Contents

Current Drug Metabolism, Volume 4 - Number 5

Preface [Hot topic: Some Quantitative Issues Pertaining to Drug Metabolism and Drug-Drug Interactions (Guest Editor : Kenneth Bachmann)]

, 4(5): iv

Kenneth Bachmann


DOI: 10.2174/13892002103040500iv




On the Estimation of Binding Affinity (ΔGbind) for Human P450 Substrates (Based on Km and KΔ Values)

, 4(5): 331 - 340

David F.V. Lewis


DOI: 10.2174/1389200033489343




Atypical Enzyme Kinetics: Their Effect on In Vitro-In Vivo Pharmacokinetic Predictions and Drug Interactions

, 4(5): 341 - 346

Timothy S. Tracy


DOI: 10.2174/1389200033489280




Physiological Approaches to the Prediction of Drug-Drug Interactions in Study Populations

, 4(5): 347 - 356

J. Y. Chien, M. A. Mohutsky and S. A. Wrighton


DOI: 10.2174/1389200033489307




Application of a Convective-Dispersion Model to Predict In Vivo Hepatic Clearance from In Vitro Measurements Utilizing Cryopreserved Human Hepatocytes

, 4(5): 357 - 369

Ryan Niro, James P. Byers, Ronald L. Fournier and Kenneth Bachmann


DOI: 10.2174/1389200033489334




Relationship Between Extent of Inhibition and Inhibitor Dose: Literature Evaluation Based on the Metabolism and Transport Drug Interaction Database

, 4(5): 371 - 380

R. H. Levy, H. Hachad, C. Yao and I. Ragueneau-Majlessi


DOI: 10.2174/1389200033489325




Prediction of Human Drug Metabolizing Enzyme Induction

, 4(5): 381 - 391

Dayna C. Mankowski and Sean Ekins


DOI: 10.2174/1389200033489352




Transporter-Enzyme Interactions: Implications for Predicting Drug-Drug Interactions from In Vitro Data

, 4(5): 393 - 398

L. Z. Benet, C. L. Cummins and C. Y. Wu


DOI: 10.2174/1389200033489389




A New Nonlinear Mixture Response Surface Paradigm for the Study of Synergism: A Three Drug Example

, 4(5): 399 - 409

Donald B. White, Harry K. Slocum, Yseult Brun, Carol Wrzosek and William R. Greco


DOI: 10.2174/1389200033489316




A Human Drug Metabolism Database: Potential Roles in the Quantitative Predictions of Drug Metabolism and Metabolism-Related Drug-Drug Interactions

, 4(5): 411 - 422

Paul W. Erhardt


DOI: 10.2174/1389200033489299




Drug Metabolism and Drug Interactions: Application and Clinical Value of In Vitro Models

, 4(5): 423 - 459

Karthik Venkatakrishnan, Lisa L. von Moltke, R. Scott Obach and David J. Greenblatt


DOI: 10.2174/1389200033489361




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