Contents

Current Drug Metabolism, Volume 9 - Number 1

Cell Lines: A Tool for In Vitro Drug Metabolism Studies

, 9(1): 1 - 11

M. J. Gomez-Lechon, M. T. Donato, A. Lahoz and J. V Castell


DOI: 10.2174/138920008783331086




Strategies to In Vitro Assessment of Major Human CYP Enzyme Activities by Using Liquid Chromatography Tandem Mass Spectrometry

, 9(1): 12 - 19

A. Lahoz, M. T. Donato, J. V Castell and M. J. Gomez-Lechon


DOI: 10.2174/138920008783331112




Comparison of Kinetic Parameters for Drug Oxidation Rates and Substrate Inhibition Potential Mediated by Cytochrome P450 3A4 and 3A5

, 9(1): 20 - 33

Hiroshi Yamazaki, Toshiro Niwa, Norie Murayama and Chie Emoto


DOI: 10.2174/138920008783331121




Epigenetic Regulation of Genes Encoding Drug-Metabolizing Enzymes and Transporters; DNA Methylation and Other Mechanisms

, 9(1): 34 - 38

Ichiro Ieiri, Takeshi Hirota, Hiroshi Takane and Shun Higuchi


DOI: 10.2174/138920008783331130




The Prediction of the Hepatic Clearance of Tanshinone IIA in Rat Liver Subcellular Fractions: Accuracy Improvement

, 9(1): 39 - 45

Guang-Ji Wang, Peng Li, Jing Li, Qian Zhang, Xin Liu, Alexander Khlentzos and Michael S. Roberts


DOI: 10.2174/138920008783331103




CSF as a Surrogate for Assessing CNS Exposure: An Industrial Perspective

, 9(1): 46 - 59

Jiunn H. Lin


DOI: 10.2174/138920008783331077




Recent Advances in the In Silico Modelling of UDP Glucuronosyltransferase Substrates

, 9(1): 60 - 69

Michael J. Sorich, Paul A. Smith, John O. Miners, Peter I. Mackenzie and Ross A. McKinnon


DOI: 10.2174/138920008783331167




The UDP-Glucuronosyltransferases as Oligomeric Enzymes

, 9(1): 70 - 76

Moshe Finel and Mika Kurkela


DOI: 10.2174/138920008783331158




Metabolic Pathways of T-2 Toxin

, 9(1): 77 - 82

Kamil Kuca, Vlastimil Dohnal, Alena Jezkova and Daniel Jun


DOI: 10.2174/138920008783331176




Effect of the NMDA-Receptor Antagonist Dextromethorphan in Infant Rat Pneumococcal Meningitis

, 9(1): 83 - 88

Stephen L. Leib, Johann Sellner, Ralph Ringer, Pierre Baumann, Michel Jonzier Perey and Bernhard Schmitt


DOI: 10.2174/138920008783331095




Metabolomics

, 9(1): 89 - 98

V. S. Gomase, S. S. Changbhale, S. A. Patil and K. V. Kale


DOI: 10.2174/138920008783331149




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