Current Drug Targets
Volume 20, 16 Issues, 2019
ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)
This journal supports open access
ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)
This journal supports open access
Editor's Choice
Drug Development Strategy for Type 2 Diabetes: Targeting Positive Energy Balances
, 2019; 20(8): 879 - 890Zhenqi Liu and Baichun Yang*
DOI: 10.2174/1389450120666181217111500
Targeting Water in the Brain: Role of Aquaporin-4 in Ischemic Brain Edema
, 2019; 20(7): 748 - 755Muyassar Mamtilahun, Guanghui Tang, Zhijun Zhang, Yongting Wang, Yaohui Tang* and Guo-Yuan Yang*
DOI: 10.2174/1389450120666190214115309
Estrogen Receptor Alpha and its Ubiquitination in Breast Cancer Cells
, 2019; 20(6): 690 - 704Angeles C. Tecalco-Cruz*, Josué O. Ramírez-Jarquín and Eduardo Cruz-Ramos
DOI: 10.2174/1389450119666181015114041
Understanding Membrane Protein Drug Targets in Computational Perspective
, 2019; 20(5): 551 - 564Jianting Gong, Yongbing Chen, Feng Pu, Pingping Sun, Fei He, Li Zhang, Yanwen Li*, Zhiqiang Ma* and Han Wang*
DOI: 10.2174/1389450120666181204164721
Influence of Ultrafine Particles Exposure on Asthma Exacerbation in Children: A Meta-Analysis
, 2019; 20(4): 412 - 420Qinyuan Li, Qian Yi, Lin Tang, Siying Luo, Yuan Tang, Guangli Zhang and Zhengxiu Luo*
DOI: 10.2174/1389450119666180829114252
A Review on Quantum Dots: Synthesis to In- silico Analysis as Next Generation Antibacterial Agents
, 2019; 20(3): 255 - 262Sounik Manna, Munmun Ghosh, Ranadhir Chakraborty, Sudipto Ghosh and Santi M. Mandal*
DOI: 10.2174/1389450119666180731142423
Gut Mycobiota and Fungal Metabolites in Human Homeostasis
, 2019; 20(2): 232 - 240Izabella Mogilnicka and Marcin Ufnal *
DOI: 10.2174/1389450119666180724125020
DNA Related Enzymes as Molecular Targets for Antiviral and Antitumoral Chemotherapy. A Natural Overview of the Current Perspectives
, 2019; 20(1): 70 - 80Hugo A. Garro* and Carlos R. Pungitore
DOI: 10.2174/1389450119666180426103558
Microbial Biofilm and Quorum Sensing Inhibition: Endowment of Medicinal Plants to Combat Multidrug-Resistant Bacteria
, 2018; 19(16): 1916 - 1932Rina Das and Dinesh Kumar Mehta*
DOI: 10.2174/1389450119666180406111143
Genetic Molecular Subtypes in Optimizing Personalized Therapy for Metastatic Colorectal Cancer
, 2018; 19(15): 1731 - 1737Marcin Włodarczyk*, Jakub Włodarczyk, Paweł Siwiński, Aleksandra Sobolewska-Włodarczyk and Jakub Fichna
DOI: 10.2174/1389450119666180803122744
Epigenetic Mechanisms: Role in Hematopoietic Stem Cell Lineage Commitment and Differentiation
, 2018; 19(14): 1683 - 1695Sanjeev Raghuwanshi, Swati Dahariya, Ravinder Kandi, Usha Gutti, Ram Babu Undi, Durga Shankar Sharma, Itishri Sahu, Narasaiah Kovuru, Nagendra Sastry Yarla, Raja Gopal Venakata Saladi and Ravi Kumar Gutti*
DOI: 10.2174/1389450118666171122141821
Aptamers and Aptasensors as Novel Approach for Microbial Detection and Identification: An Appraisal
, 2018; 19(13): 1560 - 1572Muhammad Ali Syed* and Bushra Jamil
DOI: 10.2174/1389450119666180105115429
The Role of Dietary Compounds in the Therapy of Nicotine-Induced Osteoporosis
, 2018; 19(12): 1424 - 1430Norazlina Mohamed*, Norliza Muhammad, Ahmad Nazrun Shuid and Ima-Nirwana Soelaiman
DOI: 10.2174/1389450118666170925154428
Role of the LDL Receptor-Related Protein 1 in Regulating Protease Activity and Signaling Pathways in the Vasculature
, 2018; 19(11): 1276 - 1288Dianaly T. Au, Allison L. Arai, William E. Fondrie, Selen C. Muratoglu* and Dudley K. Strickland*
DOI: 10.2174/1389450119666180511162048
The Role of DNA Repair Pathways in AML Chemosensitivity
, 2018; 19(10): 1205 - 1219Elizabeth A. Pearsall, Lisa F. Lincz and Kathryn A. Skelding*
DOI: 10.2174/1389450119666180110093713
Ubiquitin and ubiquitin-like proteins in cardiac disease and protection
, 2018; 19(9): 989 - 1002Jie Li, John A. Johnson and Huabo Su*
DOI: 10.2174/1389450117666151209114608
Mitochondrial Aconitase in Neurodegenerative Disorders: Role of a Metabolism- related Molecule in Neurodegeneration
, 2018; 19(8): 973 - 985Fariba Khodagholi, Fatemeh Shaerzadeh* and Fateme Montazeri
DOI: 10.2174/1389450118666170816124203
Optimization of Drug Safety Profile in Inflammatory Bowel Disease Through a Personalized Approach
, 2018; 19(7): 740 - 747Parambir S. Dulai and Corey A. Siegel*
DOI: 10.2174/1389450118666170525114939
Macrophage Polarization as a Therapeutic Target in Myocardial Infarction
, 2018; 19(6): 651 - 662Yuanyuan Cheng and Jianhui Rong*
DOI: 10.2174/1389450118666171031115025
Zoledronic Acid: Pleiotropic Anti-Tumor Mechanism and Therapeutic Outlook for Osteosarcoma
, 2018; 19(5): 409 - 421Zhengxiao Ouyang, Haowei Li, Zanjing Zhai, Jiake Xu, Crispin R. Dass, An Qin* and Kerong Dai*
DOI: 10.2174/1573399811666150615145409
Smart Triggered Release in Controlled Drug Delivery
, 2018; 19(4): 318 - 327Paul Catalin Balaure, Dragos Gudovan* and Iulia Alexandra Gudovan
DOI: 10.2174/1389450117666160401125034
Virulence Factor Targeting of the Bacterial Pathogen Staphylococcus aureus for Vaccine and Therapeutics
, 2018; 19(2): 111 - 127Trevor L. Kane, Katelyn E. Carothers and Shaun W. Lee*
DOI: 10.2174/1389450117666161128123536
Cytochrome P450 Structure, Function and Clinical Significance: A Review
, 2018; 19(1): 38 - 54Palrasu Manikandan and Siddavaram Nagini*
DOI: 10.2174/1389450118666170125144557
Cell Wall Associated Factors of Mycobacterium tuberculosis as Major Virulence Determinants: Current Perspectives in Drugs Discovery and Design
, 2017; 18(16): 1904 - 1918Gurdyal Singh, Arbind Kumar, Pratibha Maan and Jagdeep Kaur*
DOI: 10.2174/1389450118666170711150034
Targeting Transient Receptor Potential Channels in Cardiometabolic Diseases and Myocardial Ischemia Reperfusion Injury
, 2017; 18(15): 1733 - 1745Jipeng Ma, Lifang Yang, Yanyan Ma, Xiaowu Wang, Jun Ren* and Jian Yang*
DOI: 10.2174/1389450116666151019102052
The Smart Programmable CRISPR Technology: A Next Generation Genome Editing Tool for Investigators
, 2017; 18(14): 1653 - 1663Chiranjib Chakraborty, Seong Lin Teoh and Srijit Das*
DOI: 10.2174/1389450117666160527142321
Phytochemicals in the Treatment of Alzheimer’s Disease: A Systematic Review
, 2017; 18(13): 1487 - 1498DOI: 10.2174/1389450117666161102121553
Maintaining Plasma Fibrinogen Levels and Fibrinogen Replacement Therapies for Treatment of Intracranial Hemorrhage
, 2017; 18(12): 1349 - 1357Devin McBride, Jiping Tang and John H. Zhang*
DOI: 10.2174/1389450117666151209123857
The Molecular Concept of Atheromatous Plaques
, 2017; 18(11): 1250 - 1258Zar Chi Thent, Chiranjib Chakraborty, Pasuk Mahakkanukrauh, Nik Nik Ritza Kosai Nik Mahmood, Reynu Rajan and Srijit Das*
DOI: 10.2174/1389450117666160502151600
Epigenetic Effects of Environmental Chemicals on Reproductive Biology
, 2017; 18(10): 1116 - 1124Maria Strazzullo* and Maria Rosaria Matarazzo
DOI: 10.2174/1389450117666161025100125
Inflammasome in Dendritic Cells Immunobiology: Implications to Diseases and Therapeutic Strategies
, 2017; 18(9): 1003 - 1018Isabel Ferreira, Joana Liberal, Joao D Martins, Ana Silva, Bruno Miguel Neves* and Maria Teresa Cruz*
DOI: 10.2174/1389450117666160921144830
Rationale and Prospects of Targeting Bacterial Two-component Systems for Antibacterial Treatment of Cystic Fibrosis Patients
, 2017; 18(6): 687 - 695Nadya Velikova* and Jerry M. Wells
DOI: 10.2174/1389450117666160208145934
Docking Studies for Multi-Target Drugs
, 2017; 18(5): 592 - 604Luciana Scotti, Francisco J.B. Mendonca Junior, Hamilton M. Ishiki, Frederico F. Ribeiro, Rajeev K. Singla, Jose M. Barbosa Filho, Marcelo S. Da Silva and Marcus T. Scotti
DOI: 10.2174/1389450116666150825111818
Plant-derived Compounds as Potential Source of Novel Anti-Biofilm Agents Against Pseudomonas aeruginosa
, 2017; 18(4): 414 - 420Pooi Yin Chung
DOI: 10.2174/1389450117666161019102025
Do We Need Full Donor Chimerism? How Alloreactive Cell Therapies without Substantial Engraftment Might Treat Hematologic Cancers
, 2017; 18(3): 281 - 295Elizabeth F. Krakow, Hui-Sheng Ai, Brian Shaffer, Jean-Sebastien Delisle, Kai-Xun Hu and Anthony D. Sung
DOI: 10.2174/1389450116666150304103849
New Pharmacological Approaches Using Polyphenols on the Physiopathology of Neuropathic Pain
, 2017; 18(2): 160 - 173Pere Boadas-Vaello, Jose Miguel Vela and Enrique Verdu
DOI: 10.2174/1389450117666160527142423
Non Coding RNAs: A New Avenue for the Self-Tailoring of Blood Cancer Treatment
, 2017; 18(1): 35 - 55Gabriella Misso, Mayra Rachele Zarone, Anna Grimaldi, Maria Teresa Di Martino, Angela Lombardi, Hiromichi Kawasaki, Paola Stiuso, Pierfrancesco Tassone, Pierosandro Tagliaferri and Michele Caraglia
DOI: 10.2174/1389450117666160606104208
Astrocytes: Adhesion Molecules and Immunomodulation
, 2016; 17(16): 1871 - 1881Shane Liddelow and Daniel Hoyer
DOI: 10.2174/1389450117666160101120703
The Challenges of Modeling Drug Resistance to Antiangiogenic Therapy
, 2016; 17(15): 1747 - 1754Michalis Mastri, Spencer Rosario, Amanda Tracz, Robin E. Frink, Rolf A. Brekken and John M. L. Ebos
DOI: 10.2174/1389450117666151209123544
Pharmacological Chaperones that Protect Tetrahydrobiopterin Dependent Aromatic Amino Acid Hydroxylases Through Different Mechanisms
, 2016; 17(13): 1515 - 1526Magnus Hole, Ana Jorge-Finnigan, Jarl Underhaug, Knut Teigen and Aurora Martinez
DOI: 10.2174/1389450117666160307143512
Tapping into Mitochondria to Find Novel Targets for Diabetes Complications
, 2016; 17(12): 1341 - 1349Nicole B. Flemming, Linda A. Gallo, Micheal S. Ward and Josephine M. Forbes
DOI: 10.2174/1389450116666150727114410
Resolving Inflammation in Heart Failure: Novel Protective Lipid Mediators
, 2016; 17(10): 1206 - 1223Marta Reina-Couto, Luís Vale, Jorge Carvalho, Paulo Bettencourt, António Albino-Teixeira and Teresa Sousa
DOI: 10.2174/1389450117666160101121135
Emerging Immunotargets in Metastatic Renal Cell Carcinoma
, 2016; 17(7): 771 - 776John Kucharczyk, Marc R. Matrana, Matteo Santoni, Francesco Massari, Marina Scarpelli, Liang Cheng, Antonio Lopez-Beltran, Stefano Cascinu, Rodolfo Montironi and Moch Holger
DOI: 10.2174/1389450117666151209115753
Tuning T Cell Activation: The Function of CD6 At the Immunological Synapse and in T Cell Responses
, 2016; 17(6): 630 - 639Rita F. Santos, Liliana Oliveira and Alexandre M. Carmo
DOI: 10.2174/1389450116666150531152439
Metabotropic Glutamate Receptors in Central Nervous System Diseases
, 2016; 17(5): 538 - 616DOI: 10.2174/1389450116666150316224011
Roles of Apoptosis and Cellular Senescence in Cancer and Aging
, 2016; 17(4): 405 - 415Claudia Cerella, Cindy Grandjenette, Mario Dicato and Marc Diederich
DOI: 10.2174/1389450116666150202155915
Targeting the Bone Microenvironment in Metastatic Castration-Resistant Prostate Cancer
, 2016; 17(3): 276 - 289Pavlos Msaouel, Jose Nahun Galeas, Alejandro Recio Boiles, Ramiro Rancier Ruiz and Michael Koutsilieris
DOI: 10.2174/1389450116666150420143932
Release of Soluble Ligands for the Activating NKG2D Receptor: One More Immune Evasion Strategy Evolved by HIV-1 ?
, 2016; 17(1): 54 - 64Erica Giuliani, Lia Vassena, Cristina Cerboni and Margherita Doria
DOI: 10.2174/1389450116666150630110329
Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors
, 2015; 16(14): 1634 - 1644Cristina Campestre, Mariangela Agamennone, Marilena Tauro and Paolo Tortorella
DOI: 10.2174/1389450116666150113121733
Impairment of Liver Glycogen Storage in the db/db Animal Model of Type 2 Diabetes: A Potential Target for Future Therapeutics?
, 2015; 16(10): 1088 - 1093Mitchell A. Sullivan, Brooke E. Harcourt, Ping Xu, Josephine M. Forbes and Robert G. Gilbert
DOI: 10.2174/1389450116666150727123115
Opportunities for Photoacoustic-Guided Drug Delivery
, 2015; 16(6): 571 - 581Jun Xia, Chulhong Kim and Jonathan F. Lovell
DOI: 10.2174/1389450116666150707100328
Molecular Pathophysiology of Priapism: Emerging Targets
, 2015; 16(5): 474 - 483Uzoma A. Anele, Belinda F. Morrison and Arthur L. Burnett
DOI: 10.2174/1389450115666141111111842
Auto-Antibodies As Possible Markers and Mediators of Ischemic, Dilated, and Rhythmic Cardiopathies
, 2015; 16(4): 342 - 360Nathalie Satta and Nicolas Vuilleumier
DOI: 10.2174/1389450115666141125122416
Cardiovascular Complications in Inflammatory Bowel Disease
, 2015; 16(3): 181 - 188Rudolf Schicho, Gunther Marsche and Martin Storr
DOI: 10.2174/1389450116666150202161500
Molecular Foundations for Personalized Therapy in Prostate Cancer
, 2015; 16(2): 103 - 114Kurt W. Fisher, Rodolfo Montironi, Antonio Lopez Beltran, Holger Moch, Lisha Wang, Marina Scarpelli, Sean R. Williamson, Michael O. Koch and Liang Cheng
DOI: 10.2174/1389450115666141229154500
Affinity-Based Methods in Drug-Target Discovery
, 2015; 16(1): 60 - 76Gabriela Rylova, Tomas Ozdian, Lakshman Varanasi, Miroslav Soural, Jan Hlavac, Dusan Holub, Petr Dzubak and Marian Hajduch
DOI: 10.2174/1389450115666141120110323
Synergistic Activity of the c-Met and Tubulin Inhibitor Tivantinib (ARQ197) with Pemetrexed in Mesothelioma Cells
, 2014; 15(14): 1331 - 1340Leticia G. Leon, Maria Gemelli, Rocco Sciarrillo, Amir Avan, Niccola Funel and Elisa Giovannetti
DOI: 10.2174/1389450116666141205160924
Targeting SUMOylation Cascade for Diabetes Management
, 2014; 15(12): 1094 - 1106Dornadula Sireesh, Elango Bhakkiyalakshmi, Kunka Mohanrama Ramkumar, Shanmugakani Rathinakumar, Panneer Selvam Anto Jennifer, Palanisamy Rajaguru and Ramasamy Paulmurugan
DOI: 10.2174/1389450115666140915124747
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Editor-in-Chief
Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA
About the Journal
For Authors
For Librarians & Readers
Journal History
Current Drug Targets Journal was launched in 2000. Dr. Francis J. Castellino serves as the Editor-in-Chief of the journal.
Webmaster Contact: info@benthamscience.net