Contents

Current Drug Targets, Volume 11 - Number 10

Editorial [Hot topic: Central and Peripheral Metabolic Changes in Neurodegenerative Diseases (Guest Editor: Ana Cristina Rego)]

, 11(10): 1192

Ana Cristina Rego


DOI: 10.2174/1389450111007011192




Multiple Defects in Energy Metabolism in Alzheimers Disease

, 11(10): 1193 - 1206

I. L. Ferreira, R. Resende, E. Ferreiro, A. C. Rego and C. F. Pereira


DOI: 10.2174/1389450111007011193




Metabolic Aspects of Prion Diseases: An Overview

, 11(10): 1207 - 1217

Tanja Vranac and Mara Bresjanac


DOI: 10.2174/1389450111007011207




Mitochondrial-Associated Metabolic Changes and Neurodegeneration in Huntingtons Disease - from Clinical Features to the Bench

, 11(10): 1218 - 1236

Tatiana R. Rosenstock, Ana I. Duarte and A. Cristina Rego


DOI: 10.2174/1389450111007011218




Hypothalamic and Neuroendocrine Changes in Huntingtons Disease

, 11(10): 1237 - 1249

Sofia Hult, Kristofer Schultz, Rana Soylu and Asa Petersen


DOI: 10.2174/1389450111007011237




Skeletal Muscle in Motor Neuron Diseases: Therapeutic Target and Delivery Route for Potential Treatments

, 11(10): 1250 - 1261

Luc Dupuis and Andoni Echaniz-Laguna


DOI: 10.2174/1389450111007011250




The Role of PGC-1α in the Pathogenesis of Neurodegenerative Disorders

, 11(10): 1262 - 1269

Krisztina Rona-Voros and Patrick Weydt


DOI: 10.2174/1389450111007011262




Sirtuins: Common Targets in Aging and in Neurodegeneration

, 11(10): 1270 - 1280

Rita Machado de Oliveira, Teresa F. Pais and Tiago Fleming Outeiro


DOI: 10.2174/1389450111007011270




Potential Therapeutic Targets for Neurodegenerative Diseases: Lessons Learned from Calorie Restriction

, 11(10): 1281 - 1292

Wenzhen Duan and Christopher A. Ross


DOI: 10.2174/1389450111007011281




Editorial [Targeting Genetic Instability in Cancer Cells (Guest Editor: Francesco Colotta)]

, 11(10): 1293 - 1295

Francesco Colotta


DOI: 10.2174/1389450111007011293




The Mutator Phenotype in Cancer: Molecular Mechanisms and Targeting Strategies

, 11(10): 1296 - 1303

Marc J. Prindle, Edward J. Fox and Lawrence A. Loeb


DOI: 10.2174/1389450111007011296




Genetic and Epigenetic Heterogeneity in Cancer: The Ultimate Challenge for Drug Therapy

, 11(10): 1304 - 1316

H. H. Heng, G. Liu, J. B. Stevens, S. W. Bremer, K. J. Ye and C. J. Ye


DOI: 10.2174/1389450111007011304




Genetic Instability Influences Drug Response in Cancer Cells

, 11(10): 1317 - 1324

G. Damia and M. D'Incalci


DOI: 10.2174/1389450111007011317




Destabilizing Aneuploidy by Targeting Cell Cycle and Mitotic Checkpoint Proteins in Cancer Cells

, 11(10): 1325 - 1335

Riccardo Colombo and Jurgen Moll


DOI: 10.2174/1389450111007011325




Targeting Synthetic Lethality in DNA Damage Repair Pathways as an Anti-Cancer Strategy

, 11(10): 1336 - 1340

Benjamin J. Moeller, Wadih Arap and Renata Pasqualini


DOI: 10.2174/1389450111007011336




Targeting Karyotypic Complexity and Chromosomal Instability of Cancer Cells

, 11(10): 1341 - 1350

Anna V. Roschke and Ilan R. Kirsch


DOI: 10.2174/1389450111007011341




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