Contents

Current Drug Targets, Volume 12 - Number 12

Editorial [Hot Topic: The Plasminogen Activation System in Pathology: Use in Prognosis and Therapy (Guest Editor: Marie Ranson)]

, 12(12): 1709 - 1710

Marie Ranson


DOI: 10.2174/138945011797635894




Rational Targeting of the Urokinase Receptor (uPAR): Development of Antagonists and Non-Invasive Imaging Probes

, 12(12): 1711 - 1728

M. C. Kriegbaum, M. Persson, L. Haldager, W. Alpizar-Alpizar, B. Jacobsen, H. Gardsvoll, A. Kjaer and M. Ploug


DOI: 10.2174/138945011797635812




Structural Basis for Therapeutic Intervention of uPA/uPAR System

, 12(12): 1729 - 1743

Jacky Chi Ki Ngo, Longguang Jiang, Zhonghui Lin, Cai Yuan, Zhuo Chen, Xu Zhang, Haiyang Yu, Jundong Wang, Lin Lin and Mingdong Huang


DOI: 10.2174/138945011797635911




uPAR as Anti-Cancer Target: Evaluation of Biomarker Potential, Histological Localization, and Antibody-Based Therapy

, 12(12): 1744 - 1760

Ida K. Lund, Martin Illemann, Tine Thurison, Ib J. Christensen and Gunilla Hoyer-Hansen


DOI: 10.2174/138945011797635902




Regulation of Cell Migration and Invasion by Specific Modules of uPA: Mechanistic Insights and Specific Inhibitors

, 12(12): 1761 - 1771

Maria Vincenza Carriero, Paola Franco, Giuseppina Votta, Immacolata Longanesi-Cattani, Maria Teresa Vento, Maria Teresa Masucci, Alessandro Mancini, Mario Caputi, Ingram Iaccarino and Maria Patrizia Stoppelli


DOI: 10.2174/138945011797635777




Plasminogen Activation-Based Thrombolysis for Ischaemic Stroke: The Diversity of Targets may Demand New Approaches

, 12(12): 1772 - 1781

Robert L. Medcalf


DOI: 10.2174/138945011797635885




Effects of Altered Plasminogen Activator Inhibitor-1 Expression on Cardiovascular Disease

, 12(12): 1782 - 1789

Victoria A. Ploplis


DOI: 10.2174/138945011797635803




Editorial [Hot Topic: Anti-Platelet Therapy (Guest Editor: Susan S. Smyth)]

, 12(12): 1790 - 1791

Susan S. Smyth


DOI: 10.2174/138945011797635821




Historical Observations on the Discovery of Platelets, Platelet Function Testing and the First Antiplatelet Agent

, 12(12): 1792 - 1804

Steven R. Steinhubl


DOI: 10.2174/138945011797635858




Oral Antiplatelet Therapy for Acute Coronary Syndromes: Aspirin, P2Y12 Inhibition and Thrombin Receptor Antagonists

, 12(12): 1805 - 1812

Alison L. Bailey and Charles L. Campbell


DOI: 10.2174/138945011797635830




Current Issues with Glycoprotein IIb-IIIa Antagonists

, 12(12): 1813 - 1820

David J. Schneider


DOI: 10.2174/138945011797635768




Platelet and Soluble Glycoprotein VI - Novel Applications in Diagnosis and Therapy

, 12(12): 1821 - 1830

Boris Bigalke, Margitta Elvers, Tanja Schonberger and Meinrad Gawaz


DOI: 10.2174/138945011797635867




Bleeding and Acute Coronary Syndromes: Defining, Predicting, and Managing Risk and Outcomes

, 12(12): 1831 - 1835

Sharif A. Halim and Sunil V. Rao


DOI: 10.2174/138945011797635876




Role of Platelet Function Testing in Clinical Practice: Current Concepts and Future Perspectives

, 12(12): 1836 - 1847

Dirk Sibbing, Robert A. Byrne and Adnan Kastrati


DOI: 10.2174/138945011797635786




Progress of Antiplatelet Pharmacogenomics

, 12(12): 1848 - 1858

Julie H. Oestreich


DOI: 10.2174/138945011797635849




Big Science for Small Cells: Systems Approaches for Platelets

, 12(12): 1859 - 1870

Stephen P. Holly and Leslie V. Parise


DOI: 10.2174/138945011797635795




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