Contents

Current Drug Metabolism, Volume 13 - Number 7

Editorial

Editorial: [Hot Topics: Metabolism and Drug-Drug Interaction Potential of Biotherapeutics]

, 13(7): 881

Albert P. Li


DOI: 10.2174/138920012802138697




Disposition and Interaction of Biotherapeutics in Pediatric Populations

, 13(7): 882 - 900

Souzan Yanni


DOI: 10.2174/138920012802138624




Catabolic Fate and Pharmacokinetic Characterization of Trastuzumab Emtansine (T-DM1): an Emphasis on Preclinical and Clinical Catabolism

, 13(7): 901 - 910

Ben-Quan Shen, Daniela Bumbaca, Ola Saad, Qin Yue, Cinthia V. Pastuskovas, S. Cyrus Khojasteh, Jay Tibbitts, Surinder Kaur, Bei Wang, Yu-Waye Chu, Patricia M. LoRusso and Sandhya Girish


DOI: 10.2174/138920012802138598




Drug Interaction Potential of Trastuzumab Emtansine (T-DM1) Combined with Pertuzumab in Patients With HER2-Positive Metastatic Breast Cancer

, 13(7): 911 - 922

Dan Lu, Howard A. Burris III, Bei Wang, E. Claire Dees, Javier Cortes, Amita Joshi, Manish Gupta, Joo-Hee Yi, Yu-Waye Chu, Ted Shih, Liang Fang and Sandhya Girish


DOI: 10.2174/138920012802138688




De-Risking Bio-therapeutics for Possible Drug Interactions Using Cryopreserved Human Hepatocytes

, 13(7): 923 - 929

Shannon Dallas, Carlo Sensenhauser, Ameesha Batheja, Monica Singer, Maria Markowska, Cindy Zakszewski, Rao N.V.S. Mamidi, Michael McMillia, Chao Han, Honghui Zhou and Jose Silva


DOI: 10.2174/138920012802138589




Effects of Interleukin 1β (IL-1β) and IL-1β/Interleukin 6 (IL-6) Combinations on Drug Metabolizing Enzymes in Human Hepatocyte Culture

, 13(7): 930 - 937

Leslie J. Dickmann, Sonal K. Patel, Larry C. Wienkers and J. Greg Slatter


DOI: 10.2174/138920012802138642




Effects of Culture Duration on Gene Expression of P450 Isoforms, Uptake and Efflux Transporters in Primary Hepatocytes Cultured in the Absence and Presence of Interleukin- 6: Implications for Experimental Design for the Evaluation of Downregulatory Effects of Biotherapeutics

, 13(7): 938 - 946

Qian Yang, Utkarsh Doshi, Nicole Li and Albert P. Li


DOI: 10.2174/138920012802138570




Animal Models for Evaluation of Drug-Drug Interaction Potential of Biotherapeutics

, 13(7): 947 - 950

Eugenia Kraynov, Martin E. Dowty, Odette Odette A. Fahmi and Owen Fields


DOI: 10.2174/138920012802138705




Editorial

Editorial: [SNPs of Drug Metabolic Enzymes and Personalized Medicine Part II]

, 13(7): 951

Dong-Qing Wei and Qi Chen


DOI: 10.2174/138920012802138651




Functional Genomics- and Network-driven Systems Biology Approaches for Pharmacogenomics and Toxicogenomics

, 13(7): 952 - 967

Xia Yang, Bin Zhang and Jun Zhu


DOI: 10.2174/138920012802138633




The SmartAmp Method: Rapid Detection of SNPs in Thiopurine S-Methyltransferase and ABC Transporters ABCC4 and ABCG2

, 13(7): 968 - 977

Wanping Aw, Alexander Lezhava, Akira Andoh, Hiroshi Tanaka, Yoshihide Hayashizaki and Toshihisa Ishikawa


DOI: 10.2174/138920012802138543




SNP Web Resources and Their Potential Applications in Personalized Medicine

, 13(7): 978 - 990

Jingbo Wang, Grace S.Y. Pang, Samuel S. Chong and Caroline G.L. Lee


DOI: 10.2174/138920012802138552




The Importance of Integrating SNP and Cheminformatics Resources to Pharmacogenomics

, 13(7): 991 - 999

Hsueh-Wei Chang, Li-Yeh Chuang, Ming-Tz Tsai and Cheng-Hong Yang


DOI: 10.2174/138920012802138679




Personalized Medicine: Potential, Barriers and Contemporary Issues

, 13(7): 1000 - 1006

Michael J. Sorich and Ross A. McKinnon


DOI: 10.2174/138920012802138615




Detection of EGFR Somatic Mutations in Non-Small Cell Lung Cancer (NSCLC) Using a Novel Mutant-Enriched Liquidchip (MEL) Technology

, 13(7): 1007 - 1011

Li Zhang, Huiyi Yang, Yanwei Zhao, Wenchao Liu, Shiyang Wu, Jiaying He, Xiaodi Luo, Zeyao Zhu, Jiasen Xu, Qinghua Zhou and Lifen Ren-Heidenreich


DOI: 10.2174/138920012802138660




Prediction and Functional Analysis of Single Nucleotide Polymorphisms

, 13(7): 1012 - 1023

Li Li, Qi Chen and Dong-Qing Wei


DOI: 10.2174/138920012802138561




Negatively Cooperative Binding Properties of Human Cytochrome P450 2E1 with Monocyclic Substrates

, 13(7): 1024 - 1031

Jie Ping, Ya-Jun Wang, Jing-Fang Wang, Xuan Li, Yi-Xue Li and Pei Hao


DOI: 10.2174/138920012802138606




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