Contents

Current Drug Discovery Technologies, Volume 7 - Number 3

Editorial (Hot Topic:Emerging Technologies for the Study of Drug Metabolism and Pharmacokinetics)

, 7(3): 141 - 142

Takahiro Ochiya, Nobuyoshi Kosaka, Haruhisa Head, Section for Studies on Metastasis, National Cancer Center Research Institute, 1-1, Tsukiji, 5-chome, Chuo-ku, Tokyo 104-0045, Japan. and Yunsheng Hsieh


DOI: 10.2174/157016310793180585




Integration of Physicochemical and Pharmacokinetic Parameters in Lead Optimization: A Physiological Pharmacokinetic Model Based Approach

, 7(3): 143 - 153

Elizabeth Hong-Geller, Sofiya N. Micheva-Viteva, Biju Benjamin, Tarani Kanta Barman, Tridib Chaira and Jyoti K. Paliwal


DOI: 10.2174/157016310793180558




Glutathione Modulation and Oxidative Stress in Human Liver Slices

, 7(3): 154 - 169

Xiaoxing Luo, Jingru Meng, Xiaoyan Xue, Zheng Hou, Ying Zhou, Hui Bai, Alison E.M. Vickers, Robyn L. Fisher and John R. Sinclair


DOI: 10.2174/157016310793180530




The In Silico Prediction of Human-Specific Metabolites from Hepatotoxic Drugs

, 7(3): 170 - 187

Ravouru Nagaraju, Ande Penchala Prathusha, Rajesh Kaza, Koganti Bharathi, Luis G. Valerio and Anthony Long


DOI: 10.2174/157016310793180567




Hepatocytes as a Tool in Drug Metabolism, Transport and Safety Evaluations in Drug Discovery

, 7(3): 188 - 198

M. Akram, M. A. Iquebal, K. Naimuddin, Jasminder Sahi, Susan Grepper and Cornelia Smith


DOI: 10.2174/157016310793180576




Emerging In Vitro Tools to Evaluate Cytochrome P450 and Transporter-Mediated Drug-Drug Interactions

, 7(3): 199 - 222

Cormac Concannon, Desmond A. Hennelly, Simon Noott, Dipak K. Sarker, Chuang Lu, Mingxiang Liao, Lawrence Cohen and Cindy Q. Xia


DOI: 10.2174/157016310793180549




Hydrophilic Interaction Liquid Chromatography-Tandem Mass Spectrometry for Drug Development

, 7(3): 223 - 231

Andrea L.O.Hebb, Virender Bhan, Alexander D. Wishart, Craig S. Moore, George S. Robertson and Yunsheng Hsieh


DOI: 10.2174/157016310793180521




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