Contents

Current Drug Targets, Volume 11 - Number 5

Editorial [Hot Topic: Waiting for Action on the Osteoarthritis Front (Guest Editors: Virginia Byers Kraus and Thomas Aigner)]

, 11(5): 518 - 520

Virginia Byers Kraus


DOI: 10.2174/138945010791011974




Targets to Tackle – The Pathophysiology of the Disease

, 11(5): 521 - 527

N. Schmitz, V. B. Kraus and T. Aigner


DOI: 10.2174/138945010791011875




Disease Modifying Osteoarthritis Drugs: Facing Development Challenges and Choosing Molecular Targets

, 11(5): 528 - 535

Marie-Pierre Hellio Le Graverand-Gastineau


DOI: 10.2174/138945010791011893




A Pathway and Approach to Biomarker Validation and Qualification for Osteoarthritis Clinical Trials

, 11(5): 536 - 545

David J. Hunter, Elena Losina, Ali Guermazi, Deb Burstein, Marissa N. Lassere and Virginia Kraus


DOI: 10.2174/138945010791011947




Intraarticular Treatments for Osteoarthritis: New Perspectives

, 11(5): 546 - 560

Xavier Chevalier


DOI: 10.2174/138945010791011866




Is Cartilage Matrix Breakdown an Appropriate Therapeutic Target in Osteoarthritis – Insights from Studies of Aggrecan and Collagen Proteolysis?

, 11(5): 561 - 575

Christopher B. Little and Amanda J. Fosang


DOI: 10.2174/138945010791011956




Activated Synovial Macrophages as Targets for Osteoarthritis Drug Therapy

, 11(5): 576 - 585

Jan Bondeson


DOI: 10.2174/138945010791011965




Obesity and Inflammation – Targets for OA Therapy

, 11(5): 586 - 598

F. Iannone and G. Lapadula


DOI: 10.2174/138945010791011857




NF-κB Signaling: Multiple Angles to Target OA

, 11(5): 599 - 613

Kenneth B. Marcu, Miguel Otero, Eleonora Olivotto, Rosa Maria Borzi and Mary B. Goldring


DOI: 10.2174/138945010791011938




Novel Therapies in OA

, 11(5): 614 - 619

Carl R. Flannery


DOI: 10.2174/138945010791011884




To Seek Shelter from the Wnt in Osteoarthritis? Wnt-Signaling as a Target for Osteoarthritis Therapy

, 11(5): 620 - 629

Arjen B. Blom, Peter L. van Lent, Peter M. van der Kraan and Wim B. van den Berg


DOI: 10.2174/138945010791011901




Treatment of Choroidal Neovascularization in High Myopia

, 11(5): 630 - 644

Javier A. Montero and Jose M. Ruiz-Moreno


DOI: 10.2174/138945010791011929




Targeting Interleukin-21 in Immune-Mediated Pathologies

, 11(5): 645 - 649

Massimiliano Sarra, Francesco Pallone, Thomas T. Macdonald and Giovanni Monteleone


DOI: 10.2174/138945010791011910




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