Contents

Current Drug Metabolism, Volume 13 - Number 2

Editorial [Hot Topic: Cytochromes P450: Flexibility and Plasticity - Properties Determining Substrate Preferences (Guest Editors: Michal Otyepka and Pavel Anzenbacher)]

, 13(2): 129

Pavel Anzenbacher and Michal Otyepka


DOI: 10.2174/138920012798918435




Is There a Relationship Between the Substrate Preferences and Structural Flexibility of Cytochromes P450?

, 13(2): 130 - 142

Michal Otyepka, Karel Berka and Pavel Anzenbacher


DOI: 10.2174/138920012798918372




Multiple, Ligand-dependent Routes from the Active Site of Cytochrome P450 2C9

, 13(2): 143 - 154

Vlad Cojocaru, Peter J. Winn and Rebecca C. Wade


DOI: 10.2174/138920012798918462




The Role of Protein Plasticity in Computational Rationalization Studies on Regioselectivity in Testosterone Hydroxylation by Cytochrome P450 BM3 Mutants

, 13(2): 155 - 166

Stephanie B.A. de Beer, Laura A.H. van Bergen, Karlijn Keijzer, Vanina Rea, Harini Venkataraman, Celia Fonseca Guerra, F. Matthias Bickelhaupt, Nico P.E. Vermeulen, Jan N.M. Commandeur and Daan P. Geerke


DOI: 10.2174/138920012798918471




Plasticity of CYP2B Enzymes: Structural and Solution Biophysical Methods

, 13(2): 167 - 176

P. Ross Wilderman and James R. Halpert


DOI: 10.2174/138920012798918417




Dynamics and Hydration of the Active Sites of Mammalian Cytochromes P450 Probed by Molecular Dynamics Simulations

, 13(2): 177 - 189

Tereza Hendrychova, Karel Berka, Veronika Navratilova, Pavel Anzenbacher and Michal Otyepka


DOI: 10.2174/138920012798918408




Malleability and Versatility of Cytochrome P450 Active Sites Studied by Molecular Simulations

, 13(2): 190 - 196

Chris Oostenbrink, Anita de Ruiter, Jozef Hritz and Nico Vermeulen


DOI: 10.2174/138920012798918453




Identification of Selectivity Determinants in CYP Monooxygenases by Modelling and Systematic Analysis of Sequence and Structure

, 13(2): 197 - 202

Alexander Seifert and Jurgen Pleiss


DOI: 10.2174/138920012798918444




Interplay of β-Catenin with Xenobiotic-Sensing Receptors and its Role in Glutathione S-Transferase Expression

, 13(2): 203 - 214

Albert Braeuning


DOI: 10.2174/138920012798918381




Liver-Based In Vitro Technologies for Drug Biotransformation Studies - A Review

, 13(2): 215 - 224

Pius Fasinu, Patrick J. Bouic and Bernd Rosenkranz


DOI: 10.2174/138920012798918426




An insight into the Interaction between Clopidogrel and Proton Pump Inhibitors

, 13(2): 225 - 235

Bhavik S. Shah, Sanjay A. Parmar, Shailaja Mahajan and Anita A. Mehta


DOI: 10.2174/138920012798918390




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