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Contents

Current Drug Targets, Volume 17 - Number 13


Editorial


Review Article

Targeting Cystathionine Beta-Synthase Misfolding in Homocystinuria by Small Ligands: State of the Art and Future Directions

, 17(13): 1455 - 1470

Tomas Majtan, Angel L. Pey, June Ereño-Orbea, Luis Alfonso Martínez-Cruz and Jan P. Kraus


DOI: 10.2174/1389450117666160302094910



Review Article

Pharmacoperones as a New Therapeutic Approach: In Vitro Identification and In vivo Validation of Bioactive Molecules

, 17(13): 1471 - 1481

Alfredo Ulloa-Aguirre and P. Michael Conn


DOI: 10.2174/1389450117666160307143345



Review Article

Natural and Unnatural Compounds Rescue Folding Defects of Human Alanine: Glyoxylate Aminotransferase Leading to Primary Hyperoxaluria Type I

, 17(13): 1482 - 1491

Elisa Oppici, Riccardo Montioli, Mirco Dindo and Barbara Cellini


DOI: 10.2174/1389450117666160302095254



Review Article

Biophysical Screening for Identifying Pharmacological Chaperones and Inhibitors Against Conformational and Infectious Diseases

, 17(13): 1492 - 1505

Adrián Velazquez-Campoy, Javier Sancho, Olga Abian and Sonia Vega


DOI: 10.2174/1389450117666160201110449



Review Article

Natural Small Molecules as Stabilizers and Activators of Cancer-Associated NQO1 Polymorphisms

, 17(13): 1506 - 1514

Angel L. Pey, Clare F. Megarity, Encarnación Medina-Carmona and David J. Timson


DOI: 10.2174/1389450117666160101121610



Review Article

Pharmacological Chaperones that Protect Tetrahydrobiopterin Dependent Aromatic Amino Acid Hydroxylases Through Different Mechanisms

, 17(13): 1515 - 1526

Magnus Hole, Ana Jorge-Finnigan, Jarl Underhaug, Knut Teigen and Aurora Martinez


DOI: 10.2174/1389450117666160307143512



Review Article

Therapeutic Approaches Using Riboflavin in Mitochondrial Energy Metabolism Disorders

, 17(13): 1527 - 1534

Bárbara J. Henriques, Tânia G. Lucas and Cláudio M. Gomes


DOI: 10.2174/1389450117666160813180812



Review Article

Dysregulated Chemokine Signaling in Cystic Fibrosis Lung Disease: A Potential Therapeutic Target

, 17(13): 1535 - 1544

Xiaoqing Guan, Yuning Hou, Fei Sun, Zhe Yang and Chunying Li


DOI: 10.2174/1389450117666151209120516



Review Article

Topical and Transdermal Delivery of Drug-Loaded Nano/ Microsystems with Application of Physical Enhancement Techniques

, 17(13): 1545 - 1559

Lívia Neves Borgheti-Cardoso, Tamara Ângelo, Guilherme M. Gelfuso, Renata F.V. Lopez and Taís Gratieri


DOI: 10.2174/1389450116666151019095121



Review Article

Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review

, 17(13): 1560 - 1576

Yuanchao Xie, Comfort Alicha Ogah, Xiangrui Jiang, Jianfeng Li and Jingshan Shen


DOI: 10.2174/1389450117666151209123751




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