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Contents

Current Cancer Drug Targets, Volume 12 - Number 4

EDITORIAL [Hot Topic: Molecularly Targeted Treatments for Colorectal Cancer: Advances and Limitations (Guest Editor: Silvio Parodi)]

, 12(4): 301 - 302

Silvio Parodi


DOI: 10.2174/156800912800190947




Role of Angiogenesis Inhibitors in Colorectal Cancer: Sensitive and Insensitive Tumors

, 12(4): 303 - 315

L. Bagnasco, D. Piras, S. Parodi, I. Bauer, G. Zoppoli, F. Patrone and A. Ballestrero


DOI: 10.2174/156800912800190929




Patient-Tailored Treatments with Anti-EGFR Monoclonal Antibodies in Advanced Colorectal Cancer: KRAS and Beyond

, 12(4): 316 - 328

A. Ballestrero, A. Garuti, G. Cirmena, I. Rocco, C. Palermo, A. Nencioni, S. Scabini, G. Zoppoli, S. Parodi and F. Patrone


DOI: 10.2174/156800912800190956




Synthetic Lethality-Based Therapeutics: Perspectives for Applications in Colorectal Cancer

, 12(4): 329 - 338

D. Soncini, I. Caffa, F. Patrone, A. Ballestrero and A. Nencioni


DOI: 10.2174/156800912800190938




A Multi-Scale Approach to Colorectal Cancer: From a Biochemical- Interaction Signaling-Network Level, to Multi-Cellular Dynamics of Malignant Transformation. Interplay with Mutations and Onco-Protein Inhibitor Drugs

, 12(4): 339 - 355

L. Tortolina, N. Castagnino, C. De Ambrosi, E. Moran, F. Patrone, A. Ballestrero and S. Parodi


DOI: 10.2174/156800912800190910




DNA Damage Response Pathways and Cell Cycle Checkpoints in Colorectal Cancer: Current Concepts and Future Perspectives for Targeted Treatment

, 12(4): 356 - 371

S. Solier, Y. -W. Zhang, A. Ballestrero, Y. Pommier and G. Zoppoli


DOI: 10.2174/156800912800190901




Clinical Experience with Thalidomide and Lenalidomide in Multiple Myeloma

, 12(4): 372 - 390

T. Moehler


DOI: 10.2174/156800912800190893




Second-Generation Tyrosine Kinase Inhibitors as First-Line Treatment Strategy in Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia Patients

, 12(4): 391 - 401

M. Breccia and G. Alimena


DOI: 10.2174/156800912800190965




Genetic Variants in Genes Involved in Mechanisms of Chemoresistance to Anticancer Drugs

, 12(4): 402 - 438

J. J.G. Marin, O. Briz, M. J. Monte, A. G. Blazquez and R. I.R. Macias


DOI: 10.2174/156800912800190875




An Epigenetic Approach to Pancreatic Cancer Treatment: The Prospective Role of Histone Deacetylase Inhibitors

, 12(4): 439 - 452

Nicola Tinari, Michele De Tursi, Antonino Grassadonia, Marinella Zilli, Liborio Stuppia, Stefano Iacobelli and Clara Natoli


DOI: 10.2174/156800912800190884




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