Contents

Current Drug Metabolism, Volume 8 - Number 7

Editorial [Hot Topic: Intestinal First-Pass Metabolism - Bridging the Gap Between In Vitro and In Vivo (Prediction of Intestinal First-Pass Metabolism (Guest Editor: Aleksandra Galetin))]

, 8(7): 643 - 644

Aleksandra Galetin


DOI: 10.2174/138920007782109779




Modeling Gastrointestinal Drug Absorption Requires More In Vivo Biopharmaceutical Data: Experience from In Vivo Dissolution and Permeability Studies in Humans

, 8(7): 645 - 657

Hans Lennernas


DOI: 10.2174/138920007782109823




In Vitro Methods to Study Intestinal Drug Metabolism

, 8(7): 658 - 675

Esther G. van de Kerkhof, Inge A.M. de Graaf and Geny M.M. Groothuis


DOI: 10.2174/138920007782109742




Prediction of Intestinal First-Pass Drug Metabolism

, 8(7): 676 - 684

Jiansong Yang, Masoud Jamei, Karen Rowland Yeo, Geoffrey T. Tucker and Amin Rostami-Hodjegan


DOI: 10.2174/138920007782109733




Maximal Inhibition of Intestinal First-Pass Metabolism as a Pragmatic Indicator of Intestinal Contribution to the Drug-Drug Interactions for CYP3A4 Cleared Drugs

, 8(7): 685 - 693

Aleksandra Galetin, Laura K. Hinton, Howard Burt, R. Scott Obach and J. Brian Houston


DOI: 10.2174/138920007782109805




The Role of the Intestine in Drug Metabolism and Pharmacokinetics: An Industry Perspective

, 8(7): 694 - 699

Michael B. Fisher and Gabriel Labissiere


DOI: 10.2174/138920007782109788




Small Interfering RNA in Drug Metabolism and Transport

, 8(7): 700 - 708

Ai-Ming Yu


DOI: 10.2174/138920007782109751




Inhibition of Ataxia Telangiectasia-p53-E2F-1 Pathway in Neurons as a Target for the Prevention of Neuronal Apoptosis

, 8(7): 709 - 715

Antoni Camins, Ester Verdaguer, Jaume Folch, Carlos Beas-Zarate, Anna Maria Canudas and Merce Pallas


DOI: 10.2174/138920007782109814




Brain Metabolism of Ethanol and Alcoholism: An Update

, 8(7): 716 - 727

L. Hipolito, M. J. Sanchez, A. Polache and L. Granero


DOI: 10.2174/138920007782109797




Investigation of Xenobiotics Metabolism, Genotoxicity, and Carcinogenicity Using Cyp2e1-/- Mice

, 8(7): 728 - 749

Burhan I. Ghanayem and Undi Hoffler


DOI: 10.2174/138920007782109760




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