Contents

Current Drug Metabolism, Volume 9 - Number 9

Editorial [Hot Topic: High Throughput In Vitro ADME/Tox Profiling for Drug Discovery(Guest Editor: Edward H. Kerns)]

, 9(9): 845 - 846

Edward H. Kerns


DOI: 10.2174/138920008786485074




High Throughput ADME Screening: Practical Considerations, Impact on the Portfolio and Enabler of In Silico ADME Models

, 9(9): 847 - 853

Cornelis E.C.A. Hop, Mark J. Cole, Ralph E. Davidson, David B. Duignan, James Federico, John S. Janiszewski, Kelly Jenkins, Suzanne Krueger, Rebecca Lebowitz, Theodore E. Liston, Walter Mitchell, Mark Snyder, Stefan J. Steyn, John R. Soglia, Christine Taylor, Matt D. Troutman, John Umland, Michael West, Kevin M. Whalen, Veronica Zelesky and Sabrina X. Zhao


DOI: 10.2174/138920008786485092




Plasma / Serum Protein Binding Determinations

, 9(9): 854 - 859

Michael J. Banker and Tracey H. Clark


DOI: 10.2174/138920008786485065




Solution Stability - Plasma, Gastrointestinal, Bioassay

, 9(9): 860 - 868

Li Di and Edward H. Kerns


DOI: 10.2174/138920008786485218




Using Measured pKa, LogP and Solubility to Investigate Supersaturation and Predict BCS Class

, 9(9): 869 - 878

K. J. Box and J. E.A. Comer


DOI: 10.2174/138920008786485155




In Vitro Solubility Assays in Drug Discovery

, 9(9): 879 - 885

Edward H. Kerns, Li Di and Guy T. Carter


DOI: 10.2174/138920008786485100




Artificial Membrane Assays to Assess Permeability

, 9(9): 886 - 892

Bernard Faller


DOI: 10.2174/138920008786485227




Permeability for Intestinal Absorption: Caco-2 Assay and Related Issues

, 9(9): 893 - 900

Barry Press and Deanna Di Grandi


DOI: 10.2174/138920008786485119




Assays to Predict Drug Permeation Across the Blood-Brain Barrier, and Distribution to Brain

, 9(9): 901 - 910

N. J. Abbott, D. E.M. Dolman and A. K. Patabendige


DOI: 10.2174/138920008786485182




Permeability – In Vitro Assays for Assessing Drug Transporter Activity

, 9(9): 911 - 920

Hong Jin and Li Di


DOI: 10.2174/138920008786485056




Metabolic Stability: Main Enzymes Involved and Best Tools To Assess It

, 9(9): 921 - 927

Romuald Laine


DOI: 10.2174/138920008786485146




In Vitro Cytochrome P450 Inhibition and Induction

, 9(9): 928 - 939

Robert L. Walsky and Sherri E. Boldt


DOI: 10.2174/138920008786485128




Methods for Predicting In Vivo Pharmacokinetics Using Data from In Vitro Assays

, 9(9): 940 - 951

J. Brian Houston and Aleksandra Galetin


DOI: 10.2174/138920008786485164




In Vitro Screening Techniques for Reactive Metabolites for Minimizing Bioactivation Potential in Drug Discovery

, 9(9): 952 - 964

Chandra Prakash, Raman Sharma, Michelle Gleave and Angus Nedderman


DOI: 10.2174/138920008786485209




hERG (KCNH2 or Kv11.1) K+ Channels: Screening for Cardiac Arrhythmia Risk

, 9(9): 965 - 970

Mark R. Bowlby, Ravi Peri, Howard Zhang and John Dunlop


DOI: 10.2174/138920008786485083




Predictive Teratology: Teratogenic Risk-Hazard Identification Partnered in the Discovery Process

, 9(9): 971 - 977

K. A. Augustine-Rauch


DOI: 10.2174/138920008786485137




The Role of Genetic Toxicology in Drug Discovery and Optimization

, 9(9): 978 - 985

L. L. Custer and K. S. Sweder


DOI: 10.2174/138920008786485191




Perspectives on Bioanalytical Mass Spectrometry and Automation in Drug Discovery

, 9(9): 986 - 994

John S. Janiszewski, Theodore E. Liston and Mark J. Cole


DOI: 10.2174/138920008786485173




Webmaster Contact: info@benthamscience.org
Copyright © 2018 Bentham Science