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Current Gene Therapy

Volume 21, 5 Issues, 2021
ISSN: 1566-5232 (Print)
ISSN: 1875-5631 (Online)
This journal supports open access

In the current pandemic scenario, publication process of all articles related to Coronavirus will be expedited, for timely publication of much needed research

Aims & Scope

Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. Cell therapy manuscripts can also include application in diseases when cells have been genetically modified. Current Gene Therapy publishes full-length/mini reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of diseases.

Current Gene Therapy publishes reviews and original research containing experimental data on gene and cell therapy. The journal also includes manuscripts on technological advances, ethical and regulatory considerations of gene and cell therapy. Reviews should provide the reader with a comprehensive assessment of any area of experimental biology applied to molecular medicine that is not only of significance within a particular field of gene therapy and cell therapy but also of interest to investigators in other fields. Authors are encouraged to provide their own assessment and vision for future advances. Reviews are also welcome on late breaking discoveries on which substantial literature has not yet been amassed. Such reviews provide a forum for sharply focused topics of recent experimental investigations in gene therapy primarily to make these results accessible to both clinical and basic researchers. Manuscripts containing experimental data should be original data, not previously published.

Current Gene Therapy

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Volume 20

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Number 5



Review Article



Review Article



Review Article



Review Article



Systematic Review Article



Research Article



Research Article

Overexpressing Runx2 of BMSCs Improves the Repairment of knee Cartilage Defects

, 20(5): 395 - 404

Jing Hu, Wen-Zhong Zou, Ling Li, Zheng-shuai Shi, Xiang-Zhong Liu, Han-tao Cai, Ao-fei Yang, Da-ming Sun, Liang-liang Xu, Yi Yang and Zhang-Hua Li*


DOI: 10.2174/1566523220666201005110339


Acknowledgement   Open Access



Current Gene Therapy, Volume 21 (2021) - Number 1


This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print


Evaluation of the nucleopolyhedrovirus of Anticarsia gemmatalis as a vector for gene therapy in mammals


Cintia N. Parsza, Diego L. Mengual Gómez, Jorge Alejandro Simonin, Mariano Nicolás Belaich* and Pablo Daniel Ghiringhelli


DOI: 10.2174/1566523220999201217155945
View Abstract View on PubMed


CRISPR/Cas9 Technology as a Modern Genetic Manipulation Tool for Recapitulating of Neurodegenerative Disorders in Large Animal Models


Mahdi Barazesh, Shiva Mohammadi*, Yadollah Bahrami*, Pooneh Mokarram, Mohammad Hossein Morowvat, Massoud Saidijam, Morteza Karimipour, Soudabe Kavousi Pour, Amir Reza Vosoughi and Korosh Khanaki


DOI: 10.2174/1566523220666201214115024
View Abstract View on PubMed



Gene therapy based on lipid nanoparticles as non-viral vectors for Gliomas treatment


Marcela Tavares Luiz, Larissa Bueno Tofani, Victor Hugo Sousa Araújo, Leonardo Delello Di Filippo, Jonatas Lobato Duarte, Juliana Maldonado Marchetti and Marlus Chorilli*


DOI: 10.2174/1566523220999201230205126
View Abstract


Potential non-coding RNAs from microorganisms and its therapeutic use in the treatment of different human cancers


Raju Biswas, Dipanjana Ghosh, Bhramar Dutta, Urmi Halder, Prittam Goswami and Rajib Bandopadhyay*


DOI: 10.2174/1566523220999201230204814
View Abstract



Teratogenic Toxicity Evaluation of Bladder Cancer Specific Oncolytic Adenovirus on Mice


Keqing Lu, Fang Wang*, Baoliang Ma, Wenjuan Cao, Qi Guo, Hanzhang Wang, Ronald Rodriguez and Zhiping Wang*


DOI: 10.2174/1566523220999201217161258
View Abstract



Abstracts Ahead of Print

There are currently no Abstracts Ahead of Print available for this journal.

Published Contents

Editor's Choice




Gene Therapy for Hemophilia A: Where We Stand

, 2020; 20(2): 142 - 151

Miaojin Zhou, Zhiqing Hu, Chunhua Zhang, Lingqian Wu, Zhuo Li* and Desheng Liang*


DOI: 10.2174/1566523220666200806110849




Nano-enhanced Optical Gene Delivery to Retinal Degenerated Mice

, 2019; 19(5): 318 - 329

Subrata Batabyal, Sivakumar Gajjeraman, Sulagna Bhattacharya, Weldon Wright and Samarendra Mohanty*


DOI: 10.2174/1566523219666191017114044



Partial Reprogramming As An Emerging Strategy for Safe Induced Cell Generation and Rejuvenation

, 2019; 19(4): 248 - 254

Marianne Lehmann, Martina Canatelli-Mallat, Priscila Chiavellini, Gloria M. Cónsole, Maria D. Gallardo and Rodolfo G. Goya*


DOI: 10.2174/1566523219666190902154511



Reduction of Autophagic Accumulation in Pompe Disease Mouse Model Following Gene Therapy

, 2019; 19(3): 197 - 207

Angela L. McCall*, Sylvia G. Stankov, Gabrielle Cowen, Denise Cloutier, Zizhao Zhang, Lin Yang, Nathalie Clement, Darin J. Falk and Barry J. Byrne*


DOI: 10.2174/1566523219666190621113807





Open Access Articles

Feasibility of Mesenchymal Stem Cell Therapy for COVID-19: A Mini Review

, 2020; 20(4): 285 - 288

Jingwen Li, Xinyi Wang, Na Li , Ying Jiang, Heqing Huang*, Tao Wang, Zhicheng Lin and Nian Xiong*




Hemophilia Gene Therapy: New Development from Bench to Bed Side

, 2019; 19(4): 264 - 273

Xiao-Lu Guo, Tsai-Hua Chung, Yue Qin, Jie Zheng, Huyong Zheng, Liyuan Sheng, Tung Wynn and Lung-Ji Chang*




A Recurrent Rare SOX9 Variant (M469V) is Associated with Congenital Vertebral Malformations

, 2019; 19(4): 242 - 247

Nan Wu, Lianlei Wang, Jianhua Hu*, Sen Zhao, Bowen Liu, Yaqi Li, Huakang Du, Yuanqiang Zhang, Xiaoxin Li, Zihui Yan, Shengru Wang, Yipeng Wang, Jianguo Zhang, Zhihong Wu, DISCO (Deciphering Disorders Involving Scoliosis & Comorbidities) study group and Guixing Qiu




Reduction of Autophagic Accumulation in Pompe Disease Mouse Model Following Gene Therapy

, 2019; 19(3): 197 - 207

Angela L. McCall*, Sylvia G. Stankov, Gabrielle Cowen, Denise Cloutier, Zizhao Zhang, Lin Yang, Nathalie Clement, Darin J. Falk and Barry J. Byrne*




Three Cases of Leber’s Hereditary Optic Neuropathy with Rapid Increase in Visual Acuity After Gene Therapy

, 2019; 19(2): 134 - 138

Yong Zhang, Jia-jia Yuan, Hong-li Liu, Zhen Tian, Si-wei Liu and Bin Li*





Functional Improvement of Chimeric Antigen Receptor Through Intrinsic Interleukin-15Rα Signaling

, 2019; 19(1): 40 - 53

Sushmita Nair, Jing-Bo Wang, Shih-Ting Tsao, Yuchen Liu, Wei Zhu, William B. Slayton, Jan S. Moreb, Lujia Dong and Lung-Ji Chang*





Clinical Observation of Patients with Leber’s Hereditary Optic Neuropathy Before Gene Therapy

, 2018; 18(6): 386 - 392

Jiajia Yuan, Yong Zhang, Hongli Liu, Zhen Tian, Xin Li, Yichen Zheng, Qin Gao, Lin Song, Xiao Xiao, Jian Sun, Zhitao Wang and Bin Li*




Clinical-Grade Oncolytic Adenovirus Purification Using Polysorbate 20 as an Alternative for Cell Lysis

, 2018; 18(6): 366 - 374

Mafalda G. Moleirinho, Sara Rosa, Manuel J.T. Carrondo*, Ricardo J.S. Silva, Åsa Hagner-McWhirter, Gustaf Ahlén, Mats Lundgren, Paula M. Alves and Cristina Peixoto




Emerging Therapeutic Approaches for Diamond Blackfan Anemia

, 2018; 18(6): 327 - 335

Anna Aspesi*, Chiara Borsotti and Antonia Follenzi*




EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs

, 2018; 18(5): 275 - 285

Yan Wang, Yinping Xie, Lili Li, Yuan He, Di Zheng, Pengcheng Yu, Ling Yu, Lixu Tang, Yibin Wang* and Zhihua Wang*




Oncolytic Virotherapy for Breast Cancer Treatment

, 2018; 18(4): 192 - 205

Samia M. O`Bryan and J. Michael Mathis*




Genetics and Therapies for GM2 Gangliosidosis

, 2018; 18(2): 68 - 89

Maria Begona Cachon-Gonzalez*, Eva Zaccariotto and Timothy Martin Cox






Most Cited Articles

Review Article

Gene therapy, a novel therapeutic tool for neurological disorders: Current progress, challenges and future prospective

, 2020; 20(3): 184-194.

Ashif Iqubal, Mohammad Kashif Iqubal, Aamir Khan, Javed Ali, Sanjula Baboota and Syed Ehtaishamul Haque*


DOI: 10.2174/1566523220999200716111502


Research Article

Combined analysis of clinical data on HGF gene therapy to treat critical limb ischemia in Japan

, 2020; 20(1): 25-35.

Ryuichi Morishita*, Munehisa Shimamura, Yasushi Takeya, Hironori Nakagami, Mitsuaki Chujo, Tetsuya Ishihama, Ei Yamada and Hiromi Rakugi


DOI: 10.2174/1566523220666200516171447



Review Article

Exosomes: Structure, biogenesis, types and application in diagnosis and gene and drug delivery

, 2020; 20(3): 195-206.

Shriya Agarwal, Vinayak Agarwal, Mugdha Agarwal and Manisha Singh*


DOI: 10.2174/1566523220999200731011702


Research Article

Mirna-146a improves immunomodulatory effects of msc-derived exosomes in rheumatoid arthritis

, 2020; 20(4): 297-312.

Fataneh Tavasolian, Ahmad Zavaran Hosseini*, Sara Soudi and Mahmood Naderi


DOI: 10.2174/1566523220666200916120708


Review Article

The emerging role of stem cells in regenerative dentistry

, 2020; 20(4): 259-268.

Paolo Capparè*, Giulia Tetè, Maria Teresa Sberna and Paola Panina-Bordignon*


DOI: 10.2174/1566523220999200818115803



Research Article

γ-Aminobutyric Acid Promotes Osteogenic Differentiation of Mesenchymal Stem Cells by Inducing TNFAIP3

, 2020; 20(2): 152-161.

Hanwen Li, Yongyao Wu, Ning Huang, Qi Zhao, Quan Yuan* and Bin Shao*


DOI: 10.2174/1566523220999200727122502


Review Article

NF1, neurofibromin and gene therapy: Prospects of next-generation therapy

, 2020; 20(2): 100-108.

Xi-Wei Cui, Jie-Yi Ren, Yi-Hui Gu, Qing-Feng Li* and Zhi-Chao Wang*


DOI: 10.2174/1566523220666200806111451


Review Article

Systemic therapy for hepatocellular carcinoma: Advances and hopes

, 2020; 20(2): 84-99.

Chen-Hao Zhang, Ming Li, You-Pei Lin and Qiang Gao*


DOI: 10.2174/1566523220666200628014530


Review Article

Dissecting the therapeutic relevance of gene therapy in neuroaids: An evolving epidemic

, 2020; 20(3): 174-183.

Bushra Nabi, Saleha Rehman, Faheem Hyder Pottoo, Sanjula Baboota and Javed Ali*


DOI: 10.2174/1566523220666200615151805


Review Article

Nanoparticle based gene therapy approach: A pioneering rebellion in the management of psychiatric disorders

, 2020; 20(3): 164-173.

Saleha Rehman, Bushra Nabi, Faheem Hyder Pottoo, Sanjula Baboota and Javed Ali*


DOI: 10.2174/1566523220666200607185903


Review Article

Gene therapy in the management of parkinson’s disease: Potential of gdnf as a promising therapeutic strategy

, 2020; 20(3): 207-222.

Tapan Behl*, Ishnoor Kaur, Arun Kumar, Vineet Mehta, Gokhan Zengin and Sandeep Arora


DOI: 10.2174/1566523220999200817164051



Review Article

Gene therapy for hemophilia a: Where we stand

, 2020; 20(2): 142-151.

Miaojin Zhou, Zhiqing Hu, Chunhua Zhang, Lingqian Wu, Zhuo Li* and Desheng Liang*


DOI: 10.2174/1566523220666200806110849



Most Accessed Articles

Gene Therapy for Hemophilia A: Where We Stand

, 2020; 20(2): 142-151.

Miaojin Zhou, Zhiqing Hu, Chunhua Zhang, Lingqian Wu, Zhuo Li* and Desheng Liang*


DOI: 10.2174/1566523220666200806110849


NF1, Neurofibromin and Gene Therapy: Prospects of Next-Generation Therapy

, 2020; 20(2): 100-108.

Xi-Wei Cui, Jie-Yi Ren, Yi-Hui Gu, Qing-Feng Li* and Zhi-Chao Wang*


DOI: 10.2174/1566523220666200806111451



Feasibility of Mesenchymal Stem Cell Therapy for COVID-19: A Mini Review

, 2020; 20(4): 285-288.

Jingwen Li, Xinyi Wang, Na Li , Ying Jiang, Heqing Huang*, Tao Wang, Zhicheng Lin and Nian Xiong*


DOI: 10.2174/1566523220999200820172829




Gene Therapy, A Novel Therapeutic Tool for Neurological Disorders: Current Progress, Challenges and Future Prospective

, 2020; 20(3): 184-194.

Ashif Iqubal, Mohammad Kashif Iqubal, Aamir Khan, Javed Ali, Sanjula Baboota and Syed Ehtaishamul Haque*


DOI: 10.2174/1566523220999200716111502











Editor-in-Chief

Liang Cheng
College of Bioinformatics Science and Technology
Harbin Medical University
Harbin, Heilongjiang
(China)
Biography
View Full Editorial Board

COPE Compliant

Journal History

Current Gene Therapy Journal was launched in 2001. Dr. Ignacio Anegon was the founding editor of the journal.
Scopus CiteScore Metrics: 2.05

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