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Open Access Articles

Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

, 2018; 19(10): 830 - 838

Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*




Pharmacokinetics, Pharmacodynamics and Pharmacogenetics of Tacrolimus in Kidney Transplantation

, 2018; 19(6): 513 - 522

Meng Yu, Mouze Liu, Wei Zhang and Yingzi Ming*





Digestive Enzyme Supplementation in Gastrointestinal Diseases

, 2016; 17(2): 187 - 193

Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota




Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines

, 2015; 16(6): 412 - 426

Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti




Preclinical Pharmacokinetics, Pharmacodynamics and Safety of Sucroferric Oxyhydroxide

, 2014; 15(10): 953 - 965

Mario Cozzolino, Felix Funk, Viatcheslav Rakov, Olivier Phan and Isaac Teitelbaum




A 30-years Review on Pharmacokinetics of Antibiotics: Is the Right Time for Pharmacogenetics?

, 2014; 15(6): 581 - 598

Lorena Baietto, Silvia Corcione, Giovanni Pacini, Giovanni Di Perri, Antonio D’Avolio and Francesco Giuseppe De Rosa




Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process

, 2014; 15(2): 209 - 217

Kelly E. Caudle, Teri E. Klein, James M. Hoffman, Daniel J. Muller, Michelle Whirl-Carrillo, Li Gong, Ellen M. McDonagh, Katrin Sangkuhl, Caroline F. Thorn, Matthias Schwab, Jose A.G. Agundez, Robert R. Freimuth, Vojtech Huser, Ming Ta Michael Lee, Otito F. Iwuchukwu, Kristine R. Crews, Stuart A. Scott, Mia Wadelius, Jesse J. Swen, Rachel F. Tyndale, C. Michael Stein, Dan Roden, Mary V. Relling, Marc S. Williams and Samuel G. Johnson





Post-translational and Post-transcriptional Modifications of Pregnane X Receptor (PXR) in Regulation of the Cytochrome P450 Superfamily

, 2013; 14(10): 1059 - 1069

Tomas Smutny, Sridhar Mani and Petr Pavek





Hepatic Cell Lines for Drug Hepatotoxicity Testing: Limitations and Strategies to Upgrade their Metabolic Competence by Gene Engineering

, 2013; 14(9): 946 - 968

M. Teresa Donato, Ramiro Jover and M. José Gómez-Lechón





Neonatal Fc Receptor and its Role in the Absorption, Distribution, Metabolism and Excretion of Immunoglobulin G-Based Biotherapeutics

, 2013; 14(7): 764 - 790

Craig Giragossian, Tracey Clark, Nicole Piché-Nicholas and Christopher J. Bowman





Insight into Tissue Unbound Concentration: Utility in Drug Discovery and Development

, 2013; 14(3): 324 - 340

T. Thanga Mariappan, Sandhya Mandlekar and Punit Marathe





Yeast as a Humanized Model Organism for Biotransformation-Related Toxicity

, 2012; 13(10): 1464 - 1475

Jolanda S. van Leeuwen, Nico P.E. Vermeulen and J. Chris Vos





Isotopic Labeling of Metabolites in Drug Discovery Applications

, 2012; 13(9): 1213 - 1225

Jacobo Iglesias, Lekha Sleno and Dietrich A. Volmer





Comparison of Cytochrome P450 2C Subfamily Members in Terms of Drug Oxidation Rates and Substrate Inhibition

, 2012; 13(8): 1145 - 1159

Toshiro Niwa and Hiroshi Yamazaki





Animal Models for Evaluation of Drug-Drug Interaction Potential of Biotherapeutics

, 2012; 13(7): 947 - 950

Eugenia Kraynov, Martin E. Dowty, Odette Odette A. Fahmi and Owen Fields





Active Metabolites Resulting from Decarboxylation, Reduction and Ester Hydrolysis of Parent Drugs

, 2012; 13(6): 835 - 862

I. Hartyanszky, H. Kalasz, E. Adeghate, Zs. Gulyas, M. Y. Hasan, K. Tekes, A. Adem and P. Sotonyi





Herb-Drug Interactions and Mechanistic and Clinical Considerations

, 2012; 13(5): 640 - 651

Xiao-Wu Chen, Kevin B. Sneed, Si-Yuan Pan, Chuanhai Cao, Jagat R. Kanwar, Helen Chew and Shu- Feng Zhou





Pharmacokinetics and Disposition of Various Drug Loaded Liposomes

, 2012; 13(4): 372 - 395

Shuai Qian, Chenrui Li and Zhong Zuo





Is There a Relationship Between the Substrate Preferences and Structural Flexibility of Cytochromes P450?

, 2012; 13(2): 130 - 142

Michal Otyepka, Karel Berka and Pavel Anzenbacher





Systematic Evaluation of Dose Proportionality Studies in Clinical Pharmacokinetics

, 2010; 11(6): 526 - 537

Yucheng Sheng, Yingchun He, Xiaohui Huang, Juan Yang, Kun Wang and Qingshan Zheng




Atypical Antipsychotic Metabolism and Excretion

, 2010; 11(6): 516 - 525

J.J. Sheehan, J.K. Sliwa, J.C. Amatniek, A. Grinspan and C.M. Canuso




Bioavailability of Flavonoids: A Review of Their Membrane Transport and the Function of Bilitranslocase in Animal and Plant Organisms

, 2009; 10(4): 369 - 394

Sabina Passamonti, Michela Terdoslavich, Raffaella Franca, Andreja Vanzo, Federica Tramer, Enrico Braidot, Elisa Petrussa and Angelo Vianello





Arylamine N-Acetyltransferases in Mycobacteria

, 2008; 9(6): 510 - 519

Edith Sim, James Sandy, Dimitrios Evangelopoulos, Elizabeth Fullam, Sanjib Bhakta, Isaac Westwood, Anna Krylova, Nathan Lack and Martin Noble





Xenobiotic-Induced Transcriptional Regulation of Xenobiotic Metabolizing Enzymes of the Cytochrome P450 Superfamily in Human Extrahepatic Tissues

, 2008; 9(2): 129 - 143

Petr Pavek and Zdenek Dvorak





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