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Current Gene Therapy

Volume 20, 5 Issues, 2020
ISSN: 1566-5232 (Print)
ISSN: 1875-5631 (Online)
This journal supports open access
Order Your Article Before PrintSubscribe to this Journal

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. Cell therapy manuscripts can also include application in diseases when cells have been genetically modified. Current Gene Therapy publishes full-length/mini reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of diseases.

Current Gene Therapy publishes reviews and original research containing experimental data on gene and cell therapy. The journal also includes manuscripts on technological advances, ethical and regulatory considerations of gene and cell therapy. Reviews should provide the reader with a comprehensive assessment of any area of experimental biology applied to molecular medicine that is not only of significance within a particular field of gene therapy and cell therapy but also of interest to investigators in other fields. Authors are encouraged to provide their own assessment and vision for future advances. Reviews are also welcome on late breaking discoveries on which substantial literature has not yet been amassed. Such reviews provide a forum for sharply focused topics of recent experimental investigations in gene therapy primarily to make these results accessible to both clinical and basic researchers. Manuscripts containing experimental data should be original data, not previously published.

Current Gene Therapy

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Volume 20

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Number 1



Preface   Open Access



Biography   Open Access



Editorial   Open Access



Research Article



Research Article



Research Article

Combined Analysis of Clinical Data on HGF Gene Therapy to Treat Critical Limb Ischemia in Japan

, 20(1): 25 - 35

Ryuichi Morishita*, Munehisa Shimamura, Yasushi Takeya, Hironori Nakagami, Mitsuaki Chujo, Tetsuya Ishihama, Ei Yamada and Hiromi Rakugi


DOI: 10.2174/1566523220666200516171447


Review Article (Mini-Review)



General Review Article



Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Published Contents

Editor's Choice


Nano-enhanced Optical Gene Delivery to Retinal Degenerated Mice

, 2019; 19(5): 318 - 329

Subrata Batabyal, Sivakumar Gajjeraman, Sulagna Bhattacharya, Weldon Wright and Samarendra Mohanty*


DOI: 10.2174/1566523219666191017114044



Partial Reprogramming As An Emerging Strategy for Safe Induced Cell Generation and Rejuvenation

, 2019; 19(4): 248 - 254

Marianne Lehmann, Martina Canatelli-Mallat, Priscila Chiavellini, Gloria M. Cónsole, Maria D. Gallardo and Rodolfo G. Goya*


DOI: 10.2174/1566523219666190902154511



Reduction of Autophagic Accumulation in Pompe Disease Mouse Model Following Gene Therapy

, 2019; 19(3): 197 - 207

Angela L. McCall*, Sylvia G. Stankov, Gabrielle Cowen, Denise Cloutier, Zizhao Zhang, Lin Yang, Nathalie Clement, Darin J. Falk and Barry J. Byrne*


DOI: 10.2174/1566523219666190621113807





Neuroprotection by Human Dental Pulp Mesenchymal Stem Cells: From Billions to Nano

, 2018; 18(5): 307 - 323

Chaitra Venugopal, Shobha K, Kiranmai S. Rai, Venkata Bharatkumar Pinnelli, Bindu M. Kutty and Anandh Dhanushkodi*


DOI: 10.2174/1566523218666180913152615




Gene Therapy to Enhance Bone and Cartilage Repair in Orthopaedic Surgery

, 2018; 18(3): 154 - 170

Sofia Bougioukli, Christopher H. Evans, Ram K. Alluri, Steven C. Ghivizzani and Jay R. Lieberman*


DOI: 10.2174/1566523218666180410152842




Open Access Articles

Hemophilia Gene Therapy: New Development from Bench to Bed Side

, 2019; 19(4): 264 - 273

Xiao-Lu Guo, Tsai-Hua Chung, Yue Qin, Jie Zheng, Huyong Zheng, Liyuan Sheng, Tung Wynn and Lung-Ji Chang*




A Recurrent Rare SOX9 Variant (M469V) is Associated with Congenital Vertebral Malformations

, 2019; 19(4): 242 - 247

Nan Wu, Lianlei Wang, Jianhua Hu*, Sen Zhao, Bowen Liu, Yaqi Li, Huakang Du, Yuanqiang Zhang, Xiaoxin Li, Zihui Yan, Shengru Wang, Yipeng Wang, Jianguo Zhang, Zhihong Wu, DISCO (Deciphering Disorders Involving Scoliosis & Comorbidities) study group and Guixing Qiu




Reduction of Autophagic Accumulation in Pompe Disease Mouse Model Following Gene Therapy

, 2019; 19(3): 197 - 207

Angela L. McCall*, Sylvia G. Stankov, Gabrielle Cowen, Denise Cloutier, Zizhao Zhang, Lin Yang, Nathalie Clement, Darin J. Falk and Barry J. Byrne*




Three Cases of Leber’s Hereditary Optic Neuropathy with Rapid Increase in Visual Acuity After Gene Therapy

, 2019; 19(2): 134 - 138

Yong Zhang, Jia-jia Yuan, Hong-li Liu, Zhen Tian, Si-wei Liu and Bin Li*





Functional Improvement of Chimeric Antigen Receptor Through Intrinsic Interleukin-15Rα Signaling

, 2019; 19(1): 40 - 53

Sushmita Nair, Jing-Bo Wang, Shih-Ting Tsao, Yuchen Liu, Wei Zhu, William B. Slayton, Jan S. Moreb, Lujia Dong and Lung-Ji Chang*





Clinical Observation of Patients with Leber’s Hereditary Optic Neuropathy Before Gene Therapy

, 2018; 18(6): 386 - 392

Jiajia Yuan, Yong Zhang, Hongli Liu, Zhen Tian, Xin Li, Yichen Zheng, Qin Gao, Lin Song, Xiao Xiao, Jian Sun, Zhitao Wang and Bin Li*




Clinical-Grade Oncolytic Adenovirus Purification Using Polysorbate 20 as an Alternative for Cell Lysis

, 2018; 18(6): 366 - 374

Mafalda G. Moleirinho, Sara Rosa, Manuel J.T. Carrondo*, Ricardo J.S. Silva, Åsa Hagner-McWhirter, Gustaf Ahlén, Mats Lundgren, Paula M. Alves and Cristina Peixoto




Emerging Therapeutic Approaches for Diamond Blackfan Anemia

, 2018; 18(6): 327 - 335

Anna Aspesi*, Chiara Borsotti and Antonia Follenzi*




EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs

, 2018; 18(5): 275 - 285

Yan Wang, Yinping Xie, Lili Li, Yuan He, Di Zheng, Pengcheng Yu, Ling Yu, Lixu Tang, Yibin Wang* and Zhihua Wang*




Human Disease System Biology

, 2018; 18(5): 255 - 256

Liang Cheng and Yang Hu




Oncolytic Virotherapy for Breast Cancer Treatment

, 2018; 18(4): 192 - 205

Samia M. O`Bryan and J. Michael Mathis*




Genetics and Therapies for GM2 Gangliosidosis

, 2018; 18(2): 68 - 89

Maria Begona Cachon-Gonzalez*, Eva Zaccariotto and Timothy Martin Cox






Most Cited Articles

General Review Article

Circular RNAs serve as novel biomarkers and therapeutic targets in cancers

, 2019; 19(2): 125-133.

Shuai Fang, Jinchang Pan, Chengwei Zhou, Hui Tian, Jinxian He, Weiyu Shen, Xiaofeng Jin, Xiaodan Meng, Nan Jiang and Zhaohui Gong*


DOI: 10.2174/1566523218666181109142756



Research Article

A mendelian randomization study on infant length and type 2 diabetes mellitus risk

, 2019; 19(4): 224-231.

He Zhuang, Ying Zhang, Shuo Yang, Liang Cheng* and Shu-Lin Liu*


DOI: 10.2174/1566523219666190925115535


General Review Article

The therapeutic potential and role of miRNA, IncRNA, and circRNA in osteoarthritis

, 2019; 19(4): 255-263.

Yuangang Wu, Xiaoxi Lu, Bin Shen and Yi Zeng*


DOI: 10.2174/1566523219666190716092203


Research Article

Functional improvement of chimeric antigen receptor through intrinsic interleukin-15Rα signaling

, 2019; 19(1): 40-53.

Sushmita Nair, Jing-Bo Wang, Shih-Ting Tsao, Yuchen Liu, Wei Zhu, William B. Slayton, Jan S. Moreb, Lujia Dong and Lung-Ji Chang*


DOI: 10.2174/1566523218666181116093857


Research Article

Reduction of autophagic accumulation in pompe disease mouse model following gene therapy

, 2019; 19(3): 197-207.

Angela L. McCall*, Sylvia G. Stankov, Gabrielle Cowen, Denise Cloutier, Zizhao Zhang, Lin Yang, Nathalie Clement, Darin J. Falk and Barry J. Byrne*


DOI: 10.2174/1566523219666190621113807


Review Article

Understanding gene therapy in acute respiratory distress syndrome

, 2019; 19(2): 93-99.

Xue-Peng Zhang, Wei-Tao Zhang, Yue Qiu, Min-Jie Ju, Guo-Wei Tu* and Zhe Luo*


DOI: 10.2174/1566523219666190702154817


Review Article

The relationship between ferroptosis and tumors: A novel landscape for therapeutic approach

, 2019; 19(2): 117-124.

Xiaojun Xia, Xiaoping Fan*, Mingyi Zhao* and Ping Zhu*


DOI: 10.2174/1566523219666190628152137


Review Article

Current rna-based therapeutics in clinical trials

, 2019; 19(3): 172-196.

Ling-Yan Zhou, Zhou Qin, Yang-Hui Zhu, Zhi-Yao He* and Ting Xu*


DOI: 10.2174/1566523219666190719100526


Review Article

Functional immunoregulation by heme oxygenase 1 in juvenile autoimmune diseases

, 2019; 19(2): 110-116.

Xueyan Zhang, Shupeng Shi, Jie Shen, Mingyi Zhao* and Qingnan He*


DOI: 10.2174/1566523219666190710092935





Review Article

Correlation between MDSC and immune tolerance in transplantation: Cytokines, pathways and cell-cell interaction

, 2019; 19(2): 81-92.

Tianying Yang, Jiawei Li, Ruimin Li, Chunchen Yang, Weitao Zhang, Yue Qiu, Cheng Yang* and Ruiming Rong*


DOI: 10.2174/1566523219666190618093707


Review Article

Cell therapy in solid organ transplantation

, 2019; 19(2): 71-80.

Songjie Cai and Anil Chandraker*


DOI: 10.2174/1566523219666190603103840



Most Accessed Articles


Functional Improvement of Chimeric Antigen Receptor Through Intrinsic Interleukin-15Rα Signaling

, 2019; 19(1): 40-53.

Sushmita Nair, Jing-Bo Wang, Shih-Ting Tsao, Yuchen Liu, Wei Zhu, William B. Slayton, Jan S. Moreb, Lujia Dong and Lung-Ji Chang*


DOI: 10.2174/1566523218666181116093857


Gene Therapy for Angelman Syndrome: Contemporary Approaches and Future Endeavors

, 2019; 19(6): 359-366.

Christos Tsagkaris*, Vasiliki Papakosta, Adriana Viola Miranda, Lefkothea Zacharopoulou, Valeriia Danilchenko, Lolita Matiashova and Amrit Dhar


DOI: 10.2174/1566523220666200107151025



Current RNA-based Therapeutics in Clinical Trials

, 2019; 19(3): 172-196.

Ling-Yan Zhou, Zhou Qin, Yang-Hui Zhu, Zhi-Yao He* and Ting Xu*


DOI: 10.2174/1566523219666190719100526








Editor-in-Chief

Liang Cheng
College of Bioinformatics Science and Technology
Harbin Medical University
Harbin, Heilongjiang
(China)
Biography View Full Editorial Board

Journal History

Current Gene Therapy Journal was launched in 2001. Dr. Lung-Ji Chang serves as the Editor-in-Chief of the journal.
Scopus CiteScore Metrics: 2.05

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Probing Intracellular Regulation



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