Contents

Current Drug Metabolism, Volume 8 - Number 5

Editorial

, 8(5): 405

Chandra Prakash


DOI: 10.2174/138920007780866816




Mechanism-Based Inactivation of Cytochrome P450 Enzymes: Chemical Mechanisms, Structure-Activity Relationships and Relationship to Clinical Drug-Drug Interactions and Idiosyncratic Adverse Drug Reactions

, 8(5): 407 - 447

Amit S. Kalgutkar, R. Scott Obach and Tristan S. Maurer


DOI: 10.2174/138920007780866807




Drug-Drug Interactions via Mechanism-Based Cytochrome P450 Inactivation: Points to Consider for Risk Assessment from In Vitro Data and Clinical Pharmacologic Evaluation

, 8(5): 449 - 462

Karthik Venkatakrishnan and R. Scott Obach


DOI: 10.2174/138920007780866861




Evaluation of Human Pharmacokinetics, Therapeutic Dose and Exposure Predictions Using Marketed Oral Drugs

, 8(5): 463 - 479

D.F. McGinnity, J. Collington, R.P. Austin and R.J. Riley


DOI: 10.2174/138920007780866799




GSTP1 and MTHFR Polymorphisms Are Related with Toxicity in Breast Cancer Adjuvant Anthracycline-Based Treatment

, 8(5): 481 - 486

R. Zarate, S. Gonzalez-Santiago, E. Bandres, R. Morales, J. Salgado, A. Gomez, E. Aranda and J. Garcia-Foncillas


DOI: 10.2174/138920007780866780




Genetic Polymorphism of the Flavin-Containing Monooxygenase 3 (FMO3) Associated with Trimethylaminuria (Fish Odor Syndrome): Observations from Japanese Patients

, 8(5): 487 - 491

Hiroshi Yamazaki and Makiko Shimizu


DOI: 10.2174/138920007780866825




Phenotyping of Cytochrome P450 2E1 In Vitro and In Vivo

, 8(5): 493 - 498

Lena Ernstgard, Gunnar Johanson, Anne-Sophie Karlsson and Margareta Warholm


DOI: 10.2174/138920007780866843




Metabolism of Dietary Polyphenols and Possible Interactions with Drugs

, 8(5): 499 - 507

Joshua D. Lambert, Shengmin Sang, Anthony Y.H. Lu and Chung S. Yang


DOI: 10.2174/138920007780866870




Presystemic Metabolism of Orally Administered Peptide Drugs and Strategies to Overcome It

, 8(5): 509 - 517

A. Bernkop-Schnurch and T. Schmitz


DOI: 10.2174/138920007780866834




Calcium Metabolism and Oxidative Stress in Bone Fractures: Role of Antioxidants

, 8(5): 519 - 525

S.A. Sheweita and K.I. Khoshhal


DOI: 10.2174/138920007780866852




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