Open Access Articles

Therapeutics and Immunoprophylaxis Against Noroviruses and Rotaviruses: The Past, Present, and Future

, 2017; 18: 1 - 22 (E-Pub Ahead of Print)

Souvik Ghosh*, Yashpal Singh Malik and Nobumichi Kobayashi




Digestive Enzyme Supplementation in Gastrointestinal Diseases

, 2016; 17(2): 187 - 193

Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota




Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines

, 2015; 16(6): 412 - 426

Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti




Preclinical Pharmacokinetics, Pharmacodynamics and Safety of Sucroferric Oxyhydroxide

, 2014; 15(10): 953 - 965

Mario Cozzolino, Felix Funk, Viatcheslav Rakov, Olivier Phan and Isaac Teitelbaum




A 30-years Review on Pharmacokinetics of Antibiotics: Is the Right Time for Pharmacogenetics?

, 2014; 15(6): 581 - 598

Lorena Baietto, Silvia Corcione, Giovanni Pacini, Giovanni Di Perri, Antonio D’Avolio and Francesco Giuseppe De Rosa




Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process

, 2014; 15(2): 209 - 217

Kelly E. Caudle, Teri E. Klein, James M. Hoffman, Daniel J. Muller, Michelle Whirl-Carrillo, Li Gong, Ellen M. McDonagh, Katrin Sangkuhl, Caroline F. Thorn, Matthias Schwab, Jose A.G. Agundez, Robert R. Freimuth, Vojtech Huser, Ming Ta Michael Lee, Otito F. Iwuchukwu, Kristine R. Crews, Stuart A. Scott, Mia Wadelius, Jesse J. Swen, Rachel F. Tyndale, C. Michael Stein, Dan Roden, Mary V. Relling, Marc S. Williams and Samuel G. Johnson




Prodrugs of Quercetin and Resveratrol: A Strategy Under Development

, 2014; 15(1): 77 - 95

Lucia Biasutto and Mario Zoratti




Post-translational and Post-transcriptional Modifications of Pregnane X Receptor (PXR) in Regulation of the Cytochrome P450 Superfamily

, 2013; 14(10): 1059 - 1069

Tomas Smutny, Sridhar Mani and Petr Pavek




Pathways for Ligand Activated Nuclear Receptors to Unravel the Genomic Responses Induced by Hepatotoxicants

, 2013; 14(10): 1022 - 1028

R.R.R. Fijten, D.G.J. Jennen and J.H.M. van Delft




Hepatic Cell Lines for Drug Hepatotoxicity Testing: Limitations and Strategies to Upgrade their Metabolic Competence by Gene Engineering

, 2013; 14(9): 946 - 968

M. Teresa Donato, Ramiro Jover and M. José Gómez-Lechón




Mechanism-based Inhibition of CYP450: An Indicator of Drug-induced Hepatotoxicity

, 2013; 14(9): 921 - 945

Shan Feng and Xin He




Neonatal Fc Receptor and its Role in the Absorption, Distribution, Metabolism and Excretion of Immunoglobulin G-Based Biotherapeutics

, 2013; 14(7): 764 - 790

Craig Giragossian, Tracey Clark, Nicole Piché-Nicholas and Christopher J. Bowman




Nanoparticle- and Liposome-carried Drugs: New Strategies for Active Targeting and Drug Delivery Across Blood-brain Barrier

, 2013; 14(6): 625 - 640

Martha Leonor Pinzon-Daza, Ivana Campia, Joanna Kopecka, Ruth Garzon, Dario Ghigo and Chiara Rigant




Insight into Tissue Unbound Concentration: Utility in Drug Discovery and Development

, 2013; 14(3): 324 - 340

T. Thanga Mariappan, Sandhya Mandlekar and Punit Marathe




Drug Metabolizing Enzymes in the Perinatal and Neonatal Period: Differences in the Expression and Activity

, 2013; 14(2): 167 - 173

Laura Cuzzolin




Yeast as a Humanized Model Organism for Biotransformation-Related Toxicity

, 2012; 13(10): 1464 - 1475

Jolanda S. van Leeuwen, Nico P.E. Vermeulen and J. Chris Vos




Peroxisomes, Peroxisomal Diseases, and the Hepatotoxicity Induced by Peroxisomal Metabolites

, 2012; 13(10): 1401 - 1411

Ronald J.A. Wanders and Sacha Ferdinandusse




Isotopic Labeling of Metabolites in Drug Discovery Applications

, 2012; 13(9): 1213 - 1225

Jacobo Iglesias, Lekha Sleno and Dietrich A. Volmer




Drug-induced Liver Steatosis and Phospholipidosis: Cell-Based Assays for Early Screening of Drug Candidates

, 2012; 13(8): 1160 - 1173

M. Teresa Donato and M. Jose Gomez-Lechon




Comparison of Cytochrome P450 2C Subfamily Members in Terms of Drug Oxidation Rates and Substrate Inhibition

, 2012; 13(8): 1145 - 1159

Toshiro Niwa and Hiroshi Yamazaki




Toxicological Profile of Therapeutic Nanodelivery Systems

, 2012; 13(8): 1068 - 1086

Luis M. Bimbo, Leena Peltonen, Jouni Hirvonen and Helder A. Santos




Animal Models for Evaluation of Drug-Drug Interaction Potential of Biotherapeutics

, 2012; 13(7): 947 - 950

Eugenia Kraynov, Martin E. Dowty, Odette Odette A. Fahmi and Owen Fields




Effects of Interleukin 1β (IL-1β) and IL-1β/Interleukin 6 (IL-6) Combinations on Drug Metabolizing Enzymes in Human Hepatocyte Culture

, 2012; 13(7): 930 - 937

Leslie J. Dickmann, Sonal K. Patel, Larry C. Wienkers and J. Greg Slatter




Active Metabolites Resulting from Decarboxylation, Reduction and Ester Hydrolysis of Parent Drugs

, 2012; 13(6): 835 - 862

I. Hartyanszky, H. Kalasz, E. Adeghate, Zs. Gulyas, M. Y. Hasan, K. Tekes, A. Adem and P. Sotonyi




Physiologically-based Pharmacokinetic (PBPK) Models for Assessing the Kinetics of Xenobiotics during Pregnancy: Achievements and Shortcomings

, 2012; 13(6): 695 - 720

G. Lu, K. Abduljalil, M. Jamei, T. N. Johnson, H. Soltani and A. Rostami-Hodjegan




Herb-Drug Interactions and Mechanistic and Clinical Considerations

, 2012; 13(5): 640 - 651

Xiao-Wu Chen, Kevin B. Sneed, Si-Yuan Pan, Chuanhai Cao, Jagat R. Kanwar, Helen Chew and Shu- Feng Zhou




The Role of ABC and SLC Transporters in the Pharmacokinetics of Dietary and Herbal Phytochemicals and their Interactions with Xenobiotics

, 2012; 13(5): 624 - 639

Yan Li, Jun Lu and James W. Paxton




Pharmacokinetics and Disposition of Various Drug Loaded Liposomes

, 2012; 13(4): 372 - 395

Shuai Qian, Chenrui Li and Zhong Zuo




Inherited Copper Transport Disorders: Biochemical Mechanisms, Diagnosis, and Treatment

, 2012; 13(3): 237 - 250

Hiroko Kodama, Chie Fujisawa and Wattanaporn Bhadhprasit




Is There a Relationship Between the Substrate Preferences and Structural Flexibility of Cytochromes P450?

, 2012; 13(2): 130 - 142

Michal Otyepka, Karel Berka and Pavel Anzenbacher




Impact of Genetic Polymorphisms and Drug – Drug Interactions on Clopidogrel and Prasugrel Response Variability

, 2010; 11(8): 667 - 677

V. Ancrenaz, Y. Daali, P. Fontana, M. Besson, C. Samer, P. Dayer and J. Desmeules




Systematic Evaluation of Dose Proportionality Studies in Clinical Pharmacokinetics

, 2010; 11(6): 526 - 537

Yucheng Sheng, Yingchun He, Xiaohui Huang, Juan Yang, Kun Wang and Qingshan Zheng




Atypical Antipsychotic Metabolism and Excretion

, 2010; 11(6): 516 - 525

J.J. Sheehan, J.K. Sliwa, J.C. Amatniek, A. Grinspan and C.M. Canuso




Bioavailability of Flavonoids: A Review of Their Membrane Transport and the Function of Bilitranslocase in Animal and Plant Organisms

, 2009; 10(4): 369 - 394

Sabina Passamonti, Michela Terdoslavich, Raffaella Franca, Andreja Vanzo, Federica Tramer, Enrico Braidot, Elisa Petrussa and Angelo Vianello




Biological Actions and Metabolism of Currently Used Pharmacological Agents for the Treatment of Congestive Heart Failure

, 2009; 10(3): 206 - 219

Harjot K. Saini-Chohan and Grant M. Hatch




Arylamine N-Acetyltransferases in Mycobacteria

, 2008; 9(6): 510 - 519

Edith Sim, James Sandy, Dimitrios Evangelopoulos, Elizabeth Fullam, Sanjib Bhakta, Isaac Westwood, Anna Krylova, Nathan Lack and Martin Noble




Lack of Interaction of the NMDA Receptor Antagonists Dextromethorphan and Dextrorphan with P-Glycoprotein

, 2008; 9(2): 144 - 151

Jules Desmeules, M. Kanaan, Y. Daali and P. Dayer




Xenobiotic-Induced Transcriptional Regulation of Xenobiotic Metabolizing Enzymes of the Cytochrome P450 Superfamily in Human Extrahepatic Tissues

, 2008; 9(2): 129 - 143

Petr Pavek and Zdenek Dvorak




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