Contents

Current Drug Discovery Technologies, Volume 1 - Number 1

About Editor-in-Chief

, 1(1): i


DOI: 10.2174/1570163043484842




Editorial

, 1(1): ii

Petr Kocis


DOI: 10.2174/1570163043484860




Function Oriented Synthesis: The Design, Synthesis, PKC Binding and Translocation Activity of a New Bryostatin Analog

, 1(1): 1 - 11

Paul A. Wender, Jeremy L. Baryza, Stacey E. Brenner, Michael O. Clarke, Madeleine L. Craske, Joshua C. Horan and Tobias Meyer


DOI: 10.2174/1570163043484888




Genetically Engineered Mouse Models for Drug Discovery: New Chemical Genetic Approaches

, 1(1): 13 - 26

Susanne Heck, Xiaobing Qian and Mark Velleca


DOI: 10.2174/1570163043484806




Experiences in Implementing uHTS - Cutting Edge Technology Meets the Real World

, 1(1): 27 - 35

Philip Gribbon, Sabine Schaertl, Malcolm Wickenden, Gareth Williams, Rachel Grimley, Frank Stuhmeier, Hartwig Preckel, Christian Eggeling, Joachim Kraemer and Jeremy Everett


DOI: 10.2174/1570163043484798




Systematic Analysis of Large Screening Sets in Drug Discovery

, 1(1): 37 - 47

Paul E. Blower Jr., Kevin P. Cross, Michael A. Fligner, Glenn J. Myatt, Joseph S. Verducci and Chihae Yang


DOI: 10.2174/1570163043484879




The FlexX Database Docking Environment - Rational Extraction of Receptor Based Pharmacophores

, 1(1): 49 - 60

Holger Claussen, Marcus Gastreich, Volker Apelt, Jonathan Greene, Sally A. Hindle and Christian Lemmen


DOI: 10.2174/1570163043484815




Assessment of the Health Effects of Chemicals in Humans: I. QSAR Estimation of the Maximum Recommended Therapeutic Dose (MRTD) and No Effect Level (NOEL) of Organic Chemicals Based on Clinical Trial Data1

, 1(1): 61 - 76

Edwin J. Matthews, Naomi L. Kruhlak, R. Daniel Benz and Joseph F. Contrera


DOI: 10.2174/1570163043484789




Development of Immunopharmacotherapy Against Drugs of Abuse

, 1(1): 77 - 89

Michael M. Meijler, Masayuki Matsushita, Peter Wirsching and Kim D. Janda


DOI: 10.2174/1570163043484851




Ion Channel Drug Discovery and Research: The Automated Nano-Patch- ClampO Technology

, 1(1): 91 - 96

A. Brueggemann, M. George, M. Klau, M. Beckler, J. Steindl, J. C. Behrends and N. Fertig


DOI: 10.2174/1570163043484833




The Isolated Perfused Rat Kidney Model: A Useful Tool for Drug Discovery and Development

, 1(1): 97 - 111

David R. Taft


DOI: 10.2174/1570163043484824




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