon Antunes, Simone Gasparin Verza , Magda Susana Perassolo, Edna Sayuri Suyenaga , Gilberto Schwartsmann and Rafael Linden *
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Photo-triggered Drug Delivery Systems for Neuron-related Applications
Wei Li, Jing Lin, Tianfu Wang and Peng Huang*
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Energy Metabolism Impairment in Migraine
Sabina Cevoli*, Valentina Favoni and Pietro Cortelli
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Recent Advances in Drug Repurposing for Parkinson’s Disease
Xin Chen*, Giuseppe Gumina and Kristopher G. Virga
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Advances in the Tyrosinase Inhibitors from Plant Source
Marco Bonesi, Jianbo Xiao, Rosa Tundis*, Francesca Aiello, Vincenzo Sicari and Monica R. Loizzo
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Current Highlights About the Safety of Inorganic Nanomaterials in Healthcare
Luana Perioli, Cinzia Pagano* and Maria Rachele Ceccarini
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The Role of Matrix Gla Protein (MGP) in Vascular Calcification
Geir Bjorklund*, Erik Svanberg, Maryam Dadar, David J. Card, Salvatore Chirumbolo, Dominic J. Harrington and Jan Aaseth
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The Potential Impacts of Tylophora Alkaloids and their Derivatives in Modulating Inflammation, Viral Infections, and Cancer
Duc-Hiep Bach and Sang Kook Lee *
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State of the Art on Carbonic Anhydrase Modulators for Biomedical Purposes
Murat Bozdag, Abdulmalik Saleh Alfawaz Altamimi, Daniela Vullo, Claudiu T. Supuran and Fabrizio Carta*
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Promising Alternative Therapeutics for Oral Candidiasis
Celia Fortuna Rodrigues, Maria Elisa Rodrigues and Mariana Contente Rangel Henriques*
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Inhibitors of Serine/Threonine Protein Phosphatases: Biochemical and Structural Studies Provide Insight for Further Development
Mark R Swingle and Richard Eric Honkanen*
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Drug Repurposing in the Development of Anticancer Agents
Sureyya Olgen* and Lakshmi Kotra
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Sitosterolemia: Diagnosis, Metabolic and Hematological Abnormalities, Cardiovascular Disease and Management
Jose Maria Bastida*, Maria Luisa Giros, Rocio Benito, Kamila Janusz, Jesus Maria Hernandez-Rivas and Jose Ramon Gonzalez-Porras
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The Promising Role of Plant Tannins as Bioactive Antidiabetic Agents
Mohammed Ajebli and Mohamed Eddouks*
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Ionic Liquid-Like Pharmaceutical Ingredients and Applications of Ionic Liquids in Medicinal Chemistry: Development, Status and Prospects
Jie Tang , Hang Song , Xueting Feng , Alula Yohannes and Shun Yao*
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Delivery Systems for Birch-bark Triterpenoids and their Derivatives in Anticancer Research
Inese Mierina, Reinis Vilskersts and Maris Turks*
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Genome Wide Approaches to Identify Protein-DNA Interactions
Tao Ma, Zhenqing Ye and Liguo Wang*
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Phytosterols and Inflammation
Gemma Vilahur, Soumaya Ben-Aicha, Elisa Diaz, Lina Badimon and Teresa Padro*
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Biological Consequences of Dysfunctional HDL
Angela Pirillo , Alberico Luigi Catapano* and Giuseppe Danilo Norata
View Abstract View on PubMed
Use of Plant Sterol and Stanol Fortified Foods in Clinical Practice
Montserrat Cofan* and Emilio Ros
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The Impact of Phytosterols on the Healthy and Diseased Brain
Tess Dierckx, Jeroen F.J. Bogie and Jerome A Hendriks*
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Development and Application of Computational Methods in Phage Display Technology
Bifang He, Anthony Mackitz Dzisoo, Ratmir Derda and Jian Huang*
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An Overview of the Loading Efficacy of Cationic Lipids with Milk Proteins: A Potential Application for Lipid Delivery
P. Chanphai, Philippe Bourassa and Heidar -Ali Tajmir-Riahi*
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Computational Drug Repurposing: Current Trends
Berin Karaman* and Wolfgang Sippl
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Influence of Oxidative Stress on Catalytic and Non-glycolytic Functions of Glyceraldehyde-3-phosphate Dehydrogenase
Vladimir I. Muronetz*, Aleksandra K. Melnikova, Luciano Saso and Elena V. Schmalhausen
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The Role of Diet-Related Short-Chain Fatty Acids in Colorectal Cancer Metabolism and Survival: Prevention and Therapeutic Implications
Sara Daniela Gomes, Claudia Suellen Oliveira, Joao Azevedo-Silva, Marta Casanova, Judite Barreto, Helena Pereira, Susana Chaves, Ligia Rodrigues, Margarida Casal, Manuela Corte-Real, Fatima Baltazar and Ana Preto*
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Circulating Biomarkers in Migraine. New Opportunities for Precision Medicine
Patrizia Ferroni*, Piero Barbanti, Antonella Spila, Federica Fratangeli, Cinzia Aurilia, Luisa Fofi, Gabriella Egeo and Fiorella Guadagni
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Epigenetic Metalloenzymes
Christophe Blanquart, Camille Linot, Pierre-Francois Cartron, Daniela Tomaselli, Antonello Mai and Philippe Bertrand*
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Flavonoids and Reduction of Cardiovascular Disease (CVD) in Chronic Obstructive Pulmonary Disease (COPD)
Patrizia Russo*, Giulia Prinzi, Palma Lamonaca, Vittorio Cardaci and Massimo Fini
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Small Molecules as Drugs to Upregulate Metastasis Suppressors in Cancer Cells
Ka Ming Wong , Jiaxing Song , Vasu Saini and Yung H. Wong*
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DNA Topoisomerases of Leishmania Parasites; Druggable Targets for Drug Discovery
Rosa M Reguera, Ehab Kotb Elmahallawy, Carlos Garcia-Estrada, Ruben Carbajo-Andres and Rafael Balana-Fouce *
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A Systematic Review on Donepezil-based Derivatives as Potential Cholinesterase Inhibitors for Alzheimer’s Disease
Jan Korabecny , Katarina Spilovska, Eva Mezeiova , Ondrej Benek , Radomir Juza , Daniel Kaping and Ondrej Soukup*
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Chronic Low Back Pain: Current Pharmacotherapeutic Therapies and a New Biological Approach
Karel Pavelka*, Hana Jarosova, Olga Sleglova, Radka Svobodova, Martina Votavova, Leonello Milani, Zdenek Prochazka, Lucie Kotlarova, Pavel Kostiuk, Jiri Sliva and Alberto Marco Meroni
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Perspectives and New Aspects of Metalloproteinases’ Inhibitors in the Therapy of CNS Disorders: From Chemistry to Medicine
Anna Boguszewska-Czubara*, Barbara Budzynska, Krystyna Skalicka-Wozniak and Jacek Kurzepa
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Advances in the Treatment of Explicit Water Molecules in Docking and Binding Free Energy Calculations
Xiao Hu, Irene Maffucci and Alessandro Contini*
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Acanthamoeba Keratitis: Current Status and Urgent Research Priorities
Naveed Ahmed Khan*, Ayaz Anwar and Ruqaiyyah Siddiqui
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Genetically Engineered Elastin-based Biomaterials for Biomedical Applications
Mercedes Santos , Sofia Serrano-Ducar , Juan Gonzalez-Valdivieso , Reinaldo Vallejo, Alessandra Girotti , Purificacion Cuadrado and Francisco Javier Arias*
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Conjugates of Classical DNA/RNA Binder with Nucleobase: Chemical, Biochemical and Biomedical Applications
Dijana Saftic, Zeljka Ban , Josipa Matic, Lidija-Marija Tumir and Ivo Piantanida*
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Advances and Application of DNA-functionalized Nanoparticles
Xun Zhang *, Fei Wang, Jin-Liang Sheng and Min-Xuan Sun
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Natural Products: Key Prototypes to Drug Discovery Against Neglected Diseases Caused by Trypanosomatids
Marina Themoteo Varela and Joao Paulo S. Fernandes*
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Medicinal Chemistry of Potassium Channel Modulators: An Update of Recent Progress (2011-2017)
Vivek K. Vyas*, Palak Parikh , Jonali Ramani and Manjunath Ghate
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Drugs for Targeted Therapies of Alzheimer’s Disease
Chit Tam*, Jack Ho Wong*, Tzi Bun Ng*, Stephen Kwok Wing Tsui and Tao Zuo
View Abstract View on PubMed
Liver Radioembolization: An Analysis of Parameters that Influence the Catheter-Based Particle-Delivery via CFD
Jorge Aramburu*, Raul Anton, Alejandro Rivas, Juan Carlos Ramos, Bruno Sangro and Jose Ignacio Bilbao
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Multifunctional Mesoporous Silica Nanoparticles for Cancer Therapy and Imaging
Fahima Dilnawaz*
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Natural Alkaloids Intervening the Insulin Pathway: New Hopes for Anti-Diabetic Agents?
Maria-Ioanna Christodoulou*, Job Tchoumtchoua , Alexios-Leandros Skaltsounis , Andreas Scorilas and Maria Halabalaki
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Targeted Therapies for Autosomal Dominant Polycystic Kidney Disease
Cherie Stayner*, Darby G Brooke, Michael Bates and Michael R. Eccles
View Abstract View on PubMed
Gene Silencing Strategies in Cancer Therapy: An Update for Drug Resistance
Sanaz Naghizadeh, Behzad Mansoori, Ali Mohammadi, Ebrahim Sakhinia and Behzad Baradaran*
View Abstract View on PubMed
Insights on melatonin as an active pharmacological molecule in cancer prevention: what’s new?
Geir Bjorklund*, Samiul Alam Rajib , Nadia Saffoon, Joeri J. Pen and Salvatore Chirumbolo
View Abstract View on PubMed
Research Progress on Brucellosis
Yuming Deng, Xinyue Liu, Kaifang Duan and Qisheng Peng*
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Honey: An Effective Regenerative Medicine Product in Wound Management
Simona Martinotti*, Marcela Bucekova , Juraj Majtan and Elia Ranzato
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Current and Future Prospects of Nitro-compounds as Drugs for Trypanosomiasis and Leishmaniasis
Alan H. Fairlamb* and Stephen Patterson
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Zinc Dependent Histone Deacetylase Inhibitors in Cancer Therapeutics: Recent Update
Faria Sultana, Kesari Lakshmi Manasa, Siddiq Pasha Shaik, Srinivasa Reddy Bonam and Ahmed Kamal*
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A Chemical Approach to Overcome Tyrosine Kinase Inhibitors Resistance: Learning from Chronic Myeloid Leukemia
Enrico Zanforlin, Giuseppe Zagotto* and Giovanni Ribaudo
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The LDL-Receptor and its Molecular Properties: From Theory to Novel Biochemical and Pharmacological Approaches in Reducing LDL-cholesterol
Dimitrios Petroglou, Ilias Kanellos, Christos Savopoulos , Georgia Kaiafa*, Anastasios Chrysochoou , Panagiotis Skantzis , Stylianos Daios , Apostolos I. Hatzitolios and Georgios Giannoglou
View Abstract View on PubMed
Phytosterols in Cancer: From Molecular Mechanisms to Preventive and Therapeutic Potentials
Francisco Blanco-Vaca, Lidia Cedo and Josep Julve*
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Modulation of Immuno-biome During Radio-sensitization of Tumors by Glycolytic Inhibitors
Seema Gupta and Bilikere Dwarakanath*
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SGLT-2 inhibitors in Diabetic Kidney Disease: What Lies Behind their Renoprotective Properties?
Panagiotis I. Georgianos , Maria Divani , Theodoros Eleftheriadis, Peter R. Mertens and Vassilios Liakopoulos*
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Triglyceride-Rich Lipoproteins as a Source of Proinflammatory Lipids in the Arterial Wall
Katariina Öörni*, Satu Lehti, Peter Sjövall and Petri T. Kovanen
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Recent Advances on Glioblastoma Multiforme and Nano-drug Carriers: A Review
Wang Liao, Shengnuo Fan, Yuqiu Zheng, Shaowei Liao , Ying Xiong, Yi Li and Jun Liu *
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The Therapeutic Impact of New Migraine Discoveries
Laszlo Vecsei*, Melinda Lukacs, Janos Tajti, Ferenc Fulop, Jozsef Toldi and Lars Edvinsson
View Abstract View on PubMed
Contribution of Spinal Cord Oligodendrocytes to Neuroinflammatory Diseases and Pain
Sergio M. Borghi , Victor Fattori , Miriam S. N. Hohmann and Waldiceu A. Verri*
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Aporphines and Alzheimer’s Disease: Towards a Medical Approach Facing the Future
Seyed Mohammad Nabavi, Eugenio Uriarte, Luca Rastrelli and Eduardo Sobarzo-Sanchez*
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Neurodegenerative Process Linking the Eye and the Brain
Raffaele Mancino, Massimo Cesareo, Alessio Martucci, Emiliano Di Carlo, Elena Ciuffoletti, Luigi Antonio Morrone, Carlo Nucci*, Clarissa Giannini and Francesco Garaci
View Abstract View on PubMed
Modified LDL Immune Complexes and Cardiovascular Disease
Maria F. Lopes-Virella and Gabriel Virella*
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Neoadjuvant Therapy is Essential for Resectable Pancreatic Cancer
Jin-Zhi Xu, Wen-Quan Wang, Shi-Rong Zhang, Hua-Xiang Xu, Chun-Tao Wu, Zi-Hao Qi, He-Li Gao, Shuo Li, Quan-Xing Ni, Xian-Jun Yu and Liang Liu*
View Abstract View on PubMed
Polypharmacology in the Treatment of Chagas Disease
Elena Aguilera, Guzman Alvarez, Hugo Cerecetto and Mercedes Gonzalez *
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Diverse Targeted Approaches to Battle Multidrug Resistance in Cancer
Nagula Shankaraiah*, Shalini Nekkanti , Ojaswitha Ommi and P. S. Soukya Lakshmi
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The Design of New HIV-IN Tethered Bifunctional Inhibitors Using Multiple Microdomain Targeted Docking
Mihai Ciubotaru*, Mihaela Georgiana Musat, Marius Surleac, Elena Ionita , Andrei Jose Petrescu, Edgars Abele and Ramona Abele
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Tacrine-Natural-Product Hybrids for Alzheimer’s Disease Therapy
Maria Jesus Oset-Gasque* and Jose Marco-Contelles
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Targeting AMPK in Diabetes and Diabetic Complications: Energy Homeostasis, Autophagy and Mitochondrial Health
Y. V. Madhavi , Nikhil Gaikwad , Veera Ganesh Yerra , Anil Kumar Kalvala , Srinivas Nanduri and Ashutosh Kumar*
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Glycosides from Medicinal Plants as Potential Anticancer Agents: Emerging Trends Towards Future Drugs
Haroon Khan, Mina Saeedi, Seyed Mohammad Nabavi, Mohammad S. Mubarak and Anupam Bishayee*
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Targeting Gap Junctions: New Insights into the Treatment of Major Depressive Disorder
Denis Sarrouilhe*, Marc Mesnil and Catherine Dejean
View Abstract View on PubMed
Metabolic Remodeling Induced by Adipocytes: A New Achille Heels in Invasive Breast Cancer?
Camille Attane*, Delphine Milhas, Andrew J. Hoy and Catherine Muller
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Melatonin and Oxidative Stress in the Diabetic State: Clinical Implications and Potential Therapeutic Applications
Javier Espino, Ana Beatriz Rodriguez and Jose Antonio Pariente*
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Clinical and Pharmacologic Features of Monoclonal Antibodies and Checkpoint Blockade Therapy in Multiple Myeloma
Mattia D’Agostino, Giulia Gazzera , Giusy Cetani , Sara Bringhen, Mario Boccadoro and Francesca Gay*
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Anti-TNF Biosimilars in Inflammatory Bowel Disease: Searching the Proper Patient's Profile
Silvio Danese* and Gionata Fiorino
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Cyclooxygenase-2 Inhibitors as a Therapeutic Target in Inflammatory Diseases
Miguel D. Ferrer, Carla Busquests-Cortes, Xavier Capo, Silvia Tejada, Josep A. Tur, Antoni Pons and Antoni Sureda*
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Metabolic Routes in Inflammation: The Citrate Pathway and its Potential as Therapeutic Target
Vittoria Infantino , Ciro Leonardo Pierri and Vito Iacobazzi*
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Role of Ox-LDL and LOX-1 in Atherogenesis
Ajoe John Kattoor, Sri Harsha Kanuri and Jawahar L. Mehta*
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Freely Accessible Chemical Database Resources of Compounds for In Silico Drug Discovery
JingFang Yang, Di Wang, Chenyang Jia, Mengyao Wang , GeFei Hao and GuangFu Yang*
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Electronegative LDL: An Active Player in Atherogenesis or a By- Product of Atherosclerosis?
Andrea Rivas-Urbina, Anna Rull, Jordi Ordonez-Llanos and Jose Luis Sanchez-Quesada*
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Terpenes, Phenylpropanoids, Sulfur and Other Essential Oil Constituents as Inhibitors of Cholinesterases
Franko Burcul, Ivica Blazevic, Mila Radan and Olivera Politeo*
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Pigments from Filamentous Ascomycetes for Combination Therapy
Robert Hromadka, Zdenek Kejík , Milan Jakubek, Robert Kaplanek, Viera Sandrikova , Marian Urban , Pavel Martasek and Vladimir Kral*
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ADAM Metalloproteinases as Potential Drug Targets
Caterina Camodeca, Doretta Cuffaro, Elisa Nuti* and Armando Rossello
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Impact of Dysfunctional Protein Catabolism on Macrophage Cholesterol Handling
Takuro Miyazaki* and Akira Miyazaki
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99mTc-labeled Small Molecules for Diagnosis of Alzheimer’s Disease: Past, Recent and Future Perspectives
Sajjad Molavipordanjani, Saeed Emami and Seyed Jalal Hosseinimehr*
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NAChR α4β2 Subtype and their Relation with Nicotine Addiction, Cognition, Depression and Hyperactivity Disorder
Manuela M. Laikowski , Favero Reisdorfer and Sidnei Moura*
View Abstract View on PubMed
Mechanism and Inhibition of Matrix Metalloproteinases
Linda Cerofolini, Marco Fragai* and Claudio Luchinat
View Abstract View on PubMed
Biomarkers Determining Prognosis of Atrial Fibrillation Ablation
Dimitris Tsiachris*, George Giannopoulos, Charis Kossyvakis, Spyridon Deftereos, Constantinos Tsioufis, Gerasimos Siasos, Evangelos Oikonomou, Konstantinos Gatzoulis, Dimitris Tousoulis and Christodoulos Stefanadis
View Abstract View on PubMed
PI3K Signaling in Chronic Obstructive Pulmonary Disease: Mechanisms, Targets, and Therapy
Flora Pirozzi, Kai Ren, Alessandra Murabito and Alessandra Ghigo*
View Abstract View on PubMed
Modified and Dysfunctional Lipoproteins in Atherosclerosis: Effectors or Biomarkers?
Alexander N Orekhov* and Igor A. Sobenin
View Abstract View on PubMed
Dysfunctional HDL as a Therapeutic Target for Atherosclerosis Prevention
Alice Ossoli, Chiara Pavanello, Eleonora Giorgio, Laura Calabresi and Monica Gomaraschi*
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HDL Dysfunction Caused by Mutations in apoA-I and Other Genes that are Critical for HDL Biogenesis and Remodeling
Angeliki Chroni and Dimitris Kardassis*
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In Silico Chemogenomics Drug Repositioning Strategies for Neglected Tropical Diseases
Carolina Horta Andrade*, Bruno Junior Neves, Cleber Camilo Melo-Filho, Juliana Rodrigues, Diego Cabral Silva, Rodolpho Campos Braga and Pedro Vitor Lemos Cravo
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Flavonoids and Platelet-Derived Thrombotic Disorders
Jose J Lopez, Mohammed El haouari, Isaac Jardin, Nieves Alonso, Sergio Regodon, Raquel Diez Bello, Pedro Cosme Redondo and Juan A Rosado*
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ABC Transporters in Extrahepatic Tissues: Pharmacological Regulation in Heart and Intestine
Silvina Villanueva, Wei Zhang, Felipe Zecchinati, Aldo Mottino and Mary Vore*
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Linking Antimicrobial Potential of Natural Products Derived from Aquatic Organisms and Microbes Involved in Alzheimer’s Disease - A Review
Dejan Stojkovic*, Marina Kostic, Marija Smiljkovic, Milena Aleksic, Perica Vasiljevic, Milos Nikolic and Marina Sokovic
View Abstract View on PubMed
Speciation of Metal Complexes of Medicinal Interest: The Relationship Between Solution Equilibria and Pharmaceutical Properties
Tamas Kiss*, Eva A. Enyedy, Tamas Jakusch and Orsolya Domotor
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The Significance of Oxidized Low-Density Lipoprotein in Body Fluids as a Marker Related to Diseased Conditions
Hiroyuki Itabe*, Rina Kato, Naoko Sasabe, Takashi Obama and Matsuo Yamamoto
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Antimicrobial and Structural Properties of Metal Ions Complexes with Thiosemicarbazide Motif and Related Heterocyclic Compounds
Ewelina Namiecinska, Marta Sobiesiak, Magdalena Malecka, Piotr Guga, Barbara Rozalska and Elzbieta Budzisz*
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Organic Fluorescent Dye-based Nanomaterials: Advances in the Rational Design for Imaging and Sensing Applications
Denis Svechkarev and Aaron M. Mohs*
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Neuropharmacological Properties of the Essential Oil of Bergamot for the Clinical Management of Pain-Related BPSDs
Damiana Scuteri, Laura Rombola, Laura Tridico, Hirokazu Mizoguchi, Chizuko Watanabe, Tsukasa Sakurada, Shinobu Sakurada, Maria TIziana Corasaniti, Giacinto Bagetta and Luigi Antonio Morrone*
View Abstract View on PubMed
Environmental Training and Synaptic Functions in Young and Old Brain: A Presynaptic Perspective
Tommaso Bonfiglio , Matteo Vergassola , Guendalina Olivero and Anna Pittaluga*
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Inhibitors of Selected Bacterial Metalloenzymes
Raivis Zalubovskis* and Jean-Yves Winum
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Functional Neuroimaging Biomarkers in Migraine: Diagnostic, Prognostic and Therapeutic Implications
Antonio Russo*, Marcello Silvestro, Alessandro Tessitore and Gioacchino Tedeschi
View Abstract View on PubMed
An Update on JAK Inhibitors
Francesca Musumeci*, Chiara Greco, Ilaria Giacchello, Anna Lucia Fallacara, Munjed M. Ibrahim , Giancarlo Grossi, Chiara Brullo and Silvia Schenone
View Abstract View on PubMed
Metal Ion Complexes with Pyrazoles, Aziridines and Diaziridines – Synthesis and Biological Activity
Katarzyna Malinowska, Ingo-Peter Lorenz, Beata Sadowska and Paulina Mucha*
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Recent Advances of mTOR Inhibitors Use in Autosomal Dominant Polycystic Kidney Disease: Is the Road Still Open?
Pei Kou , Shuang Wei * and Fei Xiong
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The Role of (Modified) Lipoproteins in Vascular Function: A Duet Between Monocytes and the Endothelium
Johan G. Schnitzler, Geesje M. Dallinga-Thie and Jeffrey Kroon*
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Sensing, Transport and Other Potential Biomedical Applications of Pseudopeptides
Enrico Faggi, Santiago V Luis and Ignacio Alfonso*
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Potential Roles for G-Quadruplexes in Mitochondria
Micol Falabella, Rafael J. Fernandez, Brad Johnson and Brett A. Kaufman*
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Anti-NMDA Receptor Encephalitis: Efficacy of Treatment for Male Patients and miRNA Biomarker
Hsiuying Wang*
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Modulation of Hepatic MRP3/ABCC3 by Xenobiotics and Pathophysiological Conditions: Role in Drug Pharmacokinetics
Carolina I. Ghanem and Jose E. Manautou*
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Homocysteine and Hyperhomocysteinaemia
Bozidarka L. Zaric, Milan Obradovic, Vladan Bajic , Mohamed A. Haidara , Milos Jovanovic and Esma R. Isenovic*
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Recent Progress in the Development of Fluorometric Chemosensors to Detect Enzymatic Activity
Tingwen Wei , Fang Wang, Zhijie Zhang , Jiang Qiang, Jing Lv , Tiantian Chen, Jia Li and Xiaoqiang Chen*
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Mapping of Protein-Protein Interactions: Web-Based Resources for Revealing Interactomes
Branislava Gemovic, Neven Sumonja, Radoslav Davidovic, Vladimir Perovic and Nevena Veljkovic*
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DNA Double Strand Breaks Repair Inhibitors: Relevance as Potential New Anticancer Therapeutics
Paulina Kopa , Anna Macieja, Grzegorz Galita, Zbigniew J. Witczak* and Tomasz Poplawski
View Abstract View on PubMed
MUC1 Story: Great Expectations, Disappointments and the Renaissance
Mikhail A. Rubtsov *, Marina S. Syrkina and Yegor S. Vassetzky
View Abstract View on PubMed
Acyclovir in the Treatment of Herpes Viruses – A Review
Katarzyna Klysik, Aneta Pietraszek, Anna Karewicz and Maria Nowakowska*
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Current Trends and Future Directions of Fluoroquinolones
Hamada H. H. Mohammed , Gamal El-Din A.A. Abuo-Rahma*, Samar H. Abbas and El-Shimaa M. N. Abdelhafez
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Recent Advances in the Use of Metallic Nanoparticles with Antitumoral Action - Review
Patricia Bento da Silva, Rachel Temperani Amaral Machado , Andressa Maria Pironi, Renata Carolina Alves, Patricia Rocha de Araujo, Amanda Cutrim Dragalzew, Ingrid Dalberto and Marlus Chorilli*
View Abstract View on PubMed
Metal–Organic Framework (MOF)-based Nanomaterials for Biomedical Applications
Zhidong Luo , Shuran Fan , Chuying Gu , Weicong Liu , Baohong Li and Jianqiang Liu*
View Abstract View on PubMed
Advances in the Development of Anticancer HSP-based Vaccines
Alexey V. Baldin, Andrey A. Zamyatnin, Alexandr V. Bazhin, Wan-Hai Xu and Lyudmila V. Savvateeva*
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Innovative Therapeutic Potential of Cannabinoid Receptors as Targets in Alzheimer’s Disease and Less Well-Known Diseases
Juan A. Paez* and Nuria E. Campillo*
View Abstract View on PubMed
Ganglioside GM3 and Its Role in Cancer
Changping Zheng , Marco Terreni , Matthieu Sollogoub and Yongmin Zhang*
View Abstract View on PubMed
Role of Autophagy in Parkinson’s Disease
Silvia Cerri and Fabio Blandini*
View Abstract View on PubMed
DNA Double Strand Break Repair - Related Synthetic Lethality
Monika Toma, Tomasz Skorski and Tomasz Sliwinski*
View Abstract View on PubMed
Targeting DNA Repair Systems in Antitubercular Drug Development
Alina Minias, Anna Brzostek and Jaroslaw Dziadek*
View Abstract View on PubMed
The Role of Selenium in Oxidative Stress and in Nonthyroidal Illness Syndrome (NTIS): An Overview
Andrea Silvestrini*, Alvaro Mordente, Giuseppe Martino, Carmine Bruno, Edoardo Vergani, Elisabetta Meucci and Antonio Mancini
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Recent Advances in Lanthanide Based Nano-Architectures as Probes for Ultra High-Field Magnetic Resonance Imaging
Silvanose Biju and Tatjana Parac-Vogt*
View Abstract View on PubMed
Role of ABC Transporters in Veterinary Medicine: Pharmaco- Toxicological Implications
Guillermo Virkel, Mariana Ballent, Carlos Lanusse and Adrian Lifschitz*
View Abstract View on PubMed
Recent Progress in Chemosensors Using Aldehyde-bearing Fluorophores for the Detection of Specific Analytes and their Bioimaging
Fangjun Huo*, Yaqiong Zhang and Caixia Yin
View Abstract View on PubMed
The Use of Immunotherapy to Treat Metastatic Breast Cancer
Andrea Nicolini*, Vivian Barak, Piermario Biava, Paola Ferrari, Giuseppe Rossi and Angelo Carpi
View Abstract View on PubMed
Novel Therapeutic Approaches in Rheumatoid Arthritis: Role of Janus Kinases Inhibitors
Felice Rivellese, Antonio Lobasso, Letizia Barbieri, Bianca Liccardo, Amato De Paulis and Francesca Wanda Rossi*
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New Drugs, Therapeutic Strategies, and Future Direction for the Treatment of Pulmonary Arterial Hypertension
Valentina Mercurio*, Anna Bianco, Giacomo Campi, Alessandra Cuomo, Nermin Diab, Angela Mancini, Paolo Parrella, Mario Petretta, Paul Hassoun and Domenico Bonaduce
View Abstract View on PubMed
ABC Transporters: Regulation and Association with Multidrug Resistance in Hepatocellular Carcinoma and Colorectal Carcinoma
María Paula Ceballos, Juan Pablo Rigalli, Lucila Ines Cere, Mariana Semeniuk, Viviana Alicia Catania and Maria Laura Ruiz*
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MRP4/ABCC4 As a New Therapeutic Target: Meta-Analysis to Determine cAMP Binding Sites as a Tool for Drug Design
Agustín Yaneff*, Ana Sahores, Natalia Gomez, Alejandro Carozzo, Carina Shayo and Carlos Davio
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Surfing the Blood Coagulation Cascade: Insight into the Vital Factor Xa
Nicolas E. Nunez-Navarro, Fabian M. Santana, Loreto P. Parra and Flavia C. Zacconi*
View Abstract View on PubMed
The Role of AMPK/mTOR Modulators in the Therapy of Acute Myeloid Leukemia
Dora Visnjic*, Vilma Dembitz and Hrvoje Lalic
View Abstract View on PubMed
Looking for New Antifungal Drugs from Flavonoids: Impact of the Genetic Diversity of Candida albicans on the in-vitro Response
Maria Rosa Felice, Letterio Giuffre, Lamya El Aamri, Majida Hafidi, Giuseppe Criseo, Orazio Romeo* and Fabio Scordino
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Recent Advances in Peptide-Based Approaches for Cancer Treatment
Anne C. Conibear, Alanca Schmid, Meder Kamalov, Christian F.W. Becker and Claudia Bello*
View Abstract View on PubMed
Stimuli-responsive Carriers for Controlled Intracellular Drug Release
Yan Sheng*, Jiaming Hu, Junfeng Shi and Ly James Lee
View Abstract View on PubMed
Biomarkers of Alcohol Consumption in Body Fluids - Possibilities and Limitations of Application in Toxicological Analysis
Mateusz K. Woźniak*, Marek Wiergowski, Jacek Namieśnik and Marek Biziuk
View Abstract View on PubMed
Olfactory Loss and Dysfunction in Ciliopathies: Molecular Mechanisms and Potential Therapies
Cedric R. Uytingco*, Warren W. Green and Jeffrey R. Martens
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Breaking the DNA Damage Response via Serine/Threonine Kinase Inhibitors to Improve Cancer Treatment
Wioletta Rozpedek, Dariusz Pytel, Alicja Nowak-Zdunczyk , Dawid Lewko , Radoslaw Wojtczak , John Alan Diehl* and Ireneusz Majsterek
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Novel Biological Therapies in Severe Asthma: Targeting the Right Trait
Gilda Varricchi*, Giancarlo Marone, Giuseppe Spadaro, Michele Russo, Francescopaolo Granata, Arturo Genovese and Gianni Marone
View Abstract View on PubMed
Unfolding Cardiac Amyloidosis –From Pathophysiology to Cure
Klemens Ablasser, Nicolas Verheyen, Theresa Glantschnig, Giulio Agnetti and Peter P Rainer*
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Neuroprotective Effects of Flavonoid Compounds on Neuronal Death Associated to Alzheimer’s Disease
Antoni Sureda*, Capo Xavier and Silvia Tejada
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Fine-tuning of microRNAs in Type 2 Diabetes Mellitus
Juan A. Rosado, Raquel Diez-Bello, Gines Maria Salido and I. Jardin*
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New Insights into Adipokines as Potential Biomarkers for Type-2 Diabetes Mellitus
Marta Olivera-Santa Catalina, Pedro C. Redondo, Carlos Cantonero , Maria P. Granados, Jose Sanchez-Collado, Letizia Albarran and Jose Javier Lopez*
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Use of Antibiotic Loaded Biomaterials for the Management of Bone Prosthesis Infections: Rationale and Limits
Matilde Tschon, Maria Sartori*, Deyanira Contartese, Gianluca Giavaresi, Nicolo Nicoli Aldini and Milena Fini
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The In Silico Drug Discovery Toolbox: Applications in Lead Discovery and Optimization
Agostino Bruno, Gabriele Costantino, Luca Sartori and Marco Radi*
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γ-AApeptides as a New Strategy for Therapeutic Development
Alekhya Nimmagadda, Yan Shi and Jianfeng Cai*
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Dynamic Localization of Hepatocellular Transporters: Role in Biliary Excretion and Impairment in Cholestasis
Marcelo Gabriel Roma*, Ismael R. Barosso, Gisel S. Miszczuk, Fernando A. Crocenzi and Enrique J. Sanchez Pozzi
View Abstract View on PubMed
Trends and Prospects of Plant Proteases in Therapeutics
Anastasia V. Balakireva, Natalia V. Kuznetsova, Anastasia I. Petushkova, Lyudmila Savvateeva and Andrey A. Zamyatnin *
View Abstract View on PubMed
New Strategy on Antimicrobial-resistance: Inhibitors of DNA Replication Enzymes
Lanhua Yi and Xin Lu*
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Plant-Made Antibodies: Properties and Therapeutic Applications
Tatiana V. Komarova, Ekaterina V Sheshukova and Yuri L Dorokhov*
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Sunitinib in the Treatment of Thyroid Cancer
Silvia Martina Ferrari, Marco Centanni, Camilla Virili, Mario Miccoli , Paola Ferrari, Ilaria Ruffilli , Francesca Ragusa, Alessandro Antonelli* and Poupak Fallahi
View Abstract View on PubMed
Medical Applications of Collagen and Collagen-Based Materials
Anatoly Borisovich Shekhter, Alexey Leonidovich Fayzullin*, Marina Nikolaevna Vukolova, Tatyana Georgiyevna Rudenko, Varvara Dmitriyevna Osipycheva and Petr Francevich Litvitsky
View Abstract View on PubMed
Diet and Contaminants: Driving the Rise to Obesity Epidemics?
Agostino Di Ciaula and Piero Portincasa*
View Abstract View on PubMed
Metallodrugs in Targeted Cancer Therapeutics. Aiming at Chemoresistance- related Patterns and Immunosuppressive Tumor Networks
Athanasios Salifoglou*, Savvas Petanidis and Efrosini Kioseoglou
View Abstract View on PubMed
G4-Interacting DNA Helicases and Polymerases: Potential Therapeutic Targets
Katrina N. Estep*, Thomas J . Butler, Jun Ding and Robert M. Brosh
View Abstract View on PubMed
Biodegradable Black Phosphorus-based Nanomaterials in Biomedicine: Theranostic Applications
Zhen Wang, Zhiming Liu, Chengkang Su, Biwen Yang, Xixi Fei, Yi Li, Yuqing Hou, Henan Zhao, Yanxian Guo, Zhengfei Zhuang*, Huiqing Zhong and Zhouyi Guo*
View Abstract View on PubMed
Potential Triazole-based Molecules for the Treatment of Neglected Diseases
Susimaire Pedersoli Mantoani, Peterson de Andrade, Talita Perez Cantuaria Chierrito, Andreza Silva Figueredo and Ivone Carvalho*
View Abstract View on PubMed
High-Throughput Screening Strategies for the Development of Anti- Virulence Inhibitors Against Staphylococcus aureus
Xiaodan Cai, Weihao Zheng and Zigang Li*
View Abstract View on PubMed
Recent Progress of Crosslinking Strategies for Polymeric Micelles with Enhanced Drug Delivery in Cancer Therapy
Wei Fan, Luye Zhang, Yiwen Li and Haoxing Wu*
View Abstract View on PubMed
Recent Advances and Challenges in Steroid Metabolomics for Biomarker Discovery
Alicja Kotlowska* and Piotr Szefer
View Abstract View on PubMed
New Molecular Targets and Strategies for Antimalarial Discovery
Anna Caroline Aguiar, Lorena R. F. de Sousa, Celia R. S. Garcia, Glaucius Oliva and Rafael V. C. Guido*
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Inflammatory Biomarkers in Atrial Fibrillation
Effimia Zacharia, Nikolaos Papageorgiou*, Adam Ioannou, Gerasimos Siasos, Manolis Vavuranakis, George Latsios, Charalampos Vlachopoulos, Konstantinos Toutouzas, Spyridon Deftereos, Rui Providência and Dimitris Tousoulis
View Abstract View on PubMed
Fluorescein-Inspired Near-Infrared Chemodosimeter for Luminescence Bioimaging
Hai-Yan Wang, Huisheng Zhang, Siping Chen* and Yi Liu
View Abstract View on PubMed
Biomarkers of Atrial Fibrillation in Hypertension
Costas Tsioufis*, Dimitrios Konstantinidis, Elias Nikolakopoulos, Evi Vemou, Theodoros Kalos, Georgios Georgiopoulos, Nikos Vogiatzakis, Aristos Ifantis, Konstantinos Konstantinou, V. Gennimata and Dimitris Tousoulis
View Abstract View on PubMed
Privileged Structures in the Design of Potential Drug Candidates for Neglected Diseases
Ana Cristina Lima Leite*, José Wanderlan Pontes Espíndola, Marcos Veríssimo de Oliveira Cardoso and Gevanio Bezerra de Oliveira Filho
View Abstract View on PubMed
Modern Approach to Medical Diagnostics - the Use of Separation Techniques in Microorganisms Detection
Agnieszka Chylewska*, Malgorzata Ogryzek and Mariusz Makowski
View Abstract View on PubMed
Cysteine-rich Proteins for Drug Delivery and Diagnosis
Guang Yang, Yue Lu, Hunter N. Bomba and Zhen Gu*
View Abstract View on PubMed
Hyphenated Mass Spectrometry Techniques in the Diagnosis of Amyloidosis
Marta Spodzieja, Sylwia Rodziewicz-Motowidło and Aneta Szymanska*
View Abstract View on PubMed
Collagenolytic Enzymes and their Applications in Biomedicine
Anatoly Borisovich Shekhter*, Anastasia V. Balakireva, Natalia V. Kuznetsova, Marina N. Vukolova, Petr F. Litvitsky and Andrey A. Zamyatnin
View Abstract View on PubMed
Metabolomics and Heart Diseases: From Basic to Clinical Approach
Ignasi Barba*, Mireia Andres and D Garcia Dorado
View Abstract View on PubMed
Metabolomic Heterogeneity of Urogenital Tract Cancers Analyzed by Complementary Chromatographic Techniques Coupled with Mass Spectrometry
Arlette Yumba Mpanga, Wiktoria Struck-Lewicka, Renata Bujak, Marcin Markuszewski, Marek Roslan, Roman Kaliszan and Michał Jan Markuszewski*
View Abstract View on PubMed
Virome and Inflammasomes, a Finely Tuned Balance with Important Consequences for the Host Health
Giulia Freer, Fabrizio Maggi and Mauro Pistello*
View Abstract View on PubMed
Recent Developments in the Separation of Low Molecular Weight Heparin Anticoagulants
Radosław Sadowski, Renata Gadzała-Kopciuch* and Bogusław Buszewski
View Abstract View on PubMed
Platelet Oxidative Stress and its Relationship with Cardiovascular Diseases in Type 2 Diabetes Mellitus Patients
Mohammed El Haouari*
View Abstract View on PubMed
Recent Research Trends on Bismuth Compounds in Cancer Chemoand Radiotherapy
Mateusz Kowalik, Joanna Masternak and Barbara Barszcz*
View Abstract View on PubMed
Smart Organic-Inorganic Nanogels for Activatable Theranostics
Fangyuan Li, Zeyu Liang and Daishun Ling*
View Abstract View on PubMed
Molecular Mechanisms of Epigenetic Regulators as Activatable Targets in Cancer Theranostics
Yinglu Li*, Zhiming Li and Wei-Guo Zhu*
View Abstract View on PubMed
Protective Effects of the Caffeine Against Neurodegenerative Diseases
Ester Tellone*, Antonio Galtieri, Annamaria Russo and Silvana Ficarra
View Abstract View on PubMed
Rutin as Neuroprotective Agent: From Bench to Bedside
Barbara Budzynska, Caterina Faggio, Marta Kruk-Slomka, Dunja Samec, Seyed Fazel Nabavi, Antoni Sureda, Kasi Pandima Devi and Seyed Mohammad Nabavi*
View Abstract View on PubMed
Allosteric Targeting of Aurora A Kinase Using Small Molecules: A Step Forward Towards Next Generation Medicines
Resmi C Panicker, Anthony G. Coyne and Rajavel Srinivasan*
View Abstract View on PubMed
The Medicinal Chemistry of Therapeutic Peptides: Recent Developments in Synthesis and Design Optimizations
Anutthaman Parthasarathy, Sasikala K. Anandamma and Karunakaran A. Kalesh*
View Abstract View on PubMed
Biomarkers of Atrial Fibrillation in Metabolic Syndrome
Christos Georgakopoulos, Charalambos Vlachopoulos*, Georgios Lazaros and Dimitris Tousoulis
View Abstract View on PubMed
Hemicellulose from Plant Biomass in Medical and Pharmaceutical Application: A Critical Review
Xinxin Liu, Qixuan Lin, Yuhuan Yan, Fenf Peng, Runcang Sun and Junli Ren*
View Abstract View on PubMed
Improving Metabolic Control Through Functional Foods
John G. Jones* and Joao C.P. Silva
View Abstract View on PubMed
Effects of Isolated Isoflavones Intake on Health
Antonella Smeriglio*, Antonella Calderaro, Marcella Denaro, Giuseppina Laganà and Ersilia Bellocco
View Abstract View on PubMed
Current Progress of Lipid Analysis in Metabolic Diseases by Mass Spectrometry Methods
Adriana Mika*, Tomasz Sledzinski and Piotr Stepnowski
View Abstract View on PubMed
Modulation of ABC Transporters by Nuclear Receptors: Physiological, Pathological and Pharmacological Aspects
Juan Pablo Rigalli, Guillermo Nicolás Tocchetti and Johanna Weiss*
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Structure-based Approaches Targeting Parasite Cysteine Proteases
Rafael Pinto Vieira, Viviane Corrêa Santos and Rafaela Salgado Ferreira*
View Abstract View on PubMed
Ag+ Complexes as Potential Therapeutic Agents in Medicine and Pharmacy
Aleksandra Hecel, Paulina Kolkowska, Karolina Krzywoszynska, Agnieszka Szebesczyk, Magdalena Rowinska-Zyrek and Henryk Kozlowski*
View Abstract View on PubMed
Enzyme-Instructed Self-assembly in Biological Milieu for Theranostics Purpose
Zhentao Huang, Qingxin Yao, Simin Wei, Jiali Chen and Yuan Gao*
View Abstract View on PubMed
Organic Nanotheranostics for Photoacoustic Imaging-Guided Phototherapy
Houjuan Zhu , Chen Xie , Peng Chen and Kanyi Pu*
View Abstract View on PubMed
Protozoan Parasites Glycosylphosphatidylinositol Anchors: Structures, Functions and Trends for Drug Discovery
Ana Luísa Malaco Morotti, Maristela Braga Martins-Teixeira and Ivone Carvalho*
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ATP-binding Cassette Exporters: Structure and Mechanism with a Focus on P-glycoprotein and MRP1
Maite Rocío Arana and Guillermo Altenberg*
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Fighting Type-2 Diabetes: Present and Future Perspectives
Cai-Guo Yu , Ying Fu, Yuan Fang , Ning Zhang, Rong-Xin Sun , Dong Zhao, Ying-Mei Feng and Bao-Yu Zhang*
View Abstract View on PubMed
Biological Therapy of Hematologic Malignancies: Toward a Chemotherapy- free Era
Pavel Klener*, Tomas Etrych and Pavel Klener
View Abstract View on PubMed
Nutraceuticals and "Repurposed" Drugs of Phytochemical Origin in Prevention and Interception of Chronic Degenerative Disease and Cancer
Adriana Albini, Barbara Bassani, Denisa Baci, Katiuscia Dallaglio, Matteo Gallazzi, Paola Corradino, Antonino Bruno and Douglas Noonan*
View Abstract View on PubMed
Cu2+ Biological Imaging Probes Based on Different Sensing Mechanisms
Jiawei Li, Fangjun Huo and Caixia Yin*
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Untargeted Metabolomics Provides Insight into the Mechanisms Underlying Resistant Hypertension
Renata Bujak, Arlette Yumba-Mpanga, Wiktoria Struck-Lewicka, Marta Kordalewska, Katarzyna Polonis, Małgorzata Patejko, Monika Mironiuk, Anna Szyndle, Marzena Chrostowska, Michał Hoffmann, Ryszard T. Smoleński, Roman Kaliszan, Krzysztof Narkiewicz and Michał J. Markuszewski*
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Amino Acid Degrading Enzymes and their Application in Cancer Therapy
Vadim S Pokrovsky*, Olga E Chepikova, Denis Zh Davydov, Andrey A Zamyatnin, Alexander N Lukashev and Elena V Lukasheva
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Bacterial Protein Mimetic of Peptide Hormone as a New Class of Protein- based Drugs
S. O. Fetissov*, Romain Legrand and Nicolas Lucas
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Cardioprotective Potential of Iron Chelators and Prochelators
Hana Jansova and Tomas Simunek*
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Stem Cell Differentiation Stage Factors and their Role in Triggering Symmetry Breaking Processes during Cancer Development: A Quantum Field Theory Model for Reprogramming Cancer Cells to Healthy Phenotypes
Pier Mario Biava*, Fabio Burigana, Roberto Germano, Philip Kurian, Claudio Verzegnassi and Giuseppe Vitiello
View Abstract View on PubMed
Antibody Fragments as Potential Biopharmaceuticals for Cancer Therapy: Success and Limitations
Roman V Kholodenko*, Daniel V. Kalinovsky, Igor I Doronin, Eugene D Ponomarev and Irina V Kholodenko
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Histone Deacetylase Inhibitors in Tumor Immunotherapy
Li-Ming Zhao* and Jie-Huan Zhang
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Biomarkers in Atrial Fibrillation and Heart Failure
Evangelos Oikonomou*, Theodoros Zografos, Georgios-Angelos Papamikroulis, Gerasimos Siasos , Georgia Vogiatzi , Panagiotis Theofilis, Alexandros Briasoulis, Spyridon Papaioannou, Manolis Vavuranakis, Vasiliki Gennimata and Dimitris Tousoulis
View Abstract View on PubMed
MicroRNAs in Atrial Fibrillation
Alexandros Briasoulis*, Shikha Sharma, Tesfaye Telila, Sagar Mallikethi-Reddy, Nikolaos Papageorgiou, Evangelos Oikonomou and Dimitris Tousoulis
View Abstract View on PubMed
Atrial Fibrillation: Biomarkers Determining Prognosis
Savas Mazaris, Gerasimos Siasos*, Evangelos Oikonomou, Vicky Tsigkou, Manolis Vavuranakis, Eleni Kokkou, Marina Zaromitidou, Georgios-Angelos Papamikroulis, Athanasios G Papavassiliou, Spyridon Papaioannou, Nikolaos Papageorgiou, George Latsios, Christodoulos Stefanadis and Dimitris Tousoulis
View Abstract View on PubMed
Transient Production of Recombinant Pharmaceutical Proteins in Plants: Evolution and Perspectives
Lilya Kopertekh* and Joachim Schiemann
View Abstract View on PubMed
Recent Advances on Cellulose-Based Nano-Drug Delivery Systems: Design of Prodrugs and Nanoparticles
Lin Dai and Chuanling Si*
View Abstract View on PubMed
Immune Modulation of Asian Folk Herbal Medicines and Related Chemical Components for Cancer Management
Manee Patanaponpibul and Qiao-Hong Chen*
View Abstract View on PubMed
The Role of Dietary Approach in Irritable Bowel Syndrome
Piero Portincasa*, Antony Lembo, Ornella De Bari, Domenica M. Di Palo, Anna Maggio, Ilaria Cataldo and Giuseppe Calamita
View Abstract View on PubMed
Effects of Diets on Adipose Tissue
Silvia Ezquerro, Amaia Rodríguez, Piero Portincasa and Gema Frühbeck*
View Abstract View on PubMed
Lignocellulosic Biomass Derived Functional Materials: Synthesis and Applications in Biomedical Engineering
Lei Zhang, Linxin Zhong, Weitian Chua, Zhihua Xiang and Runcang Sun*
View Abstract View on PubMed
Rational Drug Design of Antineoplastic Agents Using 3D-QSAR, Cheminformatic, and Virtual Screening Approaches
Jelica Vucicevic, Katarina Nikolic* and John B O Mitchell
View Abstract View on PubMed
Applications of Cellulose-based Materials in Sustained Drug Delivery Systems
Bo Sun, Min Zhang, Jing Shen, Zhibin He, Pedram Fatehi* and Yonghao Ni
View Abstract View on PubMed
Exploiting Cancer Metal Metabolism using Anti-Cancer Metal- Binding Agents
Angelica M Merlot*, Danuta S Kalinowski, Zaklina Kovacevic, Patric J Jansson, Sumit Sahni, Michael L Huang, Darius L Lane, Hiu Lok and Des R Richardson
View Abstract View on PubMed
The Panomics Approach in Neurodegenerative Disorders
Balazs Szatmari, Peter Balicza, Gyorgy Nemeth and Judit Mária Molnár*
View Abstract View on PubMed
Impact of Diabetes on Cardiac and Vascular Disease: Role of Calcium Signaling
Tarik Smani*, Isabel Gallardo-Castillo, Javier Ávila-Médina, Manuel F. Jimenez-Navarro, Antonio Ordoñez and Abdelkrim Hmadcha
View Abstract View on PubMed
Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy
Weiqiang Zhou, Shanchun Guo, Mingli Liu, Matthew E. Burow and Guangdi Wang*
View Abstract View on PubMed
Biomarkers Associated with Atrial Fibrosis and Remodeling
Polychronis Dilaveris, Christos-Konstantinos Antoniou, Panagiota Manolakou, Eleftherios Tsiamis, Konstantinos Gatzoulis and Dimitris Tousoulis*
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Revalorizing Lignocellulose for the Production of Natural Pharmaceuticals and Other High Value Bioproducts
Congqiang Zhang and Heng-Phon Too*
View Abstract View on PubMed
Redox State in Atrial Fibrillation Pathogenesis and Relevant Therapeutic Approaches
Alexios S. Antonopoulos*, Athina Goliopoulou, Evangelos Oikonomou, Sotiris Tsalamandris, Georgios-Angelos Papamikroulis, George Lazaros, Eleftherios Tsiamis, George Latsios, Stella Brili, Spyridon Papaioannou, Vasiliki Gennimata and Dimitris Tousoulis
View Abstract View on PubMed
The Role of Diet in Patients with Metabolic Syndrome
Paloma Almeda-Valdes, Roberto J. Herrera-Mercadillo, Carlos A. Aguilar-Salinas, Misael Uribe and Nahum Méndez-Sánchez*
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Short-term Dietary Interventions for the Management of Nonalcoholic Fatty Liver
Caroline S. Stokes*, Frank Lammert and Marcin Krawczyk
View Abstract View on PubMed
Current Trends in Cancer Biomarker Discovery Using Urinary Metabolomics: Achievements and New Challenges
Casey Burton and Yinfa Ma*
View Abstract View on PubMed
Weighing the Impact of Diet and Lifestyle on Female Reproductive Function
Gabriella Garruti*, Raffaella De Palo and Maria De Angelisc
View Abstract View on PubMed
Post Cardiovascular Surgery Atrial Fibrillation. Biomarkers Determining Prognosis
Olivia Manfrini, Edina Cenko, Beatrice Ricci and Raffaele Bugiardini*
View Abstract View on PubMed
Nutrition as a Health Determinant in Elderly Patients
Tecla Mastronuzzi and Ignazio Grattagliano*
View Abstract View on PubMed
Natural Product Gossypol and its Derivatives in Precision Cancer Medicine
Yun Zeng , Jingwen Ma , Liang Xu * and Daocheng Wu
View Abstract View on PubMed
Modulation of Aquaporins by Dietary Patterns and Plant Bioactive Compounds
Ilaria Cataldo, Anna Maggio , Patrizia Gena, Ornella de bari, Grazia Tamma , Piero Portincasa and Giuseppe Calamita*
View Abstract View on PubMed
Green Synthesized Nanomaterials as Theranostic Platforms for Cancer Treatment: Principles, Challenges and the Road Ahead
Pala Rajasekharreddy, Chao Huang, Siddhardha Busi, Jobina Rajkumari, Ming-Hong Tai and Gang Liu
View Abstract View on PubMed
Anti-fatigue Effects of Active Ingredients from Traditional Chinese Medicine: A Review
Si-Si Zhou and Jian-Guo Jiang *
View Abstract View on PubMed
Adoptive Immunotherapy for B-cell Malignancies Using CD19- Targeted Chimeric Antigen Receptor T-Cells: A Systematic Review of Efficacy and Safety
Lu Hao, Tongtong Li, Lung-Ji Chang* and Xiaochuan Chen
View Abstract View on PubMed
Immune Checkpoint Inhibitors: Basics and Challenges
Bin Li*, Ho Lam Chan and Pingping Chen
View Abstract View on PubMed
Biomarkers in Aortic Valve Stenosis and their Clinical Significance in Transcatheter Aortic Valve Implantation
Konstantinos Toutouzas*, Konstantinos Stathogiannis, George Latsios, Andreas Synetos, Maria Drakopoulou, Vicky Penesopoulou, Archontoula Michelongona, Eleftherios Tsiamis and Dimitris Tousoulis
View Abstract View on PubMed
Biomarkers Associated with Bleeding Risk in the Setting of Atrial Fibrillation
Skevos Sideris*, Stefanos Archontakis, George Latsios, George Lazaros, Konstantinos Toutouzas, Eleftherios Tsiamis, Manolis Vavuranakis, Charalampos Vlachopoulos, Konstantinos Gatzoulis, Konstantinos Tsioufis and Dimitris Tousoulis
View Abstract View on PubMed
Biomarkers Associated with Stroke Risk in Atrial Fibrillation
Adam Ioannou, Nikolaos Papageorgiou*, Debbie Falconer, Onkar Rehal, Emma Sewart, Effimia Zacharia, Konstantinos Toutouzas, Charalampos Vlachopoulos, Gerasimos Siasos, Constantinos Tsioufis and Dimitris Tousoulis
View Abstract View on PubMed
Impact of Red Wine Consumption on Cardiovascular Health
Luca Liberale, Aldo Bonaventura, Fabrizio Montecucco*, Franco Dallegri and Federico Carbone
View Abstract View on PubMed
Na+,K+-ATPase as a Target for Treatment of Tissue Fibrosis
Sergei N. Orlov, Jenifer La, Larisa V. Smolyaninova and Nickolai O. Dulin*
View Abstract View on PubMed
Update on the Molecular Mechanisms Underlying the Effect of Cholecystokinin and Cholecystokinin-1 Receptor on the Formation of Cholesterol Gallstones
Helen H. Wang, Piero Portincasa and David Q.-H. Wang*
View Abstract View on PubMed
Therapeutic Proteins for Treatment of Corneal Epithelial Defects
Evgeni Yu. Zernii, Viktoriia E. Baksheeva, Elena V. Yani, Pavel P. Philippov and Ivan I. Senin*
View Abstract View on PubMed
Fatty Acids and Effects on In Vitro and In Vivo Models of Liver Steatosis
Laura Vergani*
View Abstract View on PubMed
The Role of Diet in the Pathogenesis of Cholesterol Gallstones
Agostino Di Ciaula, Gabriella Garruti, Gema Frühbeck, Maria De Angelis, Ornella De Bari, David Q.-H. Wang, Frank Lammert and Piero Portincasa*
View Abstract View on PubMed
Food and Gastroesophageal Reflux Disease
Teodora Surdea-Blaga, Dana E. Negrutiu, Mariana Palage and Dan L. Dumitrascu*
View Abstract View on PubMed
Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease
José Teixeira, Daniel Chavarria, Fernanda Borges, Lech Wojtczak, Mariusz R. Wieckowsk, Anieszka Karkucińska-Wieckowska and Paulo J. Oliveira*
View Abstract View on PubMed
Diet After Cholecystectomy
Donato F. Altomare*, Maria T. Rotelli and Nicola Palasciano
View Abstract View on PubMed
The Food-Gut Human Axis: The Effects of Diet on Gut Microbiota and Metabolome
Maria De Angelis*, Gabriella Garruti, Fabio Minervini, Leonilde Bonfrate, Piero Portincasa and Marco Gobbetti
View Abstract View on PubMed
Diet and Cardiovascular Disease: Effects of Foods and Nutrients in Classical and Emerging Cardiovascular Risk Factors
Lina Badimon*, Patricia Chagas and Gemma Chiva-Blanch
View Abstract View on PubMed
Biosimilars for the Management of Inflammatory Bowel Diseases: Economic Considerations
Laszlo Gulacsi, Marta Pentek, Fanni Rencz, Valentin Brodszky, Petra Baji, Zsuzsanna Vegh, Krisztina B Gecse, Silvio Danese, Laurent Peyrin- Biroulet and Peter L. Lakatos*
View Abstract View on PubMed
Lactate Dehydrogenase Inhibition: Biochemical Relevance and Therapeutical Potential
Giuseppina Laganà, Davide Barreca, Antonella Calderaro and Ersilia Bellocco
View Abstract View on PubMed
In Vitro Skin Models for the Evaluation of Sunscreen-Based Skin Photoprotection: Molecular Methodologies and Opportunities
Claire Marionnet and Françoise Bernerd
View Abstract View on PubMed
Efficacy, Safety and Immunogenicity of Biosimilars in Inflammatory Bowel Diseases: A Systematic Review
Laura Martelli and Laurent Peyrin-Biroulet
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