Jian'an Wang School of Medicine Zhejiang University Hangzhou China Biography
Biography of Jian'an Wang
Dr. Wang is the chief of heart center, and the President of the Second Affiliated Hospital, Zhejiang University School of Medicine. He is currently the chairman of Zhejiang Provincial Cardiology Association, vice-chairman of Chinese Society of Cardiology and the deputy Editor-in-Chief of Chinese Journal of Cardiology. He is full of enthusiasm in medical practice, research and education to promote health management in the population. He advocates evidence-based medicine, and is experienced in interventional cardiology, covering from invasive imaging, coronary catheterization, transcatheter aortic valve replacement (TAVR) and percutaneous mitral valve clip. He is one of the pioneers in China for cell therapy of cardiovascular diseases and won National Science & Technology Progress Award (second class) for his innovative work in cardiac repair post myocardial infarction.
Director of Cardiovascular Research Institute of Wuhan University, Professor of Cardiology (second-grade) and Chief physician (first-grade) of Renmin Hospital of Wuhan University, Director of Hubei Key Laboratory of Cardiology, Director of Hubei Cardiovascular Clinical Research Center, and Director of Hubei Cardiovascular Interventional Diagnosis and Treatment Quality Control Center. Vice President of the National Cardiovascular Disease Expert Committee, President of the Chinese Society of Pacing and Electrophysiology. Vice Editor-in-Chief of the Chinese Journal of Cardiac Arrhythmias, Editor-in-Chief of the Chinese Journal of Cardiac Pacing and Electrophysiology, Editor-in-Chief of the Medical Journal of Wuhan University, Vice Editor-in-Chief of the International Journal of Heart Rhythm, Vice Editor-in-Chief of the Journal of Cardiovascular Electrophysiology (Chinese edition), and Editorial Board Member of Chinese Journal of Cardiology.
G. Santulli Columbia University Medical Center New York, NY USA
X.-Y. YU Medical Research Center of Guangdong General Hospital Guangzhou China
General and Interventional Cardiology
D. Hou Boston Scientific Marlborough, MA USA Biography
Biography of D. Hou
Dr. Hou is Distinguished Corp. Fellow of BSC, & Visiting Professor at several Universities in China. He has published numerous scientific manuscripts and abstracts, and received the Top Abstract Place Award at both CRT and TCT. His paper entitled “Radiolabeled Cell Distribution After Intramyocardial, Intracoronary, and Interstitial Retrograde Coronary Venous Delivery Implications for Current Clinical Trials” (Circulation. 2005;112:I-150-I-156) has been cited >580 times (Google Scholar). In addition, he also served as an editorial board member for number of peer review journals; abstract reviewer for several Annual Scientific CV Conferences.
Frontiers Section Editor
Section: Diabetic Cardiovascular
L. Qian Zhejiang University Hangzhou China Biography
Biography of L. Qian
Dr. Ling-Bo Qian earned PhD from Zhejiang University, China. He completed visiting scholar at University of Copenhagen, Denmark and University of Louisville, USA. He teaches Human Physiology at the School of Basic Medical Sciences & Forensic Medicine of Hangzhou Medical College, China. He has particular interests in diabetic cardiovascular complications, and for the past decade he has focus on the pathophysiology of diabetic myocardial ischemia/reperfusion injury and the protective strategy. He published more than 30 peer-reviewed articles in cardiovascular diseases. He reviews for more than 10 journals.
Section: Vascular Biology
E. Yetkin Istinye University Istanbul Turkey Biography
Biography of E. Yetkin
Prof. Ertan Yetkin, is currently working at Istinye University Liv Hospital Dept. of cardiology, Istanbul, Turkey. Prof. Yetkin received his medical degree from the Hacettepe University Faculty of Medicine, Turkey in 1994. Later, he completed his residency training at Turkiye Yuksek Ihtisas Hospital Department of Cardiology in 1999. Dr. Yetkin worked as a research scientist in the Dept. of Cardiology at the Maastricht University Medical Center, Cardiovascular Research Institute Maastricht (CARIM), the Netherlands during 2006-2007. His research focuses on vascular biology, valvular heart disease and coagulation system. He has obtained 2 “Young investigator awards” from the European Society of Cardiology and also has more than 190 scientific publications.
Editorial Board Members
E. Alexanderson National Institute of Cardiology "Ignacio Chavez" Mexico City Mexico Biography
Biography of E. Alexanderson
Prof. Erick Alexanderson is presently the President of the Mexican Society of Cardiology and Chairman of Nuclear Cardiology Department at the Instituto Nacional de Cardiología “Ignacio Chávez” and Chair Elect of International Governors ACC. He received his Medical Degree at the Faculty of Medicine of the National Autonomous University of Mexico (UNAM), with an average of 10, winning the Gabino Barreda Medal for Scholar Merit and inducted as member of the gallery of illustrious students of the Medicine Faculty. He is also winner of the SIBIC award for “Best Cardiology Resident”. He published 130 in Level III, IV and V Journals, with over 400 quotes. He was Principal author of 3 textbooks, author of 38 chapters.
J.J. Badimon Mount Sinai School of Medicine New York, NY USA Biography
Biography of J.J. Badimon
Juan Jose Badimon, PhD, FACC, AHA.- Professor of Medicine and Director of the Atherothrombosis Research Unit, Cardiovascular Institute, Mount Sinai School of Medicine, New York. He has trained more than 30 fellows and published more than 360 peer-reviewed articles in cardiovascular diseases. He reviews for more than 10 journals.
He is Academico de Honor of the Spanish Royal Academy of Pharmacy and holds a Honoris Causa Professorship by the Catholic University of Buenos Aires and Honorary Memberships of the Cardiology societies of Spain, Argentina, Chile, Ecuador, Mexico, Peru and Venezuela.
E. Beckmann Harvard Medical School Boston, MA USA Biography
Biography of E. Beckmann
Dr. Erik Beckmann earned degrees in medicine (M.D.) from Johannes Gutenberg University, Mainz, Germany and biotechnology (M.B.) from University of Pennsylvania, Philadelphia, USA. He completed his Cardiac Surgery residency at Hannover Medical School, Germany, and pursued a fellowship in Advanced Adult Cardiac Surgery at Massachusetts General Hospital, Boston, USA. He is a staff surgeon at the Department of Cardiac Surgery at Hannover Medical School. His clinical work and his research is focused on aortic surgery and minimally-invasive surgery.
A. Bobik Baker Heart Research Institute Melbourne Australia
H.G. Bogren University of California-Davis Sacramento, CA USA
E. Braunwald Brigham and Women's Hospital Boston, MA USA
B.C. Brott The University of Alabama at Birmingham Birmingham, AL USA
D. Chambers King's College London London UK Biography
Biography of D. Chambers
Dr Chambers obtained a PhD in Biochemistry from Brunel University, Uxbridge, UK. Currently, Dr Chambers is a Consultant Clinical Scientist at Guy’s & St Thomas’ NHS Foundation Trust (St Thomas’ Hospital), is an Honorary Reader in Cardiac Surgery at King’s College London, and is an Adjunct Professor at the Medical University of Vienna, Austria. He has published over 130 scientific publications; his work concentrates on myocardial protection during ischemia/reperfusion associated with cardiac surgery. He is an Associate Editor with European Journal of CardioThoracic Surgery and with the Journal of Cardiothoracic Surgery, and is on the Editorial Board of a number of other cardiac-related journals.
L. Chen The First Affiliated Hospital of Sun Yat-Sen University Guangzhou China Biography
Biography of L. Chen
Dr. Chen Liu is by profession an associate professor, Ph.D supervisor, and the director of Heart Failure Center in the Department of Cardiovascular Diseases in the First Affiliated Hospital of Sun Yat-Sen University. He is also the associate chief commissioner of the Youth Committee, Committee of Heart Failure, Chinese Medical Doctor Association, the youth commissioner of the Chinese society of Cardiology, Chinese Medical Association, and the commissioner of the Guangdong society of Cardiology,. Chen Liu is experienced in the diagnosis and therapy of heart failure, coronary artery disease and cardiomyopathy. He has published 7 articles as the first author or the corresponding author.
D.V. Cokkinos Univeresity of Athens Athens Greece
A. Crisafulli University of Cagliari Cagliari Italy Biography
Biography of A. Crisafulli
Antonio Crisafulli is a Cardiovascular Physiologist. He leads the Laboratory of Sport Physiology of the University of Cagliari (Italy). He teaches Human Physiology at the Faculty of Medicine of the University of Cagliari. His fields of research are exercise cardiovascular physiology and physio-pathology, assessment of physical capacity and cardiovascular response during exercise in healthy and in patients suffering from cardiovascular and metabolic diseases. He has published more than 70 papers in this area.
A. Daugherty University of Kentucky Lexington, KY USA Biography
Biography of A. Daugherty
Alan Daugherty completed a BSc in Pharmacology at Sunderland Polytechnic and received his PhD and DSc from the University of Bath. He moved to Washington University in St. Louis for fellowship training. Subsequently, he was appointed to the faculty at Washington University where he continued his studies on mechanisms of lipoprotein modification and immune function on the development of atherosclerosis. In 1997, he moved to the University of Kentucky. While performing a collaborative study with Lisa Cassis on the role of hypertension in development of atherosclerosis, they serendipitously developed a model of aortic aneurysms in both the abdominal and thoracic region. Alan Daugherty is the Linda and Jack Gill Professor of Preventive Cardiology, Director of the Saha Cardiovascular Research Center, Chair of the Department of Physiology, Senior Associate Dean for Research in the College of Medicine, and Associate Vice President for Research. He is the current the Editor-in-Chief of Arteriosclerosis, Thrombosis, and Vascular Biology.
M. Doyle Allegheny General Hospital Pittsburgh, PA USA Biography
Biography of M. Doyle
Dr. Doyle obtained his doctorate degree from the University of Nottingham, England in 1983. At Nottingham he studied under Nobel Laureate Sir Peter Mansfield, where he focused on rapid imaging. He is now an adjunct Professor of Medicine at Temple University, Philadelphia. He was a founding member of the Society of Cardiovascular Magnetic Resonance.
His main research focus is on the application of Cardiovascular Magnetic Resonance Imaging to better understand and diagnose cardiovascular disease. He has over 50 publications and book chapters, including the CMR teaching book Cardiovascular MRI Tutorial: Lectures and Learning.
R. Dumaine Université de Sherbrooke Québec, QC Canada Biography
Biography of R. Dumaine
Dr. Dumaine graduated from University of Sherbrooke (Canada) in biophysics and pursued postdoctoral training at Balylor College of Medecine (TX) in cardiac electrophysiology and molecular genetics. He is now full professor at the department of Pharmacology and Physiology at the Univ. de Sherbrooke Qc. Canada. His expertise is on cardiac arrhythmias linked to potassium and sodium ion channel defects. In collaboration with P. Schwartz he published the first study linking sudden infant death syndrome (SIDS) to cardiac sodium channel defects.
M. Endoh Yamagata University Yamagata Japan Biography
Biography of M. Endoh
Emeritus Prof. Masao Endoh is presently the Director of Japanese Northeast Region Health Examination Center, All Japan Laborer-Welfare Association after retirement from the Vice-President of Yamagata University and Dean of Yamagata University School of Medicine, Yamagata, Japan. He received his Medical Degree at the Tohoku University School of Medicine, Japan. He received Keith Reimer Distinguished Lecture Award and Distinguished Leader Ward of the ISHR. He published over 220 papers in international journals of Cardiovascular Pharmacology and Physiology with peer review and is currently acting as an editorial board member of various international journals, including Circulation Research (Consulting Editor), Cardiovascular Research (Consulting Editor), Journal of Molecular and Cellular Cardiology (Associate Editor), and the Editorial board member of European Journal of Pharmacology and Journal of Cardiovascular Pharmacology.
V.A. Ferrari University of Pennsylvania Philadelphia, PA USA
D. Holmes Mayo Clinic College of Medicine and Science Rochester, MN USA Biography
Biography of D. Holmes
Dr. Holmes is currently a Professor of Medicine at the Mayo Clinic College of Medicine and a consultant in the Department of Cardiovascular Medicine at Mayo Clinic in Rochester, Minnesota.
His special areas of interest include acute coronary syndromes, interventional cardiology, restenosis, vascular biology, and risk outcomes analysis. Finally, he is involved in the development of continued application of percutaneous coronary intervention technology to noncoronary vascular beds.
Dr. Holmes received his medical degree at Medical College of Wisconsin in Milwaukee and completed his internship at Virginia Mason Hospital in Seattle. He also served in the United States Navy at the National Naval Medical Center in Bethesda.
L. Klein Rush University Medical Center Chicago, IL USA Biography
Biography of L. Klein
Dr. Klein is Professor of Medicine, Rush Medical College, Chicago, Illinois and Director, Clinical Cardiology Associates, Chicago and Melrose Park, Illinois. He is a nationally recognized expert in individualizing coronary revascularization strategies.
Dr. Klein is a pioneer in the objective assessment of quality assessment and case appropriateness in coronary interventions. He was on the steering committee of ASCERT.
He is the author of over 500 publications and editor of four books. One of his proudest accomplishments is his significant involvement as a key faculty member in interventional, general cardiology and internal medicine training programs.
L.H. Kuller University of Pittsburgh Pittsburgh, PA USA Biography
Biography of L.H. Kuller
Dr. Kuller received his BA degree in 1955 from Hamilton College in Clinton, NY, his MD in 1959 from George Washington University School of Medicine, his MPH in 1964 and DrPH in 1966 from the Johns Hopkins University School of Public Health. He was a faculty member at the Johns Hopkins University School of Public Health. At the same time he was also a faculty member at the Department of Preventive Medicine at the University of Maryland School of Medicine. He was Chair and Professor in the Department of Epidemiology at the Graduate School of Public Health at the University of Pittsburgh from 1972-2002
C.J. Lavie Alton Ochsner Medical Foundation & Ochsner Clinic New Orleans, LA USA Biography
Biography of C.J. Lavie
Dr. Lavie attended medical school at LSUMC in New Orleans, and did his Internal Medicine training at Ochsner and cardiology at the Mayo Clinic. He is currently Professor of Medicine and Medical Director of Cardiac Rehabilitation and Prevention and Director of the Exercise Laboratories at the John Ochsner Heart and Vascular Institute, Ochsner Clinical School-The University of Queensland School of Medicine in New Orleans.He has authored nearly 1000 medical publications and 2 cardiology textbooks and serves on 25 editorial boards, including the Journal of the American College of Cardiology and the American Journal of Cardiology, and is Associate Editor and Cardiovascular Section Editor of the Mayo Clinic Proceedings. He is also Editor-in Chief of Progress in Cardiovascular Diseases and is the author of the book The Obesity Paradox.
S-D. Lee Asia University Taiwan Wufong Taiwan
E. Lewandowski Sanford Burnham Prebys Medical Discovery Institute Orlando, FL USA Biography
Biography of E. Lewandowski
Dr. Lewandowski is a Professor and Director of Cardiovascular Translational Research at the Sanford Burnham Prebys Medical Discovery Institute and a Senior Principal Investigator at the Translational Research Institute at Florida Hospital in Orlando, FL. He received his PhD from the University of Texas Southwestern Medical School in Dallas, TX. He is an elected Fellow of the American Heart Association, the American Association for the Advancement of Science (AAAS), the American Physiological Society, and the International Society for Heart Research (ISHR). His research examines the metabolic basis of cardiac dysfunction and the genomics of dysregulated metabolic flux in heart disease.
J. Li Penn State University Hershey, PA USA
T. Liu Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University Tianjin PR China Biography
Biography of T. Liu
Dr. Tong Liu was graduated from Tianjin Medical University, China in 2000, and got his PhD in 2006. He received training in the research of electrophysiology in the Heart Institute, Cedars-Sinai Medical Center, Los Angeles, from 2009 to 2010. He has particular interests in cardiac electrophysiology, and for the past decade he has focus on the research on atrial fibrillation. He is the Youth Committee Member of Chinese Society of Pacing and Electrophysiology (CSPE). He is on the editorial boards of World Journal of Cardiology, Cardiovascular Diagnosis and Therapy and Current Cardiology Reviews, and a peer reviewer for more than 35 scientific journals. He has published over 70 articles in peer reviewed medical journals.
J. Mehta University of Arkansas for Medical Sciences Little Rock, AR USA Biography
Biography of J. Mehta
Prof. Mehta received his MD degree in India and PhD in Sweden, and completed his post-graduate education in New York and Minnesota. He joined the faculty of the college of medicine of the University of Florida where he rose to be University Research Foundation.
He led the Division of Cardiovascular Medicine at UAMS until 2007.
Prof. Mehta has lectured in over 30 countries. He is an honorary professor in the University of Rome, and adjunct Professor in the Clinton School of Public School in Little Rock, AR, and serves as consultant to the University of Arkansas in nanotechnology and biomedical engineering.
T. Nakata Sapporo Medical University Sapporo Japan Biography
Biography of T. Nakata
Dr. Nakata obtained a medical doctor (MD) in 1983 and a doctorate (Ph.D.) in Medicine from the Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan. He was a visiting research fellow of Cardiovascular Research, the Rayne Institute, St Thomas’ Hospital, London. He is a specialist of Cardiology, Internal Medicine, Hypertension, Nuclear Medicine and PET imaging, all of which are certificated by each Japanese Society. Currently he is a hospital superintendent of Hakodate Goryoukaku Hospital, Hakodate, Japan, a clinical associate professor (Cardiology) of Sapporo Medical University School of Medicine, and a director of Japanese Society of Nuclear Cardiology. He has published more than 100 scientific publications. He is now the editorial member of Current Cardiology Review and Journal of Nuclear Cardiology.
R. Piccolo University of Bern Bern Switzerland Biography
Biography of R. Piccolo
Dr. Raffaele Piccolo is a Clinical Researcher at the Department of Cardiology of the Bern University Hospital (Switzerland). He received his medical training in Cardiology and obtained his PhD in Clinical and Experimental Medicine from the University of Naples, Federico II, in Italy. His field of research relates to interventional cardiology with a specific focus to the field of percutaneous coronary intervention and pharmacological therapy.
Q. Qi Albert Einstein College of Medicine Bronx, NY USA
F. Santoro St Georg Hospital Hamburg Germany Biography
Biography of F. Santoro
Dr. Santoro is a cardiologist, phD student at the university of Foggia Italy and consultant in Electrophysiology at Bonomo Hospital , Andria, Italy. In 2013, he attended for six months Texas Arrhythmia Institute, Austin, Texas, USA under the supervision of Dr. Andrea Natale. Between 2015 and 2018 he attended the electrophysiology laboratory at the Department of Cardiology, Asklepios Klinik St. Georg, Hamburg. Research topic: Cardiomyopathies (Takotsubo syndrome) and catheter ablation of Atrial Fibrillation and Ventricular Tachycardia (Papillary muscles VT/VF). He authored 138 publications in indexed journals, about 135 abstracts and 6 electrophysiology book chapters.
V.B. Schini-Kerth University Strasbourg Strasbourg France Biography
Biography of V.B. Schini-Kerth
Dr. Valérie Schini-Kerth is since 2000 Professor of Pharmacology at the Université de Strasbourg, France. After her training in Pharmacy, she obtained a Master Degree in Molecular and Cellular Pharmacology in 1985 and PhD in Pharmacology in 1988 at the Université de Strasbourg. Her major research interests focus on cardiovascular pharmacology and, in particular, on the pivotal role of the endothelium in the control of vascular homeostasis in health and diseases such as hypertension and diabetes, and also in physiological ageing. She is studying mechanisms underlying endothelial dysfunction, a hallmark of major cardiovascular diseases.
A. Sekikawa University of Pittsburgh Pittsburgh, PA USA Biography
Biography of A. Sekikawa
Dr. Sekikawa obtained an MD (Tohoku University, Japan) in 1983, a PhD in medicine (Yamagata University, Japan) in 1990, and his second PhD in Epidemiology (University of Pittsburgh, US) in 1999 and is currently as Associate Professor of Epidemiology, Graduate School of Public Health, University of Pittsburgh. Dr. Sekikawa has 30 years of experience in clinical and epidemiological research. His research interests lie on international cardiovascular epidemiology contrasting Japan to other developed countries, subclinical atherosclerosis including coronary artery calcification, intima-media thickness of the carotid artery and vascular stiff ness, as well as nutrition especially omega-3 fatty acids and isoflavones.
C.M. Shanahan Addenbrookes Hospital Cambridge UK Biography
Biography of C.M. Shanahan
Professor Shanahan obtained a PhD in Genetics from the University of Adelaide in Australia and did her postdoctoral training in Sydney Australia (CSIRO) and at the University of Cambridge UK (Departments of Biochemistry and Medicine). Currently she is the Chair of Cellular Signalling in the Cardiovascular Division at King’s College London.
Professor Shanahan’s work focuses on mechanisms of vascular smooth muscle cell (VSMC) dysfunction in ageing and disease and she has published over 120 scientific papers.
Y.L. Tang University of Cincinnati Cincinnati, OH USA
G. Tocci University of Rome Sapienza Rome Italy Biography
Biography of G. Tocci
Giuliano Tocci, specialized in Cardiology in 2006 and graduated in the PhD course in Angio-Cardio-Thoraco-Vascular Physiopathology in 2011, is currently Assistant Professor in Cardiology at the University of Rome Sapienza, Italy. He works as Clinical Cardiologist at the Sant’Andrea Hospital in Rome. He is Hypertension Specialist of the European Society of Hypertension. His main clinical interests address pathophysiological alterations and cardiovascular risk profile in patients with hypertension and heart failure. He has published more than 150 scientific publications on international journals, books and chapters in the field of hypertension and hypertension-related cardiovascular diseases.
J.P. Veinot Ottawa Civic Hospital Ottawa, ON Canada Biography
Biography of J.P. Veinot
Dr. Veinot is a Cardiovascular Pathologist. He is currently Chairman of the Department of Pathology and Laboratory Medicine at the University of Ottawa, Department Head at The Ottawa Hospital and the Children’s Hospital of Eastern Ontario and the Chief Medical and Scientific Officer of the Eastern Ontario Regional Laboratory Association (EORLA).
He is a Full Professor at the University of Ottawa and a past President of the international Society for Cardiovascular Pathology.
He did his medical School at Dalhousie Medical School, Halifax, Nova Scotia, Canada. He did a Residency in Anatomical Pathology at Queen’s University, Kingston, Ontario, Canada.
He completed a Fellowship in Cardiovascular Pathology at the Mayo Clinic, Rochester MN.
H. Weiss UMDNJ Robert Wood Johnson Medical School Piscataway, NJ USA Biography
Biography of H. Weiss
Harvey Weiss received his Ph.D. in Physiology from Duke University. He did postdoctoral training at Warner-Lambert and Columbia University. Dr. Weiss is currently a Professor at Rutgers Robert Wood Johnson Medical School. He is the author of over 325 peer reviewed papers. His research interests are in the control of regional and microregional oxygen supply/consumption balance in both the heart and brain. He has been interested in how alterations in signal transduction affect both local oxygen supply and consumption. Dr. Weiss has been Associate Editor for Microvascular Research and on the editorial boards of Microcirculation Endothelium and Lymphatics, American Journal of Physiology: Heart and Circulatory Physiology and the Journal of Cardiovascular Pharmacology as well as other journals.
N.K. Wenger Emory University Atlanta, GA USA Biography
Biography of N.K. Wenger
Dr. Wenger is Professor of Medicine in the Division of Cardiology at the Emory University School of Medicine. She is a Consultant to the Emory Heart and Vascular Center.
Coronary heart disease in women is one of Dr. Wenger’s major clinical and research interests.
Dr. Wenger has participated as an author of several American College of Cardiology/American Heart Association Clinical Practice Guidelines. She is past Chair, Board of Directors, Society for Women’s Health Research. She is listed in Best Doctors in America.
Dr. Wenger has authored or coauthored over 1600 scientific and review articles and book chapters.
I.H. Zucker Nebraska Medical Center Omaha, NE USA
Associate Editorial Board Member
W. Serra University Hospital of Parma Parma Italy Biography
Biography of W. Serra
Responsible for managing patients with pulmonary hypertension. It performs a major activity in echocardiography laboratories where transesophageal eco and ecostress are performed.Collaboration with the Cardiac Surgery Institute for intra and post-operative disorders with post-embolic, post-valve and related left ventricular dysfunction. Collaboration with hemodynamics for the performance of cardiac catheterization in pulmonary hypertension.
Collaboration with DH Cardiology for the management of patients with cardiomyopathy, pulmonary hypertension and severe heart failure. He has 72 publications in Italian and foreign journals. He did some presentations at national and international congresses ESC, AMNCO, SIEC and SIC.He belongs to various heart associations, among which AMNCO, SIC, SIEC,ESC,ESC-HF.
Jian'an Wang School of Medicine Zhejiang University Hangzhou China