Contents

Current Drug Metabolism, Volume 7 - Number 3

Reactive Intermediates and the Pathogenesis of Adverse Drug Reactions: The Toxicology Perspective

, 7(3): 219 - 229

David E. Amacher


DOI: 10.2174/138920006776359284




A Literature Review of Enzyme Kinetic Parameters for CYP3A4-Mediated Metabolic Reactions of 113 Drugs in Human Liver Microsomes: Structure- Kinetics Relationship Assessment

, 7(3): 231 - 249

H.- Z. Bu


DOI: 10.2174/138920006776359329




The Impact of In Vitro Binding on In Vitro - In Vivo Extrapolations, Projections of Metabolic Clearance and Clinical Drug-Drug Interactions

, 7(3): 251 - 264

K. Grime and R. J. Riley


DOI: 10.2174/138920006776359266




Evaluation of Microsomal Incubation Conditions on CYP3A4-Mediated Metabolism of Cyclosporine A by a Statistical Experimental Design

, 7(3): 265 - 271

Monica Hermann, Eili T. Kase, Espen Molden and Hege Christensen


DOI: 10.2174/138920006776359275




Candidate Susceptibility Genes in Alzheimers Disease Are at High Risk for Being Forgotten - They Dont Give Peace of Mind...

, 7(3): 273 - 293

Andras Palotas and Janos Kalman


DOI: 10.2174/138920006776359257




Prediction of Maximum Exposure in Poor Metabolizers Following Inhibition of Nonpolymorphic Pathways

, 7(3): 295 - 299

C. Collins, R. Levy, I. Ragueneau-Majlessi and H. Hachad


DOI: 10.2174/138920006776359301




Involvement of Cytoskeleton in AhR-Dependent CYP1A1 Expression

, 7(3): 301 - 313

Zdenek Dvorak, Radim Vrzal, Jitka Ulrichova, Jean-Marc Pascussi, Patrick Maurel and Martin Modriansky


DOI: 10.2174/138920006776359310




A Critical Evaluation of the Experimental Design of Studies of Mechanism Based Enzyme Inhibition, with Implications for In Vitro-In Vivo Extrapolation

, 7(3): 315 - 334

F. Ghanbari, K. Rowland-Yeo, J. C. Bloomer, S. E. Clarke, M. S. Lennard, G. T. Tucker and A. Rostami-Hodjegan


DOI: 10.2174/138920006776359293




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