Contents

Current Alzheimer Research, Volume 4 - Number 4

Editorial [Hot Topic: Advances in Alzheimer Therapy: Development of Innovative New Strategies (Guest Editors: Nigel H. Greig, Ezio Giacobini and Debomoy K. Lahiri)]

, 4(4): 336 - 339

Nigel H. Greig, Ezio Giacobini and Debomoy K. Lahiri


DOI: 10.2174/156720507781788819




Cholinotrophic Molecular Substrates of Mild Cognitive Impairment in the Elderly

, 4(4): 340 - 350

Elliott J. Mufson, Scott E. Counts, Margaret Fahnestock and Stephen D. Ginsberg


DOI: 10.2174/156720507781788855




NGF-Cholinergic Dependency in Brain Aging, MCI and Alzheimers Disease

, 4(4): 351 - 358

A. C. Cuello, A. Bruno and K.F. S. Bell


DOI: 10.2174/156720507781788774




Amyloid Beta Protein as a Marker or Risk Factor of Alzheimers Disease

, 4(4): 359 - 363

Pankaj D. Mehta


DOI: 10.2174/156720507781788891




Computerized Methods in the Assessment and Prediction of Dementia

, 4(4): 364 - 369

Amos D. Korczyn and Vered Aharonson


DOI: 10.2174/156720507781788954




Practical Issues in Stem Cell Therapy for Alzheimers Disease

, 4(4): 370 - 377

K. Sugaya, Y. D. Kwak, O. Ohmitsu, A. Marutle, N. H. Greig and E. Choumrina


DOI: 10.2174/156720507781788936




TNF-α Inhibition as a Treatment Strategy for Neurodegenerative Disorders: New Drug Candidates and Targets

, 4(4): 378 - 385

David Tweedie, Kumar Sambamurti and Nigel H. Greig


DOI: 10.2174/156720507781788873




East Meets West in the Search for Alzheimers Therapeutics - Novel Dimeric Inhibitors from Tacrine and Huperzine A

, 4(4): 386 - 396

W. M. Li, K. K.W. Kan, P. R. Carlier, Y. P. Pang and Y. F. Han


DOI: 10.2174/156720507781788918




N-Phenylamine Derivatives as Aggregation Inhibitors in Cell Models of Tauopathy

, 4(4): 397 - 402

M. Pickhardt, J. Biernat, I. Khlistunova, Y.-P. Wang, Z. Gazova, E.-M. Mandelkow and E. Mandelkow


DOI: 10.2174/156720507781788765




Neurorescue Activity, APP Regulation and Amyloid-β Peptide Reduction by Novel Multi-Functional Brain Permeable Iron- Chelating- Antioxidants,M-30 and Green Tea Polyphenol, EGCG

, 4(4): 403 - 411

Yael Avramovich-Tirosh, Lydia Reznichenko, Tamar Amit, Hailin Zheng, Mati Fridkin, Orly Weinreb, Silvia Mandel and Moussa B.H. Youdim


DOI: 10.2174/156720507781788927




Alpha-Secretase As a Therapeutic Target

, 4(4): 412 - 417

Falk Fahrenholz


DOI: 10.2174/156720507781788837




Memapsin 2 (Beta-Secretase) Inhibitor Drug, between Fantasy and Reality

, 4(4): 418 - 422

Arun K. Ghosh, Geoffrey Bilcer, Lin Hong, Gerald Koelsch and Jordan Tang


DOI: 10.2174/156720507781788864




The γ /η-Secretase-Derived APP Intracellular Domain Fragments Regulate p53

, 4(4): 423 - 426

Frederic Checler, Claire Sunyach, Raphaelle Pardossi-Piquard, Jean Sevalle, Bruno Vincent, Toshitaka Kawarai, Nadege Girardot, Peter St George-Hyslop and Cristine Alves da Costa


DOI: 10.2174/156720507781788945




Novel Aβ Immunogens: Is Shorter Better?

, 4(4): 427 - 436

Cynthia A. Lemere, Marcel Maier, Ying Peng, Liying Jiang and Timothy J. Seabrook


DOI: 10.2174/156720507781788800




A Novel Immunotherapy for Alzheimers Disease: Antibodies against the β-Secretase Cleavage Site of APP

, 4(4): 437 - 445

Michal Arbel and Beka Solomon


DOI: 10.2174/156720507781788792




Is alpha-Synuclein Pathology a Target for Treatment of Neurodegenerative Disorders?

, 4(4): 446 - 457

M. Windisch, H. J. Wolf, B. Hutter-Paier, A. Hofmeister and R. Wronski


DOI: 10.2174/156720507781788783




Lessons from Darwin: 21st Century Designs for Clinical Trials

, 4(4): 458 - 467

Robert E. Becker


DOI: 10.2174/156720507781788828




Drug Trials in Dementia: Challenging Ethical Dilemmas

, 4(4): 468 - 472

Amos D. Korczyn


DOI: 10.2174/156720507781788909




Alzhemed: A Potential Treatment for Alzheimers Disease

, 4(4): 473 - 478

Paul S. Aisen, Serge Gauthier, Bruno Vellas, Richard Briand, Daniel Saumier, Julie Laurin and Denis Garceau


DOI: 10.2174/156720507781788882




Pharmacogenetic Aspects of Therapy with Cholinesterase Inhibitors: The Role of CYP2D6 in Alzheimers Disease Pharmacogenetics

, 4(4): 479 - 500

Ramon Cacabelos, Ruth Llovo, Carmen Fraile and Lucia Fernandez-Novoa


DOI: 10.2174/156720507781788846




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