Contents

Current Drug Targets, Volume 8 - Number 2

Editorial [ Hot Topic: Highlights on Important Signaling Pathways as Drug Targets in Hematological Malignancies (Guest Editors: H. Serve and H.C. Hasselbalch) ]

, 8(2): 203

Hubert Serve and Hans Carl Hasselbalch


DOI: 10.2174/138945007779940034




Tyrosine Kinases as Therapeutic Targets in BCR-ABL Negative Chronic Myeloproliferative Disorders

, 8(2): 205 - 216

Andreas Reiter, Christoph Walz and Nicholas C. P. Cross


DOI: 10.2174/138945007779940124




Targeting the RAS Signaling Pathway in Malignant Hematologic Diseases

, 8(2): 217 - 235

M. A. Morgan, A. Ganser and C. W. M. Reuter


DOI: 10.2174/138945007779940043




Oncogenic Signaling in Acute Myeloid Leukemia

, 8(2): 237 - 246

Christian H. Brandts, Wolfgang E. Berdel and Hubert Serve


DOI: 10.2174/138945007779940197




The Mevalonate Pathway as a Therapeutic Target in the Ph-Negative Chronic Myeloproliferative Disorders

, 8(2): 247 - 256

Hans Carl Hasselbalch and Caroline H. Riley


DOI: 10.2174/138945007779940133




Vascular Endothelial Growth Factor and Its Receptor as Drug Targets in Hematological Malignancies

, 8(2): 257 - 268

Torsten Kessler, Frauke Fehrmann, Ralf Bieker, Wolfgang E. Berdel and Rolf M. Mesters


DOI: 10.2174/138945007779940089




Editorial [ Hot Topic: Current Drug Targets in Degenerative Joint Disease (Guest Editors: T. Aigner and E. Bartnik) ]

, 8(2): 269 - 270

Thomas Aigner and Eckart Bartnik


DOI: 10.2174/138945007779940106




Pathobiology of Osteoarthritis: Pathomechanisms and Potential Therapeutic Targets

, 8(2): 271 - 282

H. I. Roach, T. Aigner, S. Soder, J. Haag and H. Welkerling


DOI: 10.2174/138945007779940160




Cytokine Targeting in Osteoarthritis

, 8(2): 283 - 292

Arjen B. Blom, Peter M. van der Kraan and Wim B. van den Berg


DOI: 10.2174/138945007779940179




Molecular Targets in Osteoarthritis: Metalloproteinases and Their Inhibitors

, 8(2): 293 - 303

P. S. Burrage and C. E. Brinckerhoff


DOI: 10.2174/138945007779940098




Inflammatory Signaling in Cartilage: MAPK and NF-κ B Pathways in Chondrocytes and the Use of Inhibitors for Research into Pathogenesis and Therapy of Osteoarthritis

, 8(2): 305 - 313

Jeremy Saklatvala


DOI: 10.2174/138945007779940115




Role of Cathepsin K in Normal Joints and in the Development of Arthritis

, 8(2): 315 - 323

H. J. Salminen-Mankonen, J. Morko and E. Vuorio


DOI: 10.2174/138945007779940188




Osteoarthritis: Aging of Matrix and Cells - Going for a Remedy

, 8(2): 325 - 331

T. Aigner, J. Haag, J. Martin and J. Buckwalter


DOI: 10.2174/138945007779940070




Cell Death and Apoptosis in Ostearthritic Cartilage

, 8(2): 333 - 345

H. A. Kim and F. J. Blanco


DOI: 10.2174/138945007779940025




Antioxidant to Treat Osteoarthritis: Dream or Reality?

, 8(2): 347 - 357

Y. Henrotin and B. Kurz


DOI: 10.2174/138945007779940151




Anabolic Factors in Degenerative Joint Disease

, 8(2): 359 - 365

L. J. Sandell


DOI: 10.2174/138945007779940142




In Vivo Osteoarthritis Target Validation Utilizing Genetically-Modified Mice

, 8(2): 367 - 376

Sonya S. Glasson


DOI: 10.2174/138945007779940061




Growth Plate Cartilage as Developmental Model in Osteoarthritis Research -Potentials and Limitations

, 8(2): 377 - 385

T. Aigner and N. Gerwin


DOI: 10.2174/138945007779940052




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