Current Alzheimer Research, Volume 2 - Number 2

Introduction: Advancing Drug Discovery for Alzheimers Disease [ ISOA Fifth Annual Investigators Meeting “Recent Advances in Drug Discovery and Development for Alzheimers Disease” Sponsored by Elan Pharmaceuticals Inc, The Graphic Expression, Glaxo Smith Kline Pharmaceuticals, Neurochem Inc, Pfizer Inc. (Guest Editors: Howard M. Fillit and Lorenzo M. Refolo)]

, 2(2): 105 - 107

Howard M. Fillit and Lorenzo M. Refolo

DOI: 10.2174/1567205053585729

Development of Novel Amyloid Imaging Agents Based Upon Thioflavin S

, 2(2): 109 - 114

Jingjun Wei, Chunying Wu, David Lankin, Anil Gulrati, Tibor Valyi-Nagy, Elizabeth Cochran, Victor W. Pike, Alan Kozikowski and Yanming Wang

DOI: 10.2174/1567205053585864

Functional Connectivity in Elderly Controls and AD Patients Using Resting State fMRI: A Pilot Study

, 2(2): 115 - 116

Serge Rombouts and Philip Scheltens

DOI: 10.2174/1567205053585783

Towards Practical Cognitive Assessment for Detection of Early Dementia: A 30-Minute Computerized Battery Discriminates as Well as Longer Testing

, 2(2): 117 - 124

Glen M. Doniger, David M. Zucker, Avraham Schweiger, Tzvi Dwolatzky, Howard Chertkow, Howard Crystal and Ely S. Simon

DOI: 10.2174/1567205053585792

C-1073 (Mifepristone) in the Adjunctive Treatment of Alzheimers Disease

, 2(2): 125 - 129

Charles DeBattista and Joseph Belanoff

DOI: 10.2174/1567205053585954

A Potential Role of the Curry Spice Curcumin in Alzheimers Disease

, 2(2): 131 - 136

John M. Ringman, Sally A. Frautschy, Gregory M. Cole, Donna L. Masterman and Jeffrey L. Cummings

DOI: 10.2174/1567205053585882

Synaptic Fatigue is More Pronounced in the APP/PS1 Transgenic Mouse Model of Alzheimers Disease

, 2(2): 137 - 140

Hong Zhang, Bing Gong, Shumin Liu, Mauro Fa, Ipe Ninan, Agnieszka Staniszewski and Ottavio Arancio

DOI: 10.2174/1567205053585936

Functional Central Nicotinic Acetylcholine Receptor Antagonism by Systemic Administration of Tinuvin 770 (BTMPS)

, 2(2): 141 - 147

John H. Graham, Roger L. Papke and Jerry J. Buccafusco

DOI: 10.2174/1567205053585747

The Expression of Activity-Dependent Neuroprotective Protein (ADNP) is Regulated by Brain Damage and Treatment of Mice with the ADNP Derived Peptide, NAP, Reduces the Severity of Traumatic Head Injury

, 2(2): 149 - 153

Illana Gozes, Roy Zaltzman, Janet Hauser, Douglas E. Brenneman, Esther Shohami and Joanna M. Hill

DOI: 10.2174/1567205053585873

The Molecular Basis of Memantine Action in Alzheimers Disease and Other Neurologic Disorders: Low-affinity, Uncompetitive Antagonism

, 2(2): 155 - 165

Stuart A. Lipton

DOI: 10.2174/1567205053585846

Neurotrophin Receptor-Based Strategies for Alzheimers Disease

, 2(2): 167 - 169

Frank M. Longo and Stephen M. Massa

DOI: 10.2174/1567205053585819

Nitric Oxide Mimetic Molecules as Therapeutic Agents in Alzheimers Disease

, 2(2): 171 - 182

Gregory R.J. Thatcher, Brian M. Bennett and James N. Reynolds

DOI: 10.2174/1567205053585945

Small Molecule TGF-beta Mimetics as Potential Neuroprotective Factors

, 2(2): 183 - 186

Hui Zhang, Kun Zou, Ina Tesseur and Tony Wyss-Coray

DOI: 10.2174/1567205053585756

Role of Fractalkine (CX3CL1) in Regulating Neuron-Microglia Interactions: Development of Viral-Based CX3CR1 Antagonists

, 2(2): 187 - 189

Wolfgang J. Streit, Christopher N. Davis and Jeffrey K. Harrison

DOI: 10.2174/1567205053585765

Extracellular Superoxide Dismutase (EC-SOD) Quenches Free Radicals and Attenuates Age-Related Cognitive Decline: Opportunities for Novel Drug Development in Aging

, 2(2): 191 - 196

Edward D. Levin

DOI: 10.2174/1567205053585710

Validation of the Neuroinflammation Cycle as a Drug Discovery Target Using Integrative Chemical Biology and Lead Compound Development with an Alzheimers Disease-Related Mouse Model

, 2(2): 197 - 205

Wenhui Hu, Hantamalala Ralay Ranaivo, Jeffrey M. Craft, Linda J. Van Eldik and D. Martin Watterson

DOI: 10.2174/1567205053585828

Analysis of Genetic Polymorphisms in Acetylcholinesterase as Reflected in Different Populations

, 2(2): 207 - 218

Yehudit Hasin, Nili Avidan, Dani Bercovich, Amos D. Korczyn, Israel Silman, Jacques S. Beckmann and Joel L. Sussman

DOI: 10.2174/1567205053585909

Screening for Inhibitors of Tau Polymerization

, 2(2): 219 - 226

Marcus Pickhardt, Martin von Bergen, Zuzana Gazova, Antje Hascher, Jacek Biernat, Eva-Maria Mandelkow and Eckhard Mandelkow

DOI: 10.2174/1567205053585891

Cytoskeletal Integrity as a Drug Target

, 2(2): 227 - 229

M. L. Michaelis, K. I. Seyb and S. Ansar

DOI: 10.2174/1567205053585837

Development of a High Throughput Drug Screening Assay for the Detection of Changes in Tau Levels - Proof of Concept with HSP90 inhibitors

, 2(2): 231 - 238

Chad A. Dickey, Jason Eriksen, Adeela Kamal, Francis Burrows, Srinivas Kasibhatla, Christopher B. Eckman, Mike Hutton and Leonard Petrucelli

DOI: 10.2174/1567205053585927

Lentiviral Vector-Based Models of Amyloid Pathology: From Cells to Animals

, 2(2): 239 - 247

Laura Shaughnessy, Mary Beth Thomas, John Wakefield, Beth Chamblin, Ayyappan Nair, Frank Koentgen and Ram Ramabhadran

DOI: 10.2174/1567205053585963

Pilot Study of the Reducing Effect on Amyloidosis In Vivo by Three FDA Pre-Approved Drugs Via the Alzheimers APP 5Untranslated Region

, 2(2): 249 - 254

Stephanie Tucker, Michelle Ahl, Ashley Bush, David Westaway, Xudong Huang and Jack T. Rogers

DOI: 10.2174/1567205053585855

Drug Library Screen to Identify Compounds that Decrease Secreted Aβ from a Human Cell Line

, 2(2): 255 - 259

Enakshi Chakrabarti and Jonathan D. Smith

DOI: 10.2174/1567205053585738

Recent Developments on the Studies of Human Memapsin 2 (β-Secretase)

, 2(2): 261 - 264

Jordan Tang, Xiangyang He, Xianping Huang and Lin Hong

DOI: 10.2174/1567205053585800

An Aβ Sequestration Approach Using Non-Antibody Aβ Binding Agents

, 2(2): 265 - 268

Yasuji Matsuoka, Li Shao, Manik Debnath, John LaFrancois, Amanda Becker, Audrey Gray, Paul Aisen, Chester Mathis, William Klunk and Karen Duff

DOI: 10.2174/1567205053585774

LRP-Mediated Clearance of Aβ is Inhibited by KPI-Containing Isoforms of APP

, 2(2): 269 - 273

Robert D. Moir and Rudolph E. Tanzi

DOI: 10.2174/1567205053585918

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