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Current Cancer Drug Targets

Volume 19, 11 Issues, 2019
ISSN: 1873-5576 (Online)
ISSN: 1568-0096 (Print)
This journal supports open access

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  • 135th of 229 in

    Oncology

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Aims & Scope

Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes.

Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer.

As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.

Current Cancer Drug Targets

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Volume 19

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Number 8



Review Article



Research Article

Bone Invasive Properties of Oral Squamous Cell Carcinoma and its Interactions with Alveolar Bone Cells: An In Vitro Study

, 19(8): 631 - 640

Omel Baneen Qallandar , Faeza Ebrahimi, Farhadul Islam, Riajul Wahab, Bin Qiao, Peter Reher, Vinod Gopalan* and Alfred King-yin Lam*


DOI: 10.2174/1568009618666181102144317


Research Article

Gender Differences in the Antioxidant Response to Oxidative Stress in Experimental Brain Tumors

, 19(8): 641 - 654

María Jesús Ramírez-Expósito, María Dolores Mayas, María Pilar Carrera-González and José Manuel Martínez-Martos*


DOI: 10.2174/1568009618666181018162549


Research Article

CT-707 Overcomes Resistance of Crizotinib through Activating PDPK1- AKT1 Pathway by Targeting FAK

, 19(8): 655 - 665

Caixia Liang, Ningning Zhang, Qiaoyun Tan, Shuxia Liu, Rongrong Luo, Yanrong Wang, Yuankai Shi* and Xiaohong Han*


DOI: 10.2174/1568009618666181031152140


Research Article



Research Article



Articles Ahead of Print

Study of Serum Soluble Programmed Death Ligand 1 as a Prognostic Factor in Hepatocellular Carcinoma in Egyptian Patients


Fatma El-Gebaly , Sabry Abou-saif , Mahmoud Elkadeem, Amal Helmy, Sherief Abd-Elsalam *, Mohamed Yousef, Reham Abdelkader Elkhouly, Ibrahim Fathi Amer and Taher El-Demerdash


DOI: 10.2174/1568009619666190718141647
View Abstract





Sam68 Promotes the Progression of Human Breast Cancer through inducing Activation of EphA3


Xinxin Chen*, Lehong Zhang*, Ziqiao Kuang, Ying Zou, Tian Tang, Wangjian Zhang, Xiaowu Hu, Ting Xia , Tengfei Cao, Haixia Jia and Min Yuan


DOI: 10.2174/1568009619666190718124541
View Abstract


The Role of Shcbp1 in Signaling and Disease


Geng-Yuan Zhang, Zhi-Jian Ma, Long Wang, Ruo-Fei Sun, Xiang-Yan Jiang, Xu-Juan Yang, Bo Long, Hui-Li Ye, Shu-Ze Zhang, Ze-Yuan Yu, Wen-Gui Shi and Zuo-Yi Jiao*


DOI: 10.2174/1568009619666190620114928
View Abstract View on PubMed


Magnesium-dependent Phosphatase (MDP) 1 is a Potential Suppressor of Gastric Cancer


Jianbo Zhu*, Lijuan Deng*, Baozhen Chen*, Wenqing Huang, Xiandong Lin, Gang Chen, Chi-Meng Tzeng, Mingang Ying and Zhongxian Lu


DOI: 10.2174/1568009619666190620112546
View Abstract View on PubMed




Polyisoprenylated Cysteinyl Amide Inhibitors Deplete K-Ras and Induce Caspase-dependent Apoptosis in Lung Cancer Cells


Augustine T. Nkembo, Felix Amissah, Elizabeth Ntantie, Rosemary A. Poku, Olufisayo O. Salako, Offiong Francis Ikpatt and Nazarius S. Lamango*


DOI: 10.2174/1568009619666190325144636
View Abstract View on PubMed


Abstracts Ahead of Print

Published Contents

Editor's Choice



Exploring Proteomic Drug Targets, Therapeutic Strategies and Protein - Protein Interactions in Cancer: Mechanistic View

, 2019; 19(6): 430 - 448

Khalid Bashir Dar, Aashiq Hussain Bhat, Shajrul Amin, Syed Anjum, Bilal Ahmad Reshi, Mohammad Afzal Zargar, Akbar Masood and Showkat Ahmad Ganie*


DOI: 10.2174/1568009618666180803104631







Specific Targeting of HER2-Positive Head and Neck Squamous Cell Carcinoma Line HN5 by Idarubicin-ZHER2 Affibody Conjugate

, 2019; 19(1): 65 - 73

Marzieh Ghanemi, Aminollah Pourshohod, Mohammad Ali Ghaffari, Alireza kheirollah, Mansour Amin, Majid Zeinali* and Mostafa Jamalan*


DOI: 10.2174/1568009617666170427105417





Open Access Articles

Linc01638 Promotes Tumorigenesis in HER2+ Breast Cancer

, 2019; 19(1): 74 - 80

Peng Liu, Hailin Tang, Jiali Wu, Xingsheng Qiu, Yanan Kong, Lijuan Zhang, Xinhua Xie* and Xiangsheng Xiao*




Role of MicroRNAs in Treatment Response in Prostate Cancer

, 2018; 18(10): 929 - 944

Anshuli Razdan, Paul de Souza* and Tara Laurine Roberts




Noxa: Role in Cancer Pathogenesis and Treatment

, 2018; 18(10): 914 - 928

Rami Z. Morsi, Rouba Hage-Sleiman, Hadile Kobeissy and Ghassan Dbaibo*








Platycodin D Induces Tumor Growth Arrest by Activating FOXO3a Expression in Prostate Cancer in vitro and in vivo

, 2014; 14(9): 860 - 871

Rui Zhou, Zongliang Lu, Kai Liu, Jing Guo, Jie Liu, Yong Zhou, Jian Yang, Mantian Mi and Hongxia Xu




Pleiotropic Role of HSF1 in Neoplastic Transformation

, 2014; 14(2): 144 - 155

Natalia Vydra, Agnieszka Toma and Wieslawa Widlak






β-Catenin Knockdown in Liver Tumor Cells by a Cell Permeable Gamma Guanidine-based Peptide Nucleic Acid

, 2013; 13(8): 867 - 878

Evan Delgado, Raman Bahal, Jing Yang, Jung M. Lee, Danith H Ly and Satdarshan P. S. Monga




Signal Transduction in Human Cutaneous Melanoma and Target Drugs

, 2013; 13(8): 843 - 866

Anatoly B. Uzdensky, Svetlana V. Demyanenko and Mikhail Y. Bibov




Use of Single Nucleotide Polymorphism Array Technology to Improve the Identification of Chromosomal Lesions in Leukemia

, 2013; 13(7): 791 - 810

Ilaria Iacobucci, Annalisa Lonetti, Cristina Papayannidis and Giovanni Martinelli




Autophagy in Chronic Myeloid Leukaemia: Stem Cell Survival and Implication in Therapy

, 2013; 13(7): 724 - 734

Gudmundur V. Helgason, Arunima Mukhopadhyay, Maria Karvela, Paolo Salomoni, Bruno Calabretta and Tessa L. Holyoake





Most Cited Articles


Research Article

TGF-β1 causes EMT by regulating N-acetyl glucosaminyl transferases via downregulation of non muscle myosin II-a through JNK/P38/PI3K pathway in lung cancer

, 1 March 2018; 18(2): 209-219.

Ghulam Jilany Khan, Yingsheng Gao, Ming Gu, Lai Wang, Sara Khan, Farah Naeem, Herve Semukunzi, Debmalya Roy, Shengtao Yuan* and Li Sun*


DOI: 10.2174/1568009617666170807120304


Review Article

Oxidative stress and cancer: The role of Nrf2

, 2018; 18(6): 538-557.

Soraya Sajadimajd and Mozafar Khazaei*


DOI: 10.2174/1568009617666171002144228


Review Article

Clinical trials with oncolytic measles virus: Current status and future prospects

, 2018; 18(2): 177-187.

Pavlos Msaouel, Mateusz Opyrchal, Angela Dispenzieri, Kah Whye Peng, Mark J. Federspiel, Stephen J. Russell and Evanthia Galanis*


DOI: 10.2174/1568009617666170222125035


Review Article

Metastatic colorectal cancer: Role of target therapies and future perspectives

, 2018; 18(5): 421-429.

Anna Nappi, Massimiliano Berretta, Carmela Romano, Salvatore Tafuto, Antonino Cassata, Rossana Casaretti, Lucrezia Silvestro, Chiara De Divitiis, Lara Alessandrini, Francesco Fiorica, Alessandro Ottaiano and Guglielmo Nasti*


DOI: 10.2174/1568009617666170209095143


Review Article

Cell-derived exosomes as promising carriers for drug delivery and targeted therapy

, 1 May 2018; 18(4): 347-354.

Xinyi Wang, Haiyang Zhang, Haiou Yang, Ming Bai, Tao Ning, Shuang Li, Jialu Li, Ting Deng, Guoguang Ying* and Yi Ba*


DOI: 10.2174/1568009617666170710120311


Review Article

Multimodal HDAC inhibitors with improved anticancer activity

, 1 January 2018; 18(1): 39-56.

Rainer Schobert and Bernhard Biersack*


DOI: 10.2174/1568009617666170206102613


Review Article

Synthetic lethality: From research to precision cancer nanomedicine

, 1 May 2018; 18(4): 337-346.

Anuradha Gupta, Anas Ahmad, Aqib Iqbal Dar and Rehan Khan*


DOI: 10.2174/1568009617666170630141931


Review Article

PARP inhibitors for the treatment of ovarian cancer

, 2018; 18(9): 877-893.

Laura Cortesi, Angela Toss* and Iole Cucinotto


DOI: 10.2174/1568009618666180308104646


Review Article

Antibody based EpCAM targeted therapy of cancer, review and update

, 2018; 18(9): 857-868.

Shirin Eyvazi, Safar Farajnia*, Siavoush Dastmalchi, Farzad Kanipour, Habib Zarredar and Mojghan Bandehpour


DOI: 10.2174/1568009618666180102102311



Review Article

MicroRNA key to angiogenesis regulation: MiRNA biology and therapy

, 2018; 18(3): 266-277.

Ankit Tiwari, Bratati Mukherjee and Manjusha Dixit*


DOI: 10.2174/1568009617666170630142725




Review Article

Current and emerging treatments for metastatic renal cell carcinoma

, 2018; 18(5): 468-479.

Carla Cavaliere, Carmine D`Aniello, Chiara Della Pepa, Salvatore Pisconti, Massimiliano Berretta and Gaetano Facchini*


DOI: 10.2174/1568009617666170209094030



Most Accessed Articles

Polyploid Giant Cancer Cells (PGCCs): The Evil Roots of Cancer

, 2019; 19(5): 360-367.

Junsong Chen, Na Niu, Jing Zhang, Lisha Qi, Weiwei Shen, Krishna Vanaja Donkena, Zhenqing Feng and Jinsong Liu*


DOI: 10.2174/1568009618666180703154233



The RNA Binding Protein HuR: a Promising Drug Target for Anticancer Therapy

, 2019; 19(5): 382-399.

Mingxia Wu, Christy W.S. Tong, Wei Yan, Kenneth K.W. To* and William C.S. Cho*


DOI: 10.2174/1568009618666181031145953







Characterization of YY1 OPB Peptide for its Anticancer Activity

, 2019; 19(6): 504-511.

Yige Qi, Ting Yan, Lu Chen, Qiang Zhang, Weishu Wang, Xu Han, Dangdang Li, Jinming Shi and Guangchao Sui*


DOI: 10.2174/1568009618666181031153151


Mesoporous Silica Nanoparticles as a Prospective and Promising Approach for Drug Delivery and Biomedical Applications

, 2019; 19(4): 285-295.

Xiaohui Pu, Jia Li, Peng Qiao, Mengmeng Li, Haiyan Wang, Lanlan Zong*, Qi Yuan and Shaofeng Duan*


DOI: 10.2174/1568009619666181206114904



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